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A hydrazide-anchored dendron scaffold for chemoselective ligation strategies


Reference:

O'Donovan, L. and De Bank, P., 2014. A hydrazide-anchored dendron scaffold for chemoselective ligation strategies. Organic and Biomolecular Chemistry, 12 (37), pp. 7290-7296.

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    Official URL:

    http://dx.doi.org/10.1039/C4OB00870G

    Abstract

    Chemoselective ligation, including “click” chemistry, has found wide utility in general synthetic strategies and the specific modification of polymers and biomolecules. This has resulted in a number of applications of such approaches, particularly in the biomedical area, including diagnostic imaging and drug delivery. However, tools to chemoselectively decorate target molecules with multiple copies of a particular drug, ligand or label are lacking. We describe the design and synthesis of a hydrazide-anchored dendron scaffold for chemoselective ligation to carbonyl moieties, and demonstrate its use in the modification of aldehyde-rich surfaces with the RGD integrin-binding ligand.

    Details

    Item Type Articles
    CreatorsO'Donovan, L.and De Bank, P.
    DOI10.1039/C4OB00870G
    DepartmentsFaculty of Science > Pharmacy & Pharmacology
    Research CentresCentre for Regenerative Medicine
    RefereedYes
    StatusPublished
    ID Code40461

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