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Macrophage Migration Inhibitory Factor is subjected to glucose modification and oxidation in Alzheimer's Disease


Reference:

Kassaar, O., Pereira Morais, M., Xu, S., Adam, E. L., Chamberlain, R. C., Jenkins, B., James, T., Francis, P. T., Ward, S., Williams, R. J. and Van Den Elsen, J., 2017. Macrophage Migration Inhibitory Factor is subjected to glucose modification and oxidation in Alzheimer's Disease. Scientific Reports, 7, 42874.

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Official URL:

https://doi.org/10.1038/srep42874

Abstract

Glucose and glucose metabolites are able to adversely modify proteins through a non-enzymatic reaction called glycation, which is associated with the pathology of Alzheimer's Disease (AD) and is a characteristic of the hyperglycaemia induced by diabetes. However, the precise protein glycation profile that characterises AD is poorly defined and the molecular link between hyperglycaemia and AD is unknown. In this study, we define an early glycation profile of human brain using fluorescent phenylboronate gel electrophoresis and identify early glycation and oxidation of macrophage migration inhibitory factor (MIF) in AD brain. This modification inhibits MIF enzyme activity and ability to stimulate glial cells. MIF is involved in immune response and insulin regulation, hyperglycaemia, oxidative stress and glycation are all implicated in AD. Our study indicates that glucose modified and oxidised MIF could be a molecular link between hyperglycaemia and the dysregulation of the innate immune system in AD.

Details

Item Type Articles
CreatorsKassaar, O., Pereira Morais, M., Xu, S., Adam, E. L., Chamberlain, R. C., Jenkins, B., James, T., Francis, P. T., Ward, S., Williams, R. J. and Van Den Elsen, J.
DOI10.1038/srep42874
DepartmentsFaculty of Science > Biology & Biochemistry
Faculty of Science > Chemistry
Faculty of Science > Pharmacy & Pharmacology
Research CentresCentre for Sustainable Chemical Technologies
Centre for Regenerative Medicine
RefereedYes
StatusPublished
ID Code54540

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