A thermostable aldolase for the synthesis of 3-deoxy-2-ulosonic acids
Lamble, H. J., Royer, S. F., Hough, D. W., Danson, M. J., Taylor, G. L. and Bull, S. D., 2007. A thermostable aldolase for the synthesis of 3-deoxy-2-ulosonic acids. Advanced Synthesis & Catalysis, 349 (6), pp. 817-821.
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A stereochemically promiscuous 2-keto3-deoxygluconate aldolase has been used as an efficient biocatalyst to catalyse the aldol reaction of pyruvate with C-3- and C-4-aldoses to afford syn- and anti-3-deoxy-2-ulosonic acids in poor to good de. A continuous flow bioreactor containing immobilised aldolase has been developed that enables gram quantities of C-6- and C-7-3-deoxyhept-2-ulosonic acids to be produced in an efficient manner.
|Creators||Lamble, H. J., Royer, S. F., Hough, D. W., Danson, M. J., Taylor, G. L. and Bull, S. D.|
|Departments||Faculty of Science > Chemistry|
Faculty of Science > Biology & Biochemistry
|Additional Information||ID number: ISI:000246040000006|
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