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Bcl-x(L) expression in vivo in rheumatoid synovium


Reference:

Busteed, S., Bennett, M. W., Molloy, C., Houston, A., Stone, M. A., Shanahan, F., Molloy, M. G. and O'Connell, J., 2006. Bcl-x(L) expression in vivo in rheumatoid synovium. Clinical Rheumatology, 25 (6), pp. 789-793.

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Abstract

To examine the expression of the apoptosis regulatory protein, Bcl-x(L), in the synovium of patients with rheumatoid arthritis (RA) and osteoarthritis (OA). Immunohistochemistry for Bcl-x(L) was carried out on synovial samples from patients with RA and OA. Reverse transcriptase polymerase chain reaction (RT-PCR) and Western blot analysis were performed to qualitatively examine the expression of Bcl-x(L). Bcl-x(L) expression was detected in the lining, endothelium and inflammatory cells of both RA (n=20) and OA (n=10) samples. However, there was significantly more expression in the lining of RA synovium compared to OA (77 vs 61%, p < 0.05). Many of the positive cells in the RA subsynovium were noted to be plasma cells. There was a significant correlation between Bcl-x(L) expression and the number of inflammatory cells in the subsynovium of RA and OA patients (r (s)=0.376, p < 0.05, n=30). Age and disease duration did not correlate with Bcl-x(L) expression in rheumatoid patients. Bcl-x(L) may play a role in the extended survival of synoviocytes and inflammatory cells in rheumatoid synovium.

Details

Item Type Articles
CreatorsBusteed, S., Bennett, M. W., Molloy, C., Houston, A., Stone, M. A., Shanahan, F., Molloy, M. G. and O'Connell, J.
DOI10.1007/s10067-005-0191-0
DepartmentsFaculty of Humanities & Social Sciences > Health
Faculty of Science > Pharmacy & Pharmacology
RefereedYes
StatusPublished
ID Code6454
Additional InformationID number: ISI:000240807600004

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