Dirofilaria immitis: identification of a novel ligand-gated ion channel-related polypeptide


Yates, D. M. and Wolstenholme, A. J., 2004. Dirofilaria immitis: identification of a novel ligand-gated ion channel-related polypeptide. Experimental Parasitology, 108 Nov-Dec (3-4), pp. 182-185.

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We have isolated a cDNA from Dirofilaria immitis that encodes a predicted ion channel subunit, Di-LGR-1. Secondary structure predictions and database searches reveal that Di-LGR-1 is distantly related to ligand-gated anion channels, such as the GABA(A) receptors, though there are marked differences in the sequences of the putative channel forming regions. Di-LGR-1 has 52%. sequence identity to the Caenorhabditis elegans predicted polypeptide, T27A1.4: neighbour-joining trees show that these two polypeptides are the most divergent members of the nematode ligand-gated anion channel family. No close homologues are present in vertebrates, suggesting that their function may be specific to nematodes. RNAi experiments using a fragment of T27A1.4 with C elegans failed to reveal any obvious phenotype, so the function of these channels remains unknown. (C) 2004 Elsevier Inc. All rights reserved.


Item Type Articles
CreatorsYates, D. M.and Wolstenholme, A. J.
DepartmentsFaculty of Science > Biology & Biochemistry
ID Code3880
Additional InformationID number: ISI:000225933400013


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