Phosphoinositide lipid phosphatases: Natural regulators of phosphoinositide 3-kinase signaling in T lymphocytes

Reference:

Harris, S. J., Parry, R. V., Westwick, J. and Ward, S. G., 2008. Phosphoinositide lipid phosphatases: Natural regulators of phosphoinositide 3-kinase signaling in T lymphocytes. Journal of Biological Chemistry, 283 (5), pp. 2465-2469.

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Official URL:

http://dx.doi.org/10.1074/jbc.R700044200

Abstract

The phosphoinositide 3-kinase signaling pathway has been implicated in a range of T lymphocyte cellular functions, particularly growth, proliferation, cytokine secretion, and survival. Dysregulation of phosphoinositide 3-kinase-dependent signaling and function in leukocytes, including B and T lymphocytes, has been implicated in many inflammatory and autoimmune diseases. As befits a pivotal signaling cascade, several mechanisms exist to ensure that the pathway is tightly regulated. This minireview focuses on two lipid phosphatases, viz. the 3'-phosphatase PTEN ( phosphatase and tensin homolog deleted on chromosome 10) and SHIP ((S) under bar rc (h) under bar omology 2domain-(c) under bar ontaining (i) under bar nositol-5-(p) under bar hosphatase). We discuss their role in regulating T lymphocyte signaling as well their potential as future therapeutic targets.

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