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Killing bacteria within biofilms by sustained release of tetracycline from triple-layered electrospun micro/nanofibre matrices of polycaprolactone and poly(ethylene-co-vinyl acetate)


Reference:

Alhusein, N., De Bank, P. A., Blagbrough, I. S. and Bolhuis, A., 2013. Killing bacteria within biofilms by sustained release of tetracycline from triple-layered electrospun micro/nanofibre matrices of polycaprolactone and poly(ethylene-co-vinyl acetate). Drug Delivery and Translational Research, 3 (6), pp. 531-541.

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    Official URL:

    http://dx.doi.org/10.1007/s13346-013-0164-9

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    Abstract

    We report the controlled release of the antibiotic tetracycline (tet) HCl from a triple-layered electrospun matrix consisting of a central layer of poly(ethylene-co-vinyl acetate (PEVA) sandwiched between outer layers of poly-ε-caprolactone (PCL). These micro/nanofibre layers with tet successfully encapsulated (essentially quantitatively at 3 and 5 % w/w) in each layer, efficiently inhibited the growth of a panel of bacteria, including clinical isolates, as shown by a modified Kirby–Bauer disc assay. Furthermore, they demonstrated high biological activity in increasingly complex models of biofilm formation (models that are moving closer to the situation in a wound) by stopping biofilm formation, by killing preformed biofilms and killing mature, dense biofilm colonies of Staphylococcus aureus MRSA252. Tet is clinically useful with potential applications in wound healing and especially in complicated skin and skin-structure infections; electrospinning provides good encapsulation efficiency of tet within PCL/PEVA/PCL polymers in micro/nanofibre layers which display sustained antibiotic release in formulations that are anti-biofilm.

    Details

    Item Type Articles
    CreatorsAlhusein, N., De Bank, P. A., Blagbrough, I. S. and Bolhuis, A.
    DOI10.1007/s13346-013-0164-9
    Related URLs
    URLURL Type
    http://www.scopus.com/inward/record.url?scp=84887210859&partnerID=8YFLogxKUNSPECIFIED
    DepartmentsFaculty of Science > Pharmacy & Pharmacology
    Research CentresCentre for Regenerative Medicine
    Centre for Extremophile Research (CER)
    Publisher Statement2013c_DDTR_biofilms_accepted_manuscript.pdf: The final publication is available at Springer via http://dx.doi.org/10.1007/s13346-013-0164-9
    RefereedYes
    StatusPublished
    ID Code37273

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