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A thermostable aldolase for the synthesis of 3-deoxy-2-ulosonic acids


Reference:

Lamble, H. J., Royer, S. F., Hough, D. W., Danson, M. J., Taylor, G. L. and Bull, S. D., 2007. A thermostable aldolase for the synthesis of 3-deoxy-2-ulosonic acids. Advanced Synthesis & Catalysis, 349 (6), pp. 817-821.

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Official URL:

http://dx.doi.org/10.1002/adsc.200600520

Abstract

A stereochemically promiscuous 2-keto3-deoxygluconate aldolase has been used as an efficient biocatalyst to catalyse the aldol reaction of pyruvate with C-3- and C-4-aldoses to afford syn- and anti-3-deoxy-2-ulosonic acids in poor to good de. A continuous flow bioreactor containing immobilised aldolase has been developed that enables gram quantities of C-6- and C-7-3-deoxyhept-2-ulosonic acids to be produced in an efficient manner.

Details

Item Type Articles
CreatorsLamble, H. J., Royer, S. F., Hough, D. W., Danson, M. J., Taylor, G. L. and Bull, S. D.
DOI10.1002/adsc.200600520
DepartmentsFaculty of Science > Chemistry
Faculty of Science > Biology & Biochemistry
RefereedYes
StatusPublished
ID Code4580
Additional InformationID number: ISI:000246040000006

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