Simple protocols for NMR analysis of the enantiomeric purity of chiral diols
Kelly, A. M., Perez-Fuertes, Y., Fossey, J. S., Yeste, S. L., Bull, S. D. and James, T. D., 2008. Simple protocols for NMR analysis of the enantiomeric purity of chiral diols. Nature Protocols, 3 (2), pp. 215-219.
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A three-component chiral derivatization protocol for determining the enantiopurity of chiral diols by H-1 NMR spectroscopic analysis is described here. The present approach involves the derivatization of 1,2-1,3- and 1,4-diols with 2-formylphenylboronic acid and enantiopure alpha-methylbenzylamine. This method affords a mixture of diastereoisomeric iminoboronate esters whose ratio can be determined by integration of well-resolved diastereotopic resonances in their H-1 NMR spectra, thus enabling the determination of the enantiopurity of the parent diol. The protocol as described takes less than 90 min to complete.
|Creators||Kelly, A. M., Perez-Fuertes, Y., Fossey, J. S., Yeste, S. L., Bull, S. D. and James, T. D.|
|Departments||Faculty of Science > Chemistry|
|Additional Information||ID number: ISI:000254137000008|
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