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Human antisense genes have unusually short introns: evidence for selection for rapid transcription


Reference:

Chen, J. J., Sun, M., Hurst, L. D., Carmichael, G. G. and Rowley, J. D., 2005. Human antisense genes have unusually short introns: evidence for selection for rapid transcription. Trends in Genetics, 21 (4), pp. 203-207.

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Abstract

We suggest that small introns are favored in genes requiring a minimal response time ('nimble' genes), and that antisense genes might be prime candidates for such nimble genes. In this article, we show that antisense genes have significantly shorter introns than all other gene categories, which supports our proposal that the short introns of antisense genes might be functionally important and integrally related to their potential role in efficient gene regulation.

Details

Item Type Articles
CreatorsChen, J. J., Sun, M., Hurst, L. D., Carmichael, G. G. and Rowley, J. D.
DOI10.1016/j.tig.2005.02.003
DepartmentsFaculty of Science > Biology & Biochemistry
RefereedYes
StatusPublished
ID Code3853
Additional InformationID number: ISI:000228286300003

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