Research

Ibuprofen delivery into and through the skin from novel oxidized cellulose-based gels and conventional topical formulations


Reference:

Celebi, D., Edler, K., Scott, J. and Guy, R., 2016. Ibuprofen delivery into and through the skin from novel oxidized cellulose-based gels and conventional topical formulations. International Journal of Pharmaceutics, 514, pp. 238-243.

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    Official URL:

    http://dx.doi.org/10.1016/j.ijpharm.2016.09.028

    Abstract

    The delivery of ibuprofen into and through the skin from novel formulations containing TEMPO-oxidized cellulose nanofibril-based (TOCN) gels was compared to that from two conventional and commercially available products. The gels were evaluated in-vitro (using both silicone membranes, and pig skin) and in-vivo in human volunteers. All gels showed consistent behaviour in a standard in vitro release test. The stratum corneum (SC) uptake and skin penetration of ibuprofen in vitro from the novel gels and the marketed formulations were generally comparable even though the drug loading in the TOCN-based vehicles was only 20% of that in the ‘reference’ products. In vivo, the new gels appeared to enhance drug uptake into the SC following a relatively short application time, again matching the performance of the commercial formulations. Taken together, the results of this research provide proof-of-concept for the idea that the sustainable, oxidised cellulose gels may provide more efficient drug delivery into and through the skin, thereby improving drug utilisation and reducing potential adverse effects when such formulations are applied chronically over large skin areas.

    Details

    Item Type Articles
    CreatorsCelebi, D., Edler, K., Scott, J. and Guy, R.
    DOI10.1016/j.ijpharm.2016.09.028
    DepartmentsFaculty of Science > Pharmacy & Pharmacology
    Faculty of Science > Chemistry
    Research CentresCentre for Sustainable Chemical Technologies
    EPSRC Centre for Doctoral Training in Statistical Mathematics (SAMBa)
    RefereedYes
    StatusPublished
    ID Code51348

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