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Room Temperature Regioselective Catalytic Hydrodefluorination of Fluoroarenes with trans-[Ru(NHC)4H2] Via a Converted Nucleophlic Ru-H Attack Pathway


Reference:

Cybulski, M., McKay, D., Macgregor, S., Mahon, M. and Whittlesey, M., 2017. Room Temperature Regioselective Catalytic Hydrodefluorination of Fluoroarenes with trans-[Ru(NHC)4H2] Via a Converted Nucleophlic Ru-H Attack Pathway. Angewandte Chemie-International Edition, 56 (6), pp. 1515-1519.

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    Official URL:

    https://doi.org/10.1002/anie.201610820

    Abstract

    The efficient and highly selective room temperature hydrodefluorination (HDF) of fluoroarenes by the trans-[Ru(IMe4)4H2] catalyst, 3, is reported. Mechanistic studies show 3 acts directly in catalysis without any ligand dissociation and DFT calculations indicate a concerted nucleophilic attack mechanism. The calculations fully account for the observed selectivities which corroborate earlier predictions regarding the selectivity of HDF.

    Details

    Item Type Articles
    CreatorsCybulski, M., McKay, D., Macgregor, S., Mahon, M. and Whittlesey, M.
    DOI10.1002/anie.201610820
    DepartmentsFaculty of Science > Chemistry
    Publisher StatementFINAL_Whittlesey_revised_manuscript_PURE.pdf: This is the peer reviewed version of the following article: Cybulski, M., McKay, D., Macgregor, S., Mahon, M., & Whittlesey, M. (2017). Room Temperature Regioselective Catalytic Hydrodefluorination of Fluoroarenes with trans-[Ru(NHC)4H2] Via a Converted Nucleophlic Ru-H Attack Pathway. Angewandte Chemie-International Edition, 56(6), 1515-1519. , which has been published in final form at https://doi.org/10.1002/anie.201610820. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
    RefereedYes
    StatusPublished
    ID Code55009

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