Research

Neural crest:origin, migration and differentiation


Reference:

Kelsh, R. N. and Erickson, C. A., 2013. Neural crest:origin, migration and differentiation. eLS

Related documents:

This repository does not currently have the full-text of this item.
You may be able to access a copy if URLs are provided below. (Contact Author)

Official URL:

http://dx.doi.org/10.1002/9780470015902.a0000786.pub2

Abstract

The neural crest is a population of cells that emigrates from the dorsal neural tube during early embryogenesis and migrates extensively to give rise to a myriad of cell types. Patterns of migration are controlled largely by extracellular cues in the environment. Neural crest cells are initially multipotent. Cell fate specification – the selection of an individual cell fate from all the possibilities available to a multipotent progenitor – is likely to involve a series of steps, in which cells become progressively restricted to individual fates, a process that is likely to begin while still in the dorsal neural tube, but which then is usually completed during, or even after migration. Extracellular cues in the migratory and postmigratory environment act together with intrinsic transcription factors to ensure that specific fates are chosen. Together, these result in expression of one or more transcription factors that activate or cement a gene regulatory network that establishes and maintains expression of the differentiated phenotype.

Details

Item Type Articles
CreatorsKelsh, R. N.and Erickson, C. A.
DOI10.1002/9780470015902.a0000786.pub2
DepartmentsFaculty of Science > Biology & Biochemistry
Research CentresCentre for Regenerative Medicine
EPSRC Centre for Doctoral Training in Statistical Mathematics (SAMBa)
Centre for Mathematical Biology
RefereedYes
StatusPublished
ID Code45577

Export

Actions (login required)

View Item