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An efficient synthesis of argifin: a natural product chitinase inhibitor with chemotherapeutic potential


Reference:

Dixon, M. J., Andersen, O. A., van Aalten, D. M. F. and Eggleston, I. M., 2005. An efficient synthesis of argifin: a natural product chitinase inhibitor with chemotherapeutic potential. Bioorganic & Medicinal Chemistry Letters, 15 (21), pp. 4717-4721.

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Official URL:

http://dx.doi.org/10.1016/j.bmcl.2005.07.068

Abstract

The first synthesis of the cyclopentapeptide family 18 chitinase inhibitor argifin has been achieved by a combination of solid phase and solution chemistry. Synthetic argifin is a nanomolar inhibitor of chitinase B1 from Aspergillus fumigatus and the high-resolution X-ray structure of the synthesized material in complex with the same enzyme is identical to that previously obtained for the natural product.

Details

Item Type Articles
CreatorsDixon, M. J., Andersen, O. A., van Aalten, D. M. F. and Eggleston, I. M.
DOI10.1016/j.bmcl.2005.07.068
DepartmentsFaculty of Science > Pharmacy & Pharmacology
RefereedYes
StatusPublished
ID Code7932

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