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A practical synthesis of enantiopure (S)-4-(4-hydroxybenzyl)-oxazolidin-2-one


Reference:

Green, R., Taylor, P. J. M., Bull, S. D., James, T. D., Mahon, M. F. and Merritt, A. T., 2003. A practical synthesis of enantiopure (S)-4-(4-hydroxybenzyl)-oxazolidin-2-one. Tetrahedron: Asymmetry, 14 (17), pp. 2619-2623.

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Abstract

A high yielding four-step synthesis of enantiopure 4-(4-hydroxybenzyl)-oxazolidin-2-one (S)-1 from N-Boc-L-tyrosine is described. (S)-1 is a key intermediate for the preparation of a number of polymer supported Evans' oxazolidin-2-ones that have been employed previously for solid supported asymmetric synthesis. (C) 2003 Elsevier Ltd. All rights reserved.

Details

Item Type Articles
CreatorsGreen, R., Taylor, P. J. M., Bull, S. D., James, T. D., Mahon, M. F. and Merritt, A. T.
DOI10.1016/s0957-4166(03)00482-8
DepartmentsFaculty of Science > Chemistry
RefereedYes
StatusPublished
ID Code5019
Additional InformationID number: ISI:000185311200020

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