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Informing the management of pediatric heart transplant waiting lists:complementary use of simulation and analytical modeling


Reference:

Crowe, S., Vasilakis, C., Gallivan, S., Bull, C. and Fenton, M., 2016. Informing the management of pediatric heart transplant waiting lists:complementary use of simulation and analytical modeling. In: Proceedings of the 2015 Winter Simulation Conference. Piscataway, U. S. A.: IEEE Press, pp. 1654-1665.

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    Official URL:

    http://dx.doi.org/10.1109/WSC.2015.7408285

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    Abstract

    A clinical intervention known as 'bridging to transplant', in which a patient is placed on life-sustaining support, can be used to increase the chance of an individual surviving until a donor heart becomes available. However, the impact of this on other patients on the waiting list and the wider implications for the resourcing of cardiac units remains unclear. Initial insights have previously been generated using a birth-death queuing model, but this model did not incorporate realistic donor-recipient assumptions regarding blood type and weight. Here we report on a complementary simulation study that examined how estimates from the analytical model might change if organ matching were better taken into account. Simulation results showed that system metrics changed substantially when recipient donor compatibility was modelled. However, the effects of blood type compatibility were countered by that of weight compatibility and when combined, these have a relatively small net effect on results.

    Details

    Item Type Book Sections
    CreatorsCrowe, S., Vasilakis, C., Gallivan, S., Bull, C. and Fenton, M.
    DOI10.1109/WSC.2015.7408285
    Related URLs
    URLURL Type
    http://www.scopus.com/inward/record.url?scp=84962863009&partnerID=8YFLogxKUNSPECIFIED
    DepartmentsSchool of Management
    Research Centres & Institutes > Institute for Policy Research
    Research CentresEPSRC Centre for Doctoral Training in Statistical Mathematics (SAMBa)
    Publisher Statementinv150s3_file2_Revised2.pdf: © 2015 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other users, including reprinting/ republishing this material for advertising or promotional purposes, creating new collective works for resale or redistribution to servers or lists, or reuse of any copyrighted components of this work in other works.
    StatusPublished
    ID Code47204

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