The evolutionary dynamics of eukaryotic gene order
Hurst, L. D., Pal, C. and Lercher, M. J., 2004. The evolutionary dynamics of eukaryotic gene order. Nature Reviews Genetics, 5 (4), pp. 299-310.
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In eukaryotes, unlike in bacteria, gene order has typically been assumed to be random. However, the first statistically rigorous analyses of complete genomes, together with the availability of abundant gene-expression data, have forced a paradigm shift: in every complete eukaryotic genome that has been analysed so far, gene order is not random. It seems that genes that have similar and/or coordinated expression are often clustered. Here, we review this evidence and ask how such clusters evolve and how this relates to mechanisms that control gene expression.
|Creators||Hurst, L. D., Pal, C. and Lercher, M. J.|
|Departments||Faculty of Science > Biology & Biochemistry|
|Additional Information||ID number: ISI:000220559200015|
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