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Visualization of the crystallization of lactose from the amorphous state


Reference:

Price, R. and Young, P. M., 2004. Visualization of the crystallization of lactose from the amorphous state. Journal of Pharmaceutical Sciences, 93 (1), pp. 155-164.

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Abstract

The physical stability and solid-state recrystallization of spray-dried 'amorphous' lactose particles were visualized using environmentally controlled atomic force microscopy (EC-AFM) and conventional optical microscopy. The morphology and crystalline state were investigated as a function of relative humidity (RH) and were correlated with bulk gravimetric vapor sorption measurements that were run in parallel. The metastable nature of amorphous spray-dried lactose particles was apparent at low RHs (

Details

Item Type Articles
CreatorsPrice, R.and Young, P. M.
DOI10.1002/jps.10513
DepartmentsFaculty of Science > Pharmacy & Pharmacology
RefereedYes
StatusPublished
ID Code8021
Additional InformationID number: ISI:000187668400017

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