Research

Neuropathic pain


Reference:

Colloca, L., Ludman, T., Bouhassira, D., Baron, R., Dickenson, A. H., Yarnitsky, D., Freeman, R., Truini, A., Attal, N., Finnerup, N. B., Eccleston, C., Kalso, E., Bennett, D. L., Dworkin, R. H. and Raja, S. N., 2017. Neuropathic pain. Nature Reviews Disease Primers, 3, 17002.

Related documents:

[img]
Preview
PDF (Accepted Version) - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
Download (817kB) | Preview

    Official URL:

    http://dx.doi.org/10.1038/nrdp.2017.2

    Related URLs:

    Abstract

    Neuropathic pain is caused by a lesion or disease of the somatosensory system, including peripheral fibres (Aβ, AÎ and C fibres) and central neurons, and affects 7-10% of the general population. Multiple causes of neuropathic pain have been described and its incidence is likely to increase owing to the ageing global population, increased incidence of diabetes mellitus and improved survival from cancer after chemotherapy. Indeed, imbalances between excitatory and inhibitory somatosensory signalling, alterations in ion channels and variability in the way that pain messages are modulated in the central nervous system all have been implicated in neuropathic pain. The burden of chronic neuropathic pain seems to be related to the complexity of neuropathic symptoms, poor outcomes and difficult treatment decisions. Importantly, quality of life is impaired in patients with neuropathic pain owing to increased drug prescriptions and visits to health care providers, as well as the morbidity from the pain itself and the inciting disease. Despite challenges, progress in the understanding of the pathophysiology of neuropathic pain is spurring the development of new diagnostic procedures and personalized interventions, which emphasize the need for a multidisciplinary approach to the management of neuropathic pain.

    Details

    Item Type Articles
    CreatorsColloca, L., Ludman, T., Bouhassira, D., Baron, R., Dickenson, A. H., Yarnitsky, D., Freeman, R., Truini, A., Attal, N., Finnerup, N. B., Eccleston, C., Kalso, E., Bennett, D. L., Dworkin, R. H. and Raja, S. N.
    DOI10.1038/nrdp.2017.2
    Related URLs
    URLURL Type
    http://www.scopus.com/inward/record.url?scp=85013188047&partnerID=8YFLogxKUNSPECIFIED
    DepartmentsFaculty of Humanities & Social Sciences > Health
    RefereedYes
    StatusPublished
    ID Code54797

    Export

    Actions (login required)

    View Item

    Document Downloads

    More statistics for this item...