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Promiscuity in the part-phosphorylative Entner-Doudoroff pathway of the archaeon Sulfolobus solfataricus


Reference:

Lamble, H. J., Theodossis, A., Milburn, C. C., Taylor, G. L., Bull, S., Hough, D. W. and Danson, M. J., 2005. Promiscuity in the part-phosphorylative Entner-Doudoroff pathway of the archaeon Sulfolobus solfataricus. FEBS Letters, 579 (30), pp. 6865-6869.

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Official URL:

http://dx.doi.org/10.1016/j.febslet.2005.11.028

Abstract

The hyperthermophilic archaeon Sulfolobus solfataricus metabolises glucose and galactose by a 'promiscuous' non-phosphorylative variant of the Entner-Doudoroff pathway, in which a series of enzymes have sufficient substrate promiscuity to permit the metabolism of both sugars. Recently, it has been proposed that the part-phosphorylative Entner-Doudoroff pathway occurs in parallel in S. solfataricus as an alternative route for glucose metabolism. In this report we demonstrate, by in vitro kinetic studies of D-2-keto-3-deoxygluconate (KDG) kinase and KDG aldolase, that the part-phosphorylative pathway in S. solfataricus is also promiscuous for the metabolism of both glucose and galactose. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

Details

Item Type Articles
CreatorsLamble, H. J., Theodossis, A., Milburn, C. C., Taylor, G. L., Bull, S., Hough, D. W. and Danson, M. J.
DOI10.1016/j.febslet.2005.11.028
DepartmentsFaculty of Science > Chemistry
Faculty of Science > Biology & Biochemistry
Research CentresCentre for Sustainable Chemical Technologies
Centre for Extremophile Research (CER)
RefereedYes
StatusPublished
ID Code4793

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