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Book Sections

Day, J. M., Purohit, A., Tutill, H. J., Foster, P. A., Woo, L. W. L., Potter, B. V. L. and Reed, M. J., 2009. The development of steroid sulfatase iInhibitors for hormone-dependent cancer therapy. In: Bradlow, H. L. and Carruba, G., eds. Steroid Enzymes and Cancer. Vol. 1155. Blackwell Publishing, pp. 80-87. (Annals of the New York Academy of Sciences)

Newman, S. P. and Potter, B. V. L., 2002. Steroid sulfatase. In: Wiley Encyclopedia of Molecular Medicine [5 vol. set]. John Wiley & Sons, Inc., pp. 3012-3013.

Newman, S. P., Purohit, A., Potter, B. V. L. and Reed, M. J., 2002. Steroid sulfatase. In: Encyclopedia of Molecular MEdicine. Vol. 5. John Wiley & Sons, Inc., pp. 3012-3013.

Potter, B. V. L., 1999. Structure-activity relationships of adenophostin A and related molecules at the 1-D-myo-inositol 1,4,5-triphosphate receptor. In: Bruzik, K. S., ed. Phosphoinositides. Washington, U. S. A.: ACS, p. 158. (ACS Symposium Series; 718)

Jenkins, D. J., Riley, A. M. and Potter, B. V. L., 1998. Carbohydrates as sources of chiral inositol polyphosphates and their mimics. In: Chapleur, Y., ed. Carbohydrate Mimics, Concepts and Methods. Chichester, U. K.: Wiley-VCH, pp. 171-208.

Trigg, W. J., Hardick, D. J., Grangier, G., Wonnacott, S., Lewis, T., Rowan, M. G., Potter, B. V. L. and Blagbrough, I. S., 1998. Selective probes for nicotinic acetylcholine receptors from substituted AE-bicyclic analogs of methyllycaconitine. In: Baker, D. R., Fenyes, J. G., Basarab, G. S. and Hunt, D. A., eds. Synthesis and Chemistry of Agrochemicals V. Washington, U. S. A.: ACM, pp. 194-205. (ACS Symposium Series; 686)

Guse, A. H., da Silva, C. P., Potter, B. V. L. and Mayr, G. W., 1997. Ca2+-signalling in human T-lymphocytes : potential roles for cyclic ADP-ribose and 2'- phospho-cyclic ADP-ribose. In: Koch-Nolte, F. and Haag, F., eds. ADP Ribosylation in Animal Tissues. London, U. K.: Plenum, pp. 431-436. (Advances in Experimental Medicine and Biology; 419)

Potter, B. V. L., 1993. Synthesis and biology of inositol polyphosphates and analogues. In: Claassen, V., ed. Trends in Drug Research. Amsterdam, The Netherlands: Elsevier, pp. 185-214. (Pharmacochemistry Library; 20)

Potter, B. V. L. and Nahorski, S. R., 1993. Synthetic inositol polyphosphates and analogues as molecular probes for neuronal second messenger receptors. In: Kozikowski, A. P., ed. Drug Design, Molecular Modelling and the Neurosciences. New York, U. S. A.: Raven Press, pp. 383-416.

Potter, B. V. L., 1992. Analogues of intracellular messengers. In: Boulton, A. A., Baker, G. B. and Taylor, C. W., eds. Intracellular Messengers. New Jersey, U, S. A.: Humana Press, pp. 273-312. (Neuromethods; 20)

Nahorski, S. R. and Potter, B. V. L., 1992. Interaction of inositol polyphosphate analogues with intracellular receptors. In: Krogsgaard-Larsen, P., Brogger Christensen, S. and Kofod, H., eds. New Leads and Targets in Drug Research. Copenhagen, Denmark: Munksgaard, pp. 211-223.

Potter, B. V. L., 1991. Phosphorothioate analogues of D-myo-inositol 1,4,5-trisphosphate : chemistry and biology. In: Inositol Phospahtes and Related Compounds. Vol. 463. ACS Publications, pp. 186-201. (ACS Symposium Series)

Potter, B. V. L., 1990. Synthesis and biology of second messenger analogues. In: Nahorski, S. R., ed. Transmembrane Signalling, Intracellular Messengers and Implications for Drug Development. London, U. K: Wiley, pp. 207-239. (Biological Council Symposia on Drug Action)

Potter, B. V. L., 1990. Transmembrane signalling, second messenger analogues and inositol phosphates. In: Ramsden, C. A., ed. Comprehensive Medicinal Chemistry. Vol. 4. Oxford, U. K.: Pergamon, pp. 101-132.

Taylor, C. W. and Potter, B. V. L., 1989. Actions and metabolism of synthetic inositol phosphate analogues. In: Reid, E., Cook, G. M. W. and Luzio, J. P., eds. Biochemical Approaches to Cellular Calcium. London, U. K.: Royal Society of Chemistry, pp. 199-210. (Methodological Surveys in Biochemistry and Analysis; 19)

Nahorski, S. R., Batty, I. H., Willcocks, A. L., Strupish, J. and Potter, B. V. L., 1989. Metabolism and intracellular receptors for inositol 1, 4, 5-trisphosphate in brain. In: Freysz, L., Hawthorne, J. N. and Toffano, G., eds. Neurochemical Aspects of Phospholipid Metabolism. Springer-Verlag, pp. 95-98. (Fidia Research Series; 20)

Nahorski, S. R., Batty, I. H., Willcocks, A. L., Strupish, J. and Potter, B. V. L., 1989. Receptor-mediated phosphoinositide metabolism in brain. In: Segawa, T., Endo, M., Ui, M. and Kurihara, K., eds. Physiology and Pharmacology of Transmembrane Signalling. Amsterdam, the Netherlands: Elsevier Science B.V., pp. 217-221.

Hamblin, M. R., Potter, B. V. L. and Gigg, R., 1987. Synthesis of myo-inositol phosphates and analogues using a phosphite chemistry approach. In: Biochemical Society Transactions, 1987. Vol. 15. 3 ed. Biochemical Society, pp. 1289-1290.

Hamblin, M. R., Cummins, J. H. and Potter, B. V. L., 1986. Mung bean nuclease catalyses DNA cleavage with inversion of configuration at phosphorus. In: Biochemical Society Transactions, 1986. Vol. 14. 5 ed. Biochemical Society, pp. 899-900.

Cummins, J. H. and Potter, B. V. L., 1986. Stereochemical mechanism of the cleavage reaction catalysed by bovine intestinal mucosa 5′-nucleotide phosphodiesterase. In: Biochemical Society Transactions, 1986. Vol. 14. 6 ed. Biochemical Society, pp. 1289-1290.

Lowe, G., Cullis, P. M., Jarvest, R. L. and Potter, B. V. L., 1981. Chiral [16O, 17O, 18O] phosphate monoesters for determining the stereochemical course of phosphokinases. In: Phosphorus Chemistry. Vol. 171. ACS Publications, pp. 103-107. (ACS Symposium Series)

Articles

Dohle, W., Leese, M.P., Jourdan, F.L., Chapman, C.J., Hamel, E., Ferrandis, E. and Potter, B.V.L., 2014. Optimisation of tetrahydroisoquinoline-based chimeric microtubule disruptors. ChemMedChem, 9 (8), pp. 1783-1793.

Wang, H., Godage, H. Y., Riley, A. M., Weaver, J. D., Shears, S. B. and Potter, B. V. L., 2014. Synthetic inositol phosphate analogs reveal that PPIP5K2 has a surface-mounted substrate capture site that is a target for drug discovery. Chemistry & Biology, 21 (5), pp. 689-699.

Leese, M. P., Jourdan, F. L., Major, M. R., Dohle, W., Thomas, M. P., Hamel, E., Ferrandis, E., Mahon, M. F., Newman, S. P., Purohit, A. and Potter, B. V. L., 2014. Synthesis, anti-tubulin and antiproliferative SAR of steroidomimetic dihydroisoquinolinones. ChemMedChem, 9 (4), pp. 798-812.

Swarbrick, J. M., Graeff, R., Garnham, C., Thomas, M. P., Galione, A. and Potter, B. V. L., 2014. 'Click cyclic ADP-ribose' : A neutral second messenger mimic. Chemical Communications, 50 (19), pp. 2458-2461.

Pulloor, N.K., Nair, S., Kostic, A.D., Bist, P., Weaver, J.D., Riley, A.M., Tyagi, R., Uchil, P.D., York, J.D., Snyder, S.H., García-Sastre, A., Potter, B.V.L., Lin, R., Shears, S.B., Xavier, R.J. and Krishnan, M.N., 2014. Human Genome-Wide RNAi Screen Identifies an Essential Role for Inositol Pyrophosphates in Type-I Interferon Response. PLoS Pathogens, 10 (2).

Dohle, W., Leese, M. P., Jourdan, F. L., Major, M. R., Bai, R., Hamel, E., Ferrandis, E., Kasprzyk, P. G., Fiore, A., Newman, S. P., Purohit, A. and Potter, B. V. L., 2014. Synthesis, Antitubulin, and Antiproliferative SAR of C3/C1-Substituted Tetrahydroisoquinolines. ChemMedChem, 9 (2), pp. 350-370.

Riley, A. M., Windhorst, S., Lin, H.-Y. and Potter, B. V. L., 2014. Cellular internalisation of an inositol phosphate visualised by using fluorescent InsP5. ChemBiochem, 15 (1), pp. 57-67.

Leese, M. P., Jourdan, F. L., Major, M. R., Dohle, W., Hamel, E., Ferrandis, E., Fiore, A., Kasprzyk, P. G. and Potter, B. V. L., 2014. Tetrahydroisoquinolinone-based steroidomimetic and chimeric microtubule disruptors. ChemMedChem, 9 (1), pp. 85-108.

Thomas, M. P. and Potter, B. V. L., 2014. The enzymes of human diphosphoinositol polyphosphate metabolism. FEBS Journal, 281 (1), pp. 14-33.

Moreau, C., Kirchberger, T., Swarbrick, J. M., Bartlett, S. J., Fliegert, R., Yorgan, T., Bauche, A., Harneit, A., Guse, A. H. and Potter, B. V. L., 2013. Structure–ativity relationship of adenosine 5′-diphosphoribose at the transient receptor potential melastatin 2 (TRPM2) channel : rational design of antagonists. Journal of Medicinal Chemistry, 56 (24), pp. 10079-10102.

Tsuzuki, T., Sakaguchi, N., Kudoh, T., Takano, S., Uehara, M., Murayama, T., Sakurai, T., Hashii, M., Higashida, H., Weber, K., Guse, A. H., Kameda, T., Hirokawa, T., Kumaki, Y., Potter, B. V. L., Fukuda, H., Arisawa, M. and Shuto, S., 2013. Design and synthesis of cyclic ADP-4-thioribose as a stable equivalent of cyclic ADP-ribose, a calcium ion-mobilizing second messenger. Angewandte Chemie-International Edition, 52 (26), pp. 6633-6637.

Moreau, C., Liu, Q., Graeff, R., Wagner, G.K., Thomas, M.P., Swarbrick, J.M., Shuto, S., Lee, H.C., Hao, Q. and Potter, B.V.L., 2013. CD38 Structure-Based Inhibitor Design Using the N1-Cyclic Inosine 5′-Diphosphate Ribose Template. PLoS ONE, 8 (6), e66247.

Nebel, M., Schwoerer, A. P., Warszta, D., Siebrands, C. C., Limbrock, A.-C., Swarbrick, J. M., Fliegert, R., Weber, K., Bruhn, S., Hohenegger, M., Geisler, A., Herich, L., Schlegel, S., Carrier, L., Eschenhagen, T., Potter, B. V. L., Ehmke, H. and Guse, A. H., 2013. Nicotinic acid adenine dinucleotide phosphate (NAADP)-mediated calcium signaling and arrhythmias in the heart evoked by β-adrenergic stimulation. Journal of Biological Chemistry, 288 (22), pp. 16017-16030.

Veiga, N., Torres, J., Macho, I., Gómez, K., Godage, H.Y., Riley, A.M., Potter, B.V.L., González, G. and Kremer, C., 2013. Inframolecular acid-base and coordination properties towards Na+ and Mg2+ of myo-inositol 1,3,4,5,6-pentakisphosphate : A structural approach to biologically relevant species. Dalton Transactions, 42 (17), pp. 6021-6032.

Woo, L.W.L., Wood, P.M., Bubert, C., Thomas, M.P., Purohit, A. and Potter, B.V.L., 2013. Synthesis and structure-activity relationship studies of derivatives of the dual aromatase-sulfatase inhibitor 4-{[(4-Cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]methyl}phenyl sulfamate. ChemMedChem, 8 (5), pp. 779-799.

Khan, S. A., Rossi, A. M., Riley, A. M., Potter, B. V.L. and Taylor, C. W., 2013. Subtype-selective regulation of IP3 receptors by thimerosal via cysteine residues within the IP3-binding core and suppressor domain. Biochemical Journal, 451 (2), pp. 177-184.

Godage, H. Y., Riley, A. M., Woodman, T. J., Thomas, M. P., Mahon, M. F. and Potter, B. V. L., 2013. Regioselective opening of myo-inositol orthoesters : Mechanism and synthetic utility. Journal of Organic Chemistry, 78 (6), pp. 2275-2288.

Saleem, H., Tovey, S.C., Riley, A.M., Potter, B.V.L. and Taylor, C.W., 2013. Stimulation of inositol 1,4,5-trisphosphate (IP3) receptor subtypes by Adenophostin A and its analogues. PLoS ONE, 8 (2), e58027.

Day, J.M., Foster, P.A., Tutill, H.J., Schmidlin, F., Sharland, C.M., Hargrave, J.D., Vicker, N., Potter, B.V.L., Reed, M.J. and Purohit, A., 2013. STX2171, a 17β-hydroxysteroid dehydrogenase type 3 inhibitor, is efficacious in vivo in a novel hormone-dependent prostate cancer model. Endocrine-Related Cancer, 20 (1), pp. 53-64.

Saleem, H., Tovey, S.C., Rahman, T., Riley, A.M., Potter, B.V.L. and Taylor, C.W., 2013. Stimulation of Inositol 1,4,5-Trisphosphate (IP3) Receptor Subtypes by Analogues of IP3. PLoS ONE, 8 (1), 54877.

Thomas, M. P. and Potter, B. V. L., 2013. The structural biology of oestrogen metabolism. Journal of Steroid Biochemistry and Molecular Biology, 137, pp. 27-49.

Grint, T., Riley, A. M., Mills, S. J., Potter, B. V. L. and Safrany, S. T., 2012. Fibrinogen—a possible extracellular target for inositol phosphates. Messenger, 1 (2), pp. 160-166.

Su, X., Halem, H. A., Thomas, M. P., Moutrille, C., Culler, M. D., Vicker, N. and Potter, B. V. L., 2012. Adamantyl carboxamides and acetamides as potent human 11β- hydroxysteroid dehydrogenase type 1 inhibitors. Bioorganic and Medicinal Chemistry, 20 (21), pp. 6394-6402.

Riley, A. M., Wang, H., Weaver, J. D., Shears, S. B. and Potter, B. V. L., 2012. First synthetic analogues of diphosphoinositol polyphosphates: interaction with PP-InsP5 kinase. Chemical Communications, 48 (92), pp. 11292-11294.

Pradaux-Caggiano, F., Su, X., Vicker, N., Thomas, M. P., Smithen, D., Halem, H. A., Culler, M. D. and Potter, B. V. L., 2012. Synthesis and evaluation of thiadiazole derivatives as inhibitors of 11β-hydroxysteroid dehydrogenase type 1. MedChemComm, 3 (9), pp. 1117-1124.

Mills, S. J., Persson, C., Cozier, G., Thomas, M. P., Trésaugues, L., Erneux, C., Riley, A. M., Nordlund, P. and Potter, B. V. L., 2012. A synthetic polyphosphoinositide headgroup surrogate in complex with SHIP2 provides a rationale for drug discovery. ACS Chemical Biology, 7 (5), pp. 822-828.

Woo, L. W. L., Leblond, B., Purohit, A. and Potter, B. V. L., 2012. Synthesis and evaluation of analogues of estrone-3-O-sulfamate as potent steroid sulfatase inhibitors. Bioorganic and Medicinal Chemistry, 20 (8), pp. 2506-2519.

Moreau, C., Kirchberger, T., Zhang, B., Thomas, M. P., Weber, K., Guse, A. H. and Potter, B. V. L., 2012. Aberrant cyclization affords a C-6 modified cyclic adenosine 5′-diphosphoribose analogue with biological activity in Jurkat T cells. Journal of Medicinal Chemistry, 55 (4), pp. 1478-1489.

Nebel, M., Schworer, A., Siebrands, C. C., Limbrock, A.-C., Swarbrick, J. M., Hohenegger, M., Geisler, A., Herich, L., Schlegel, S., Carrier, L., Eschenhagen, T., Potter, B. V. L., Ehmke, H. and Guse, A. H., 2012. Forthcoming. Antagonism of NAADP mediated calcium signaling ameliorates arrythmias in the heart. Circulation

Sureshan, K. M., Riley, A. M., Thomas, M. P., Tovey, S. C., Taylor, C. W. and Potter, B. V. L., 2012. Contribution of phosphates and adenine to the potency of adenophostins at the IP 3 receptor : synthesis of all possible bisphosphates of adenophostin A. Journal of Medicinal Chemistry, 55 (4), pp. 1706-1720.

Turner, B. L., Cheesman, A. W., Godage, H. Y., Riley, A. M. and Potter, B. V. L., 2012. Determination of neo-and D-chiro-inositol hexakisphosphate in soils by solution 31P NMR spectroscopy. Environmental Science & Technology, 46 (9), pp. 4994-5002.

Leese, M. P., Jourdan, F., Dohle, W., Kimberley, M. R., Thomas, M. P., Bai, R., Hamel, E., Ferrandis, E. and Potter, B. V. L., 2012. Steroidomimetic tetrahydroisoquinolines for the design of new microtubule disruptors. ACS Medicinal Chemistry Letters, 3 (1), pp. 5-9.

Swarbrick, J. M. and Potter, B. V. L., 2012. Total synthesis of a cyclic adenosine 5′-diphosphate ribose receptor agonist. Journal of Organic Chemistry, 77 (9), pp. 4191-4197.

Woo, L. W. L., Ganeshapillai, D., Thomas, M. P., Sutcliffe, O. B., Malini, B., Mahon, M. F., Purohit, A. and Potter, B. V. L., 2011. Structure-activity relationship for the first-in-class clinical steroid sulfatase inhibitor irosustat (STX64, BN83495). ChemMedChem, 6 (11), pp. 2019-2034.

Su, X., Pradaux-Caggiano, F., Vicker, N., Thomas, M. P., Halem, H., Culler, M. D. and Potter, B. V. L., 2011. Adamantyl ethanone pyridyl derivatives : potent and selective inhibitors of human 11 beta-hydroxysteroid dehydrogenase type 1. ChemMedChem, 6 (9), pp. 1616-1629.

Wood, P. M., Woo, L. W. L., Thomas, M. P., Mahon, M. F., Purohit, A. and Potter, B. V. L., 2011. Aromatase and dual aromatase-steroid sulfatase inhibitors from the letrozole and vorozole templates. ChemMedChem, 6 (8), pp. 1423-1438.

Su, X., Vicker, N., Thomas, M. P., Pradaux-Caggiano, F., Halem, H., Culler, M. D. and Potter, B. V. L., 2011. Discovery of adamantyl heterocyclic ketones as potent 11 beta-hydroxysteroid dehydrogenase type 1 inhibitors. ChemMedChem, 6 (8), pp. 1439-1451.

Jourdan, F., Leese, M. P., Dohle, W., Ferrandis, E., Newman, S. P., Chander, S., Purohit, A. and Potter, B. V. L., 2011. Structure-activity relationships of C-17-substituted estratriene-3-O-sulfamates as anticancer agents. Journal of Medicinal Chemistry, 54 (13), pp. 4863-4879.

Woo, L. W. L., Purohit, A. and Potter, B. V. L., 2011. Development of steroid sulfatase inhibitors. Molecular and Cellular Endocrinology, 340 (2), pp. 175-185.

Purohit, A., Woo, L. W. L. and Potter, B. V. L., 2011. Steroid sulfatase : a pivotal player in estrogen synthesis and metabolism. Molecular and Cellular Endocrinology, 340 (2), pp. 154-160.

Thomas, M. P. and Potter, B. V. L., 2011. Crystal structures of II beta-hydroxysteroid dehydrogenase type I and their use in drug discovery. Future Medicinal Chemistry, 3 (3), pp. 367-390.

Woo, L. W. L., Bubert, C., Purohit, A. and Potter, B. V. L., 2011. Hybrid dual aromatase-steroid sulfatase inhibitors with exquisite picomolar inhibitory activity. ACS Medicinal Chemistry Letters, 2 (3), pp. 243-247.

Moreau, C., Ashamu, G. A., Bailey, V. C., Galione, A., Guse, A. H. and Potter, B. V. L., 2011. Synthesis of cyclic adenosine 5 '-diphosphate ribose analogues : a C2 ' endo/syn "southern" ribose conformation underlies activity at the sea urchin cADPR receptor. Organic and Biomolecular Chemistry, 9 (1), pp. 278-290.

Newman, S. P., Day, J. M., Potter, B. V. L., Reed, M. J. and Purohit, A., 2011. Forthcoming. The effects of paclitaxel and STX140 on early-and late-stage breast cancer in tte clinically relevant C3(1)/SV40 mouse model. European Journal of Cancer

Koob, Z., Perez, A., Bascompta, E., Soulard, C., Caroline, C., Hillairet de Boisferon, M., Woo, L. W. L., Potter, B. V. L., Reed, M. J., Ali, T., Bichat, F. and Prevost, G., 2011. Forthcoming. The steroid sulfatase inhibitor BN-83495 inhibits the growth of DMBA induced mammary tumors in rats alone or in combination with estradiol receptor blockers. Breast Cancer Research and Treatment

Leese, M. P., Jourdan, F., Ferrandis, E., Regis-Lydi, S., Kasprzyk, P. G., Stengel, C., Newman, S. P., Purohit, A., Reed, M. J. and Potter, B. V. L., 2010. Optimisation of tetrahydroisoquinoline based microtubule disruptors as anti-cancer agents. EJC Supplements, 8 (7), p. 141.

Rossi, A. M., Sureshan, K. M., Riley, A. M., Potter, B. V. L. and Taylor, C. W., 2010. Selective determinants of inositol 1,4,5-trisphosphate and adenophostin A interactions with type 1 inositol 1,4,5-trisphosphate receptors. British Journal of Pharmacology, 161 (5), pp. 1070-1085.

Wood, P. M., Woo, L. W. L., Labrosse, J.-R., Thomas, M. P., Mahon, M. F., Chander, S. K., Purohit, A., Reed, M. J. and Potter, B. V. L., 2010. Bicyclic derivatives of the potent dual aromatase-steroid sulfatase inhibitor 2-bromo-4-{ (4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino methyl}phenylsul famate : synthesis, SAR, crystal structure, and in vitro and in vivo activities. ChemMedChem, 5 (9), pp. 1577-1593.

Su, X., Pradaux-Caggiano, F., Thomas, M. P., Szeto, M. W. Y., Halem, H. A., Culler, M. D., Vicker, N. and Potter, B. V. L., 2010. Discovery of adamantyl ethanone derivatives as potent 11β-hydroxysteroid dehydrogenase Type 1 (11β-HSD1) inhibitors. ChemMedChem, 5 (7), pp. 1026-1044.

Cordiglieri, C., Odoardi, F., Zhang, B., Nebel, M., Kawakami, N., Klinkert, W. E. F., Lodygin, D., Luhder, F., Breunig, E., Schild, D., Ulaganathan, V. K., Dornmair, K., Dammermann, W., Potter, B. V. L., Guse, A. H. and Flugel, A., 2010. Nicotinic acid adenine dinucleotide phosphate-mediated calcium signalling in effector T cells regulates autoimmunity of the central nervous system. Brain, 133 (7), pp. 1930-1943.

Leese, M. P., Jourdan, F., Kimberley, M. R., Cozier, G. E., Thiyagarajan, N., Stengel, C., Regis-Lydi, S., Foster, P. A., Newman, S. P., Acharya, K. R., Ferrandis, E., Purohit, A., Reed, M. J. and Potter, B. V. L., 2010. Chimeric microtubule disruptors. Chemical Communications, 46 (17), pp. 2907-2909.

Raimondi, C., Maffucci, T., Potter, B. V. L. and Falasca, M., 2010. A novel and selective PDK1 inhibitor reduces breast cancer cell invasion and tumour growth. Breast Cancer Research, 12 (Supplement 1), S3.

Cozier, G. E., Leese, M. P., Lloyd, M. D., Baker, M. D., Thiyagarajan, N., Acharya, K. R. and Potter, B. V. L., 2010. Structures of human carbonic anhydrase II/inhibitor complexes reveal a second binding site for steroidal and nonsteroidal inhibitors. Biochemistry, 49 (16), pp. 3464-3476.

Jourdan, F., Leese, M. P., Dohle, W., Hamel, E., Ferrandis, E., Newman, S. P., Purohit, A., Reed, M. J. and Potter, B. V. L., 2010. Synthesis, antitubulin, and antiproliferative SAR of analogues of 2-Methoxyestradiol-3,17-O,O-bis-sulfamate. Journal of Medicinal Chemistry, 53 (7), pp. 2942-2951.

Woo, L. .W. L., Jackson, T., Putey, A., Cozier, G., Leonard, P., Acharya, K. R., Chander, S. K., Purohit, A., Reed, M. J. and Potter, B. V. L., 2010. Highly potent first examples of dual aromatase-steroid sulfatase inhibitors based on a biphenyl template. Journal of Medicinal Chemistry, 53 (5), pp. 2155-2170.

Falasca, M., Chiozzotto, D., Godage, H. Y., Mazzoletti, M., Riley, A. M., Previdi, S., Potter, B. V. L., Broggini, M. and Maffucci, T., 2010. A novel inhibitor of the PI3K/Akt pathway based on the structure of inositol 1,3,4,5,6-pentakisphosphate. British Journal of Cancer, 102 (1), pp. 104-114.

Stengel, C., Newman, S. P., Leese, M. P., Potter, B. V. L., Reed, M. J. and Purohit, A., 2010. Class III β-tubulin expression and in vitro resistance to microtubule targeting agents. British Journal of Cancer, 102 (2), pp. 316-324.

Rossi, A. M., Riley, A. M., Potter, B. V. L. and Taylor, C. W., 2010. Adenophostins : high-affinity agonists of IP3 receptors. Current Topics in Membranes, 66, pp. 209-233.

Ding, Z., Rossi, A. M., Riley, A. M., Rahman, T., Potter, B. V. L. and Taylor, C. W., 2010. Binding of inositol 1,4,5-trisphosphate (IP3) and adenophostin A to the N-terminal region of the (IP3) receptor : thermodynamic analysis using fluorescence polarization with a novel (IP3) receptor ligand. Molecular Pharmacology, 77 (6), pp. 995-1004.

Foster, P. A., Ho, Y. T., Newman, S. P., Leese, M. P., Potter, B. V. L., Reed, M. J. and Purohit, A., 2009. STX140 and STX641 cause apoptosis via the intrinsic mitochondrial pathway and down-regulate survivin and XIAP expression in ovarian and prostate cancer cells. Anticancer Research, 29 (10), pp. 3751-3757.

Liu, Q., Graeff, R., Kriksunov, I. A., Jiang, H., Zhang, B., Oppenheimer, N., Lin, H. N., Potter, B. V. L., Lee, H. C. and Hao, Q., 2009. Structural basis for enzymatic evolution from a dedicated ADP-ribosyl cyclase to a multifunctional NAD Hydrolase. Journal of Biological Chemistry, 284 (40), pp. 27637-27645.

Rossi, A. M., Riley, A. M., Tovey, S. C., Rahman, T., Dellis, O., Taylor, E. J. A., Veresov, V. G., Potter, B. V. L. and Taylor, C. W., 2009. Synthetic partial agonists reveal key steps in IP3 receptor activation. Nature Chemical Biology, 5 (9), pp. 631-639.

Dammermann, W., Zhang, B., Nebel, M., Cordiglieric, C., Odoardi, F., Kirchberger, T., Kawakami, N., Dowden, J., Schmid, F., Dornmair, K., Hohenegger, M., Flugel, A., Guse, A. H. and Potter, B. V. L., 2009. NAADP-mediated Ca2+ signaling via type 1 ryanodine receptor in T cells revealed by a synthetic NAADP antagonist. Proceedings of the National Academy of Sciences of the United States of America, 106 (26), pp. 10678-10683.

Vicker, N., Sharland, C. M., Heaton, W. B., Ramos Gonzalez, A. M., Bailey, H. V., Smith, A., Springall, J. S., Day, J. M., Tutill, H. J., Reed, M. J., Purohit, A. and Potter, B. V. L., 2009. The design of novel 17 beta-hydroxysteroid dehydrogenase type 3 inhibitors. Molecular and Cellular Endocrinology, 301 (1-2), pp. 259-265.

Sureshan, K. M., Riley, A. M., Rossi, A. M., Tovey, S. C., Dedos, S. G., Taylor, C. W. and Potter, B. V. L., 2009. Activation of IP3 receptors by synthetic bisphosphate ligands. Chemical Communications, 2009 (10), pp. 1204-1206.

Su, X., Vicker, N., Trusselle, M., Halem, H., Culler, M. D. and Potter, B. V. L., 2009. Discovery of novel inhibitors of human 11β-hydroxysteroid dehydrogenase type 1. Molecular and Cellular Endocrinology, 301 (1-2), pp. 169-173.

Day, J. M., Foster, P. A., Tutill, H. J., Newman, S. P., Ho, Y. T., Leese, M. P., Potter, B. V. L., Reed, M. J. and Purohit, A., 2009. BCRP expression does not result in resistance to STX140 in vivo, despite the increased expression of BCRP in A2780 cells in vitro after long-term STX140 exposure. British Journal of Cancer, 100 (3), pp. 476-486.

Kirchberger, T., Moreau, C., Wagner, G. K., Fliegert, R., Siebrands, C. C., Nebel, M., Schmid, F., Harneit, A., Odoardi, F., Flugel, A., Potter, B. V. L. and Guse, A. H., 2009. 8-Bromo-cyclic inosine diphosphoribose : towards a selective cyclic ADP-ribose agonist. Biochemical Journal, 422 (1), pp. 139-149.

Abbate, S., Longhi, G., Castiglioni, E., Lebon, F., Wood, P. M., Woo, L. W. L. and Potter, B. V. L., 2009. Determination of the absolute configuration of aromatase and dual aromatase-sulfatase inhibitors by vibrational and electronic circular dichroism spectra analysis. Chirality, 21 (9), pp. 802-808.

Day, J. M., Tutill, H. J., Foster, P. A., Bailey, H. V., Heaton, W. B., Sharland, C. M., Vicker, N., Potter, B. V. L., Purohit, A. and Reed, M. J., 2009. Development of hormone-dependent prostate cancer models for the evaluation of inhibitors of 17β-hydroxysteroid dehydrogenase Type 3. Molecular and Cellular Endocrinology, 301 (1-2), pp. 251-258.

Veiga, N., Torres, J., Godage, H. Y., Riley, A. M., Dominguez, S., Potter, B. V. L., Diaz, A. and Kremer, C., 2009. The behaviour of inositol 1,3,4,5,6-pentakisphosphate in the presence of the major biological metal cations. Journal of Biological Inorganic Chemistry, 14 (7), pp. 1001-1013.

Foster, P. A., Chander, S. K., Newman, S. P., Woo, L. W. L., Sutcliffe, O. B., Bubert, C., Zhou, D. J., Chen, S. A., Potter, B. V. L., Reed, M. J. and Purohit, A., 2008. A new therapeutic strategy against hormone-dependent breast cancer : the preclinical development of a dual aromatase and sulfatase inhibitor. Clinical Cancer Research, 14 (20), pp. 6469-6477.

Parsons, M. F. C., Foster, P. A., Chander, S. K., Jhalli, R., Newman, S. P., Leese, M. P., Potter, B. V. L., Purohit, A. and Reed, M. J., 2008. The in vivo properties of STX243 : A potent angiogenesis inhibitor in breast cancer. British Journal of Cancer, 99 (9), pp. 1433-1441.

Kudoh, T., Murayama, T., Hashii, M., Higashida, H., Sakurai, T., Maechling, C., Spiess, B., Weber, K., Guse, A. H. and Potter, B. V. L., 2008. Design and synthesis of 4″,6″-unsaturated cyclic ADP-carbocyclic-ribose, a Ca2+-mobilizing agent selectively active in T cells. Tetrahedron, 64 (41), pp. 9754-9765.

Bubert, C., Woo, L. W. L., Sutcliffe, O. B., Mahon, M. F., Chander, S. K., Purohit, A., Reed, M. J. and Potter, B. V. L., 2008. Synthesis of aromatase inhibitors and dual aromatase steroid sulfatase inhibitors by linking an arylsulfamate motif to 4-(4H-1,2,4-triazol-4-ylamino)benzonitrile : SAR, crystal structures, in vitro and in vivo activities. ChemMedChem, 3 (11), pp. 1708-1730.

Reed, M. J., Purohit, A., Woo, L. W. L. and Potter, B. V. L., 2008. Steroid sulfatase inhibitors for the tropical treatment of skin disorders. Drugs of the Future, 33 (7), pp. 597-606.

Newman, S. P., Foster, P. A., Stengel, C., Day, J. M., Ho, Y. T., Judde, J.-G., Lassalle, M., Prevost, G., Leese, M. P., Potter, B. V. L., Reed, M. J. and Purohit, A., 2008. STX140 is efficacious in vitro and in vivo in taxane-resistant breast carcinoma cells. Clinical Cancer Research, 14 (2), pp. 597-606.

Fusi, L., Purohit, A., Brosens, J., Woo, L. W. L., Potter, B. V. L. and Reed, M. J., 2008. Inhibition of steroid sulfatase activity in endometriotic Implants by STX64 (667Coumate) : a potential new therapy. The Scientific World Journal, 8, pp. 1325-1327.

Day, J. M., Foster, P. A., Tutill, H. J., Parsons, M. F. C., Newman, S. P., Chander, S. K., Allan, G. M., Lawrence, H. R., Vicker, N., Potter, B. V. L., Reed, M. J. and Purohit, A., 2008. 17β-hydroxysteroid dehydrogenase Type 1, and not Type 12, is a target for endocrine therapy of hormone-dependent breast cancer. International Journal of Cancer, 122 (9), pp. 1931-1940.

Su, X., Vicker, N. and Potter, B. V. L., 2008. 2 inhibitors of 11β-hydroxysteroid dehydrogenase type 1. Progress in Medicinal Chemistry, 46, pp. 29-130.

Zhang, B., Wagner, G. K., Weber, K., Garnham, C., Morgan, A. J., Galione, A., Guse, A. H. and Potter, B. V. L., 2008. 2'-Deoxy clyclic adenosine 5'-diphosphate ribose derivatives : importance of the 2'-hydroxyl motif for the antagonistic activity of 8-substituted cADPR derivatives. Journal of Medicinal Chemistry, 51 (6), pp. 1623-1636.

Foster, P. A., Ho, Y. T., Newman, S. P., Kasprzyk, P. G., Leese, M. P., Potter, B. V. L., Reed, M. J. and Purohit, A., 2008. 2-MeOE2bisMATE and 2-EtE2bisMATE induce cell cycle arrest and apoptosis in breast cancer xenografts as shown by a novel ex vivo technique. Breast Cancer Research and Treatment, 111 (2), pp. 251-260.

Tagg, S. L. C., Foster, P. A., Leese, M. P., Potter, B. V. L., Reed, M. J., Purohit, A. and Newman, S. P., 2008. 2-Methoxyoestradiol-3,17-O,O-bis-sulphamate and 2-deoxy-D-glucose in combination : a potential treatment for breast and prostate cancer. British Journal of Cancer, 99 (11), pp. 1842-1848.

Sureshan, K. M., Trusselle, M., Tovey, S. C., Taylor, C. W. and Potter, B. V. L., 2008. 2-Position base-modified analogues of adenophostin A as high-affinity agonists of the D-myo-inositol trisphosphate receptor : in vitro evaluation and molecular modeling. Journal of Organic Chemistry, 73 (5), pp. 1682-1692.

Foster, P. A., Stengel, C., Ali, T., Leese, M. P., Potter, B. V. L., Reed, M. J., Purohit, A. and Newman, S. P., 2008. A comparison of two orally bioavailable anti-cancer agents, IRC-110160 and STX140. Anticancer Research, 28 (3A), pp. 1483-1491.

Foster, P. A., Newman, S. P., Leese, M. P., Bernetiere, S., Diolez, C., Camara, J., Hacher, B., Baronnet, M.-M., Ali, T., Potter, B. V. L., Reed, M. J. and Purohit, A., 2008. A new micronized formulation of 2-methoxyestradiol- bis -sulfamate (STX140) is therapeutically potent against breast cancer. Anticancer Research, 28 (2A), pp. 577-581.

Woo, L. W. L., Fischer, D. S., Sharland, C. M., Trusselle, M., Foster, P. A., Chander, S. K., Di Fiore, A., Supuran, C. T., De Simone, G., Purohit, A., Reed, M. J. and Potter, B. V. L., 2008. Anticancer steroid sulfatase inhibitors : synthesis of a potent fluorinated second-generation agent, in vitro and in vivo activities, molecular modeling, and protein crystallography. Molecular Cancer Therapeutics, 7 (8), pp. 2435-2444.

Mills, S. J., Vandeput, F., Trusselle, M. N., Safrany, S. T., Erneux, C. and Potter, B. V. L., 2008. Benzene polyphosphates as tools for cell signalling: inhibition of inositol 1,4,5‐trisphosphate 5‐phosphatase and interaction with the PH domain of protein kinase Bα. ChemBiochem, 9 (11), pp. 1757-1766.

Zhang, B., Bailey, V. C. and Potter, B. V. L., 2008. Chemoenzymatic synthesis of 7-deaza cyclic adenosine 5'-diphosphate ribose anlaogues, membrane-permeant modulators of intracellular calcium release. Journal of Organic Chemistry, 73 (5), pp. 1693-1703.

Wood, P. M., Woo, L. W. L., Labrosse, J.-R., Trusselle, M. N., Abbate, S., Longhi, G., Castiglioni, E., Lebon, F., Purohit, A., Reed, M. J. and Potter, B. V. L., 2008. Chiral aromatase and dual aromatase−steroid sulfatase inhibitors from the letrozole template : synthesis, absolute configuration, and in vitro activity. Journal of Medicinal Chemistry, 51 (14), pp. 4226-4238.

Kudoh, T., Weber, K., Guse, A. H., Potter, B. V. L., Hashii, M., Higashida, H., Arisawa, M., Matsuda, A. and Shuto, S., 2008. Design and synthesis of 4",6"-unsaturated cyclic ADP-carbocyclic ribose as a Ca 2+-mobilizing agent. Tetrahedron Letters, 49 (25), pp. 3976-3979.

Bojarová, P., Denehy, E., Walker, I., Loft, K., De Souza, D. P., Woo, L. W. L., Potter, B. V. L., McConville, M. J. and Williams, S. J., 2008. Direct evidence for ArO-S bond cleavage upon inactivation of Pseudomonas aeruginosa Arylsulfatase by Aryl Sulfamates. ChemBiochem, 9 (4), pp. 613-623.

Jourdan, F., Bubert, C., Leese, M. P., Smith, A., Ferrandis, E., Regis-Lydi, S., Newman, S. P., Purohit, A., Reed, M. J. and Potter, B. V. L., 2008. Effects of C-17 heterocyclic substituents on the anticancer activity of 2-ethylestra-1,3,5(10)-triene-3-O-sulfamates : synthesis, in vitro evaluation and computational modelling. Organic and Biomolecular Chemistry, 6 (22), pp. 4108-4119.

Foster, P. A., Chander, S. K., Parsons, M. F. C., Newman, S. P., Woo, L. W. L., Potter, B. V. L., Reed, M. J. and Purohit, A., 2008. Efficacy of three potent steroid sulfatase inhibitors : pre-clinical investigations for their use in the treatment of hormone-dependent breast cancer. Breast Cancer Research and Treatment, 111 (1), pp. 129-138.

Purohit, A., Fusi, L., Brosens, J., Woo, L. W. L., Potter, B. V. L. and Reed, M. J., 2008. Inhibition of steroid sulfatase activity in endometriotic implants by (667Coumate) : a potential new therapy. Human Reproduction, 23 (2), pp. 290-297.

Purohit, A., Chander, S. K., Woo, L. W. L., Parsons, M. F. C., Jhalli, R., Potter, B. V. L. and Reed, M. J., 2008. Inhibition of steroid sulphatase activity via the percutaneous route : a new option for breast cancer therapy. Anticancer Research, 28 (3A), pp. 1517-1523.

Jackson, T., Woo, L. W. L., Trusselle, M. N., Purohit, A., Reed, M. J. and Potter, B. V. L., 2008. Non-steroidal aromatase inhibitors based on a biphenyl scaffold : synthesis, in vitro SAR, and molecular modelling. ChemMedChem, 3 (4), pp. 603-618.

Jackson, T., Woo, L. W. L., Trusselle, M. N., Purohit, A., Reed, M. J. and Potter, B. V. L., 2008. Non-steroidal aromatase inhibitors based ona biphenyl scaffold: synthesis, in vitro SAR, and molecular modelling. ChemMedChem, 3, pp. 603-618.

Allan, G. M., Vicker, N., Lawrence, H. R., Tutill, H. J., Day, J. M., Huchet, M., Ferrandis, E., Reed, M. J., Purohit, A. and Potter, B. V. L., 2008. Novel inhibitors of 17β-hydroxysteroid dehydrogenase type 1 : templates for design. Bioorganic and Medicinal Chemistry, 16 (8), pp. 4438-4456.

Leese, M. P., Jourdan, F. L., Gaukroger, K., Mahon, M. F., Newman, S. P., Foster, P. A., Stengel, C., Regis-Lydi, S., Ferrandis, E., Di Fiore, A., De Simone, G., Supuran, C. T., Purohit, A., Reed, M. J. and Potter, B. V. L., 2008. Structure-activity relationships of C-17 cyano-substituted estratrienes as anticancer agents. Journal of Medicinal Chemistry, 51 (5), pp. 1295-1308.

Foster, P. A., Woo, L. W. L., Potter, B. V. L., Reed, M. J. and Purohit, A., 2008. The use of steroid sulfatase inhibitors as a novel therapeutic strategy against hormone-dependent endometrial cancer. Endocrinology, 149 (8), pp. 4035-4042.

Vandeput, F., Combettes, L., Mills, S. J., Backers, K., Wohlkönig, A., Parys, J. B., De Smedt, H., Missiaen, L., Dupont, G., Potter, B. V. L. and Erneux, C., 2007. Biphenyl 2,3',4,5',6-pentakisphosphate, a novel inositol polyphosphate surrogate, modulates Ca 2+ responses in rat hepatocytes. FASEB Journal, 21 (7), pp. 1481-1491.

Liu, Q., Kriksunov, I. A., Moreau, C., Graeff, R., Potter, B. V. L., Lee, H. C. and Hao, Q., 2007. Catalysis-associated conformational changes revealed by human CD38 complexed with a non-hydrolyzable substrate analog. Journal of Biological Chemistry, 282 (34), pp. 24825-24832.

Woo, L. W. L., Bubert, C., Sutcliffe, O. B., Smith, A., Chander, S. K., Mahon, M. F., Purohit, A., Reed, M. J. and Potter, B. V. L., 2007. Dual aromatase-steroid sulfatase inhibitors. Journal of Medicinal Chemistry, 50 (15), pp. 3540-3560.

Jackson, T., Woo, L. W. L., Trusselle, M. N., Chander, S. K., Purohit, A., Reed, M. J. and Potter, B. V. L., 2007. Dual aromatase-sulfatase inhibitors based on the anastrozole template : synthesis, in vitro SAR, molecular modelling and in vivo activity. Organic and Biomolecular Chemistry, 5, pp. 2940-2952.

Chander, S. K., Foster, P. A., Leese, M. P., Newman, S. P., Potter, B. V. L., Purohit, A. and Reed, M. J., 2007. In vivo inhibition of angiogenesis by sulphamoylated derivatives of 2-methoxyoestradiol. British Journal of Cancer, 96 (9), pp. 1368-1376.

Su, X., Vicker, N., Lawrence, H., Smith, A., Purohit, A., Reed, M. J. and Potter, B. V. L., 2007. Inhibition of human and rat 11β-hydroxysteroid dehydrogenase type 1 by 18β-glycyrrhetinic acid derivatives. Journal of Steroid Biochemistry and Molecular Biology, 104 (3-5), pp. 312-320.

Zhang, B., Muller-Steffner, H., Schuber, F. and Potter, B. V. L., 2007. Nicotinamide 2-fluoroadenine dinucleotide unmasks the NAD + glycohydrolase activity of Aplysia californica adnosine 5'-diphosphate ribosyl cyclase. Biochemistry, 46 (13), pp. 4100-4109.

Mills, S. J., Komander, D., Trusselle, M. N., Safrany, S. T., van Aalten, D. M. F. and Potter, B. V. L., 2007. Novel inositol phospholipid headgroup surrogate crystallized in the pleckstrin homology domain of protein kinase Bα. ACS Chemical Biology, 2 (4), pp. 242-246.

Vicker, N., Su, X., Ganeshapillai, D., Smith, A., Purohit, A., Reed, M. J. and Potter, B. V. L., 2007. Novel non-steroidal inhibitors of human 11β-hydroxysteroid dehydrogenase type 1. Journal of Steroid Biochemistry and Molecular Biology, 104 (3-5), pp. 123-129.

Sureshan, K. M., Riley, A. M. and Potter, B. V. L., 2007. Rapid and efficient routes to phosphatidylinositol 3,4,5-trisphosphates via myo -inositol orthobenzoate. Tetrahedron Letters, 48 (11), pp. 1923-1926.

Stanway, S. J., Delavault, P., Purohit, A., Woo, L. W. L., Thurieau, C., Potter, B. V. L. and Reed, M. J., 2007. Steroid sulfatase : a new target for the endocrine therapy of breast cancer. The Oncologist, 12 (4), pp. 370-374.

Newman, S. P., Foster, P. A., Ho, Y. T., Day, J. M., Raobaikady, B., Kasprzyk, P. G., Leese, M. P., Potter, B. V. L., Reed, M. J. and Purohit, A., 2007. The therapeutic potential of a series of orally bioavailable anti-angiogenic microtubule disruptors as therapy for hormone-independent prostate and breast cancers. British Journal of Cancer, 97 (12), pp. 1673-1682.

Stanway, S. J., Purohit, A., Woo, L. W. L., Sufi, S., Vigushin, D., Ward, R., Wilson, R. H., Stanczyk, F. Z., Dobbs, N., Kulinskaya, E., Elliott, M., Potter, B. V. L., Reed, M. J. and Coombes, R. C., 2006. Phase I study of STX 64 (667 Coumate) in breast cancer patients: the first study of a steroid sulfatase inhibitor. Clinical Cancer Research, 12 (5), pp. 1585-1592.

Day, J. M., Tutill, H. J., Newman, S. P., Purohit, A., Lawrence, H. R., Vicker, N., Potter, B. V. L. and Reed, M. J., 2006. 17β-hydroxysteroid dehydrogenase type 1 and type 2 : association between mRNA expression and activity in cell lines. Molecular and Cellular Endocrinology, 248 (1), pp. 246-249.

Leese, M. P., Leblond, B., Smith, A., Newman, S. P., Di Fiore, A., De Simone, G., Supuran, C. T., Purohit, A., Reed, M. J. and Potter, B. V. L., 2006. 2-substituted estradiol bis-sulfamates, multitargeted antitumor agents : synthesis, in vitro SAR, protein crystallography, and in vivo activity. Journal of Medicinal Chemistry, 49 (26), pp. 7683-7696.

Mills, S. J., Dozol, H., Vandeput, F., Backers, K., Woodman, T., Erneux, C., Spiess, B. and Potter, B. V. L., 2006. 3-hydroxybenzene 1,2,4-trisphosphate, a novel second messenger mimic and unusual substrate for type-I myo-inositol 1,4,5-trisphosphate 5-phosphatase : synthesis and physicochemistry. ChemBiochem, 7 (11), pp. 1696-1706.

Terauchi, M., Abe, H., Tovey, S. C., Dedos, S. G., Taylor, C. W., Paul, M., Trusselle, M., Potter, B. V. L., Matsuda, A. and Shuto, S., 2006. A systematic study of C-Glucoside trisphosphates as myo-inositol trisphosphate receptor ligands. Synthesis of β-C-glucoside trisphosphates based on the conformational restriction strategy. Journal of Medicinal Chemistry, 49 (6), pp. 1900-1909.

Su, X., Vicker, N., Ganeshapillai, D., Smith, A., Purohit, A., Reed, M. J. and Potter, B. V. L., 2006. Benzothiazole derivatives as novel inhibitors of human 11β-hydroxysteroid dehydrogenase type. Molecular and Cellular Endocrinology, 248 (1), pp. 214-217.

Williams, R., Searcey, M. and Potter, B. V. L., 2006. Cancer treatments for the new millenium. Drug News and Perspectives, 19 (4), pp. 229-232.

Dowden, J., Berridge, G., Moreau, C., Yamasaki, M., Churchill, G. C., Potter, B. V. L. and Galione, A., 2006. Cell-permeant small-molecule modulators of NAADP-mediated Ca2+ release. Chemistry & Biology, 13 (6), pp. 659-665.

Riley, A. M., Godage, H. Y., Mahon, M. F. and Potter, B. V. L., 2006. Chiral desymmetrisation of myo -inositol 1,3,5-orthobenzoate gives rapid access to precursors for second messenger analogues. Tetrahedron: Asymmetry, 17, pp. 171-174.

Riley, A. M., Godage, H. Y., Mahon, M. F. and Potter, B. V. L., 2006. Chiral desymmetrisation of myo-inositol 1,3,5-orthobenzoate gives rapid access to precursors for second messenger analogues. Tetrahedron: Asymmetry, 17 (2), pp. 171-174.

Mochizuki, T., Kondo, Y., Abe, H., Taylor, C. W., Potter, B. V. L., Matsuda, A. and Shuto, S., 2006. Design and synthesis of 5‘-deoxy-5‘-phenyladenophostin A, a highly potent IP3 receptor ligand 1. Organic Letters, 8 (7), pp. 1455-1458.

Vicker, N., Lawrence, H. R., Allan, G. M., Bubert, C., Smith, A., Tutill, H. J., Purohit, A., Day, J. M., Mahon, M. F., Reed, M. J. and Potter, B. V. L., 2006. Focused libraries of 16-substituted estrone derivatives and modified E-ring steroids : inhibitors of 17β-hydroxysteroid dehydrogenase type 1. ChemMedChem, 1 (4), pp. 464-481.

Sureshan, K. M., Trusselle, M., Tovey, S. C., Taylor, C. W. and Potter, B. V. L., 2006. Guanophostin A : synthesis and evaluation of a high affinity agonist of the D-myo-inositol 1,4,5-triphosphate receptor. Chemical Communications, 2006 (19), pp. 2015-2017.

Foster, P. A., Newman, S. P., Chander, S. K., Stengel, C., Jhalli, R., Woo, L. L. W., Potter, B. V. L., Reed, M. J. and Purohit, A., 2006. In vivo efficacy of STX213, a second-generation steroid sulfatase inhibitor, for hormone-dependent breast cancer therapy. Clinical Cancer Research, 12 (18), pp. 5543-5549.

Allan, G. M., Lawrence, H. R., Cornet, J., Bubert, C., Fischer, D. S., Vicker, N., Smith, A., Tutill, H. J., Purohit, A., Day, J. M., Mahon, M. F., Reed, M. J. and Potter, B. V. L., 2006. Modification of estrone at the 6, 16, and 17 positions : novel potent inhibitors of 17β-hydroxysteroid dehydrogenase type 1. Journal of Medicinal Chemistry, 49 (4), pp. 1325-1345.

Allan, G. M., Bubert, C., Vicker, N., Smith, A., Tutill, H. J., Purohit, A., Reed, M. J. and Potter, B. V. L., 2006. Novel, potent inhibitors of 17β-hydroxysteroid dehydrogenase type 1. Molecular and Cellular Endocrinology, 248 (1), pp. 204-207.

Riley, A. M., Deleu, S., Qian, X., Mitchell, J., Chung, S.-k., Adelt, S., Vogel, G., Potter, B. V. L. and Shears, S. B., 2006. On the contribution of stereochemistry to human ITPK1 specificity : Ins(1,4,5,6)P4 is not a physiologic substrate. FEBS Letters, 580 (1), pp. 324-330.

Bailey, H. V., Heaton, W., Vicker, N. and Potter, B. V. L., 2006. Rapid microwave-assisted reductive amination of ketones with anilines. Synlett, 2006 (15), pp. 2444-2448.

Godage, H. Y., Riley, A. M., Woodman, T. J. and Potter, B. V. L., 2006. Regioselective hydrolysis of myo-inositol 1,3,5-orthobenzoate via a 1,2-bridged 2'-phenyl-1,3'-dioxolan-2'-ylium ion provides a rapid route to the anticancer agent Ins(1,3,4,5,6,)P5. Chemical Communications, 2006 (28), pp. 2989-2991.

Moreau, C., Wagner, G. K., Weber, K., Guse, A. H. and Potter, B. V. L., 2006. Structural determinants for N1/N7 cyclization of nicotinamide hypoxanthine 5‘-dinucleotide (NHD+ ) derivatives by ADP-ribosyl cyclase from Aplysia Californica : Ca 2+ -mobilizing activity of 8-substituted cyclic inosine 5‘-diphosphoribose analogues in T-lymphocytes. Journal of Medicinal Chemistry, 49 (17), pp. 5162-5176.

Mochizuki, T., Kondo, Y., Abe, H., Tovey, S. C., Dedos, S. G., Taylor, C. W., Paul, M., Potter, B. V. L., Matsuda, A. and Shuto, S., 2006. Synthesis of Adenophostin A analogues conjugating an aromatic group at the 5'-position as potent IP3 receptor ligands. Journal of Medicinal Chemistry, 49 (19), pp. 5750-5758.

Purohit, A., Tutill, H. J., Day, J. M., Chander, S. K., Lawrence, H. R., Allan, G. M., Fischer, D. S., Vicker, N., Newman, S. P., Potter, B. V. L. and Reed, M. J., 2006. The regulation and inhibition of 17β-hydroxysteroid dehydrogenase in breast cancer. Molecular and Cellular Endocrinology, 248 (1), pp. 199-203.

Newman, S. P., Ireson, C. R., Tutill, H. J., Day, J. M., Parsons, M. F.C., Leese, M. P., Potter, B. V. L., Reed, M. J. and Purohit, A., 2006. The role of 17β-hydroxysteroid dehydrogenases in modulating the activity of 2-methoxyestradiol in breast cancer cells. Cancer Research, 66 (1), pp. 324-330.

Moreau, C., Woodman, T. J. and Potter, B. V. L., 2006. Unusual entry to the novel 8-halo-N-ribosyl hypoxanthine system by degradation of a cyclic adenosine-5'-diphosphate ribose analogue. Chemical Communications, 2006 (10), pp. 1127-1129.

Riley, A. M., Trusselle, M., Kuad, P., Borkovec, M., Cho, J., Choi, J. H., Qian, X., Shears, S. B., Spiess, B. and Potter, B. V. L., 2006. scyllo-inositol pentakisphosphate as an analogue of myo-inositol 1,3,4,5,6-pentakisphosphate : chemical synthesis, physicochemistry and biological applications. ChemBiochem, 7 (7), pp. 1114-1122.

Reed, M. J., Purohit, A., Woo, L. W. L., Newman, S. P. and Potter, B. V. L., 2005. Steroid sulfatase : molecular biology, regulation, and inhibition. Endocrine Reviews, 26 (2), pp. 171-202.

Wood, P. M., Woo, L. W. L., Humphreys, A., Chander, S. K., Purohit, A., Reed, M. J. and Potter, B. V. L., 2005. A Letrozole-based dual aromatase-sulphatase inhibitor with in vivo activity. Steroid Biochemistry & Molecular Biology, 94 (1-3), pp. 123-130.

Leese, M. P., Hejaz, H. A. M., Mahon, M. F., Newman, S. P., Purohit, A., Reed, M. J. and Potter, B. V. L., 2005. A-Ring-Substituted Estrogen-3- O -sulfamates : potent multitargeted anticancer agents. Journal of Medicinal Chemistry, 48 (16), pp. 5243-5256.

Leese, M. P., Hejaz, H. A. M., Mahon, M. F., Newman, S. P., Purohit, A., Reed, M. J. and Potter, B. V. L., 2005. A-ring-substituted estrogen-3- 0 -sulfamates: potent multitargeted anticancer agents. Journal of Medicinal Chemistry, 48, pp. 5243-5256.

Borissow, C. N., Black, S. J., Paul, M., Tovey, S. C., Dedos, S. G., Taylor, C. W. and Potter, B. V. L., 2005. Adenophostin A and analogues modified at the adenine moiety: synthesis, conformational analysis and biological activity. Organic and Biomolecular Chemistry, 3, pp. 245-252.

Leese, M. P., Leblond, B., Newman, S. P., Purohit, A., Reed, M. J. and Potter, B. V. L., 2005. Anti-cancer activities of novel D-ring modified 2-substituted estrogen-3- 0 -sulfamates. Steroid Biochemistry & Molecular Biology, 94 (1), pp. 239-251.

Dowden, J., Brown, R. S., Moreau, C., Galione, A. and Potter, B. V. L., 2005. Chemical synthesis of the novel Ca 2+ messenger NAADP. Nucleosides, Nucleotides and Nucleic Acids, 24 ((5-7)), pp. 513-518.

Lloyd, M. D., Pederick, R. L., Natesh, R., Woo, L. W. L., Purohit, A., Reed, M. J., Acharya, R. and Potter, B. V. L., 2005. Crystal structure of human carbonic anhydrase II at 1.95 Å resolution in complex with 667-coumate, a novel anti-cancer agent. Biochemical Journal, 385 (Pt 3), pp. 715-720.

Lloyd, M. D., Thiyagarajan, N., Ho, Y. T., Woo, L. W. L., Sutcliffe, O. B., Purohit, A., Reed, M. J., Acharya, K. R. and Potter, B. V. L., 2005. First crystal structures of human carbonic anhydrase II in complex with dual aromatase-steroid sulfatase inhibitors. Biochemistry, 44 (18), pp. 6858-6866.

Raobaikady, B., Reed, M. J., Leese, M. P., Potter, B. V. L. and Purohit, A., 2005. Inhibition of MDA-MB-231 cell cycle progression and cell proliferation by C-2-substituted oestradiol mono - and bis -3- 0 -sulphamates. International Journal of Cancer, 117 (1), pp. 150-159.

Maffucci, T., Piccolo, E., Cumashi, A., Lezzi, M., Riley, A. M., Saiardi, A., Godage, H. Y., Rossi, C., Broggini, M., Iacobelli, S., Potter, B. V. L., Innocenti, P. and Falasca, M., 2005. Inhibition of the phosphatidylinositol 3-kinase/Akt pathway by inositol pentakisphosphate results in antiangiogenic and antitumor effects. Cancer Research, 65 (18), pp. 8339-8349.

Poinas, A., Backers, K., Riley, A. M., Mills, S. J., Moreau, C., Potter, B. V. L. and Erneux, C., 2005. Interaction of the catalytic domain of inositol 1,4,5-trisphosphate 3-kinase A with inositol phosphate analogues. ChemBiochem, 6, pp. 1449-1457.

Poinas, A., Backers, K., Riley, A. M., Mills, S. J., Moreau, C., Potter, B. V. L. and Erneux, C., 2005. Interaction of the catalytic domain of inositol 1,4,5-trisphosphate 3-kinase A with inositol phosphate analogues. ChemBiochem, 6 (8), pp. 1449-1457.

Lawrence, H. R., Vicker, N., Allan, G. M., Smith, A., Mahon, M. F., Tutill, H. J., Purohit, A., Reed, M. J. and Potter, B. V. L., 2005. Novel and potent 17 β -hydroxysteroid dehydrogenase type 1 inhibitors. Journal of Medicinal Chemistry, 48 (8), pp. 2759-2762.

Laude, A. J., Tovey, S. C., Dedos, S. G., Potter, B. V. L., Lummis, S. C. R. and Taylor, C. W., 2005. Rapid functional assays of recombinant IP3 receptors. Cell Calcium, 38 (1), pp. 45-51.

Wagner, G. K., Guse, A. H. and Potter, B. V. L., 2005. Rapid synthetic route toward structurally modified derivatives of cyclic adenosine 5'-diphosphate ribose. Journal of Organic Chemistry, 70, pp. 4810-4819.

Purohit, A., Ghilchik, M. W., Leese, M. P., Potter, B. V. L. and Reed, M. J., 2005. Regulation of aromatase activity by cytokines, PGE2 and 2-methoxyoestrone-3-0 -sulphamate in fibroblasts derived from normal and malignant breast tissues. Steroid Biochemistry & Molecular Biology, 94 (1), pp. 167-172.

Terauchi, M., Yahiro, Y., Abe, H., Ichikawa, S., Tovey, S. C., Dedos, S. G., Taylor, C. W., Potter, B. V. L., Matsuda, A. and Shuto, S., 2005. Synthesis of 4,8-anhydro-D- glycero-D-ido-nonanitol 1,6,7-trisphosphate as a novel IP3 receptor ligand using a stereoselective radical cyclization reaction based on a conformational restriction strategy. Tetrahedron, 61 (15), pp. 3697-3707.

Kudoh, T., Fukuoka, M., Ichikawa, S., Murayama, T., Ogawa, Y., Hashii, M., Higashida, H., Kunerth, S., Weber, K., Guse, A. H., Potter, B. V. L., Matsuda, A. and Shuto, S., 2005. Synthesis of stable and cell-type selective analogues of cyclic ADP-ribose, a Ca2 + -mobilizing second messenger. Structure-activity relationship of the N1-ribose moiety. Journal of the American Chemical Society, 127 (24), pp. 8846-8855.

Utsumi, T., Lees, M. P., Chander, S. K., Gaukroger, K., Purohit, A., Newman, S. P., Potter, B. V. L. and Reed, M. J., 2005. The effects of 2-methoxyoestrogen sulphamates on the in vitro and in vivo proliferation of breast cancer cells. Steroid Biochemistry & Molecular Biology, 94 (1), pp. 219-227.

Raobaikady, B., Day, J. M., Purohit, A., Potter, B. V. L. and Reed, M. J., 2005. The nature of inhibition of steroid sulphatase activity by tibolone and its metabolites. Steroid Biochemistry & Molecular Biology, 94 (1), pp. 229-237.

Riley, A. M., Dozol, H., Spiess, B. and Potter, B. V. L., 2004. 2- 0 -(2-Aminoethyl)-myo-inositol 1,4,5-trisphosphate as a novel ligand for conjugation : physicochemical properties and synthesis of a new Ins(1,4,5)P3 affinity matrix. Biochemical and Biophysical Research Communications, 318 (2), pp. 444-452.

Leese, M. P., Newman, S. P., Purohit, A., Reed, M. J. and Potter, B. V. L., 2004. 2-Alkylsulfanyl estrogen derivatives: synthesis of a novel class of multi-targeted anti-tumour agents. Bioorganic & Medicinal Chemistry Letters, 14 (12), pp. 3135-3138.

Leese, M. P., Newman, S. P., Purohit, A., Reed, M. J. and Potter, B. V. L., 2004. 2-Alkylsulfanyl estrogen derivatives: synthesis of a novel class of multi-targeted anti-tumour agents. Bioorganic & Medicinal Chemistry Letters, 14, pp. 3135-3138.

Reed, J. E., Woo, L. W. L., Robinson, J. J., Leblond, B., Leese, M. P., Purohit, A., Reed, M. J. and Potter, B. V. L., 2004. 2-Difluoromethyloestrone 3-0-sulphamate, a highly potent steroid sulphatase inhibitor. Biochemical and Biophysical Research Communications, 317 (1), pp. 169-175.

Wood, L., Leese, M. P., Mouzakiti, A., Purohit, A., Potter, B. V. L., Reed, M. J. and Packham, G., 2004. 2-MeOE2bisMATE induces caspase-dependent apoptosis in CAL51 breast cancer cells and overcomes resistance to TRAIL via cooperative activation of caspases. Apoptosis, 9 (3), pp. 323-332.

Vicker, N., Su, X., Lawrence, H., Cruttenden, A., Purohit, A., Reed, M. J. and Potter, B. V. L., 2004. A novel 18β-glycyrrhetinic acid analogue as a potent and selective inhibitor of 11β-hydroxysteroid dehydrogenase 2. Bioorganic & Medicinal Chemistry Letters, 14 (12), pp. 3263-3267.

Kunerth, S., Langhorst, M. F., Schwarzmann, N., Gu, X., Huang, L., Yang, Z., Zhang, L., Mills, S. J., Zhang, L.-h., Potter, B. V. L. and Guse, A. H., 2004. Amplification and propagation of pacemaker Ca 2+ signals by cyclic ADP-ribose and the type 3 ryanodine receptor in T cells. Journal of Cell Science, 117, pp. 2141-2149.

Mort, C. J. W., Migaud, M. E., Galione, A. and Potter, B. V. L., 2004. Aplysia californica mediated cyclisation of novel 3'-modified NAD analogues : a role for hydrogen bonding in the recognition of cyclic adenosine 5'-diphosphate ribose. Bioorganic and Medicinal Chemistry, 12 (2), pp. 475-487.

Abbate, F., Winum, J.-Y., Potter, B. V. L., Casini, A., Montero, J.-L., Scozzafava, A. and Supuran, C. T., 2004. Carbonic anhydrase inhibitors : X-ray crystallographic structure of the adduct of human isozyme II with EMATE, a dual inhibitor of carbonic anhydrases and steroid sulfatase. Bioorganic & Medicinal Chemistry Letters, 14 (1), pp. 231-234.

Dowden, J., Moreau, C., Brown, R. S., Berridge, G., Galione, A. and Potter, B. V. L., 2004. Chemical synthesis of the second messenger nicotinic acid adenine dinucleotide phosphate by total synthesis of nicotinamide adenine dinucleotide phosphate. Angewandte Chemie-International Edition, 43 (35), 4637 -4640.

Horne, G., Maechling, C., Fleig, A., Hirata, M., Penner, R., Spiess, B. and Potter, B. V. L., 2004. D-6-Deoxy-myo-inositol 1,3,4,5-tetrakisphosphate, a mimic of D-myo-inositol 1,3,4,5-tetrakisphosphate : biological activity and pH-dependent conformational properties. Biochemical and Biophysical Research Communications, 320 (4), pp. 1262-1270.

Riley, A. M., Laude, A. J., Taylor, C. W. and Potter, B. V. L., 2004. Dimers of D-myo-inositol 1,4,5-trisphosphate : design, synthesis, and interaction with Ins(1,4,5)P3 receptors. Bioconjugate Chemistry, 15 (2), pp. 278-289.

Horne, G., Mills, S. J. and Potter, B. V. L., 2004. First derivatives of myo-inositol 1,4,6-trisphosphate modified at positions 2 and 3 : structural an analogues of D- myo -inositol 1,4,5-trisphosphate. Carbohydrate Research, 339, pp. 51-65.

Newman, S. P., Leese, M. P., Purohit, A., James, D. R. C., Rennie, C. E., Potter, B. V. L. and Reed, M. J., 2004. Inhibition of in vitro angiogenesis by 2-methoxy- and 2-ethyl-estrogen sulfamates. International Journal of Cancer, 109 (4), pp. 533-540.

Piccolo, E., Vignati, S., Maffucci, T., Innominato, P. F., Riley, A. M., Potter, B. V. L., Pandolfi, P. P., Broggini, M., Iacobelli, S., Innocenti, P. and Falasca, M., 2004. Inositol pentakisphosphate promotes apoptosis through the PI 3-K/Akt pathway. Oncogene, 23 (9), pp. 1754-1765.

Gregory, R. B., Hughes, R., Riley, A. M., Potter, B. V. L., Wilcox, R. A. and Barritt, G. J., 2004. Inositol trisphosphate analogues selective for types I and II inositol trisphosphate receptors exert differential effects on vasopressin-stimulated Ca 2+ inflow and Ca 2+ release from intracellular stores in rat hepatocytes. Biochemical Journal, 381 (Pt 2), pp. 519-526.

Potter, B. V. L. and Walseth, T. F., 2004. Medicinal chemistry and pharmacology of cyclic ADP-Ribose. Current Molecular Medicine, 4 (3), pp. 303-311.

Su, X., Lawrence, H., Ganeshapillai, D., Cruttenden, A., Purohit, A., Reed, M. J., Vicker, N. and Potter, B. V. L., 2004. Novel 18β-glycyrrhetinic acid analogues as potent and selective inhibitors of 11β-hydroxysteroid dehydrogenases. Bioorganic and Medicinal Chemistry, 12 (16), pp. 4439-4457.

Ireson, C. R., Chander, S. K., Purohit, A., Perera, S., Newman, S. P., Parish, D., Leese, M. P., Smith, A. C., Potter, B. V. L. and Reed, R. J., 2004. Pharmacokinetics and efficacy of 2-methoxyoestradiol and 2-methoxyoestradiol-bis-sulphamate in vivo in rodents. British Journal of Cancer, 90 (4), pp. 932-937.

Ireson, C. R., Chander, S. K., Purohit, A., Parish, D. C., Woo, L. W. L., Potter, B. V. L. and Reed, M. J., 2004. Pharmacokinetics of the nonsteroidal sulphatase inhibitor 667 COUMATE and its sequestration into red blood cells in rats. British Journal of Cancer, 91 (7), pp. 1399-1404.

Solyakov, L., Cain, K., Tracey, B. M., Jukes, R., Riley, A. M., Potter, B. V. L. and Tobin, A. B., 2004. Regulation of casein kinase-2 (CK2) activity by inositol phosphates. Journal of Biological Chemistry, 279 (42), pp. 43403-43410.

Hejaz, H. A. M., Woo, L. W. L., Purohit, A., Reed, M. J. and Potter, B. V. L., 2004. Synthesis, in vitro and in vivo activity of benzophenone-based inhibitors of steroid sulfatase. Bioorganic and Medicinal Chemistry, 12 (10), pp. 2759-2772.

Chander, S. K., Purohit, A., Woo, L. W. L., Potter, B. V. L. and Reed, M. J., 2004. The role of steroid suophatase in regulating the oestrogenicity of oestrogen sulphamates. Biochemical and Biophysical Research Communications, 322 (1), pp. 217-222.

Mills, S. J., Riley, A. M., Liu, C., Mahon, M. F. and Potter, B. V. L., 2003. A definitive synthesis of D-myo-inositol 1,4,5,6-tetrakisphosphate and its enantiomer D-myo-inositol 3,4,5,6-tetrakisphosphate from a novel butane-2,3-diacetal-protected inositol. Chemistry - A European Journal, 9 (24), pp. 6207-6214.

Wagner, G. K., Riley, A. M., Rosenberg, H. J., Taylor, C. W., Guse, A. H. and Potter, B. V. L., 2003. Analogues of cyclic adenosine 5'-diphosphate ribose and adenophostin A, n ucleotides in cellular signal transduction. Nucleic Acids Research Supplement No.3

Shuto, S., Fukuoka, M., Kudoh, T., Garnham, C., Galione, A., Potter, B. V. L. and Matsuda, A., 2003. Convergent synthesis and unexpected Ca2+ -mobilizing activity of 8-substituted analogues of cycle ADP-Carbocyclic-ribose, a stable mimic of the Ca 2+ -mobilizing second messenger cyclic ADP-Ribose. Journal of Medicinal Chemistry, 46 (22), pp. 4741-4749.

Fischer, D. S., Woo, L. W. L., Mahon, M. F., Purohit, A., Reed, M. J. and Potter, B. V. L., 2003. D-ring modified estrone derivatives as novel potent inhibitors of steroid sulfatase. Bioorganic and Medicinal Chemistry, 11 (8), pp. 1685-1700.

Ireson, C. R., Parish, D., Purohit, A., Woo, L. W. L., Potter, B. V. L., Chander, S. K. and Reed, M. J., 2003. Development of a sensitive high-performance liquid chromatography method for the detection of 667 COUMATE in vivo. Journal of Steroid Biochemistry and Molecular Biology, 84 (2), pp. 337-342.

Vicker, N., Ho, Y., Robinson, J., Woo, L. W. L., Purohit, A., Reed, M. J. and Potter, B. V. L., 2003. Docking studies of sulphamate inhibitors of estrone sulphatase in human carbonic anhydrase II. Bioorganic & Medicinal Chemistry Letters, 13 (5), pp. 863-865.

Woo, L. W. L., Sutcliffe, O. B., Bubert, C., Grasso, A., Chander, S., Purohit, A., Reed, M. J. and Potter, B. V. L., 2003. First dual aromatase-steroid sulfatase inhibitor. Journal of Medicinal Chemistry, 46 (15), pp. 3193-3196.

Wagner, G., Black, S., Guse, A. H. and Potter, B. V. L., 2003. First enzymatic synthesis of an N1-cyclised cADPR (cyclic-ADP ribose) analogue with a hypoxanthine partial structure : discovery of a membrane permeant cADPR agonist. Chemical Communications, 2003 (15), pp. 1944-1945.

Suzuki, R. N., Newman, S. P., Purohit, A., Leese, M. P., Potter, B. V. L. and Reed, M. J., 2003. Growth inhibition of multi-drug-resistant breast cancer cells by 2-methoxyoestradiol-bis-sulphamate and 2-ethyloestradiol-bis-sulphamate. Steroid Biochemistry & Molecular Biology, 84 (2), pp. 269-278.

Whitley, P., Reaves, B. J., Hashimoto, M., Riley, A. M., Potter, B. V. L. and Holman, G. D., 2003. Identification of mammalian Vps24p as an effector of phosphatidylinosital 3,5-bisphosphate-dependent endosome compartmentalization. Journal of Biological Chemistry, 278 (40), pp. 38786-38795.

Raobaikady, B., Purohit, A., Chander, S. K., Woo, L. W. L., Leese, M. P., Potter, B. V. L. and Reed, M. J., 2003. Inhibition of MCF-7 breast cancer cell proliferation and in vivo steroid sulphatase activity by 2-methoxyoestradiol-bis-sulphamate. Steroid Biochemistry & Molecular Biology, 84 (2), pp. 351-358.

Ho, Y. T., Purohit, A., Vicker, N., Newman, S. P., Robinson, J. J., Leese, M. P., Ganeshapillai, D., Woo, L. W. L., Potter, B. V. L. and Reed, M. J., 2003. Inhibition of carbonic anhydrase II by steroidal and non-steroidal sulphamates. Biochemical and Biophysical Research Communications, 305 (4), pp. 909-914.

Fischer, D. S., Chander, S. K., Woo, L. W. L., Fenton, J. C., Purohit, A., Reed, M. J. and Potter, B. V. L., 2003. Novel D-ring modified steroid derivatives as potent, non-estrogenic steroid sulfatase inhibitors with in vivo activity. Steroid Biochemistry & Molecular Biology, 84 (2-3), pp. 343-349.

Purohit, A., Woo, L. W. L., Chander, S. K., Newman, S. P., Ireson, C., Ho, Y., Grasso, A., Leese, M. P., Potter, B. V. L. and Reed, M. J., 2003. Steroid sulphatase inhibitors for breast cancer therapy. Steroid Biochemistry & Molecular Biology, 86 (3), pp. 423-432.

Rosenberg, H. J., Riley, A. M., Laude, A. J., Taylor, C. W. and Potter, B. V. L., 2003. Synthesis and Ca 2+ -mobilizing activity of purine-modified mimics of adenophostin A : a model for the adenopostin-Ins(1,4,5)P3 receptor interaction. Journal of Medicinal Chemistry, 46, pp. 4860-4871.

Mills, S. J., Backers, K., Erneux, C. and Potter, B. V. L., 2003. Synthesis of D- and L-myo-inisitol 1,2,4,6-tetrakisphosphate regioisomers of myo -inisitol 1,3,4,5 tetrakisphosphate : activity against Ins(1,4,5)P3 binding proteins. Organic & Biomolecular Chemistry, 2003 (1), pp. 3546-3556.

Mills, S. J. and Potter, B. V. L., 2003. Synthesis of potent Ins(1,4,5)P3 5-phosphatase inhibitors by modification of myo -inositol 1,3,4,6-tetrakisphosphate. Bioorganic and Medicinal Chemistry, 11 (19), pp. 4245-4253.

Ho, Y. T., Newman, S. P., Purohit, A., Leese, M. P., Potter, B. V. L. and Reed, M. J., 2003. The effects of 2-methoxy oestrogens and their sulphamoylated derivatives in conjunction with TNF-α on endothelial and fibroblast cell growth, morphology and apoptosis. Steroid Biochemistry & Molecular Biology, 86 (2), pp. 189-196.

Ho, Y. T., Newman, S. P., Purohit, A., Leese, M. P., Potter, B. V. L. and Reed, M. J., 2003. The effects of 2-methyl oestrogens and their sukphamaoylated derivatives in conjunction with TNF-α on endothelial and fibroblast cell growth, morphology and apoptosis. Steroid Biochemistry & Molecular Biology, 86, pp. 189-196.

Day, J. M., Newman, S. P., Comninos, A., Solomon, C., Purohit, A., Leese, M. P., Potter, B. V. L. and Reed, M. J., 2003. The effects of 2-substituted oestrogen sulphamates on the growth of prostate and ovarian cancer cells. Steroid Biochemistry & Molecular Biology, 84 (2-3), pp. 317-325.

Brown, R. S., Dowden, J., Moreau, C. and Potter, B. V. L., 2002. A concise route to tiazofurin. Tetrahedron Letters, 43 (37), pp. 6561-6562.

Parekh, A. B., Riley, A. M. and Potter, B. V. L., 2002. Adenophostin A and ribophostin, but not inositol 1,4,5-triphosphate or manno -adenophostin, activate the Ca2+ release-activated Ca2+ current, /CRAC , in weak intracellular Ca2+ buffer. Biochemical Journal, 361, pp. 133-141.

Morris, S. A., Nerou, E. P., Riley, A. M., Potter, B. V. L. and Taylor, C. W., 2002. Determinants of adenophostin A binding to inositol trisphosphate receptors. Biochemical Journal, 367 (Pt 1), pp. 113-120.

Howarth, N. M., Purohit, A., Robinson, J. J., Vicker, N., Reed, M. J. and Potter, B. V. L., 2002. Estrone 3-sulfate mimics, inhibitors of estrone sulfatase activity : homology model construction and docking studies. Biochemistry, 41 (50), pp. 14801-14814.

Wood, L., Leese, M. P., Leblond, B., Woo, L. W. L., Ganeshapillai, D., Purohit, A., Reed, M. J., Potter, B. V. L. and Packham, G., 2002. Inhibition of superoxide dismutase by 2-methoxyoestradiol analogues and oestrogen derivatives: structure-activity relationships. Anti-Cancer Drug Design, 16 (4), pp. 209-215.

Riley, A. M., Morris, S. A., Nerou, E. P., Correa, V., Potter, B. V. L. and Taylor, C. W., 2002. Interactions of inositol 1,4,5-Trisphosphate (IP3) receptors with synthetic poly(ethylene glycol)-linked dimers of IP3 suggest close spacing of the IP3 -binding sites. Journal of Biological Chemistry, 277 (43), pp. 40290-40295.

Guse, A. H., Cakir-Kiefer, C., Fukuoka, M., Shuto, S., Weber, K., Bailey, V. C., Matsuda, A., Mayr, G. W., Oppenheimer, N., Schuber, F. and Potter, B. V. L., 2002. Novel hydrolysis-resistant analogues of cyclic ADP-ribose : modification of the "northern" ribose and calcium release activity. Biochemistry, 41 (21), pp. 6744-6751.

Ho, M. W. Y., Yang, X., Carew, M. A., Zhang, T., Hua, L., Kwon, Y.-U., Chung, S.-K., Adelt, S., Vogel, G., Riley, A. M., Potter, B. V. L. and Shears, S. B., 2002. Regulation of Ins(3,4,5,6)P 4 signaling by a reversible kinase/phosphatase. Current Biology, 12 (6), pp. 477-482.

Mills, S. J., Liu, C. and Potter, B. V. L., 2002. Synthesis of D-and L-myo -inositol 2,4,5-trisphosphate and trisphosphorothioate : structural analogues of D-myo-inositol 1,4,5-trisphosphate. Carbohydrate Research, 337 (20), pp. 1795-1801.

Riley, A. M., Jenkins, D. J., Marwood, R. D. and Potter, B. V. L., 2002. Synthesis of glucopyranoside-based ligands for D-myo-inositol 1,4,5-trisphosphate receptors. Carbohydrate Research, 337 (12), pp. 1067-1082.

Riley, A. M., Correa, V., Mahon, M. F., Taylor, C. W. and Potter, B. V. L., 2001. Bicyclic analogues of D-myo-Inositol 1,4,5-trisphosphate related to adenophostin A : synthesis and biological activity. Journal of Medicinal Chemistry, 44 (13), pp. 2108-2117.

Ukhanov, K., Mills, S. J., Potter, B. V. L. and Walz, B., 2001. InsP3 -induced Ca2+ release in permeabilized invertebrate photoreceptors : a link between phototransduction and Ca2+ stores. Cell Calcium, 29 (5), pp. 335-345.

Schöttelndreier, H., Potter, B. V. L., Mayr, G. W. and Guse, A. H., 2001. Mechanisms involved in α6β1-integrin-mediated Ca2+ signalling. Cellular Signalling, 13 (12), pp. 895-899.

Purohit, A., Woo, L. W. L., Barrow, D., Hejaz, H. A. M., Nicholson, R. I., Potter, B. V. L. and Reed, M. J., 2001. Non-steroidal and steroidal sulfamates : new drugs for cancer therapy. Molecular and Cellular Endocrinology, 171 (1-2), pp. 129-135.

Nerou, E. P., Riley, A. M., Potter, B. V. L. and Taylor, C. W., 2001. Selective recognition of inositol phosphates by subtypes of the inositol trisphosphate receptor. Journal of Biological Chemistry, 355 (Pt 1), pp. 59-69.

Correa, V., Riley, A. M., Shuto, S., Horne, G., Nerou, E. P., Marwood, R. D., Potter, B. V. L. and Taylor, C. W., 2001. Structural determinants of adenophostin A activity at inositol trisphosphate receptors. Molecular Pharmacology, 59 (5), pp. 1206-1215.

Liu, C., Riley, A. M., Yang, X., Shears, S. B. and Potter, B. V. L., 2001. Synthesis and biological activity of D-and L-chiro-inositol 2,3,4,5-tetrakisphosphate : design of a novel and potent inhibitor of ins(3,4,5,6)P4 1-kinase/ins(1,3,4)P3 5/6-kinase. Journal of Medicinal Chemistry, 44 (18), pp. 2984-2989.

Horne, G. and Potter, B. V. L., 2001. Synthesis of the enantiomers of 6-deoxy-myo-inositol 1,3,4,5-tetrakisphosphate, structural analogues of myo-inositol 1,3,4,5-tetrakisphosphate. Chemistry - A European Journal, 7 (1), pp. 80-87.

Shuto, S., Horne, G., Marwood, R. D. and Potter, B. V. L., 2001. Total synthesis of nucleobase-modified Adenophostin A mimics. Chemistry - A European Journal, 7 (22), pp. 4937-4946.

Rosenberg, H. J., Riley, A. M., Marwood, R. D., Correa, V., Taylor, C. W. and Potter, B. V. L., 2001. Xylopyranoside-based agonists of D-myo -inositol 1,4,5-trisphosphate receptors : synthesis and effect of stereochemistry on biological activity. Carbohydrate Research, 332, pp. 53-66.

Lind, R. J., Hardick, D. J., Blagbrough, I. S., Potter, B. V. L., Wolstenholme, A. J., Davies, A. R. L., Clough, M. S., Earley, F. G. P., Reynolds, S. E. and Wonnacott, S., 2001. [3H]-methyllycaconitine : a high affinity radioligand that labels invertebrate nicotinic acetylcholine receptors. Insect Biochemistry and Molecular Biology, 31 (6-7), pp. 533-542.

Woo, L. W. L., Purohit, A., Malini, B., Reed, M. J. and Potter, B. V. L., 2000. Potent active site-directed inhibition of steroid sulphatase by tricyclic coumarin-based sulphamates. Chemistry & Biology, 7 (10), pp. 773-791.

Glouchankova, L., Krishna, U. M., Potter, B. V. L., Falck, J. R. and Bezprozvanny, I., 2000. Association of the inositol (1,4,5)-trisphosphate receptor ligand binding site with phosphatidylinositol (4,5)-bisphosphate and adenophostin A. Molecular Cell Biology Research Communications, 3 (3), pp. 153-158.

Rosenberg, H. J., Riley, A. M., Correa, V., Taylor, C. W. and Potter, B. V. L., 2000. C-Glycoside based mimics of d-myo-inositol 1,4,5-trisphosphate. Carbohydrate Research, 329 (1), pp. 7-16.

Marwood, R. D., Shuto, S., Jenkins, D. J. and Potter, B. V. L., 2000. Convergent synthesis of adenophostin A analogues via a base replacement strategy. Chemical Communications, 2000 (3), pp. 219-220.

MacCarthy-Morrogh, L., Townsend, P. A., Purohit, A., Hejaz, H. A. M., Potter, B. V. L., Reed, M. J. and Packham, G., 2000. Differential effects of estrone and estrone-3-0-sulfamate derivatives on mitotic arrest, apoptosis and microtubule assembly in human breast cancer cells. Cancer Research, 60 (19), pp. 5441-5450.

Bonser, J., Walker, J., Purohit, A., Reed, M. J., Potter, B. V. L., Willis, D. S., Franks, S. and Mason, H. D., 2000. Human granulosa cells are a site of sulphatase activity and are able to utilize dehydroepiandrosterone sulphate as a precursor for oestradiol production. The Journal of Endocrinology, 167 (3), pp. 465-471.

Purohit, A., Woo, L. W. L., Potter, B. V. L. and Reed, M. J., 2000. In vivo inhibition of estrone sulfatase activity and growth of nitrosomethylurea-induced mammary tumors by 667 coumate. Cancer Research, 60 (13), pp. 3394-3396.

Singh, A., Purohit, A., Hejaz, H. A. M., Potter, B. V. L. and Reed, M. J., 2000. Inhibition of deoxyglucose uptake in MCF-7 breast cancer cells by 2-methoxyestrone and 2-methoxyestrone-3-O-sulfamate. Molecular and Cellular Endocrinology, 160 (1-2), pp. 61-66.

Malini, B., Purohit, A., Ganeshapillai, D., Woo, L. W. L., Potter, B. V. L. and Reed, M. J., 2000. Inhibition of steroid sulphatase activity by tricyclic coumarin sulphamates. Steroid Biochemistry & Molecular Biology, 75 (4-5), pp. 253-258.

Penner, R., Hermosura, M. C., Takeuchi, H., Fleig, A., Riley, A. M., Potter, B. V. L. and Hirata, M., 2000. InsP4 facilitates store-operated calcium influx by inhibition of InsP3 5-phosphatase. Nature, 408 (6813), pp. 735-740.

Murphy, C. T., Riley, A. M., Mills, S. J., Lindley, C. J., Potter, B. V. L. and Westwick, J., 2000. Myo-inositol 1,4,6-trisphosphorothioate and myo-inositol 1,3,6-trisphosphorothioate : partial agonists with very low intrinsic activity at the platelet myo-Inositol 1,4,5-trisphosphate receptor. Molecular Pharmacology, 57 (3), pp. 595-601.

Berg, I., Potter, B. V. L., Mayr, G. W. and Guse, A. H., 2000. Nicotinic acid adenine dinucleotide phosphate (NAADP+) is an essential regulator of T-lymphocyte Ca2+-signaling. The Journal of Cell Biology (JCB), 150 (3), pp. 581-588.

Riley, A. M. and Potter, B. V. L., 2000. Poly(ethylene glycol)-linked dimers of d-myo-inositol 1,4,5-trisphosphate. Chemical Communications, 2000 (11), pp. 983-984.

Adkins, C. E., Wissing, F., Potter, B. V. L. and Taylor, C. W., 2000. Rapid activation and partial inactivation of inositol trisphosphate receptors by adenophostin A. Biochemical Journal, 352, pp. 929-933.

Newman, S. P., Purohit, A., Ghilchik, M. W., Potter, B. V. L. and Reed, M. J., 2000. Regulation of steroid sulphatase expression and activity in breast cancer. Journal of Steroid Biochemistry and Molecular Biology, 75 (4-5), pp. 259-264.

Marwood, R. D., Correa, V., Taylor, C. W. and Potter, B. V. L., 2000. Synthesis of adenophostin A. Tetrahedron: Asymmetry, 11 (2), pp. 397-403.

Marwood, R. D., Riley, A. M., Jenkins, D. J. and Potter, B. V. L., 2000. Synthesis of adenophostin A and congeners modified at glucose. Journal of the Chemical Society, Perkin Transactions 1

De Kort, M., Correa, V., Valentijn, A. R. P. M., Van Der Marel, G. A., Potter, B. V. L., Taylor, C. W. and Van Boom, J. H., 2000. Synthesis of potent agonists of the D-myo -inositol 1,4,5-trisphosphate receptor based on clustered disaccharide polyphosphate analogues of adenophostin A. Journal of Medicinal Chemistry, 43 (17), pp. 3295-3303.

Purohit, A., Hejaz, H. A. M., Walden, L., MacCarthy-Morrogh, L., Packham, G., Potter, B. V. L. and Reed, M. J., 2000. The effect of 2-methoxyoestrone-3-O-sulphamate on the growth of breast cancer cells and induced mammary tumours. International Journal of Cancer, 85 (4), pp. 584-589.

Whiteaker, P., Davies, A. R. L., Marks, M. J., Blagbrough, I. S., Potter, B. V. L., Wolstenholme, A. J., Collins, A. C. and Wonnacott, S., 1999. An autoradiographic study of the distribution of binding sites for the novel ∝7-selective nicotinic radioligand [3H]-methyllycaconitine in the mouse brain. European Journal of Neuroscience, 11 (8), pp. 2689-2696.

Yang, X., Rudolf, M., Carew, M. A., Yoshida, M., Nerreter, V., Riley, A. M., Chung, S.-K., Bruzik, K. S., Potter, B. V. L. and Schultz, C., 1999. Inositol 1,3,4-trisphosphate acts in vivo as a specific regulator of cellular signaling by inositol 3,4,5,6-tetrakisphosphate. Journal of Biological Chemistry, 274 (27), pp. 18973-18980.

Migaud, M. E., Pederick, R. L., Bailey, V. C. and Potter, B. V. L., 1999. Probing Aplysia californica adenosine 5‘-diphosphate ribosyl cyclase for substrate binding requirements : design of potent inhibitors. Biochemistry, 38 (28), pp. 9105-9114.

Rakovic, S., Cui, Y., Lino, S., Galione, A., Ashamu, G. A., Potter, B. V. L. and Terrar, D. A., 1999. An antagonist of cADP-ribose inhibits arrhythmogenic oscillations of intracellular Ca2+ In heart cells. Journal of Biological Chemistry, 274 (25), pp. 17820-17827.

Surdo, P. L., Bottomley, M. J., Arcaro, A., Siegal, G., Panayotou, G., Sankar, A., Gaffney, P. R. J., Riley, A. M., Potter, B. V. L., Waterfield, M. D. and Driscoll, P. C., 1999. Structural and biochemical evaluation of the interaction of the phosphatidylinositol 3-kinase p85 ∞ Src homology 2 domains with phosphoinositides and inositol polyphosphates. Journal of Biological Chemistry, 274 (22), pp. 15678-15685.

Davies, A. R. L., Hardick, D. J., Blagbrough, I. S., Potter, B. V. L., Wolstenholme, A. J. and Wonnacott, S., 1999. Characterisation of the binding of [3H]methyllycaconitine : a new radioligand for labelling α7-type neuronal nicotinic acetylcholine receptors. Neuropharmacology, 38 (5), pp. 679-690.

Baraldi, E., Carugo, K. D., Hyvönen, M., Surdo, P. L., Riley, A. M., Potter, B. V. L., O’Brien, R., Ladbury, J. E. and Saraste, M., 1999. Structure of the PH domain from Bruton's tyrosine kinase in complex with inositol 1,3,4,5-tetrakisphosphate. Structure, 7 (4), pp. 449-460.

Purohit, A., Hejaz, H. A. M., Woo, L. W. L., Van Strien, A. E., Potter, B. V. L. and Reed, M. J., 1999. Recent advances in the development of steroid sulphatase inhibitors. Steroid Biochemistry & Molecular Biology, 69 (1-6), pp. 227-238.

Reyes-Harde, M., Empson, R., Potter, B. V. L., Galione, A. and Stanton, P. K., 1999. Evidence of a role for cyclic ADP-ribose in long-term synaptic depression in hippocampus. Proceedings of the National Academy of Sciences of the United States of America, 96 (7), pp. 4061-4066.

Guse, A. H., Da Silva, C. P., Berg, I., Skapenko, A. L., Weber, K., Heyer, P., Hohenegger, M., Ashamu, G. A., Schulze-koops, H., Potter, B. V. L. and Mayr, G. W., 1999. Regulation of calcium in T lymphocytes by the second messenger cyclic ADP-ribose. Nature, 398 (6722), pp. 70-73.

Riley, A. M. and Potter, B. V. L., 1999. Bicyclic analogues of inositol 1,4,5-trisphosphate based upon adenophostin A. Tetrahedron Letters, 40 (11), pp. 2213-2216.

Hirst, P. H., Riley, A. M., Mills, S. J., Spiers, I. D., Poyner, D. R., Freeman, S., Potter, B. V. L. and Smith, A. W., 1999. Inositol polyphosphate-mediated iron transport in Pseudomonas aeruginosa. Journal of Applied Microbiology, 86 (3), pp. 537-543.

Marwood, R. D., Riley, A. M., Correa, V., Taylor, C. W. and Potter, B. V. L., 1999. Simplification of adenophostin A defines a minimal structure for potent glucopyranoside-based mimics of 1,4,5-trisphosphate. Bioorganic & Medicinal Chemistry Letters, 9 (3), pp. 453-458.

Beecroft, M. D., Marchant, J. S., Riley, A. M., Van Straten, N. C. R., Van Der Marel, G. A., Van Boom, J. H., Potter, B. V. L. and Taylor, C. W., 1999. Acyclophostin : a ribose-modified analog of adenophostin A with high affinity for inositol 1,4,5-trisphosphate receptors and pH-dependent efficacy. Molecular Pharmacology, 55 (1), pp. 109-117.

Reyes-Harde, M., Potter, B. V. L., Galione, A. and Stanton, P. K., 1999. Induction of hippocampal LTD requires nitric- oxide-stimulated PKG activity and Ca2+ release from cyclic ADP-ribose- sensitive stores. Journal of Neurophysiology, 82 (3), pp. 1569-1576.

Felemez, M., Schlewer, G., Jenkins, D. J., Correa, V., Taylor, C. W., Potter, B. V. L. and Spiess, B., 1999. Inframolecular studies of the protonation of 1d-1,2,4/3,5-cyclopentanepentaol 1,3,4-trisphosphate, a ring-contracted analogue of 1d-myo-inositol 1,4,5-trisphosphate. Carbohydrate Research, 322 (1-2), pp. 95-101.

Felemez, M., Marwood, R. D., Potter, B. V. L. and Spiess, B., 1999. Inframolecular studies of the protonation of adenophostin A : comparison with 1-D-myo-inositol 1,4,5-trisphosphate. Biochemical and Biophysical Research Communications, 266 (2), pp. 334-340.

Hohenegger, M., Berg, I., Weigl, L., Mayr, G. W., Potter, B. V. L. and Guse, A. H., 1999. Pharmacological activation of the ryanodine receptor in Jurkat T-lymphocytes. British Journal of Pharmacology, 128 (6), pp. 1235-1240.

Hejaz, H. A. M., Purohit, A., Mahon, M. F., Reed, M. J. and Potter, B. V. L., 1999. Synthesis and biological activity of the superestrogen (E)-17-oximino-3-O -sulfamoyl-1,3,5(10)-estratriene : x-ray crystal structure of (E)-17-oximino-3-hydroxy-1,3,5(10)-estratriene. Journal of Medicinal Chemistry, 42 (16), pp. 3188-3192.

Liu, C., Davis, R. J., Nahorski, S. R., Ballereau, S., Spiess, B. and Potter, B. V. L., 1999. Synthesis, calcium mobilizing, and physicochemical properties of d-chiro-inositol 1,3,4,6-tetrakisphosphate, a novel and potent ligand at the d-myo-inositol 1,4,5-trisphosphate receptor. Journal of Medicinal Chemistry, 42 (11), pp. 1991-1998.

Riley, A. M., Jenkins, D. J. and Potter, B. V. L., 1998. A concise synthesis of neo-inositol. Carbohydrate Research, 314 (3-4), pp. 277-281.

Doisy, X., Blagbrough, I. S., Thomas, N. F. and Potter, B. V. L., 1998. Studies on the substituted 3-aminopropan-1-ol motif of lycoctonine class norditerpenoid alkaloids: A novel route to 3-hydroxymethylcyclohex-2-enone. Tetrahedron Letters, 39 (46), pp. 8525-8528.

Riley, A. M. and Potter, B. V. L., 1998. l-α-Phosphatidyl-d-myo-inositol 3,5-bisphosphate: total synthesis of a new inositol phospholipid via myo-inositol orthoacetate. Tetrahedron Letters, 39 (37), pp. 6769-6772.

Doisy, X., Blagbrough, I. S., Wonnacott, S. and Potter, B. V. L., 1998. Design, synthesis and biological evaluation of substituted benzoate analogues of the selective nicotinic acetylcholine receptor antagonist, methyllycaconitine. Pharmacy and Pharmacology Communications, 4 (7), pp. 313-317.

Da Silva, C. P., Potter, B. V. L., Mayr, G. W. and Guse, A. H., 1998. Quantification of intracellular levels of cyclic ADP-ribose by high-performance liquid chromatography. Journal of Chromatography B: Biomedical Sciences and Applications, 707 (1-2), pp. 43-50.

Woo, L. W. L., Howarth, N. M., Purohit, A., Hejaz, H. A. M., Reed, M. J. and Potter, B. V. L., 1998. Steroidal and nonsteroidal sulfamates as potent inhibitors of steroid sulfatase. Journal of Medicinal Chemistry, 41 (7), pp. 1068-1083.

Purohit, A., Vernon, K. A., Wagenaar Hummelinck, A. E., Woo, L. W. L., Hejaz, H. A. M., Potter, B. V. L. and Reed, M. J., 1998. The development of A-ring modified analogues of oestrone-3-O-sulphamate as potent steroid sulphatase inhibitors with reduced oestrogenicity. Steroid Biochemistry & Molecular Biology, 64 (5-6), pp. 269-275.

Trigg, W. J., Grangier, G., Lewis, T., Rowan, M. G., Potter, B. V. L. and Blagbrough, I. S., 1998. Synthesis of novel unsaturated AE-bicyclic analogues of lycoctonine, inuline and methyllycaconitine: with olefinic J = 13.5 Hz, but still cis. Tetrahedron Letters, 39 (8), pp. 893-896.

Purohit, A., Potter, B. V. L., Parker, M. G. and Reed, M. J., 1998. Steroid sulphatase : expression, isolation and inhibition for active-site identification studies. Chemico-Biological Interactions, 109 (1-3), pp. 183-193.

Grangier, G., Trigg, W. J., Lewis, T., Rowan, M. G., Potter, B. V. L. and Blagbrough, I. S., 1998. Synthesis of C5-substituted AE-bicyclic analogues of lycoctonine, inuline and methyllycaconitine. Tetrahedron Letters, 39 (8), pp. 889-892.

Riley, A. M., Guédat, P., Schlewer, G., Spiess, B. and Potter, B. V. L., 1998. A conformationally restricted cyclic phosphate analogue of inositol trisphosphate : synthesis and physicochemical properties. Journal of Organic Chemistry, 63 (2), pp. 295-305.

Garrett, S. W., Liu, C., Riley, A. M. and Potter, B. V. L., 1998. Rapid and practical synthesis of D-myo-inositol 1,4,5-trisphosphate. Journal of the Chemical Society, Perkin Transactions 1, 1998 (8), pp. 1367-1368.

Jenkins, D. J. and Potter, B. V. L., 1998. Total synthesis, from D-xylose, of chiral, ring-contracted 1D-myo-inositol 1,4,5-trisphosphate and 1,3,4,5-tetrakisphosphate analogues with C-2 excised. Journal of the Chemical Society, Perkin Transactions 1, 1998 (1), pp. 41-50.

Lockyer, P. J., Bottomley, J. R., Reynolds, J. S., McNulty, T. J., Venkateswarlu, K., Potter, B. V. L., Dempsey, C. E. and Cullen, P. J., 1997. Distinct subcellular localisations of the putative inositol 1,3,4,5-tetrakisphosphate receptors GAP1IP4BP and GAP1m result from the GAP1IP4BP PH domain directing plasma membrane targeting. Current Biology, 7 (12), pp. 1007-1010.

Woo, L. W. L., Purohit, A., Reed, M. J. and Potter, B. V. L., 1997. Oestrone 3-O-(N-acetyl)sulphamate, a potential molecular probe of the active site of oestrone sulphatase. Bioorganic & Medicinal Chemistry Letters, 7 (24), pp. 3075-3080.

Hirata, M., Takeuchi, H., Riley, A. M., Mills, S. J., Watanabe, Y. and Potter, B. V. L., 1997. Inositol 1,4,5-trisphosphate receptor subtypes differentially recognize regioisomers of D-myo-inositol 1,4,5-trisphosphate. Biochemical Journal, 328 (1), pp. 93-98.

Liu, C. and Potter, B. V. L., 1997. Synthesis of 3-Position-Modified Analogues of myo -inositol 1,4,5-trisphosphate, tools for investigation of the polyphosphoinositide pathway of cellular signaling. Journal of Organic Chemistry, 62 (24), pp. 8335-8340.

Marchant, J. S., Beecroft, M. D., Riley, A. M., Jenkins, D. J., Marwood, R. D., Taylor, C. W. and Potter, B. V. L., 1997. Disaccharide polyphosphates based upon adenophostin A activate hepatic D-myo -inositol 1,4,5-trisphosphate receptors. Biochemistry, 36 (42), pp. 12780-12790.

Riley, A. M., Mahon, M. F. and Potter, B. V. L., 1997. Rapid synthesis of the enantiomers of myo-inositol-1,3,4,5-tetrakisphosphate by direct chiral desymmetrization of myo-inositol orthoformate. Angewandte Chemie-International Edition, 36 (13-14), pp. 1472-1474.

Ashamu, G. A., Sethi, J. K., Galione, A. and Potter, B. V. L., 1997. Roles for adenosine ribose hydroxyl groups in cyclic adenosine 5‘-diphosphate ribose-mediated Ca2+ release. Biochemistry, 36 (31), pp. 9509-9517.

Riley, A. M., Mahon, M. F. and Potter, B. V. L., 1997. Einfache Synthese der Enantiomere von myo-Inosit-1,3,4,5-tetrakisphosphat durch direkte chirale Desymmetrisierung von myo-Inositorthoformiat. Angewandte Chemie-International Edition, 109 (13-14), pp. 1583-1585.

Fortt, S. M. and Potter, B. V. L., 1997. An approach to a carbocyclic analogue of cyclic adenosine 5′-diphosphate ribose. The synthesis and bisphosphorylation of N1-[(1S, 3R)-3-(Hydroxymethyl)cyclopent-1-yl]inosine. Tetrahedron Letters, 38 (30), pp. 5371-5374.

Sethi, J. K., Empson, R. M., Bailey, V. C., Potter, B. V. L. and Galione, A., 1997. 7-deaza-8-bromo-cyclic ADP-ribose, the first membrane-permeant, hydrolysis-resistant cyclic ADP-ribose antagonist. Journal of Biological Chemistry, 272 (26), pp. 16358-16363.

Purohit, A., Froome, V. A., Wang, D. Y., Potter, B. V. L. and Reed, M. J., 1997. Measurement of oestrone sulphatase activity in white blood cells to monitor in vivo inhibition of steroid sulphatase activity by oestrone-3-O-sulphamate. Steroid Biochemistry & Molecular Biology, 62 (1), pp. 45-51.

Guse, A. H., Silva, C. P., Weber, K., Armah, C. N., Ashamu, G. A., Schulze, C., Potter, B. V. L., Mayr, G. W. and Hilz, H., 1997. 1-(5-Phospho-beta-D-ribosyl)2'-phosphoadenosine 5'-phosphate cyclic anhydride induced Ca2+ release in human T-cell lines. European Journal of Biochemistry, 245 (2), pp. 411-417.

DeLisle, S., Marksberry, E. W., Bonnett, C., Jenkins, D. J., Potter, B. V. L., Takahashi, M. and Tanzawa, K., 1997. Adenophostin A can stimulate Ca2+ influx without depleting the inositol 1,4,5-trisphosphate-sensitive Ca2+ stores in the Xenopus oocyte. Journal of Biological Chemistry, 272 (15), pp. 9956-9961.

Howarth, N. M., Purohit, A., Reed, M. J. and Potter, B. V. L., 1997. Estrone sulfonates as inhibitors of estrone sulfatase. Steroids, 62 (4), pp. 346-350.

Guse, A. H., Berg, I., da Silva, C. P., Potter, B. V. L. and Mayr, G. W., 1997. Ca2+ entry induced by cyclic ADP-ribose in intact T-lymphocytes. Journal of Biological Chemistry, 272 (13), pp. 8546-8550.

Jenkins, D. J., Marwood, R. D. and Potter, B. V. L., 1997. A disaccharide polyphosphate mimic of 1D-myo-inositol 1,4,5-trisphosphate. Chemical Communications, 1997 (5), pp. 449-450.

Guédat, P., Schlewer, G., Krempp, E., Riley, A. M., Potter, B. V. L. and Spiess, B., 1997. Investigation of the inframolecular acid–base properties of d-myo-inositol 1,3,4,5-tetrakisphosphate and DL-myo-inositol 1,2,4,5-tetrakisphosphate. Chemical Communications, 1997 (6), pp. 625-626.

Bailey, V. C., Sethi, J. K., Galione, A. and Potter, B. V. L., 1997. Synthesis of 7-deaza-8-bromo cyclic adenosine 5′-diphosphate ribose : the first hydrolysis resistant antagonist at the cADPR receptor. Chemical Communications, 1997 (7), pp. 695-696.

Bailey, V. C., Sethi, J. K., Fortt, S. M., Galione, A. and Potter, B. V. L., 1997. 7-Deaza cyclic adenosine 5′-diphosphate ribose : first example of a Ca2+-mobilizing partial agonist related to cyclic adenosine 5′-diphosphate ribose. Chemistry & Biology, 4 (1), pp. 51-61.

Murphy, C. T., Riley, A. M., Lindley, C. J., Jenkins, D. J., Westwick, J. and Potter, B. V. L., 1997. Structural analogues of D-myo-inositol 1,4,5-trisphosphate and adenophostin A : recognition by cerebellar and platelet inositol 1,4,5-trisphosphate receptors. Molecular Pharmacology, 52 (4), pp. 741-748.

Mills, S. J. and Potter, B. V. L., 1997. Synthesis of the enantiomers of myo-inositol 1,2,4,5-tetrakisphosphate, a regioisomer of myo-inositol 1,3,4,5-tetrakisphosphate. Journal of the Chemical Society, Perkin Transactions 1, 1997 (9), pp. 1279-1286.

Purohit, A., Woo, L. W. L., Singh, A., Winterborn, C. J., Potter, B. V. L. and Reed, M. J., 1996. In vivo activity of 4-methyl coumarin 7-0-sulfamate : a non-steroidal non-estrogenic steroid sulfatase inhibitor. Cancer Research, 56 (21), pp. 4950-4955.

Guse, A. H., da Silva, C. P., Weber, K., Ashamu, G. A., Potter, B. V. L. and Mayr, G. W., 1996. Regulation of cADP-ribose-induced Ca2+ Release by Mg2+ and inorganic phosphate. Journal of Biological Chemistry, 271 (39), pp. 23946-23953.

Riley, A. M., Murphy, C. T., Lindley, C. J., Westwick, J. and Potter, B. V. L., 1996. 6-Deoxy-6-hydroxymethyl scyllo-inositol 1,2,4-trisphosphate : a potent agonist at the inositol 1,4,5-trisphosphate receptor. Bioorganic & Medicinal Chemistry Letters, 6 (18), pp. 2197-2200.

Hidalgo Aragones, M. I., Purohit, A., Parish, D., Sahm, U. G., Pouton, C. W., Potter, B. V., L. and Reed, M. J., 1996. Pharmacokinetics of oestrone-3-O-sulphamate. Steroid Biochemistry & Molecular Biology, 58 (5-6), pp. 611-617.

Rakovic, S., Galione, A., Ashamu, G. A., Potter, B. V. L. and Terrar, D. A., 1996. A specific cyclic ADP-ribose antagonist inhibits cardiac excitation–contraction coupling. Current Biology, 6 (8), pp. 989-996.

Jenkins, D. J. and Potter, B. V. L., 1996. A Ca2+-mobilising carbohydrate-based polyphosphate : synthesis of 2-hydroxyethyl α-d-glucopyranoside 2′,3,4-trisphosphate. Carbohydrate Research, 287 (2), pp. 169-182.

Purohit, A., Reed, M. J., Morris, N. C., Williams, G. J. and Potter, B. V. L., 1996. Regulation and inhibition of steroid sulfatase activity in breast cancer. Annals of the New York Academy of Sciences, 784 (1), pp. 40-49.

Reed, M. J., Purohit, A., Woo, L. W. L. and Potter, B. V. L., 1996. The development of steroid sulphatase inhibitors. Endocrine-Related Cancer, 3 (1), pp. 9-23.

Bailey, V. C., Fortt, S. M., Summerhill, R. J., Galione, A. and Potter, B. V.l., 1996. Cyclic aristeromycin diphosphate ribose : a potent and poorly hydrolysable Ca2+-mobilising mimic of cyclic adenosine diphosphate ribose. FEBS Letters, 379 (3), pp. 227-230.

Coates, P. A., Blagbrough, I. S., Rowan, M. G., Pearson, D. P. J., Lewis, T. and Potter, B. V. L., 1996. Preliminary synthetic studies of methyllycaconitine, a potent nicotinic acetylcholine receptor antagonist : rapid syntheses of AE-bicyclic analogues. Journal of Pharmacy and Pharmacology, 48 (2), pp. 210-213.

Callis, D. J., Thomas, N. F., Pearson, D. P. J. and Potter, B. V. L., 1996. A tandem Horner−Emmons olefination−conjugate addition approach to the synthesis of 1,5-disubstituted-6-azabicyclo[3.2.1]octanes based on the AE ring structure of the norditerpenoid alkaloid methyllycaconitine. Journal of Organic Chemistry, 61 (14), pp. 4634-4640.

Woo, L. W. L., Purohit, A., Reed, M. J. and Potter, B. V. L., 1996. Active site directed inhibition of estrone sulfatase by nonsteroidal coumarin sulfamates. Journal of Medicinal Chemistry, 39 (7), pp. 1349-1351.

Jenkins, D. J., Riley, A. M. and Potter, B. V. L., 1996. Chiral cyclopentane-based mimics of D-myo -inositol 1,4,5-trisphosphate from D- glucose. Journal of Organic Chemistry, 61 (22), pp. 7719-7726.

Woo, L. W. L., Lightowler, M., Purohit, A., Reed, M. J. and Potter, B. V. L., 1996. Heteroatom-substituted analogues of the active-site directed inhibitor estra-1,3,5(10)-trien-17-one-3-sulphamate inhibit estrone sulphatase by a different mechanism. Steroid Biochemistry & Molecular Biology, 57 (1-2), pp. 79-88.

Hardick, D. J., Blagbrough, I. S. and Potter, B. V. L., 1996. Isotopic enrichment by asymmetric deuteriation : an investigation of the synthesis of deuteriated (S)-(−)-methylsuccinic acids from itaconic acid. Journal of the American Chemical Society, 118 (25), pp. 5897-5903.

Hardick, D. J., Blagbrough, I. S., Cooper, G., Potter, B. V. L., Critchley, T. and Wonnacott, S., 1996. Nudicauline and elatine as potent norditerpenoid ligands at rat neuronal α-bungarotoxin binding sites : importance of the 2-(methylsuccinimido)benzoyl moiety for neuronal nicotinic acetylcholine receptor binding. Journal of Medicinal Chemistry, 39 (24), pp. 4860-4866.

Jenkins, D. J., Dubreuil, D. and Potter, B. V. L., 1996. Synthesis of D-2-deoxy-myo-inositol 1,3,4,5-tetrakisphosphate from D-glucose. Journal of the Chemical Society - Perkin Transcriptions 1, 1996 (12), pp. 1365-1372.

Lampe, D., Liu, C., Mahon, M. F. and Potter, B. V. L., 1996. Synthesis of L-scyllo-inositol 1,2,4-trisphosphate, scyllo-inositol 1,2,4,5-tetrakisphosphate and phosphorothioate and DL-2-deoxy-2-fluoro-myo-inositol 1,4,5-trisphosphate: optical resolution of DL-1-O-allyl-3,6-di-O-benzyl-4,5-O-isopropylidene-scyllo-inositol. Journal of the Chemical Society - Perkin Transcriptions 1, 1996 (14), pp. 1717-1727.

Sahm, U. G., Williams, G. J., Purohit, A., Hidalgo Aragones, M. I., Parish, D., Reed, M. J., Potter, B. V. L. and Pouton, C. W., 1996. Development of an oral formulation for oestrone-3-O-sulphamate, a potent sulphatase inhibitor. Pharmacy and Pharmacology Communications, 2 (1), pp. 17-20.

Williams, G. J., Woo, L. W. L., Mahon, M. F., Purohit, A., Reed, M. J. and Potter, B. V. L., 1996. X-ray crystal structure and mechanism of action of oestrone 3-O-sulphamate, a synthetic active site-directed inhibitor of oestrone sulphatase. Pharmacy and Pharmacology Communications, 2 (1), pp. 11-16.

Murphy, C. T., Bullock, A., Lindley, C. J., Mills, S. J., Riley, A., Potter, B. V. L. and Westwick, J., 1996. Enantiomers of myo-inositol-1,3,4-trisphosphate and myo-inositol-1,4,6 -trisphosphate: stereospecific recognition by cerebellar and platelet myo-inositol-1,4,5-trisphosphate receptors. Molecular Pharmacology, 50 (5), pp. 1223-1230.

Mills, S. J. and Potter, B. V. L., 1996. Synthesis of D- and L- myo-inositol 1,4,6-trisphosphate, regioisomers of a ubiquitous second messenger. Journal of Organic Chemistry, 61 (25), pp. 8980-8987.

Coates, P. A., Blagbrough, I. S., Lewis, T., Potter, B. V. L. and Rowan, M. G., 1995. An HPLC assay for the norditerpenoid alkaloid methyllycaconitine, a potent nicotinic acetylcholine receptor antagonist. Journal of Pharmaceutical and Biomedical Analysis, 13 (12), pp. 1541-1544.

Guse, A. H., da Silva, C. P., Emmrich, F., Ashamu, G. A., Potter, B. V. L. and Mayr, G. W., 1995. Characterization of cyclic adenosine diphosphate-induced Ca2-release in T-lymphocyte cell lines. The Journal of Immunology, 155 (7), pp. 3353-3359.

Purohit, A., Williams, G. J., Roberts, C. J., Potter, B. V. L. and Reed, M. J., 1995. In vivo inhibition of oestrone sulphatase and dehydroepiandrosterone sulphatase by oestrone-3-O-sulphamate. International Journal of Cancer, 63 (1), pp. 106-111.

Purohit, A., Williams, G. J., Howarth, N. M., Potter, B. V. L. and Reed, M. J., 1995. Inactivation of steroid sulfatase by an active site-directed inhibitor, estrone-3-O-sulfamate. Biochemistry, 34 (36), pp. 11508-11514.

Riley, A. M. and Potter, B. V. L., 1995. Synthesis of a conformationally restricted cyclic phosphate analog of inositol triphosphate. Journal of Organic Chemistry, 60 (16), pp. 4970-4971.

Reed, M. J., Purohit, A., Duncan, L. J., Singh, A., Roberts, C. J., Williams, G. J. and Potter, B. V. L., 1995. The role of cytokines and sulphatase inhibitors in regulating oestrogen synthesis in breast tumours. Steroid Biochemistry & Molecular Biology, 53 (1-6), pp. 413-420.

Hardick, D. J., Cooper, G., Scott-Ward, T., Blagbrough, I. S., Potter, B. V. L. and Wonnacott, S., 1995. Conversion of the sodium channel activator aconitine into a potent α7-selective nicotinic ligand. FEBS Letters, 365 (1), pp. 79-82.

Ward, S. G., Mills, S. J., Liu, C., Westwick, J. and Potter, B. V. L., 1995. D-myo-inositol 1,4,5-trisphosphate analogues modified at the 3-position inhibit phosphatidylinositol 3-kinase. Journal of Biological Chemistry, 270 (20), pp. 12075-12084.

Riley, A. M., Jenkins, D. J. and Potter, B. V. L., 1995. Pentagon IP3 : synthesis of a ring-contracted mimic of a second messenger. Journal of the American Chemical Society, 117 (11), pp. 3300-3301.

Mills, S. J., Riley, A. M., Murphy, C. T., Bullock, A. J., Westwick, J. and Potter, B. V. L., 1995. Myo-inositol 1,4,6-trisphosphorothioate and myo-inositol 1,3,4-trisphosphorothioate: new synthetic Ca2+-mobilising partial agonists at the inositol 1,4,5-trisphosphate receptor. Bioorganic & Medicinal Chemistry Letters, 5 (3), pp. 203-208.

Jenkins, D. J. and Potter, B. V. L., 1995. (2-Hydroxyethyl)-∝-D-glucopyranoside-2',3,4-trisphosphate : synthesis of a second messenger mimic related to adenophostin A. Journal of the Chemical Society, Chemical Communications, 1995 (11), pp. 1169-1170.

Ashamu, G. A., Galione, A. and Potter, B. V. L., 1995. Chemoenzymatic synthesis of analogues of the second messenger candidate cyclic adenosine 5′-diphosphate ribose. Journal of the Chemical Society, Chemical Communications, 1995 (13), pp. 1359-1360.

Potter, B. V. L. and Lampe, D., 1995. Chemistry of inositol lipid-mediated cellular signalling. Angewandte Chemie-International Edition, 34 (18), pp. 1933-1972.

Potter, B. V. L. and Lampe, D., 1995. Die Chemie der Inositlipid-vermittelten zellulären Signalübertragung. Angewandte Chemie-International Edition, 107 (18), pp. 2085-2125.

Jenkins, D. J. and Potter, B. V. L., 1994. On the selectivity of stannylene-mediated alkylation and esterification of methyl 4,6-O-benzylidene α-D-glucopyranoside. Carbohydrate Research, 265 (1), pp. 145-149.

Duken, P., Lammers, A. A., Ozaki, S., Potter, B. V. L., Erneux, C. and Van Haastert, P. J. M., 1994. Phosphorylation of inositol 1,4,5-trisphosphate analogues by 3-kinase and dephosphorylation of inositol 1,3,4,5-tetrakisphosphate analogues by 5-phosphatase. European Journal of Biochemistry, 226 (2), pp. 561-566.

Blagbrough, I. S., Coates, P. A., Hardick, D. J., Lewis, T., Rowan, M. G., Wonnacott, S. and Potter, B. V. L., 1994. Acylation of lycoctonine : semi-synthesis of inuline, delsemine analogues and methyllycaconitine. Tetrahedron Letters, 35 (46), pp. 8705-8708.

Coates, P. A., Blagbrough, I. S., Rowan, M. G., Potter, B. V. L., Pearson, D. P. J. and Lewis, T., 1994. Rapid and efficient entry to substituted 2-succinimidobenzoate-3-azabicyclo[3.3.1]nonanes : AE-bicyclic analogues of methyllycaconitine. Tetrahedron Letters, 35 (46), pp. 8709-8712.

Coates, P. A., Blagbrough, I. S., Hardick, D. J., Rowan, M. G., Wonnacott, S. and Potter, B. V. L., 1994. Rapid and efficient isolation of the nicotinic receptor antagonist methyllycaconitine from delphinium : assignment of the methylsuccinimide absolute stereochemistry as S. Tetrahedron Letters, 35 (46), pp. 8701-8704.

Liu, C. and Potter, B. V.L., 1994. Synthesis of (±)-3-O-alkylated Myo-inositol 1,4,5-trisphosphate analogues as potent receptor ligands and enzyme inhibitors. Tetrahedron Letters, 35 (45), pp. 8457-8460.

Safrany, S. T., Mills, S. J., Liu, C., Lampe, D., Noble, N. J., Nahorski, S. R. and Potter, B. V. L., 1994. Design of potent and selective inhibitors of myo-Inositol 1,4,5-trisphosphate 5-phosphatase. Biochemistry, 33 (35), pp. 10763-10769.

Levitan, I., Payne, R., Potter, B. V. L. and Hillman, P., 1994. Facilitation of the responses to injections of inositol 1,4,5-trisphosphate analogs in Limulus ventral photoreceptors. Biophysical Journal, 67 (3), pp. 1161-1172.

Wilcox, R. A., Safrany, S. T., Lampe, D., Mills, S. J., Nahorski, S. R. and Potter, B. V. L., 1994. Modification at C2 of myo-inositol 1,4,5-trisphosphate produces inositol trisphosphates and tetrakisphosphates with potent biological activities. European Journal of Biochemistry, 223 (1), pp. 115-124.

Purohit, A., Dauvois, S., Parker, M.G., Williams, G. J., Reed, M. J. and Potter, B. V. L., 1994. The hydrolysis of oestrone sulphate and dehydroepiandrosterone sulphate by human steroid sulphatase expressed in transfected COS-1 cells. Steroid Biochemistry & Molecular Biology, 50 (1-2), pp. 101-104.

Ward, S. G., Lampe, D., Liu, C., Potter, B. V. L. and Westwick, J., 1994. Calcium release activity and metabolism of inositol 1,4,5-trisphosphate in T cells : modulation by novel inositol 1,4,5-trisphosphate 5-phosphatase inhibitors. European Journal of Biochemistry, 222 (2), pp. 515-523.

Foster, P. S., Hogan, S. P., Hansbro, P. M., O'Brien, R., Potter, B. V. L., Ozaki, S. and Denborough, M. A., 1994. The metabolism of d-myo-inositol 1,4,5-trisphosphate and d-myo-inositol 1,3,4,5-tetrakisphosphate by porcine skeletal muscle. European Journal of Biochemistry, 222 (3), pp. 955-964.

Hardick, D. J., Blagbrough, I. S., Wonnacott, S. and Potter, B. V. L., 1994. Regioselective anthranoylation of demethylated aconitine : novel analogues of aconitine inuline and methyllycaconitine. Tetrahedron Letters, 35 (20), pp. 3371-3374.

Blagbrough, I. S., Hardick, D. J., Wonnacott, S. and Potter, B. V. L., 1994. Regioselective demethylation of aconitine. Tetrahedron Letters, 35 (20), pp. 3367-3370.

Hansbro, P.M., Foster, P. S., Liu, C. S., Potter, B. V. L. and Denborough, M. A., 1994. Kinetic analysis of novel inhibitors of inositol polyphosphate metabolism. Biochemical and Biophysical Research Communications, 200 (1), pp. 8-15.

Purohit, A., Howarth, N. M., Reed, M. J. and Potter, B. V. L., 1994. Inhibition of steroid sulphatase activity by steroidal methylthiophosphonates : potential therapeutic agents in breast cancer. Steroid Biochemistry & Molecular Biology, 48 (5-6), pp. 523-527.

Liu, C., Al-Hafidh, J., Westwick, J. and Potter, B. V. L., 1994. Synthesis of 1L-chiro-inositol 2,3,5-trisphosphorothioate, the first partial agonist at the platelet myo-inositol 1,4,5-trisphosphate receptor. Bioorganic and Medicinal Chemistry, 2 (4), pp. 253-257.

Lampe, D., Liu, C. and Potter, B. V. L., 1994. Synthesis of selective non-Ca2+ Mobilizing Inhibitors of D-myo-Inositol 1,4,5-trisphosphate 5-phosphatase. Journal of Medicinal Chemistry, 37 (7), pp. 907-912.

Liu, C. and Potter, B. V. L., 1994. Synthesis of myo-inositol 1,4,5-trisphosphate 3-phosphorothioate as an inhibitor of myo-inositol 1,3,4,5-tetrakisphosphate 3-phosphatase. Tetrahedron Letters, 35 (10), pp. 1605-1608.

Hodgkin, M., Craxton, A., Parry, J. B., Hughes, P. J., Potter, B. V. L., Michell, R. H. and Kirk, C. J., 1994. Bovine testis and human erythrocytes contain different subtypes of membrane-associated Ins(1,4,5)P3/Ins(1,3,4,5)P4 5-phosphomonoesterases. Biochemical Journal, 297 (3), pp. 637-645.

Howarth, N. M., Purohit, A., Reed, M. J. and Potter, B. V. L., 1994. Estrone sulfamates: potent inhibitors of estrone sulfatase with therapeutic potential. Journal of Medicinal Chemistry, 37 (2), pp. 219-221.

Wilcox, R. A., Whitham, E. M., Liu, C., Potter, B. V.L. and Nahorski, S. R., 1993. Myo-inositol 1,3,4,5-tetrakisphosphate can independently mobilise intracellular calcium, via the inositol 1,4,5-trisphosphate receptor: studies with myo-inositol 1,4,5-trisphosphate-3-phosphorothioate and myo-inositol hexakisphosphate. FEBS Letters, 336 (2), pp. 267-271.

Mills, S. J., Al-hafidh, J., Westwick, J. and Potter, B. V.L., 1993. Myo-inositol 1,4,6-trisphosphate: A new synthetic Ca2+-mobilising inositol phosphate. Bioorganic & Medicinal Chemistry Letters, 3 (12), pp. 2599-2604.

Galione, A., White, A., Willmott, N., Turner, M., Potter, B. V. L. and Watson, S. P., 1993. cGMP mobilizes intracellular Ca2+ in sea urchin eggs by stimulating cyclicADP-ribose synthesis. Nature, 365 (6445), pp. 456-459.

Mills, S. J., Safrany, S. T., Wilcox, R. A., Nahorski, S. R. and Potter, B. V. L., 1993. Synthesis of myo-inositol 1,2,4,5-tetrakisphosphate, a Ca2+-mobilising tetrakisphosphate with a potency similar to myo-inositol 1,4,5-trisphosphate. Bioorganic & Medicinal Chemistry Letters, 3 (8), pp. 1505-1510.

Wilcox, R. A., Challiss, R. A. J., Liu, C., Potter, B. V. L. and Nahorski, S. R., 1993. Inositol-1,3,4,5-tetrakisphosphate induces calcium mobilization via the inositol-1,4,5-trisphosphate receptor in SH-SY5Y neuroblastoma cells. Molecular Pharmacology, 44 (4), pp. 810-817.

Lampe, D. and Potter, B. V. L., 1993. Synthesis of 2-fluoro-2-deoxy-myo-inositol 1,4,5-trisphosphate and scyllo-inositol 1,2,4-trisphosphate, novel analogues of the second messenger myo-inositol 1,4,5-trisphosphate. Tetrahedron Letters, 34 (14), pp. 2365-2368.

Safrany, S. T., Wilcox, R. A., Liu, C., Dubreuil, D., Potter, B. V. L. and Nahorski, S. R., 1993. Identification of partial agonists with low intrinsic activity at the inositol-1,4,5-trisphosphate receptor. Molecular Pharmacology, 43 (4), pp. 499-503.

Howarth, N. M., Cooper, G., Purohit, A., Duncan, L., Reed, M. J. and Potter, B. V. L., 1993. Phosphonates and thiophosphonates as sulfate surrogates : synthesis of estrone 3-methylthiophosphonate, a potent inhibitor of estrone sulfatase. Bioorganic & Medicinal Chemistry Letters, 3 (2), pp. 313-318.

Duncan, L., Purohit, A., Howarth, N. M., Potter, B. V. L. and Reed, M. J., 1993. Inhibition of estrone sulfatase activity by estrone-3-methylthiophosphonate : a potential therapeutic agent in breast cancer. Cancer Research, 53, pp. 298-303.

Liu, C., Thomas, N. F. and Potter, B. V. L., 1993. Synthesis of racemic myo-inositol 1,4,5-trisphosphate 3-O-methylenecarboxylate, a Ca2+-mobilising myo-lnositol 1,3,4,5-tetrakisphosphate analogue. Journal of the Chemical Society, Chemical Communications, 1993 (22), pp. 1687-1689.

Wilcox, R. A., Challiss, R. A. J., Baudin, G., Vasella, A., Potter, B. V. L. and Nahorski, S. R., 1993. Stereoselectivity of Ins(1,3,4,5)P4 recognition sites : implications for the mechanism of the Ins(1,3,4,5)P4-induced Ca2+ mobilization. Biochemical Journal, 294, pp. 191-194.

Liu, C., Safrany, S. T., Nahorski, S. R. and Potter, B. V. L., 1992. Synthesis of L-chiro-inositol 1,4,6-trisphosphorothioate, a potent and selective inhibitor of myo-inositol 1,4,5-trisphosphate 5-phosphatase. Bioorganic & Medicinal Chemistry Letters, 2 (12), pp. 1523-1528.

Potter, B. V. L. and Gigg, R., 1992. Inositol lipid-mediated cellular signalling. Carbohydrate Research, 234, xi-xxi.

Liu, C., Nahorski, S. R. and Potter, B. V. L., 1992. Synthesis from quebrachitol of 1L-chiro-inositol 2,3,5-trisphosphate, an inhibitor of the enzymes of 1D-myo-inositol 1,4,5-trisphosphate metabolism. Carbohydrate Research, 234, pp. 107-115.

Noble, N. J., Cooke, A. M. and Potter, B. V.L., 1992. Synthesis of (±)-myo-inositol 1,4,5-trisphosphate and the novel analogue (±)-myo-inositol 1,4-bisphosphate 5-phosphorothioate. Carbohydrate Research, 234, pp. 177-187.

Wilcox, R. A., Nahorski, S. R., Sawyer, D. A., Liu, C. and Potter, B. V. L., 1992. The role of the 2- and 3-hydroxyl groups of 1D-myo-inositol 1,4,5-trisphosphate in the mobilisation of calcium from permeabilised human 1321N1 astrocytoma cells. Carbohydrate Research, 234, pp. 237-246.

Safrany, S. T., Wilcox, R. A., Liu, C., Potter, B. V. L. and Nahorski, S. R., 1992. 3-Position modification of myo-inositol 1,4,5-trisphosphate: consequences for intracellular Ca 2+ mobilisation and enzyme recognition. European Journal of Pharmacology, 226 (3), pp. 265-272.

DeLisle, S., Pittet, D., Potter, B. V. L., Lew, P. D. and Welsh, M. J., 1992. InsP3 and Ins(1,3,4,5)P4 act in synergy to stimulate influx of extracellular Ca2+ in Xenopus oocytes. American Journal of Physiology - Cell Physiology, 262 (6), C1456-C1463.

Valdivia, C., Vaughan, D., Potter, B. V. L. and Coronado, R., 1992. Fast release of 45Ca2+ induced by inositol 1,4,5-trisphosphate and Ca2+ in the sarcoplasmic reticulum of rabbit skeletal muscle : evidence for two types of Ca2+ release channels. Biophysical Journal, 61 (5), pp. 1184-1193.

Lampe, D., Mills, S. J. and Potter, B. V. L., 1992. Total synthesis of the second messenger analogue D-myo-inositol 1-phosphorothioate 4,5-bisphosphate: optical resolution of DL-1-O-allyl-2,3,6-tri-O-benzyl-myo-inositol and fluorescent labelling of myo-inositol 1,4,5-trisphosphate. Journal of the Chemical Society - Perkin Transcriptions 1, 1992 (21), pp. 2899-2906.

Safrany, S. T., Sawyer, D. A., Nahorski, S. R. and Potter, B. V. L., 1992. Synthetic D- and L-enantiomers of 2,2-difluoro-2-deoxy-myo-inositol 1,4,5-trisphosphate interact differently with myo-inositol 1,4,5-trisphosphate binding proteins: Identification of a potent small molecule 3-kinase inhibitor. Chirality, 4 (7), pp. 415-422.

Sawyer, D. A. and Potter, B. V. L., 1992. Total synthesis of fluorinated analogues of inositol and inositol 1,4,5-trisphosphate. Journal of the Chemical Society, Perkin Transactions 1, 1992 (7), pp. 923-932.

Noble, N. J., Dubreuil, D. and Potter, B. V. L., 1992. Total synthesis of myo-inositol 1-phosphate4,5-pyrophosphate, a novel second messenger analogue, via myo-inositol 1-phosphate 4,5-bisphosphorothioate. Bioorganic & Medicinal Chemistry Letters, 2 (5), pp. 471-476.

Menniti, F. S., Bird, G. S. J., Takemura, H., Thastrup, O., Potter, B. V. L. and Putney Jr., J. W., 1991. Mobilization of calcium by inositol trisphosphates from permeabilized rat parotid acinar cells : evidence for translocation of calcium from uptake to release sites within the inositol 1,4,5-trisphosphate- and thapsigargin-sensitive calcium pool. Journal of Biological Chemistry, 266 (21), pp. 13646-13653.

Strupish, J., Wojcikiewicz, R. J. H., Challiss, R. A. J., Safrany, S. T., Willcocks, A. L., Potter, B. V. L. and Nahorski, S. R., 1991. Is decavanadate a specific inositol 1, 4, 5-triphosphate receptor antagonist? Biochemical Journal, 277 (1), p. 294.

Payne, R. and Potter, B. V., 1991. Injection of inositol trisphosphorothioate into Limulus ventral photoreceptors causes oscillations of free cytosolic calcium. The Journal of General Physiology, 97 (6), pp. 1165-1186.

Gawler, D. J., Potter, B. V. L., Gigg, R. and Nahorski, S. R., 1991. Interactions between inositol tris- and tetrakis-phosphates : effects on intracellular Ca2+ mobilization in SH-SY5Y cells. Biochemical Journal, 276 (1), pp. 163-167.

Challiss, R. A. J., Smith, S. M., Potter, B. V. L. and Nahorski, S. R., 1991. D-[35S(U)]Inositol 1,4,5-trisphosphorothioate, a novel radioligand for the inositol 1,4,5-trisphosphate receptor Complex binding to rat cerebellar membranes. FEBS Letters, 281 (1-2), pp. 101-104.

Challiss, R. A. J., Willcocks, A. L., Mulloy, B., Potter, B. V. L. and Nahorski, S. R., 1991. Characterization of inositol 1,4,5-trisphosphate- and inositol 1,3,4,5-tetrakisphosphate-binding sites in rat cerebellum. Biochemical Journal, 274 (3), pp. 861-867.

Harootunian, A. T., Kao, J. P. Y., Paranjape, S., Adams, S.R., Potter, B. V. L. and Tsien, R. Y., 1991. Cytosolic Ca2+ oscillations in REF52 fibroblasts : Ca2+-stimulated IP3 production or voltage-dependent Ca2+ channels as key positive feedback elements. Cell Calcium, 12 (2-3), pp. 153-164.

Safrany, S. T., Wojcikiewicz, R. J. H., Strupish, J., Nahorski, S. R., Dubreuil, D., Cleophax, J., Gero, S. D. and Potter, B. V. L., 1991. Interaction of synthetic D-6-deoxy-myo-inositol 1,4,5-trisphosphate with the Ca2+-releasing D-myo-inositol 1,4,5-trisphosphate receptor, and the metabolic enzymes 5-phosphatase and 3-kinase. FEBS Letters, 278 (2), pp. 252-256.

Cunningham, S. A., Else, A. J., Potter, B. V. L. and Eperon, I. C., 1991. Influences of separation and adjacent sequences on the use of alternative 5′ splice sites. Journal of Molecular Biology, 217 (2), pp. 265-281.

Strunecka, A., Desouki, N. I., Palacek, J., Kmonickova, E., Krpjesova, L. and Potter, B. V. L., 1991. The effect of inositol 1,4,5-trisphosphate and inositol 1,4,5-trisphosphorothioate on calcium release and membrane skeleton organization in the human red blood cell. Receptor, 1 (3), pp. 141-154.

Liu, C., Nahorski, S. R. and Potter, B. V. L., 1991. Total synthesis from L-quebrachitol of the D-myo-inositol 1,4,5-trisphosphate analogue, L-chiro-inositol 2,3,5-trisphosphate, a potent inositol 1,4,5-trisphosphate 5-phosphatase and 3-kinase inhibitor. Journal of the Chemical Society, Chemical Communications, 1991 (15), pp. 1014-1016.

Sawyer, D. A. and Potter, B. V. L., 1991. Total synthesis of L-2,2-difluoro-2-deoxy-myo-inositol 1,4,5-trisphosphate, a potent inhibitor of the enzymes of d-myo-inositol 1,4,5-trisphosphate metabolism. Bioorganic & Medicinal Chemistry Letters, 1 (12), pp. 705-710.

Safrany, S. T., Sawyer, D., Wojcikiewicz, R. J. H., Nahorski, S. R. and Potter, B. V. L., 1990. Ca2+-mobilising properties of synthetic fluoro-analogues of myo-inositol 1,4,5-trisphosphate and their interaction with myo-inositol 1,4,5-trisphosphate 3-kinase and 5-phosphatase. FEBS Letters, 276 (1-2), pp. 91-94.

Ferguson, J. E., Potter, B. V. L. and Nuccitelli, R., 1990. The effect of myo-inositol 1, 4, 5-trisphosphorothioate on Cl-current pattern and intracellular Ca2+ in the Xenopus laevis oocyte. Biochemical and Biophysical Research Communications, 172 (1), pp. 229-236.

Wojcikiewicz, R. J. H., Cooke, A. M., Potter, B. V. L. and Nahorski, S. R., 1990. Inhibition of inositol 1,4,5-trisphosphate metabolism in permeabilised SH-SY5Y human neuroblastoma cells by a phosphorothioate-containing analogue of inositol 1,4,5-trisphosphate. European Journal of Biochemistry, 192 (2), pp. 459-467.

Berridge, M. J. and Potter, B. V. L., 1990. Inositol trisphosphate analogues induce different oscillatory patterns in Xenopus oocytes. Cell Regulation, 1 (9), pp. 675-681.

DeLisle, S., Krause, K.-H., Denning, G., Potter, B. V. L. and Welsh, M. J., 1990. Effect of inositol trisphosphate and calcium on oscillating elevations of intracellular calcium in Xenopus oocytes. Journal of Biological Chemistry, 265 (20), pp. 11726-11730.

Valdivia, C., Valdivia, H. H., Potter, B. V. L. and Coronado, R., 1990. Ca2+ release by inositol-trisphosphorothioate in isolated triads of rabbit skeletal muscle. Biophysical Journal, 57 (6), pp. 1233-1243.

Taylor, C. W. and Potter, B. V. L., 1990. The size of inositol 1,4,5-trisphosphate-sensitive Ca2+ stores depends on inositol 1,4,5-trisphosphate concentration. Biochemical Journal, 266, pp. 189-194.

Chilvers, E. R., Challiss, R. J., Willcocks, A. L., Potter, B. V. L., Barnes, P. J. and Nahorski, S. R., 1990. Characterisation of stereospecific binding sites for inositol 1,4,5-trisphosphate in airway smooth muscle. British Journal of Pharmacology, 99 (2), pp. 297-302.

Nunn, D. L., Potter, B. V. L. and Taylor, C. W., 1990. Molecular target sizes of inositol 1,4,5-trisphosphate receptors in liver and cerebellum. Biochemical Journal, 265 (2), pp. 393-398.

Gawler, D. J., Potter, B. V. L. and Nahorski, S. R., 1990. Inositol 1,3,4,5-tetrakisphosphate-induced release of intracellular Ca2+ in SH-SY5Y neuroblastoma cells. Biochemical Journal, 272 (2), pp. 519-524.

Potter, B. V. L., 1990. Recent advances in the chemistry and biochemistry of inositol phosphates of biological interest. Natural Product Reports, 7 (1), pp. 1-24.

Lampe, D. and Potter, B. V. L., 1990. Synthesis of myo-inositol 1-phosphorothioate 4,5-bisphosphate : preparation of a fluorescently labelled myo-inositol 1,4,5-trisphosphate analogue. Journal of the Chemical Society, Chemical Communications, 1990 (21), pp. 1500-1501.

McCarren, M., Potter, B. V. L. and Miller, R. J., 1989. A metabolically stable analog of 1,4,5-inositol trisphosphate activates a novel K+ conductance in pyramidal cells of the rat hippocampal slice. Neuron, 3 (4), pp. 461-471.

Potter, B. V. L., 1989. Synthesis of [17O]- and [18O]-labelled hypophosphate. Journal of Labelled Compounds & Radiopharmaceuticals, 27 (8), pp. 955-963.

Thevenod, F., Dehlinger-Kremer, M., Kemmer, T. P., Christian, A.-L., Potter, B. V. L. and Schulz, I., 1989. Characterization of inositol 1,4,5-trisphosphate-sensitive (IsCaP) and-insensitive (IisCaP) nonmitochondrial Ca2+ pools in rat pancreatic acinar cells. Journal of Membrane Biology, 109 (2), pp. 173-186.

Changya, L., Gallacher, D. V., Irvine, R. F., Potter, B. V. L. and Petersen, O. H., 1989. Inositol 1,3,4,5-tetrakisphosphate is essential for sustained activation of the Ca2+-dependent K+ current in single internally perfused mouse lacrimal acinar cells. Journal of Membrane Biology, 109 (1), pp. 85-93.

Wakui, M., Potter, B. V. L. and Petersen, O. H., 1989. Pulsatile intracellular calcium release does not depend on fluctuations in inositol trisphosphate concentration. Nature, 339 (6222), pp. 317-320.

Taylor, C. W., Berridge, M. J., Cooke, A. M. and Potter, B. V. L., 1989. Inositol 1,4,5-trisphosphorothioate, a stable analogue of inositol trisphosphate which mobilizes intracellular calcium. Biochemical Journal, 259 (3), pp. 645-650.

Nahorski, S. R. and Potter, B. V. L., 1989. Molecular recognition of inositol polyphosphates by intracellular receptors and metabolic enzymes. Trends in Pharmacological Sciences, 10 (4), pp. 139-144.

Lowe, G. and Potter, B. V. L., 1989. Synthesis of inorganic P1-[(S)-16O, 17O, 18O]pyrophosphate. Journal of Labelled Compounds & Radiopharmaceuticals, 27 (1), pp. 63-73.

Cooke, A. M., Nahorski, S. R. and Potter, B. V. L., 1989. myo-Inositol 1,4,5-trisphosphorothioate is a potent competitive inhibitor of human erythrocyte 5-phosphatase. FEBS Letters, 242 (2), pp. 373-377.

Noble, N. J. and Potter, B. V. L., 1989. Desulphurisation of vicinal bisphosphorothioates : a novel synthetic route to substituted cyclic pyrophosphates. Journal of the Chemical Society, Chemical Communications, 1989 (17), pp. 1194-1195.

Cooke, A. M., Noble, N. J., Payne, S., Gigg, R. and Potter, B. V. L., 1989. Synthesis of myo-inositol 1,4-bisphosphate-5-phosphorothioate. Journal of the Chemical Society, Chemical Communications, 1989 (5), pp. 269-271.

Willcocks, A. L., Potter, B. V. L., Cooke, A. M. and Nahorski, S. R., 1988. Myo-inositol(1,4,5)trisphosphorothioate binds to specific [3H]inositol(1,4,5)trisphosphate sites in rat cerebellum and is resistant to 5-phosphatase. European Journal of Pharmacology, 155 (1-2), pp. 181-183.

Griffiths, A. D., Potter, B. V. L. and Eperon, I. C., 1988. Substitution of pre-mRNA with phosphorothioate linkages reveals a new splicing-related reaction. Journal of Biological Chemistry, 263 (25), pp. 12295-12304.

Strupish, J., Cooke, A. M., Potter, B. V. L., Gigg, R. and Nahorski, S. R., 1988. Stereospecific mobilization of intracellular Ca2+ by inositol 1,4,5-triphosphate. Comparison with inositol 1,4,5-trisphosphorothioate and inositol 1,3,4-trisphosphate. Biochemical Journal, 253 (3), pp. 901-905.

Taylor, C. W., Berridge, M. J., Brown, K. D., Cooke, A. M. and Potter, B. V. L., 1988. DL-Myo-inositol 1,4,5-trisphosphorothioate mobilizes intracellular calcium in Swiss 3T3 cells and Xenopus oocytes. Biochemical and Biophysical Research Communications, 150 (2), pp. 626-632.

Breuer, E., Karaman, R., Goldblum, A., Gibson, D., Leader, H., Potter, B. V. L. and Cummins, J. H., 1988. α-Oxyiminophosphonates : chemical and physical properties. Reactions, theoretical calculations, and X-ray crystal structures of (E) and (Z)-dimethyl α-hydroxyiminobenzylphosphonates. Journal of the Chemical Society, Perkin Transactions 1, 1988 (11), pp. 3047-3057.

Willcocks, A. L., Cooke, A. M., Potter, B. V. L. and Nahorski, S. R., 1987. Stereospecific recognition sites for [3H]inositol(1,4,5)-trisphosphate in particulate preparations of rat cerebellum. Biochemical and Biophysical Research Communications, 146 (3), pp. 1071-1078.

Griffiths, A. D., Potter, B. V. L. and Eperon, I. C., 1987. Stereospecificity of nucleases towards phosphorothioate-substituted RNA : stereochemistry of transcription by T7 RNA polymerase. Nucleic Acids Research, 15 (10), pp. 4145-4162.

Cummins, J. H. and Potter, B. V. L., 1987. A general chemical method for the stereochemical analysis of nucleoside-5′ [ 16O, 18 O] phosphorothioates. Phosphorus Sulfur and Silicon and the Related Elements, 30 (3-4), pp. 589-592.

Hamblin, M. R., Cummins, J. H. and Potter, B. V. L., 1987. Mung bean (Phaseolus aureus) nuclease. Biochemical Journal, 241 (3), pp. 827-833.

Hamblin, M. R., Gigg, R. and Potter, B. V. L., 1987. Bisphosphorylation of a vic-diol using a phosphite approach : synthesis of myo-inositol 4,5-bisphosphate. Journal of the Chemical Society, Chemical Communications, 1987 (8), pp. 626-627.

Cummins, J. H. and Potter, B. V. L., 1987. On the mechanism of action of bovine intestinal mucosa 5′-nucleotide phosphodiesterase : stereochemical evidence for a nucleotidyl-enzyme intermediate. European Journal of Biochemistry, 162 (1), pp. 123-128.

Cooke, A. M., Gigg, R. and Potter, B. V. L., 1987. Synthesis of DL-Myo-inositol 1,4,5-triphosphate. Tetrahedron Letters, 28 (20), pp. 2305-2308.

Cooke, A. M., Gigg, R. and Potter, B. V. L., 1987. myo-Inositol 1,4,5-trisphosphorothioate : a novel analogue of a biological second messenger. Journal of the Chemical Society, Chemical Communications, 1987 (20), pp. 1525-1526.

Hamblin, M. R., Flora, J. S. and Potter, B. V. L., 1987. myo-Inositol phosphorothioates, phosphatase-resistant analogues of myo-inositol phosphates. Synthesis of DL-myo-inositol 1,4-bisphosphate and DL-myo-inositol 1,4-bisphosphorothioate. Biochemical Journal, 246 (3), pp. 771-774.

Potter, B. V. L., 1986. On the bromine oxidation of hypophosphate : a 31P (18O) positional isotope investigation. Journal of the Chemical Society, Chemical Communications, 1986 (1), pp. 21-22.

Hamblin, M. R. and Potter, B. V. L., 1985. E. coli Ada regulatory protein repairs the Sp diastereoisomer of alkylated DNA. FEBS Letters, 189 (2), pp. 315-317.

Cummins, J. H. and Potter, B. V. L., 1985. A simple method for the configurational analysis of a deoxynucleoside 5′- [16O,18O ,S] phosphorothioate. Journal of the Chemical Society, Chemical Communications, 1985 (13), pp. 851-853.

Cummins, J. H. and Potter, B. V. L., 1985. Stereochemical evidence for a phosphorylpyridinium intermediate in the iodine-mediated desulphurisation of a phosphorothioate diester. Journal of the Chemical Society, Chemical Communications, 1985 (12), pp. 800-802.

Seela, F., Ott, J., Potter, B. V. L. and Herdering, W., 1985. Oxygen chiral phosphate in ribo- and 2′-deoxyribodinucleoside monophosphates by oxidation of phosphite intermediates. Nucleosides and nucleotides, 4 (1-2), pp. 131-133.

Potter, B. V. L. and Eckstein, F., 1984. Cleavage of phosphorothioate-substituted DNA by restriction endonucleases. Journal of Biological Chemistry, 259 (22), pp. 14243-14248.

Connolly, B. A., Potter, B. V. L., Eckstein, F., Pingoud, A. and Grotjahn, L., 1984. Synthesis and characterization of an octanucleotide containing the EcoRI recognition sequence with a phosphorothioate group at the cleavage site. Biochemistry, 23 (15), pp. 3443-3453.

Lowe, G. and Potter, B. V. L., 1984. Measurement of the 31P–31P geminal coupling constant in pyrophosphate using the scalar relaxation between 17O and 31P nuclei. Journal of the Chemical Society, Chemical Communications, 1984 (13), pp. 877-879.

Potter, B. V. L., Eckstein, F. and Uznanski, B., 1983. A stereospeifically 18O-labelled deoxydinucleoside phosphate block for incorporation into an oligonucleotide. Nucleic Acids Research, 11 (20), pp. 7087-7103.

Seela, F., Ott, J. and Potter, B. V. L., 1983. Oxygen chiral phosphate in uridylyl (3'.fwdarw.5') adenosine by oxidation of a phosphite intermediate : synthesis and absolute configuration. Journal of the American Chemical Society, 105 (18), pp. 5879-5886.

Potter, B. V. L., Connolly, B. A. and Eckstein, F., 1983. Synthesis and configurational analysis of a dinucleoside phosphate isotopically chiral at phosphorus. Stereochemical course of Penicillium citrinum nuclease P1 reaction. Biochemistry, 22 (6), pp. 1369-1377.

Potter, B. V. L., Romaniuk, P. J. and Eckstein, F., 1983. The stereochemical course of DNA hydrolysis by nuclease S1. Journal of Biological Chemistry, 258 (3), pp. 1758-1760.

Pollard-Knight, D., Potter, B. V. L., Cullis, P. M., Lowe, G. and Cornish-Bowden, A., 1983. The stereochemical course of phosphoryl transfer catalysed by glucokinase. Biochemical Journal, 201 (2), pp. 421-423.

Lowe, G. and Potter, B. V. L., 1982. The stereochemical course of phosphoryl transfer catalysed by glucose 6-phosphotase. Biochemical Journal, 201 (3), pp. 421-423.

Jarvest, R. L., Lowe, G. and Potter, B. V. L., 1981. The stereochemical course of phosphoryl transfer catalysed by Bacillus stearothermophilus and rabbit skeletal-muscle phosphofructokinase with a chiral [160,170,18O] phosphate ester. Biochemical Journal, 199 (2), pp. 427-432.

Lowe, G., Cullis, P. M., Jarvest, R. L., Potter, B. V. L. and Sproat, B. S., 1981. The stereochemistry of phosphoryl transfer. Philosophical Transactions of the Royal Society B, 293, pp. 75-92.

Lowe, G. and Potter, B. V. L., 1981. The stereochemical course of yeast hexokinase-catalysed phosphoryl transfer by using adenosine 5'[gamma(S)-16O,17O,18O]triphosphate as substrate. Biochemical Journal, 199 (1), pp. 227-233.

Lowe, G. and Potter, B. V. L., 1981. A stereochemical investigation of phosphoryl transfer catalysed by phosphoglucomutase by the use of a-D-glucose 1 -[(S)-160,170,180] phosphate. Biochemical Journal, 199 (3), pp. 693-698.

Jarvest, R. L., Lowe, G. and Potter, B. V. L., 1981. Analysis of the chirality of [16O,17O,18O] phosphate esters by 31P nuclear magnetic resonance spectroscopy. Journal of the Chemical Society, Perkin Transactions 1

Cullis, P. M., Jarvest, R. L., Lowe, G. and Potter, B. V. L., 1981. The stereochemistry of 2-substituted-2-oxo-4,5-diphenyl-1,3,2-dioxaphospholans and the related chiral [16O,17O,18O]phosphate monoesters. Journal of the Chemical Society, Chemical Communications, 5, pp. 245-246.

Jarvest, R. L., Lowe, G. and Potter, B. V. L., 1980. A stereochemical investigation of the cyclisation of D-glucose-6[(R)-16O,17O,18O]phosphate and adenosine-5′[(R)-16O,17O,18O]phosphate. Journal of the Chemical Society, Chemical Communications, 1980 (23), pp. 1142-1145.

Lowe, G. and Potter, B., 1980. Bacteriostatic activity of fluoro-analogues of 5-(2-hydroxyethyl)-4-methylthiazole, a metabolic intermediate in the biosynthesis of thiamine. Journal of the Chemical Society: Perkin Transactions 1, 1980, pp. 2026-2028.

Jones, V. T., Lowe, G. and Potter, B. V. L., 1980. Evidence against a step-wise mechanism for the fumarase-catalysed dehydration of (2S)-malate. European Journal of Biochemistry, 108 (2), pp. 433-437.

Lowe, G. and Potter, B. V. L., 1980. Synthesis, absolute configuration, and circular dichroism of the enantiomers of fluorosuccinic acid. Journal of the Chemical Society: Perkin Transactions 1, 1980, pp. 2029-2032.

Lowe, G., Potter, B. V. L., Sproat, B. S. and Hull, W. E., 1979. The effect of 17O and the magnitude of the 18O-isotope shift in 31P nuclear magnetic resonance spectroscopy. Journal of the Chemical Society, Chemical Communications, 17, pp. 733-735.

Patent

Falasca, M., Riley, A., Godage, H. and Potter, B., 2011. Novel Inositol Phosphate Derivatives. A61K31/661-WO2011064559 (A2), 03 June 2011.

Potter, B., Dowden, J., Galione, A., Guse, A. H. and Alexander, F., 2007. Therapeutics. A61K31/452-WO2007132179 (A2), 22 November 2007.

Potter, B., Dowden, J. and Galione, A., 2005. Therapeutics. A61K31/4425-WO2005054198 (A2), 16 June 2005.

Shears, S. B., Potter, B. and Riley, A., 2003. Regulation of Ins(3456)P4 Signalling by a Reversible Kinase/Phosphatase and Methods and Compositions Related thereto. C12N9/16-WO03080804 (A2), 02 October 2003.

Potter, B., Guse, A. H., Mayr, G. W. and Schweitzer, K., 2002. Therapeutics. A61K31/7084-WO02098397 (A2), 12 December 2002.

Potter, B., Guse, A. H., Mayr, G. W. and Berg, I., 2002. Naadp Analogues for Modulating T-Cell Activity. A61K31/70-WO0211736 (A1), 14 February 2002.

Potter, B., Guse, A. H., Schulze-Koops, H., Berg, I. and Mayr, G. W., 2000. Cyclic Adenosine Diphosphate Ribose Analogues for Modulating T Cell Activity. G01N33/50-WO0037089 (A1), 29 June 2000.

Reed, M. J. and Potter, B., 2000. Non-steroidal polycyclic ring sulphamate derivatives, comprising two or more rings wherein at least two of the rings mimic the A and B rings of oestrone, the preparation and their use as oestrone sulphatase inhibitors. A61K31/37-NZ331326 (A), 27 March 2000.

Reed, M. J. and Potter, B., 1999. Steroid 3-O-Sulphamate Derivatives As Inhibitors Of Oestrone Sulphatase. A61K31/565-WO9927936 (A1), 10 June 1999.

Reed, M. J. and Potter, B., 1999. Steroid 3-O-Sulphamate Derivatives As Inhibitors Of Oestrone Sulphatase. A61K31/565-WO9927935 (A1), 10 June 1999.

Galione, A. and Potter, B., 1998. Cyclic Adenosine Diphosphate Ribose Analogues. C07H19/20-WO9843992 (A1), 08 October 1998.

Reed, M. J. and Potter, B., 1997. Compounds with a Sulfamate Group. A61K31/00-WO9732872 (A1), 12 September 1997.

This list was generated on Mon Oct 20 01:30:00 2014 IST.