Rhodium-catalyzed conjugate addition-enantioselective protonation: The synthesis of alpha,alpha'-dibenzyl esters

Reference:

Frost, C. G., Penrose, S. D., Lambshead, K., Raithby, P. R., Warren, J. E. and GleaveO, R., 2007. Rhodium-catalyzed conjugate addition-enantioselective protonation: The synthesis of alpha,alpha'-dibenzyl esters. Organic Letters, 9 (11), pp. 2119-2122.

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Official URL:

http://dx.doi.org/10.1021/ol070603g

Abstract

alpha-Benzyl acrylates, which are conveniently prepared from the corresponding aldehydes, can be employed as substrates in a tandem rhodium-catalyzed conjugate addition-enantioselective protonation protocol to afford enantiomerically enriched alpha, alpha'-dibenzyl esters. The synergistic effect of enantiopure ligand and proton source was rapidly optimized with use of a microwave reactor.

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