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Items by Brown, David

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Number of items: 142.

2013

Brown, D. R., 2013. α-Synuclein as a ferrireductase. Biochemical Society Transactions, 41 (6), pp. 1513-1517.

Wright, J. A., Mchugh, P. C., Pan, S., Cunningham, A. and Brown, D. R., 2013. Counter-regulation of alpha- and beta-synuclein expression at the transcriptional level. Molecular and Cellular Neuroscience, 57, pp. 33-41.

Younan, N.D., Sarell, C.J., Davies, P., Brown, D.R. and Viles, J.H., 2013. The cellular prion protein traps Alzheimer's Aβ in an oligomeric form and disassembles amyloid fibers. FASEB Journal, 27 (5), pp. 1847-1858.

2012

McHugh, P. C., Wright, J. A., Williams, R. J. and Brown, D. R., 2012. Prion protein expression alters APP cleavage without interaction with BACE-1. Neurochemistry International, 61 (5), pp. 672-680.

Younan, N.D., Nadal, R.C., Davies, P., Brown, D. R. and Viles, J.H., 2012. Methionine oxidation perturbs the structural core of the prion protein and suggests a generic misfolding pathway. Journal of Biological Chemistry, 287 (34), pp. 28263-28275.

Brown, D. R., 2012. Brain Diseases and Metalloproteins. Pan Stanford Publishing.

Brown, D. R., 2012. Introduction. In: Brown, D. R., ed. Brain Diseases and Metalloproteins. Pan Stanford Publishing, pp. 1-10.

Davies, P. and Brown, D. R., 2012. Prion diseases, metals and antioxidants. In: Brown, D. R., ed. Brain Diseases and Metalloproteins. Singapore: Pan Stanford Publishing, pp. 249-293.

Meloni, G., Crameri, A., Fritz, G., Davies, P., Brown, D. R., Kroneck, P. M. H. and Vašák, M., 2012. The catalytic redox activity of prion protein-cuII is controlled by metal exchange with the ZnII-Thiolate clusters of Zn7Metallothionein-3. ChemBiochem, 13 (9), pp. 1261-1265.

Hesketh, S., Thompsett, A. R. and Brown, D. R., 2012. Prion protein polymerisation triggered by manganese-generated prion protein seeds. Journal of Neurochemistry, 120 (1), pp. 177-189.

Wojtera, M., Sobów, T., Kłoszewska, I., Liberski, P. P., Brown, D. R. and Sikorska, B., 2012. Expression of immunohistochemical markers on microglia in Creutzfeldt-Jakob disease and Alzheimer's disease : Morphometric study and review of the literature. Folia Neuropathologica, 50 (1), pp. 74-84.

2011

Mot, A. I., Wedd, A. G., Sinclair, L., Brown, D. R., Collins, S. J. and Brazier, M. W., 2011. Metal attenuating therapies in neurodegenerative disease. Expert Review of Neurotherapeutics, 11 (12), pp. 1717-1745.

Younan, N. D., Klewpatinond, M., Davies, P., Ruban, A. V., Brown, D. R. and Viles, J. H., 2011. Copper(II)-Induced Secondary Structure Changes and Reduced Folding Stability of the Prion Protein. Journal of Molecular Biology, 410 (3), pp. 369-382.

Brown, D. R., 2011. Prions and manganese: A maddening beast. Metallomics, 3 (3), pp. 229-238.

Davies, P., Wang, X. Y., Sarell, C. J., Drewett, A., Marken, F., Viles, J. H. and Brown, D. R., 2011. The synucleins are a family of redox-active copper binding proteins. Biochemistry, 50 (1), pp. 37-47.

Davies, P., Moualla, D. and Brown, D. R., 2011. α-Synuclein is a cellular ferrireductase. PLoS ONE, 6 (1), e15814.

Brown, D. R., 2011. Metals in neurodegenerative disease. Metallomics, 3 (3), pp. 226-228.

McHugh, P. C., Wright, J. A. and Brown, D. R., 2011. Transcriptional regulation of the beta-synuclein 5 '-promoter metal response element by metal transcription factor-1. PLoS ONE, 6 (2), e17354.

2010

Wang, X., Moualla, D., Wright, J. A. and Brown, D. R., 2010. Copper binding regulates intracellular alpha-synuclein localisation, aggregation and toxicity. Journal of Neurochemistry, 113 (3), pp. 704-714.

Brown, D. R., 2010. Metalloproteins and neuronal death. Metallomics, 2 (3), pp. 186-194.

Brown, D. R., 2010. Oligomeric alpha-synuclein and its role in neuronal death. IUBMB Life, 62 (5), pp. 334-339.

Wang, X. and Brown, D. R., 2010. Synuclein proteins and their roles as metal binding proteins. In: Huang, S., ed. Metals and Neurodegeneration. Research Signpost, pp. 177-210.

2009

Wright, J. A., Mchugh, P. C., Stockbridge, M., Lane, S., Kralovicova, S. and Brown, D. R., 2009. Activation and repression of prion protein expression by key regions of intron 1. Cellular and Molecular Life Sciences (CMLS), 66 (23), pp. 3809-3820.

Davies, P. and Brown, D. R., 2009. Manganese enhances prion protein survival in model soils and increases prion infectivity to cells. PLoS ONE, 4 (10), e7518.

Brown, D. R., 2009. Role of microglia in age-related changes to the nervous system. TheScientificWorldJOURNAL, 9, pp. 1061-1071.

Nadal, R. C., Davies, P., Brown, D. R. and Viles, J. H., 2009. Evaluation of Copper(2+) Affinities for the Prion Protein. Biochemistry, 48 (38), pp. 8929-8931.

Wright, J. A., Wang, X. and Brown, D. R., 2009. Unique copper-induced oligomers mediate alpha-synuclein toxicity. FASEB Journal, 23 (8), pp. 2384-2393.

Madine, J., Wang, X., Brown, D. R. and Middleton, D. A., 2009. Evaluation of β-Alanine- and GABA-substituted peptides as inhibitors of disease-linked protein aggregation. ChemBiochem, 10 (12), pp. 1982-1987.

Brown, D. R., 2009. Gene regulation as a potential avenue for the treatment of neurodegenerative disorders. Expert Opinion on Drug Discovery, 4 (5), pp. 515-524.

Fontaine, S. N. and Brown, D. R., 2009. Mechanisms of prion protein aggregation. Protein and Peptide Letters, 16 (1), pp. 14-26.

Brown, D. R., 2009. Brain proteins that mind metals: a neurodegenerative perspective. Dalton Transactions, 21, pp. 4069-4076.

O'Sullivan, D. B. D., Jones, C. E., Abdelraheim, S., Brazier, M. W., Toms, H., Brown, D. R. and Viles, J. H., 2009. Dynamics of a truncated prion protein, PrP(113-231), from 15N NMR relaxation: Order parameters calculated and slow conformational fluctuations localized to a distinct region. Protein Science, 18 (2), pp. 410-423.

Stevens, D. J., Walter, E. D., Rodriguez, A., Draper, D., Davies, P., Brown, D. R. and Millhauser, G. L., 2009. Early Onset Prion Disease from Octarepeat Expansion Correlates with Copper Binding Properties. PLoS Pathogens, 5 (4), e1000390.

Brown, D. R., 2009. Metal binding to alpha-synuclein peptides and its contribution to toxicity. Biochemical and Biophysical Research Communications, 380 (2), pp. 377-381.

Chang, B. G., Gray, P., Piltch, M., Bulgin, M. S., Sorensen-Melson, S., Miller, M. W., Davies, P., Brown, D. R., Coughlin, D. R. and Rubenstein, R., 2009. Surround optical fiber immunoassay (SOFIA): An ultra-sensitive assay for prion protein detection. Journal of Virological Methods, 159 (1), pp. 15-22.

Kralovicova, S., Fontaine, S. N., Alderton, A., Alderman, J., Ragnarsdottir, K. V., Collins, S. J. and Brown, D. R., 2009. The effects of prion protein expression on metal metabolism. Molecular and Cellular Neuroscience, 41 (2), pp. 135-147.

Davies, P., Marken, F., Salter, S. and Brown, D. R., 2009. Thermodynamic and Voltammetric Characterization of the Metal Binding to the Prion Protein: Insights into pH Dependence and Redox Chemistry. Biochemistry, 48 (12), pp. 2610-2619.

2008

Sellarajah, S., Boussard, C., Lekishvili, T., Brown, D. R. and Gilbert, I. H., 2008. Synthesis and testing of peptides for anti-prion activity. European Journal of Medicinal Chemistry, 43 (11), pp. 2418-2427.

Büchl, A., Hawkesworth, C., Ragnarsdottir, K. V. and Brown, D. R., 2008. Re-partitioning of Cu and Zn isotopes by modified protein expression. Geochemical Transactions, 9 (11).

Uppington, K. M. and Brown, D. R., 2008. Resistance of cell lines to prion toxicity aided by phospho-ERK expression. Journal of Neurochemistry, 105 (3), pp. 842-852.

Hesketh, S., Sassoon, J., Knight, R. and Brown, D. R., 2008. Elevated manganese levels in blood and CNS in human prion disease. Molecular and Cellular Neuroscience, 37 (3), pp. 590-598.

Zhu, F., Davies, P., Thompsett, A. R., Kelly, S. M., Tranter, G. E., Hecht, L., Isaacs, N. W., Brown, D. R. and Barron, L. D., 2008. Raman optical activity and circular dichroism reveal dramatic differences in the influence of divalent copper and manganese ions on prion protein folding. Biochemistry, 47 (8), pp. 2510-2517.

Wright, J. A. and Brown, D. R., 2008. Alpha-synuclein and its role in metal binding: Relevance to Parkinson's disease. Journal of Neuroscience Research, 86 (3), pp. 496-503.

Davies, P., Fontaine, S. N., Moualla, D., Wang, X. Y., Wright, J. A. and Brown, D. R., 2008. Amyloidogenic metal-binding proteins: new investigative pathways. Biochemical Society Transactions, 36, pp. 1299-1303.

Liberski, P. P., Brown, D. R., Sikorska, B., Caughey, B. and Brown, P., 2008. Cell death and autophagy in prion diseases (transmissible spongiform encephalopathies). Folia Neuropathologica, 46 (1), pp. 1-25.

Klewpatinond, M., Davies, P., Bowen, S., Brown, D. R. and Viles, J. H., 2008. Deconvoluting the Cu2+ binding modes of full-length prion protein. Journal of Biological Chemistry, 283 (4), pp. 1870-1881.

Goni, F., Prelli, F., Schreiber, F., Scholtzova, H., Chung, E., Kascsak, R., Brown, D. R., Sigurdsson, E. M., Chabalgoity, J. A. and Wisniewski, T., 2008. High titers of mucosal and systemic anti-PrP antibodies abrogate oral prion infection in mucosal-vaccinated mice. Neuroscience, 153 (3), pp. 679-686.

Haigh, C. L. and Brown, D. R., 2008. Investigation of PrPC Metabolism and Function in Live Cells. Methods in Molecular Biology, 459, pp. 21-34.

Brazier, M., Davies, P., Player, E., Marken, F., Viles, J. H. and Brown, D., 2008. Manganese binding to the prion protein. Journal of Biological Chemistry, 283 (19), pp. 12831-12839.

Brown, D. R., 2008. Prions and trace elements. In: Schlegel, P., Durosoy, S. and Jongbloed, A. W., eds. Trace elements in animal production systems OTEANE. Wageningen, Netherlands: Wageningen Academic Publishers, pp. 231-242.

Davies, P. and Brown, D. R., 2008. The chemistry of copper binding to PrP: is there sufficient evidence to elucidate a role for copper in protein function? Biochemical Journal, 410, pp. 237-244.

2007

Alderton, A., Davies, P., Illman, K. and Brown, D. R., 2007. Ancient conserved domain protein-1 binds copper and modifies its retention in cells. Journal of Neurochemistry, 103 (1), pp. 312-321.

Butowt, R., Davies, P. and Brown, D. R., 2007. Anterograde axonal transport of chicken cellular prion protein (PrPc) in vivo requires its N-terminal part. Journal of Neuroscience Research, 85 (12), pp. 2567-2579.

Brown, D. R., 2007. Copper and amyloid fibril formation. FEBS Journal, 274 (15), p. 3755.

Thompsett, A. R. and Brown, D. R., 2007. Dual polarisation interferometry analysis of copper binding to the prion protein: Evidence for two folding states. Biochimica Et Biophysica Acta-Proteins and Proteomics, 1774 (7), pp. 920-927.

Hesketh, S., Sassoon, J., Knight, R., Hopkins, J. and Brown, D. R., 2007. Elevated manganese levels in blood and central nervous system occur before onset of clinical signs in scrapie and bovine spongiform encephalopathy. Journal of Animal Science, 85 (6), pp. 1596-1609.

Brown, D. R., 2007. Interactions between metals and alpha-synuclein - function or artefact? FEBS Journal, 274 (15), pp. 3766-3774.

Webb, S., Lekishvili, T., Loeschner, C., Sellarajah, S., Prelli, F., Wisniewski, T., Gilbert, I. H. and Brown, D. R., 2007. Mechanistic insights into the cure of prion disease by novel antiprion compounds. Journal of Virology, 81 (19), pp. 10729-10741.

Uppington, K. M. and Brown, D. R., 2007. Modelling neurodegeneration in prion disease - applications for drug development. Expert Opinion on Drug Discovery, 2, pp. 777-788.

O'Sullivan, D. B. D., Jones, C. E., Abdelraheim, S. R., Thompsett, A. R., Brazier, M. W., Toms, H., Brown, D. R. and Viles, J. H., 2007. NMR characterization of the pH 4 beta-intermediate of the prion protein: the N-terminal half of the protein remains unstructured and retains a high degree of flexibility. Biochemical Journal, 401, pp. 533-540.

Nadal, R. C., Abdelraheim, S. R., Brazier, M. W., Rigby, S. E. J., Brown, D. R. and Viles, J. H., 2007. Prion protein does not redox-silence Cu2+, but is a sacrificial quencher of hydroxyl radicals. Free Radical Biology and Medicine, 42 (1), pp. 79-89.

Treiber, C., Thompsett, A. R., Pipkorn, R., Brown, D. R. and Multhaup, G., 2007. Real-time kinetics of discontinuous and highly conformational metal-ion binding sites of prion protein. Journal of Biological Inorganic Chemistry, 12 (5), pp. 711-720.

Haigh, C. L., Wright, J. A. and Brown, D. R., 2007. Regulation of prion protein expression by noncoding regions of the Prnp gene. Journal of Molecular Biology, 368 (4), pp. 915-927.

2006

Butowt, R., Abdelraheim, S., Brown, D. R. and von Bartheld, C. S., 2006. Anterograde axonal transport of the exogenous cellular isoform of prion protein in the chick visual system. Molecular and Cellular Neuroscience, 31 (1), pp. 97-108.

Cheng, F., Lindqvist, J. N., Haigh, C. L., Brown, D. R. and Mani, K., 2006. Copper-dependent co-internalization of the prion protein and glypican-1. Journal of Neurochemistry, 98 (5), pp. 1445-1457.

Zerovnik, E., Skerget, K., Tusek-Znidaric, M., Loeschner, C., Brazier, M. W. and Brown, D. R., 2006. High affinity copper binding by stefin B (cystatin B) and its role in the inhibition of amyloid fibrillation. FEBS Journal, 273 (18), pp. 4250-4263.

Abdelraheim, S. R., Kralovicova, S. and Brown, D. R., 2006. Hydrogen peroxide cleavage of the prion protein generates a fragment able to initiate polymerisation of full length prion protein. The International Journal of Biochemistry & Cell Biology, 38 (8), pp. 1429-1440.

Brown, D. R., 2006. Metallic prions: Mining the core of transmissible spongiform encephalopathies. Metal Ions in Life Science, 1, pp. 89-114.

Kozlowski, H., Brown, D. R. and Valensin, G., 2006. Metallochemistry of Neurodegeneration. UK: Royal society of Chemistry Publishing.

Lekishvili, T., Hesketh, S., Brazier, M. W. and Brown, D. R., 2006. Mouse galectin-1 inhibits the toxicity of glutamate by modifying NR1 NMDA receptor expression. European Journal of Neuroscience, 24 (11), pp. 3017-3025.

Haigh, C. L. and Brown, D. R., 2006. Prion protein reduces both oxidative and non-oxidative copper toxicity. Journal of Neurochemistry, 98 (3), pp. 677-689.

Haigh, C. L. and Brown, D. R., 2006. Regulation of prion protein expression: A potential site for therapeutic intervention in the transmissible spongiform encephalopathies. International Journal of Biomedical Science (IJBS), 2, pp. 315-323.

2005

Brown, D. R., 2005. A field on fire: the biochemistry of mad cows. The Biochemist, 27, pp. 6-8.

Pan, T., Chang, B. G., Wong, P., Li, C. Y., Li, R. L., Kang, S. C., Robinson, J. D., Thompsett, A. R., Tein, P., Yin, S. M., Barnard, G., McCconnell, I., Brown, D. R., Wisniewski, T. and Sy, M. S., 2005. An aggregation-specific enzyme-linked immunosorbent assay: Detection of conformational differences between recombinant PrP protein dimers and PrPSc aggregates. Journal of Virology, 79 (19), pp. 12355-12364.

Haigh, C. L., Edwards, K. and Brown, D. R., 2005. Copper binding is the governing determinant of prion protein turnover. Molecular and Cellular Neuroscience, 30 (2), pp. 186-196.

Thompsett, A. R., Abdelraheim, S. R., Daniels, M. and Brown, D. R., 2005. High affinity binding between copper and full-length prion protein identified by two different techniques. Journal of Biological Chemistry, 280 (52), pp. 42750-42758.

Goni, F., Knudsen, E., Schreiber, F., Scholtzova, H., Pankiewicz, J., Carp, R., Meeker, H. C., Rubenstein, R., Brown, D. R., Sy, M. S., Chabalgoity, J. A., Sigurdsson, E. M. and Wisniewski, T., 2005. Mucosal vaccination delays or prevents prion infection via an oral route. Neuroscience, 133 (2), pp. 413-421.

Brown, D. R., 2005. Neurodegeneration and Prion Disease. Springer.

Brown, D. R., 2005. Neurodegeneration and oxidative stress: prion disease results from loss of antioxidant defence. Folia Neuropathologica, 43 (4), pp. 229-243.

Jones, C. E., Klewpatinond, M., Abdelraheim, S. R., Brown, D. R. and Viles, J. H., 2005. Probing copper(2+) binding to the prion protein-using diamagnetic nicke(2+) and H-1 NMR: The unstructured N terminus facilitates the coordination of six copper(2+) ions at physiological concentrations. Journal of Molecular Biology, 346 (5), pp. 1393-1407.

Brown, D. R., 2005. The use of peptides that pick up prions: protection or poison? Expert Opinion on Therapeutic Patents, 15 (9), pp. 1287-1290.

Sassoon, J., Sadowski, M., Wisniewski, T. and Brown, D. R., 2005. Therapeutics and prion disease: Can immunisation or drugs be effective? Mini-Reviews in Medicinal Chemistry, 5 (4), pp. 361-366.

2004

Thompsett, A. R. and Brown, D. R., 2004. A functional role for a copper binding prion protein. In: Telling, G., ed. Prions and Prion Diseases: Current Perspectives. Wymondham, UK: Horizon Bioscience, pp. 1-40.

Sassoon, J., Daniels, M. and Brown, D. R., 2004. Astrocytic regulation of NMDA receptor subunit composition modulates the toxicity of prion peptide PrP106-126. Molecular and Cellular Neuroscience, 25 (1), pp. 181-191.

Lekishvili, T., Sassoon, J., Thompsett, A. R., Green, A., Ironside, J. W. and Brown, D. R., 2004. BSE and vCJD cause disturbance to uric acid levels. Experimental Neurology, 190 (1), pp. 233-244.

Brown, D. R. and Kozlowski, H., 2004. Biological inorganic and bioinorganic chemistry of neurodegeneration based on prion and Alzheimer diseases. Dalton Transactions, 2004, pp. 1907-1917.

Brown, D. R., Guantieri, V., Grasso, G., Impellizzeri, G., Pappalardo, G. and Rizzarelli, E., 2004. Copper(II) complexes of peptide fragments of the prion protein. Conformation changes induced by copper(II) and the binding motif in C-terminal protein region. Journal of Inorganic Biochemistry, 98 (1), pp. 133-143.

Calissano, M., Ensor, E., Brown, D. R. and Latchman, D. S., 2004. Doppel expression is regulated by the Brn-3a and Brn-3b transcription factors. Neuroreport, 15 (3), pp. 483-486.

Brown, D. R., 2004. Metallic prions. In: Free Radicals: Enzymology, Signalling and Disease. , pp. 193-202. (Biochemical Society Symposium)

Sassoon, J. and Brown, D. R., 2004. Neuronal death in prion disease. Timely Topics in medicine, 3, pp. 1-16.

Sassoon, J., Banks, F. and Brown, D. R., 2004. Neurotoxicity and prion disease. In: Ferrarese, C. and Beal, M. F., eds. Excitotoxicity in Neurological Disease, New Therapeutic Challenge. Hingham: Kluwer, pp. 265-283.

Jones, C. E., Abdelraheim, S. R., Brown, D. R. and Viles, J. H., 2004. Preferential Cu2+ coordination by His(96) and His(111) induces beta-sheet formation in the unstructured amyloidogenic region of the prion protein. Journal of Biological Chemistry, 279 (31), pp. 32018-32027.

Tsenkova, R. N., Iordanova, I. K., Toyoda, K. and Brown, D. R., 2004. Prion protein fate governed by metal binding. Biochemical and Biophysical Research Communications, 325 (3), pp. 1005-1012.

Kang, S. C., Brown, D. R., Whiteman, M., Li, R. L., Pan, T., Perry, G., Wisniewski, T., Sy, M. S. and Wong, B. S., 2004. Prion protein is ubiquitinated after developing protease resistance in the brains of scrapie-infected mice. The Journal of Pathology, 203 (1), pp. 603-608.

Brown, D. R. and Sassoon, J., 2004. Role of glia in prion disease. Advances in Molecular Cell Biology, 31, pp. 1085-1104.

Brown, D. R., 2004. Role of the prion protein in copper turnover in astrocytes. Neurobiology of Disease, 15 (3), pp. 534-543.

Sellarajah, S., Lekishvili, T., Bowring, C., Thompsett, A. R., Rudyk, H., Birkett, C. R., Brown, D. R. and Gilbert, I. H., 2004. Synthesis of analogues of Congo red and evaluation of their anti-prion activity. Journal of Medicinal Chemistry, 47 (22), pp. 5515-5534.

2003

Holme, A., Daniels, M., Sassoon, J. and Brown, D. R., 2003. A novel method of generating neuronal cell lines from gene-knockout mice to study prion protein membrane orientation. European Journal of Neuroscience, 18 (3), pp. 571-579.

Cui, T., Holme, A., Sassoon, J. and Brown, D. R., 2003. Analysis of doppel protein toxicity. Molecular and Cellular Neuroscience, 23 (1), pp. 144-155.

Brown, D. R., 2003. Conformational exposure: a new handle on prions. Lancet, 362 (9388), pp. 929-930.

Sassoon, J. and Brown, D. R., 2003. Copper and prion disease. In: Zatta, P., ed. Metal Ions and Neurodegeneration. New Jersey: World Scientific, pp. 279-306.

Sigurdsson, E. M., Brown, D. R., Alim, M. A., Scholtzova, H., Carp, R., Meeker, H. C., Prelli, F., Frangione, B. and Wisniewski, T., 2003. Copper chelation delays the onset of prion disease. Journal of Biological Chemistry, 278 (47), pp. 46199-46202.

Turnbull, S., Tabner, B. J., Brown, D. R. and Allsop, D., 2003. Copper-dependent generation of hydrogen peroxide from the toxic prion protein fragment PrP106-126. Neuroscience Letters, 336 (3), pp. 159-162.

Brown, D. R. and Sinclair, K., 2003. Deer slaughter outrage. Veterinary Times, 33 (14), p. 18.

Thackray, A. M., Madec, J. Y., Wong, E., Morgan-Warren, R., Brown, D. R., Baron, T. and Bujdoso, R., 2003. Detection of bovine spongiform encephalopathy, ovine scrapie prion-related protein (PrPSc) and normal PrPc by monoclonal antibodies raised to copper-refolded prion protein. Biochemical Journal, 370, pp. 81-90.

Liberski, P. P., Sikorska, B., Bratosiewicz-Wlsik, J., Walic, A., Brown, P. and Brown, D. R., 2003. Exuberant cellular reaction of the optic nerves in experimental Creutzfeldt-Jakob disease. Acta Neurobiologiae Experimentalis, 63, pp. 309-318.

Turubull, S., Tabner, B. J., Brown, D. R. and Allsop, D., 2003. Generation of hydrogen peroxide from mutant forms of the prion protein fragment PrP121-231. Biochemistry, 42 (25), pp. 7675-7681.

Wong, B. S., Li, R., Sassoon, J., Kang, S. C., Liu, T., Pan, T., Greenspan, N. S., Wisniewski, T., Brown, D. R. and Sy, M. S., 2003. Mapping the antigenicity of copper-treated cellular prion protein with the scrapie isoform. Cellular and Molecular Life Sciences (CMLS), 60 (6), pp. 1224-1234.

Cui, T., Daniels, M., Wong, B. S., Li, R. L., Sy, M. S., Sassoon, J. and Brown, D. R., 2003. Mapping the functional domain of the prion protein. European Journal of Biochemistry, 270 (16), pp. 3368-3376.

Brown, D. R., 2003. Prion protein expression modulates neuronal copper content. Journal of Neurochemistry, 87 (2), pp. 377-385.

Turnbull, S., Tabner, B. J., Brown, D. R. and Allsop, D., 2003. Quinacrine acts as an antioxidant and reduces the toxicity of the prion peptide PrPI06-126. Neuroreport, 14 (13), pp. 1743-1745.

2002

Brown, D. R. and Sassoon, J., 2002. Copper-dependent functions for the prion protein. Molecular Biotechnology, 22 (2), pp. 165-178.

Brown, D. R., 2002. Don't lose sleep over prions: role of prion protein in sleep regulation. Neuroreport, 13 (1), A1-A1.

Daniels, M. and Brown, D. R., 2002. High extracellular potassium protects against the toxicity of cytosine arabinoside but is not required for the survival of cerebellar granule cells in vitro. Molecular and Cellular Neuroscience, 19 (2), pp. 281-291.

Sigurdsson, E. M., Brown, D. R., Daniels, M., Kascsak, R. J., Kascsak, R., Carp, R., Meeker, H. C., Frangione, B. and Wisniewski, T., 2002. Immunization delays the onset of prion disease in mice. American Journal Of Pathology, 161 (1), pp. 13-17.

Brown, D. R., Nicholas, R. S. J. and Canevari, L., 2002. Lack of prion protein expression results in a neuronal phenotype sensitive to stress. Journal of Neuroscience Research, 67 (2), pp. 211-224.

Brown, D. R., 2002. Mayhem of the multiple mechanisms: modelling neurodegeneration in prion disease. Journal of Neurochemistry, 82 (2), pp. 209-215.

Thackray, A. M., Knight, R., Haswell, S. J., Bujdoso, R. and Brown, D. R., 2002. Metal imbalance and compromised antioxidant function are early changes in prion disease. Biochemical Journal, 362, pp. 253-258.

Brown, D. R., 2002. Metal toxicity and therapeutic intervention. Biochemical Society Transactions, 30, pp. 742-745.

Brown, D. R., 2002. Molecular advances in understanding inherited prion diseases. Molecular Neurobiology, 25 (3), pp. 287-302.

Brown, D. R., 2002. Prion Diseases and Copper Metabolism. Chichester, UK: Horwood Press.

Brown, D. R., 2002. Prion protein: A synaptic cuproprotein. In: Massaro, E., ed. Handbook of Copper Pharmacology and Toxiciology. Totowa, New Jersey: Humana Press, pp. 115-129.

Wong, B. S., Sy, M. S. and Brown, D. R., 2002. Prion-like doppel protein expression correlates with heme oxygenase and nitric oxide synthase induction. In: Abraham, N. G., ed. Heme Oxygenase in Biology and Medicine. New York: Plenum Press, pp. 423-430.

Daniels, M. and Brown, D. R., 2002. Purification and preparation of prion protein: Synaptic superoxide dismutase. In: Superoxide Dismutase. Vol. 349. , pp. 258-267. (Methods in Enzymology)

Wisniewski, T., Brown, D. R. and Sigurdsson, E. M., 2002. Therapeutics in Alzheimer's and prion diseases. Biochemical Society Transactions, 30, pp. 574-578.

2001

Daniels, M. and Brown, D. R., 2001. Astrocytes regular N-methyl-D-aspartate receptor subunit composition increasing neuronal sensitivity to excitotoxicity. Journal of Biological Chemistry, 276, p. 22446.

Brown, D. R. and Jones, I. M., 2001. A function for the prion protein? In: Baker, H., ed. Molecular Pathology of Prion Diseases. Totowa, New Jersey: Humana Press, pp. 31-50.

Wong, B. S., Brown, D. R. and Sy, M. S., 2001. A yin-yang role for metals in prion disease. Panminerva Med, 43, pp. 283-287.

Wong, B. S., Chen, S. G., Colucci, M., Xie, Z. L., Pan, T., Liu, T., Li, R. L., Gambetti, P., Sy, M. S. and Brown, D. R., 2001. Aberrant metal binding by prion protein in human prion disease. Journal of Neurochemistry, 78 (6), pp. 1400-1408.

Brown, D. R., Clive, C. and Haswell, S. J., 2001. Antioxidant activity related to copper binding of native prion protein. Journal of Neurochemistry, 76, pp. 69-76.

Brown, D. R., 2001. BSE did not cause variant CJD: an alternative cause related to post-industrial environmental contamination. Medical Hypotheses, 57 (5), pp. 555-560.

Brown, D. R., 2001. BSE: A post-industrial disease? Chemistry & Industry, 3, pp. 73-76.

Brown, D. R., 2001. Copper and prion disease. Brain Research Bulletin, 55 (2), pp. 165-173.

Wong, B. S., Liu, T., Ruliang Li, R., Pan, T., Peterson, R. B., smith, M. S., Pierluigi Gambetti, P., Perry, G., Mnson, J., Brown, D. R. and Sy, M. S., 2001. Increased levels of oxidative stress markers detected in the brains of mice devoid of prion protein. Journal of Neurochemistry, 76, pp. 565-572.

Wong, B. S., Liu, T., Piaisley, d., Li, R., Pan, T., Chen, S. G., Perry, G., Petersen, R. B., Smith, M. A., Melton, D. W., Gambetti, P., Brown, D. R. and Sy, M. S., 2001. Induction of HO-1 and NOS in doppel-expressing mice devoid of PrP: Implications for Doppel function. Molecular and Cellular Neuroscience, 17, pp. 768-775.

Nicholas, R. S. J., Compston, A. and Brown, D. R., 2001. Inhibition of TNFa induced NF-kB p52 converts the metabolic effects of microglia-derived TNFa on mouse cerebellar neurons to neurotoxicity. Journal of Neurochemistry, 76, pp. 1431-1438.

Brown, D. R., 2001. Microglia and Prion Disease. Microscopy Research and Technique, 54, pp. 71-80.

Wong, B. S., Brown, D. R., Pan, T., Whiteman, M., Liu, T., Bu, X., Li, R., Gambetti, P., Olesik, J., Rubinstein, R. and Sy, M. S., 2001. Oxidative impairment in scrapie-infected mice is associated with brain metal perturbations and altered ani-oxidantion activities. Journal of Neurochemistry, 79, pp. 689-698.

Brown, D. R., 2001. Prion and prejudice: normal protein at the synapse. Trends in Neurosciences, 24, pp. 85-90.

Brown, D. R., 2001. Prion protein peptides: agents of death for neurons. In: Baker, H., ed. Molecular Pathology of Prion Diseases. Totowa, New Jersey: Humana Press, pp. 51-70.

Daniels, M., Cereghetti, G. M. and Brown, D. R., 2001. Toxicity of novel C-terminal prion protein fragments and peptides harbouring disease-related C-terminal mutations. European Journal of Biochemistry, 268 (23), pp. 6155-6164.

2000

Post, K., Brown, D. R., Groschup, M., Kretzschmar, H. A. and Riesner, D., 2000. Neurotoxicity but not infectivity of prion proteins can be induced reversibly in vitro. In: Groschup, M. H. and Kretzschmar, H. A., eds. Prion Diseases - Diagnosis and Pathogenesis. , pp. 265-273.

This list was generated on Mon Dec 22 21:21:29 2014 GMT.