Chemical modification of mammalian cell surfaces

Reference:

Barrie, K., Paul, A. D. B. and Kevin, M. S., 2003. Chemical modification of mammalian cell surfaces. Chemical Society Reviews, 32, 327--337.

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Abstract

The mammalian cell surface is a highly heterogeneous chemical environment with proteins, carbohydrates, lipids and composite molecules controlling vital cell functions. Chemical modification of this environment is a challenge due to the complexity of the surface chemistry and the fragility of the cell. Here, we review recent attempts to perform targeted, non-genetically controlled, changes to cell surface chemistry. Potential applications of cell surface engineering are presented.

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