Studies towards the total synthesis of cycloaraneosene and ophiobolin M: A general strategy for the construction of the 5-8 bicyclic ring system
Reference:
Ruprah, P. K., Cros, J. P., Pease, J. E., Whittingham, W. G. and Williams, J. M. J., 2002. Studies towards the total synthesis of cycloaraneosene and ophiobolin M: A general strategy for the construction of the 5-8 bicyclic ring system. European Journal of Organic Chemistry
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Abstract
The synthesis of the core unit of cycloaraneosene and ophiobolin M has been investigated, following a general strategy applicable to both 5-8 bicyclic systems. The synthetic strategy includes a ring-closing metathesis reaction to generate the central eight-membered ring as well as a palladium-mediated coupling of a Grignard reagent to introduce the exocyclic side-chain. The stereochemistry of the ring junction is also discussed and moderate diastereoselectivity has been achieved. (C) Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002.
Details
| Item Type | Articles |
| Creators | Ruprah, P. K., Cros, J. P., Pease, J. E., Whittingham, W. G. and Williams, J. M. J. |
| Departments | Faculty of Science > Chemistry |
| Refereed | Yes |
| Status | Published |
| ID Code | 5094 |
| Additional Information | ID number: ISI:000178079100008 |
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