Items by Vicker, Nigel

2013

Day, J.M., Foster, P.A., Tutill, H.J., Schmidlin, F., Sharland, C.M., Hargrave, J.D., Vicker, N., Potter, B.V.L., Reed, M.J. and Purohit, A., 2013. STX2171, a 17β-hydroxysteroid dehydrogenase type 3 inhibitor, is efficacious in vivo in a novel hormone-dependent prostate cancer model. Endocrine-Related Cancer, 20 (1), pp. 53-64.

2012

Su, X., Halem, H. A., Thomas, M. P., Moutrille, C., Culler, M. D., Vicker, N. and Potter, B. V. L., 2012. Adamantyl carboxamides and acetamides as potent human 11β- hydroxysteroid dehydrogenase type 1 inhibitors. Bioorganic and Medicinal Chemistry, 20 (21), pp. 6394-6402.

Pradaux-Caggiano, F., Su, X., Vicker, N., Thomas, M. P., Smithen, D., Halem, H. A., Culler, M. D. and Potter, B. V. L., 2012. Synthesis and evaluation of thiadiazole derivatives as inhibitors of 11β-hydroxysteroid dehydrogenase type 1. MedChemComm, 3 (9), pp. 1117-1124.

Day, J. M., Foster, P. A., Tutill, H. J., Schmidlin, F., Hargrave, J. D., Vicker, N., Potter, B. V. L., Reed, M. J. and Purohit, A., 2012. STX2171, a 17 beta-hydroxysteroid dehydrogenase type 3 (17 beta-HSD3) inhibitor, is efficacious in vivo in a novel hormone-dependent prostate cancer model. Endocrine-Related Cancer, 20 (1), pp. 53-64.

2011

Su, X., Pradaux-Caggiano, F., Vicker, N., Thomas, M. P., Halem, H., Culler, M. D. and Potter, B. V. L., 2011. Adamantyl ethanone pyridyl derivatives : potent and selective inhibitors of human 11 beta-hydroxysteroid dehydrogenase type 1. ChemMedChem, 6 (9), pp. 1616-1629.

Su, X., Vicker, N., Thomas, M. P., Pradaux-Caggiano, F., Halem, H., Culler, M. D. and Potter, B. V. L., 2011. Discovery of adamantyl heterocyclic ketones as potent 11 beta-hydroxysteroid dehydrogenase type 1 inhibitors. ChemMedChem, 6 (8), pp. 1439-1451.

2010

Su, X., Pradaux-Caggiano, F., Thomas, M. P., Szeto, M. W. Y., Halem, H. A., Culler, M. D., Vicker, N. and Potter, B. V. L., 2010. Discovery of adamantyl ethanone derivatives as potent 11β-hydroxysteroid dehydrogenase Type 1 (11β-HSD1) inhibitors. ChemMedChem, 5 (7), pp. 1026-1044.

2009

Vicker, N., Sharland, C. M., Heaton, W. B., Ramos Gonzalez, A. M., Bailey, H. V., Smith, A., Springall, J. S., Day, J. M., Tutill, H. J., Reed, M. J., Purohit, A. and Potter, B. V. L., 2009. The design of novel 17 beta-hydroxysteroid dehydrogenase type 3 inhibitors. Molecular and Cellular Endocrinology, 301 (1-2), pp. 259-265.

Su, X., Vicker, N., Trusselle, M., Halem, H., Culler, M. D. and Potter, B. V. L., 2009. Discovery of novel inhibitors of human 11β-hydroxysteroid dehydrogenase type 1. Molecular and Cellular Endocrinology, 301 (1-2), pp. 169-173.

Day, J. M., Tutill, H. J., Foster, P. A., Bailey, H. V., Heaton, W. B., Sharland, C. M., Vicker, N., Potter, B. V. L., Purohit, A. and Reed, M. J., 2009. Development of hormone-dependent prostate cancer models for the evaluation of inhibitors of 17β-hydroxysteroid dehydrogenase Type 3. Molecular and Cellular Endocrinology, 301 (1-2), pp. 251-258.

2008

Day, J. M., Foster, P. A., Tutill, H. J., Parsons, M. F. C., Newman, S. P., Chander, S. K., Allan, G. M., Lawrence, H. R., Vicker, N., Potter, B. V. L., Reed, M. J. and Purohit, A., 2008. 17β-hydroxysteroid dehydrogenase Type 1, and not Type 12, is a target for endocrine therapy of hormone-dependent breast cancer. International Journal of Cancer, 122 (9), pp. 1931-1940.

Su, X., Vicker, N. and Potter, B. V. L., 2008. 2 inhibitors of 11β-hydroxysteroid dehydrogenase type 1. Progress in Medicinal Chemistry, 46, pp. 29-130.

Allan, G. M., Vicker, N., Lawrence, H. R., Tutill, H. J., Day, J. M., Huchet, M., Ferrandis, E., Reed, M. J., Purohit, A. and Potter, B. V. L., 2008. Novel inhibitors of 17β-hydroxysteroid dehydrogenase type 1 : templates for design. Bioorganic and Medicinal Chemistry, 16 (8), pp. 4438-4456.

2007

Su, X., Vicker, N., Lawrence, H., Smith, A., Purohit, A., Reed, M. J. and Potter, B. V. L., 2007. Inhibition of human and rat 11β-hydroxysteroid dehydrogenase type 1 by 18β-glycyrrhetinic acid derivatives. Journal of Steroid Biochemistry and Molecular Biology, 104 (3-5), pp. 312-320.

Vicker, N., Su, X., Ganeshapillai, D., Smith, A., Purohit, A., Reed, M. J. and Potter, B. V. L., 2007. Novel non-steroidal inhibitors of human 11β-hydroxysteroid dehydrogenase type 1. Journal of Steroid Biochemistry and Molecular Biology, 104 (3-5), pp. 123-129.

2006

Day, J. M., Tutill, H. J., Newman, S. P., Purohit, A., Lawrence, H. R., Vicker, N., Potter, B. V. L. and Reed, M. J., 2006. 17β-hydroxysteroid dehydrogenase type 1 and type 2 : association between mRNA expression and activity in cell lines. Molecular and Cellular Endocrinology, 248 (1), pp. 246-249.

Su, X., Vicker, N., Ganeshapillai, D., Smith, A., Purohit, A., Reed, M. J. and Potter, B. V. L., 2006. Benzothiazole derivatives as novel inhibitors of human 11β-hydroxysteroid dehydrogenase type. Molecular and Cellular Endocrinology, 248 (1), pp. 214-217.

Vicker, N., Lawrence, H. R., Allan, G. M., Bubert, C., Smith, A., Tutill, H. J., Purohit, A., Day, J. M., Mahon, M. F., Reed, M. J. and Potter, B. V. L., 2006. Focused libraries of 16-substituted estrone derivatives and modified E-ring steroids : inhibitors of 17β-hydroxysteroid dehydrogenase type 1. ChemMedChem, 1 (4), pp. 464-481.

Allan, G. M., Lawrence, H. R., Cornet, J., Bubert, C., Fischer, D. S., Vicker, N., Smith, A., Tutill, H. J., Purohit, A., Day, J. M., Mahon, M. F., Reed, M. J. and Potter, B. V. L., 2006. Modification of estrone at the 6, 16, and 17 positions : novel potent inhibitors of 17β-hydroxysteroid dehydrogenase type 1. Journal of Medicinal Chemistry, 49 (4), pp. 1325-1345.

Allan, G. M., Bubert, C., Vicker, N., Smith, A., Tutill, H. J., Purohit, A., Reed, M. J. and Potter, B. V. L., 2006. Novel, potent inhibitors of 17β-hydroxysteroid dehydrogenase type 1. Molecular and Cellular Endocrinology, 248 (1), pp. 204-207.

Bailey, H. V., Heaton, W., Vicker, N. and Potter, B. V. L., 2006. Rapid microwave-assisted reductive amination of ketones with anilines. Synlett, 2006 (15), pp. 2444-2448.

Purohit, A., Tutill, H. J., Day, J. M., Chander, S. K., Lawrence, H. R., Allan, G. M., Fischer, D. S., Vicker, N., Newman, S. P., Potter, B. V. L. and Reed, M. J., 2006. The regulation and inhibition of 17β-hydroxysteroid dehydrogenase in breast cancer. Molecular and Cellular Endocrinology, 248 (1), pp. 199-203.

2005

Lawrence, H. R., Vicker, N., Allan, G. M., Smith, A., Mahon, M. F., Tutill, H. J., Purohit, A., Reed, M. J. and Potter, B. V. L., 2005. Novel and potent 17 β -hydroxysteroid dehydrogenase type 1 inhibitors. Journal of Medicinal Chemistry, 48 (8), pp. 2759-2762.

2004

Vicker, N., Su, X., Lawrence, H., Cruttenden, A., Purohit, A., Reed, M. J. and Potter, B. V. L., 2004. A novel 18β-glycyrrhetinic acid analogue as a potent and selective inhibitor of 11β-hydroxysteroid dehydrogenase 2. Bioorganic & Medicinal Chemistry Letters, 14 (12), pp. 3263-3267.

Su, X., Lawrence, H., Ganeshapillai, D., Cruttenden, A., Purohit, A., Reed, M. J., Vicker, N. and Potter, B. V. L., 2004. Novel 18β-glycyrrhetinic acid analogues as potent and selective inhibitors of 11β-hydroxysteroid dehydrogenases. Bioorganic and Medicinal Chemistry, 12 (16), pp. 4439-4457.

2003

Vicker, N., Ho, Y., Robinson, J., Woo, L. W. L., Purohit, A., Reed, M. J. and Potter, B. V. L., 2003. Docking studies of sulphamate inhibitors of estrone sulphatase in human carbonic anhydrase II. Bioorganic & Medicinal Chemistry Letters, 13 (5), pp. 863-865.

2002

Howarth, N. M., Purohit, A., Robinson, J. J., Vicker, N., Reed, M. J. and Potter, B. V. L., 2002. Estrone 3-sulfate mimics, inhibitors of estrone sulfatase activity : homology model construction and docking studies. Biochemistry, 41 (50), pp. 14801-14814.