Research

Topical bioavailability of diclofenac from locally-acting, dermatological formulations


Reference:

Cordery, S. F., Pensado, A., Chiu, W. S., Shehab, M. Z., Bunge, A. L., Delgado-Charro, M. B. and Guy, R. H., 2017. Topical bioavailability of diclofenac from locally-acting, dermatological formulations. International Journal of Pharmaceutics, 529 (1-2), pp. 55-64.

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    Official URL:

    http://dx.doi.org/10.1016/j.ijpharm.2017.06.063

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    Abstract

    Assessment of the bioavailability of topically applied drugs designed to act within or beneath the skin is a challenging objective. A number of different, but potentially complementary, techniques are under evaluation. The objective of this work was to evaluate in vitro skin penetration and stratum corneum tape-stripping in vivo as tools with which to measure topical diclofenac bioavailability from three approved and commercialized products (two gels and one solution). Drug uptake into, and its subsequent clearance from, the stratum corneum of human volunteers was used to estimate the input rate of diclofenac into the viable skin layers. This flux was compared to that measured across excised porcine skin in conventional diffusion cells. Both techniques clearly demonstrated (a) the superiority in terms of drug delivery from the solution, and (b) that the two gels performed similarly. There was qualitative and, importantly, quantitative agreement between the in vitro and in vivo measurements of drug flux into and beyond the viable skin. Evidence is therefore presented to support an in vivo − in vitro correlation between methods to assess topical drug bioavailability. The potential value of the stratum corneum tape-stripping technique to quantify drug delivery into (epi)dermal and subcutaneous tissue beneath the barrier is demonstrated.

    Details

    Item Type Articles
    CreatorsCordery, S. F., Pensado, A., Chiu, W. S., Shehab, M. Z., Bunge, A. L., Delgado-Charro, M. B. and Guy, R. H.
    DOI10.1016/j.ijpharm.2017.06.063
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    URLURL Type
    http://www.scopus.com/inward/record.url?scp=85021193710&partnerID=8YFLogxKUNSPECIFIED
    Uncontrolled Keywordsdermato-pharmacokinetics,diclofenac,skin,topical bioavailability,topical bioequivalence,pharmaceutical science
    DepartmentsFaculty of Science > Pharmacy & Pharmacology
    Research CentresCentre for Mathematical Biology
    EPSRC Centre for Doctoral Training in Statistical Mathematics (SAMBa)
    Centre for Sustainable Chemical Technologies
    Centre for Nanoscience and Nanotechnology
    RefereedYes
    StatusPublished
    ID Code56634

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