Research

The design of multifunctional antioxidants against the damaging ingredients of oxidative stress


Reference:

Mecklenburg, S., Collins, C. A., Doring, M., Burkholz, T., Abbas, M., Fry, F. H., Pourzand, C. and Jacob, C., 2008. The design of multifunctional antioxidants against the damaging ingredients of oxidative stress. Phosphorus Sulfur and Silicon and the Related Elements, 183 (4), pp. 863-888.

Related documents:

This repository does not currently have the full-text of this item.
You may be able to access a copy if URLs are provided below. (Contact Author)

Official URL:

http://dx.doi.org/10.1080/10426500801898200

Abstract

Oxidative stress is a biochemical condition associated with a sharp increase in intracellular concentrations of a range of oxidative stressors, including reactive oxygen species, reactive nitrogen species and labile metal ions. It is associated with a wide range of human disorders, such as inflammatory diseases, neurodegenerative diseases, glaucoma, and cancer. Equally importantly, oxidative stress is pronounced in older people, which makes it an important matter in an ageing society. Not surprisingly, antioxidants have become a major focus of modern drug development. While natural antioxidants, such as phenolic aromatic compounds, vitamin C, vitamin E and curcumin have shown promising results, the development of effective synthetic antioxidants is often problematic. We have recently proposed the rational design of multifunctional antioxidants which target oxidative stressors in a more comprehensive manner. Such compounds may, for instance, combine catalytic sites with metal binding sites. Here we present the synthesis of representative molecules with combined catalytic and metal binding properties. The apparent 'antioxidant' activities have been studied in vitro and, for the most promising compound, have been confirmed in cultured skin cells exposed to UVA radiation.

Details

Item Type Articles
CreatorsMecklenburg, S., Collins, C. A., Doring, M., Burkholz, T., Abbas, M., Fry, F. H., Pourzand, C. and Jacob, C.
DOI10.1080/10426500801898200
DepartmentsFaculty of Science > Pharmacy & Pharmacology
RefereedYes
StatusPublished
ID Code7519
Additional InformationID number: ISI:000255436000006

Export

Actions (login required)

View Item