T-lymphocyte navigation and migration: beyond the PI3K paradigm


Smith, L., Webb, A. and Ward, S. G., 2007. T-lymphocyte navigation and migration: beyond the PI3K paradigm. Biochemical Society Transactions, 35, pp. 193-198.

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The co-ordinated and directional trafficking of T-lymphocytes in lymphoid and peripheral tissues is an important process in lymphoid development, immunosurveillance and immune responses. Members of the chemokine superfamily play a key role in providing navigational cues for T-cells and chemokine receptors couple with a wide range of biochemical signals including phosphoinositide lipid metabolism, elevation of intracellular calcium levels, activation of a wide array of protein kinases as well as small GTPases. one of the most robust biochemical signals elicited by chemokines in T-lymphocytes is the activation of several members of the PI3K (phosphoinositide 3-kinase) family. In many cell systems, PI3Ks are known to contribute to several aspects of the migratory machinery, although their role in T-cell migration has been unclear and will be considered in the present paper.


Item Type Articles
CreatorsSmith, L., Webb, A. and Ward, S. G.
DepartmentsFaculty of Science > Pharmacy & Pharmacology
ID Code7579
Additional InformationID number: ISI:000245705800008


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