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Why doesn't nicotinic ACh receptor immunoreactivity knock out?


Reference:

Jones, I. W. and Wonnacott, S., 2005. Why doesn't nicotinic ACh receptor immunoreactivity knock out? Trends in Neurosciences, 28 (7), pp. 343-345.

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Official URL:

http://dx.doi.org/10.1016/j.tins.2005.04.010

Abstract

Immunochemical analyses of protein expression and localization rely on the specificity of primary immunoreagents. A recent report, using transgenic mice, casts doubt on the specificity of three antibodies commonly used to immunolocalize alpha 7 nicotinic ACh receptors. These data highlight the conundrum facing histologists - how 'real' is the labelling they see?

Details

Item Type Articles
CreatorsJones, I. W.and Wonnacott, S.
DOI10.1016/j.tins.2005.04.010
DepartmentsFaculty of Science > Biology & Biochemistry
RefereedYes
StatusPublished
ID Code3810

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