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A novel apparatus for the determination of solubility in pressurized metered dose inhalers


Reference:

Traini, D., Young, P. M., Price, R. and Rogueda, P., 2006. A novel apparatus for the determination of solubility in pressurized metered dose inhalers. Drug Development and Industrial Pharmacy, 32 Nov-Dec (10), pp. 1159-1163.

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Abstract

The accurate solubility of salbutamol sulfate, budesonide, and formoterol fumarate dihydrate in hydrofluoroalkane propellant 134a at 25 degrees C for 24 h, are reported. The authors describe a novel reusable in-line pressurized solubility apparatus containing an integral filter holder and a continuous decrimpable valve for the determination of drug/excipients solubility in pressurized metered dose inhalers. The solubility was determined by high-performance liquid chromatography. Solubility of salbutamol sulfate was determined as being below the detection limits while budesonide and formoterol fumarate dihydrate solubility were 23.136 +/- 2.951 mu g. g(-1) and 0.776 +/- 1.023 mu g. g(-1), respectively (n = 3). This novel solubility apparatus offers an improved ease of use and potential higher analytical throughput.

Details

Item Type Articles
CreatorsTraini, D., Young, P. M., Price, R. and Rogueda, P.
DOI10.1080/03639040600920325
DepartmentsFaculty of Science > Pharmacy & Pharmacology
RefereedYes
StatusPublished
ID Code7673
Additional InformationID number: ISI:000241847300006

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