Vascular physiology and pathology of circulating xanthine oxidoreductase: from nucleotide sequence to functional enzyme

Reference:

Hewinson, J., Stevens, C. R. and Millar, T. M., 2004. Vascular physiology and pathology of circulating xanthine oxidoreductase: from nucleotide sequence to functional enzyme. Redox Report, 9 (2), pp. 71-79.

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Abstract

The evolutionarily conserved, cofactor-dependent, enzyme xanthine oxidoreductase exists in both cell-associated and circulatory forms. The exact role of the circulating form is not known; however, several putative physiological and pathological functions have been suggested that range from purine catabolism to a mediator of acute respiratory distress syndrome. Regulation of gene expression, cofactor synthesis and insertion, post-translational conversion, entry into the circulation, and putative physiological and pathological roles for human circulating xanthine oxidoreductase are discussed.

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