Modelling natural burst firing in nigral dopamine neurons
Reference:
Penney, M. S. and Britton, N. F., 2002. Modelling natural burst firing in nigral dopamine neurons. Journal of Theoretical Biology, 219 (2), pp. 207-223.
Related documents:
This repository does not currently have the full-text of this item.You may be able to access a copy if URLs are provided below.
Abstract
The natural burst firing observed in vivo in mesolimbic dopamine neurons is of great significance regarding these neurons' involvement in response to sensory stimuli associated with primary reward. The cellular mechanisms underlying a natural burst have been experimentally characterized previously and hypothesized to be caused by a calcium-sensitive inactivation of a potassium channel. We present a mathematical model of a mesolimbic neuron that demonstrates how such a mechanism can produce realistic bursting patterns, but only A hen combined with an appropriately timed membrane depolarization from an external source.
Details
| Item Type | Articles |
| Creators | Penney, M. S.and Britton, N. F. |
| Departments | Faculty of Science > Mathematical Sciences |
| Refereed | Yes |
| Status | Published |
| ID Code | 7392 |
| Additional Information | ID number: ISI:000180138700005 |
Export
Actions (login required)
| View Item |
