Bcl-x(L) expression in vivo in rheumatoid synovium
Busteed, S., Bennett, M. W., Molloy, C., Houston, A., Stone, M. A., Shanahan, F., Molloy, M. G. and O'Connell, J., 2006. Bcl-x(L) expression in vivo in rheumatoid synovium. Clinical Rheumatology, 25 (6), pp. 789-793.
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To examine the expression of the apoptosis regulatory protein, Bcl-x(L), in the synovium of patients with rheumatoid arthritis (RA) and osteoarthritis (OA). Immunohistochemistry for Bcl-x(L) was carried out on synovial samples from patients with RA and OA. Reverse transcriptase polymerase chain reaction (RT-PCR) and Western blot analysis were performed to qualitatively examine the expression of Bcl-x(L). Bcl-x(L) expression was detected in the lining, endothelium and inflammatory cells of both RA (n=20) and OA (n=10) samples. However, there was significantly more expression in the lining of RA synovium compared to OA (77 vs 61%, p < 0.05). Many of the positive cells in the RA subsynovium were noted to be plasma cells. There was a significant correlation between Bcl-x(L) expression and the number of inflammatory cells in the subsynovium of RA and OA patients (r (s)=0.376, p < 0.05, n=30). Age and disease duration did not correlate with Bcl-x(L) expression in rheumatoid patients. Bcl-x(L) may play a role in the extended survival of synoviocytes and inflammatory cells in rheumatoid synovium.
|Creators||Busteed, S., Bennett, M. W., Molloy, C., Houston, A., Stone, M. A., Shanahan, F., Molloy, M. G. and O'Connell, J.|
|Departments||Faculty of Humanities & Social Sciences > Health|
Faculty of Science > Pharmacy & Pharmacology
|Additional Information||ID number: ISI:000240807600004|
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