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Synthesis of biotinylated bis(D-glucose) derivatives for glucose transporter photoaffinity labelling


Reference:

Hashimoto, M., Hatanaka, Y., Yang, J., Dhesi, J. and Holman, G. D., 2001. Synthesis of biotinylated bis(D-glucose) derivatives for glucose transporter photoaffinity labelling. Carbohydrate Research, 331 (2), pp. 119-127.

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Abstract

New diazirine based bis-glucose derivatives for tagging glucose transporters have been synthesised. These included two biotinylated compounds linked either by an aminocaproate or by a cleavable dithiol link. These compounds have been derivatised via a key skeleton compound that can be easily used for introduction of additional tags. Studies on the erythrocyte glucose transporter (GLUT1) and the insulin-stimulated adipose cell transporter (GLUT-I) have revealed the biotinylated photoreactive bis-glucose compounds are effective labelling reagents, (C) 2001 Elsevier Science Ltd. All rights reserved.

Details

Item Type Articles
CreatorsHashimoto, M., Hatanaka, Y., Yang, J., Dhesi, J. and Holman, G. D.
DepartmentsFaculty of Science > Biology & Biochemistry
RefereedYes
StatusPublished
ID Code4355
Additional InformationID number: ISI:000167801900002

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