Herkenne, C., Alberti, I., Naik, A., Kalia, Y. N., Mathy, F. X., Préat, V. and Guy, R. H., 2008. In vivo methods for the assessment of topical drug bioavailability. Pharmaceutical Research, 25 (1), pp. 87-103.
This paper reviews some current methods for the in vivo assessment of local cutaneous bioavailability in humans after topical drug application. After an introduction discussing the importance of local drug bioavailability assessment and the limitations of the predictive calculations, the focus turns to the relevance of experimental studies. The available techniques are then reviewed in detail, with particular emphasis on the tape stripping and microdialysis methodologies. Other less developed techniques, including the skin biopsy, suction blister, follicle removal and confocal Raman spectroscopy techniques are also described.
|Item Type ||Articles|
|Creators||Herkenne, C., Alberti, I., Naik, A., Kalia, Y. N., Mathy, F. X., Préat, V. and Guy, R. H.|
|Uncontrolled Keywords||dermatopharmacokinetics., tape stripping, cutaneous bioavailability, microdialysis, cutaneous drug concentration|
|Departments||Faculty of Science > Pharmacy & Pharmacology|
|Publisher Statement||Herkenne_final.pdf: The original publication is available at www.springerlink.com|
|Additional Information||Fulltext freely available from PubMed Central via the link shown above.|
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