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The Wnt/beta-catenin pathway: master regulator of liver zonation?


Reference:

Burke, Z. D. and Tosh, D., 2006. The Wnt/beta-catenin pathway: master regulator of liver zonation? Bioessays, 28 (11), pp. 1072-1077.

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Official URL:

http://dx.doi.org/10.1002/bies.20485

Abstract

The liver contains two systems for the removal of ammonia-the urea cycle and the enzyme glutamine synthetase. These systems are expressed in a complementary fashion in two distinct populations of hepatocytes, referred to as periportal and perivenous cells. One of the unresolved problems in hepatology has been to elucidate the molecular mechanisms responsible for induction and maintenance of the cellular heterogeneity for ammonia detoxification. There is now a potential molecular explanation for the zonation of the urea cycle and glutamine synthetase based on the Wnt/beta-catenin pathway.

Details

Item Type Articles
CreatorsBurke, Z. D.and Tosh, D.
DOI10.1002/bies.20485
DepartmentsFaculty of Science > Biology & Biochemistry
RefereedYes
StatusPublished
ID Code3722

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