Evidence for purifying selection acting on silent sites in BRCA1


Hurst, L. D. and Pal, C., 2001. Evidence for purifying selection acting on silent sites in BRCA1. Trends in Genetics, 17 (2), pp. 62-65.

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In mammals, it is usually assumed that selection cannot be strong enough to act on nucleotide mutations that do not cause a change at the protein level (i.e. 'silent' or 'synonymous' mutations). Here we report the results of a molecular evolutionary analysis of BRCA1. We find a repeatable pronounced peak in the ratio of nonsynonymous to synonymous substitutions between codons 200-300. Unusually,this peak is caused by a plummet in the silent-site rate of evolution. The most parsimonious interpretation of these data is that purifying selection is acting on silent sites.


Item Type Articles
CreatorsHurst, L. D.and Pal, C.
DepartmentsFaculty of Science > Biology & Biochemistry
ID Code4344
Additional InformationID number: ISI:000168718000004


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