The development of a novel high-dose pressurized aerosol dry-powder device (PADD) for the deliverv of pumactant for inhalation therapy

Reference:

Young, P. M., Thompson, J., Woodcock, D., Aydin, M. and Price, R., 2004. The development of a novel high-dose pressurized aerosol dry-powder device (PADD) for the deliverv of pumactant for inhalation therapy. Journal of Aerosol Medicine-Deposition Clearance and Effects in the Lung, 17 Sum (2), pp. 123-128.

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Abstract

The performance of a novel dry powder inhaler designed to deliver exceptionally high doses was investigated using pumactant as a model powder. Pumactant (a synthetic lung surfactant consisting of a phospholipid mixture), with a 90th percentile particle size of 2.92mum is highly cohesive, has a high moisture affinity (6.2% w/w at 45% RH), and is predominately amorphous. The device (pressurized aerosol dry-powder delivery [PADD]) utilizes pressurized gas to aerosolize a powder bed from a reservoir and delivers it through a conventional mouthpiece. The influence of loaded dose on dry powder delivery and can pressure on aerosolization efficiency was investigated. Analysis of the delivered dose studies suggested a linear relationship between loaded dose and delivered dose (R-2 = 0.96, for loaded doses of 0-250 mg), with a delivery efficiency of 70%. Analysis of the aerosolization efficiency using a Marple Miller type impactor suggested fine particle fractions (particles with an aerodynamic diameter of

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