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Vascular physiology and pathology of circulating xanthine oxidoreductase: from nucleotide sequence to functional enzyme


Reference:

Hewinson, J., Stevens, C. R. and Millar, T. M., 2004. Vascular physiology and pathology of circulating xanthine oxidoreductase: from nucleotide sequence to functional enzyme. Redox Report, 9 (2), pp. 71-79.

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Abstract

The evolutionarily conserved, cofactor-dependent, enzyme xanthine oxidoreductase exists in both cell-associated and circulatory forms. The exact role of the circulating form is not known; however, several putative physiological and pathological functions have been suggested that range from purine catabolism to a mediator of acute respiratory distress syndrome. Regulation of gene expression, cofactor synthesis and insertion, post-translational conversion, entry into the circulation, and putative physiological and pathological roles for human circulating xanthine oxidoreductase are discussed.

Details

Item Type Articles
CreatorsHewinson, J., Stevens, C. R. and Millar, T. M.
DOI10.1179/135100004225004797
DepartmentsFaculty of Humanities & Social Sciences > Health
RefereedYes
StatusPublished
ID Code6640
Additional InformationID number: ISI:000222735600002

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