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How cells change their phenotype


Reference:

Tosh, D. and Slack, J. M. W., 2002. How cells change their phenotype. Nature Reviews Molecular Cell Biology, 3 (3), pp. 187-194.

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Official URL:

http://dx.doi.org/10.1038/nrm761

Abstract

Recent attention has focused on the remarkable ability of adult stem cells to produce differentiated cells from embryologically unrelated tissues. This phenomenon is an example of metaplasia and shows that embryological commitments can be reversed or erased under certain circumstances. In some cases, even fully differentiated cells can change their phenotype (transdifferentiation). This review examines recently discovered cases of metaplasia, and speculates on the potential molecular and cellular mechanisms that underlie the switches, and their significance to developmental biology and medicine.

Details

Item Type Articles
CreatorsTosh, D.and Slack, J. M. W.
DOI10.1038/nrm761
DepartmentsFaculty of Science > Biology & Biochemistry
RefereedYes
StatusPublished
ID Code4164

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