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The exclusion problem in seasonally forced epidemiological systems


Reference:

Greenman, J. V. and Adams, B., 2015. The exclusion problem in seasonally forced epidemiological systems. Journal of Theoretical Biology, 367, pp. 49-60.

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    Official URL:

    http://dx.doi.org/10.1016/j.jtbi.2014.11.011

    Abstract

    The pathogen exclusion problem is the problem of finding control measures that will exclude a pathogen from an ecological system or, if the system is already disease-free, maintain it in that state. To solve this problem we work within a holistic control theory framework which is consistent with conventional theory for simple systems (where there is no external forcing and constant controls) and seamlessly generalises to complex systems that are subject to multiple component seasonal forcing and targeted variable controls. We develop, customise and integrate a range of numerical and algebraic procedures that provide a coherent methodology powerful enough to solve the exclusion problem in the general case. An important aspect of our solution procedure is its two-stage structure which reveals the epidemiological consequences of the controls used for exclusion. This information augments technical and economic considerations in the design of an acceptable exclusion strategy. Our methodology is used in two examples to show how time-varying controls can exploit the interference and reinforcement created by the external and internal lag structure and encourage the system to ‘take over’ some of the exclusion effort. On–off control switching, resonant amplification, optimality and controllability are important issues that emerge in the discussion.

    Details

    Item Type Articles
    CreatorsGreenman, J. V.and Adams, B.
    DOI10.1016/j.jtbi.2014.11.011
    DepartmentsFaculty of Science > Mathematical Sciences
    Research CentresCentre for Mathematical Biology
    RefereedYes
    StatusPublished
    ID Code42823

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