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Biological inorganic and bioinorganic chemistry of neurodegeneration based on prion and Alzheimer diseases


Reference:

Brown, D. R. and Kozlowski, H., 2004. Biological inorganic and bioinorganic chemistry of neurodegeneration based on prion and Alzheimer diseases. Dalton Transactions, 2004, pp. 1907-1917.

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Official URL:

http://dx.doi.org/10.1039/b401985g

Abstract

A change of the prion protein conformation results in a class of neurodegenerative diseases called the transmissible spongiform encephalopathies (like mad cow and Creutzfeld–Jakob diseases). The function of the normal prion protein is unknown, although much of recent research demonstrates the it may be a copper binding protein selective for Cu(II). Amyloid precursor protein (APP) releases the 39–42 amino acid peptide, a major constituent of the deposit in plaques of Alzheimer disease brain. Also APP is a metal binding protein, including copper ions. The link between copper and both proteins may provide insight into the role of metals in neurodegenerative pathologies.

Details

Item Type Articles
CreatorsBrown, D. R.and Kozlowski, H.
DOI10.1039/b401985g
DepartmentsFaculty of Science > Biology & Biochemistry
RefereedYes
StatusPublished
ID Code4005
Additional InformationID number: ISI:000222311700001

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