Synthesis of biotinylated bis(D-glucose) derivatives for glucose transporter photoaffinity labelling

Reference:

Hashimoto, M., Hatanaka, Y., Yang, J., Dhesi, J. and Holman, G. D., 2001. Synthesis of biotinylated bis(D-glucose) derivatives for glucose transporter photoaffinity labelling. Carbohydrate Research, 331 (2), pp. 119-127.

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Abstract

New diazirine based bis-glucose derivatives for tagging glucose transporters have been synthesised. These included two biotinylated compounds linked either by an aminocaproate or by a cleavable dithiol link. These compounds have been derivatised via a key skeleton compound that can be easily used for introduction of additional tags. Studies on the erythrocyte glucose transporter (GLUT1) and the insulin-stimulated adipose cell transporter (GLUT-I) have revealed the biotinylated photoreactive bis-glucose compounds are effective labelling reagents, (C) 2001 Elsevier Science Ltd. All rights reserved.

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