Fundamental differences in spontaneous synaptic inhibition between deep and superficial layers of the rat entorhinal cortex
Woodhall, G. L., Bailey, S. J., Thompson, S. E., Evans, D. I. P. and Jones, R. S. G., 2005. Fundamental differences in spontaneous synaptic inhibition between deep and superficial layers of the rat entorhinal cortex. Hippocampus, 15 (2), pp. 232-245.
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We have previously shown that there are clear differences between spontaneous excitatory synaptic currents recorded in layers V and 11 of the rat entorhinal cortex (EC) in vitro, and have suggested that these might contribute to a more pronounced susceptibility of the deeper layer to epileptogenesis. In the present study, we have made a detailed comparison of spontaneous synaptic inhibition between the two layers by recording spontaneous inhibitory synaptic currents (sIPSCs) using whole-cell patch-clamp techniques in EC slices. Pharmacological studies indicated that sIPSCs were mediated exclusively by gamma-aminobutyric acid (GABA)A receptors. There was little difference in average amplitudes, rise or decay times of sIPSCs in layer 11 compared with layer V. However, in the former, events occurred at 4-5 times the frequency seen in the latter, and frequencies of
|Creators||Woodhall, G. L., Bailey, S. J., Thompson, S. E., Evans, D. I. P. and Jones, R. S. G.|
|Departments||Faculty of Science > Pharmacy & Pharmacology|
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