Research

Genomic regionality in rates of evolution is not explained by clustering of genes of comparable expression profile


Reference:

Lercher, M. J., Chamary, J. V. and Hurst, L. D., 2004. Genomic regionality in rates of evolution is not explained by clustering of genes of comparable expression profile. Genome Research, 14 (6), pp. 1002-1013.

Related documents:

This repository does not currently have the full-text of this item.
You may be able to access a copy if URLs are provided below.

Abstract

In mammalian genomes, linked genes show similar rates of evolution, both at fourfold degenerate synonymous sites (K-4) and at nonsynonymous sites (K-A). Although it has been suggested that the local similarity in the synonymous Substitution rate is an artifact caused by the inclusion of disparately evolving gene pairs, we demonstrate here that this is not the case: after removal of disparately evolving genes, both (1) linked genes and (2) introns from the same gene have more similar silent Substitution rates than expected by chance. What causes the local similarity in both synonymous and nonsynonymous substitution rates? One class of hypotheses argues that both may be related to the observed clustering of genes of comparable expression profile. We investigate these hypotheses using substitution rates from both human-mouse and mouse-rat comparisons, and employing three different methods to assay expression parameters. Although we confirm a negative correlation of expression breadth with both K-4 and K-A, we find no evidence that clustering of similarly expressed genes explains the clustering of genes of comparable substitution rates. If gene expression is not responsible, what about other Causes? At least in the human-mouse comparison, the local similarity in K-A can be explained by the covariation of K-A and K-4. As regards K-4, Our results appear consistent with the notion that local similarity is due to processes associated with melotic recombination.

Details

Item Type Articles
CreatorsLercher, M. J., Chamary, J. V. and Hurst, L. D.
DOI10.1101/gr.1597404
DepartmentsFaculty of Science > Biology & Biochemistry
RefereedYes
StatusPublished
ID Code3949
Additional InformationID number: ISI:000221852400002

Export

Actions (login required)

View Item