Why doesn't nicotinic ACh receptor immunoreactivity knock out?
Jones, I. W. and Wonnacott, S., 2005. Why doesn't nicotinic ACh receptor immunoreactivity knock out? Trends in Neurosciences, 28 (7), pp. 343-345.
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Immunochemical analyses of protein expression and localization rely on the specificity of primary immunoreagents. A recent report, using transgenic mice, casts doubt on the specificity of three antibodies commonly used to immunolocalize alpha 7 nicotinic ACh receptors. These data highlight the conundrum facing histologists - how 'real' is the labelling they see?
|Creators||Jones, I. W.and Wonnacott, S.|
|Departments||Faculty of Science > Biology & Biochemistry|
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