Simple protocol for NMR analysis of the enantiomeric purity of diols
Reference:
Kelly, A. M., Perez-Fuertes, Y., Arimori, S., Bull, S. D. and James, T. D., 2006. Simple protocol for NMR analysis of the enantiomeric purity of diols. Organic Letters, 8 (10), pp. 1971-1974.
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Abstract
A practically simple three-component chiral derivatization protocol for determining the enantiopurity of chiral 1,2-, 1,3-, and 1,4-diols by H-1 NMR spectroscopic analysis is described. The method involves treatment with 2-formylphenylboronic acid and enantiopure alpha-methylbenzylamine to afford a mixture of diastereolsomeric iminoboronate esters whose ratio is an accurate reflection of the enantiopurity of the parent diol.
Details
| Item Type | Articles |
| Creators | Kelly, A. M., Perez-Fuertes, Y., Arimori, S., Bull, S. D. and James, T. D. |
| DOI | 10.1021/ol0602351 |
| Departments | Faculty of Science > Chemistry |
| Refereed | Yes |
| Status | Published |
| ID Code | 4694 |
| Additional Information | ID number: ISI:000237420200003 |
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