Research

Items by Lloyd, Matthew

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Number of items: 87.

Book Sections

Lloyd, M. D., Mukherji, M., Kershaw, N. J., Chien, W., Wierzbicki, A. S., Schofield, C. J., Roels, F., Baes, M. and De Bie, S., 2005. Role of phytanoyl-CoA 2-hydroxylase in phytanic acid metabolism. In: Peroxisomal disorders and regulation of genes. Ghent: Kluwer Academic/Plenum Publishers, pp. 303-304. (Advances in Experimental Medicine and Biology)

Articles

Twum, E. A., Nathubhai, A., Wood, P. J., Lloyd, M. D., Thompson, A. S. and Threadgill, M. D., 2015. Initial development of a cytotoxic amino-seco-CBI warhead for delivery by prodrug systems. Bioorganic and Medicinal Chemistry, 23, pp. 3481-3489. Item availability may be restricted.

Yevglevskis, M., Bowskill, C.R., Chan, C.C.Y., Heng, J.H.-J., Threadgill, M. D., Woodman, T.J. and Lloyd, M.D., 2014. A study on the chiral inversion of mandelic acid in humans. Organic and Biomolecular Chemistry, 12 (34), pp. 6737-6744.

Qu, X., Allan, A., Chui, G., Hutchings, T. J., Jiao, P., Johnson, L., Leung, W. Y., Li, P. K., Steel, G. R., Thompson, A. S., Threadgill, M. D., Woodman, T. J. and Lloyd, M. D., 2013. Hydrolysis of ibuprofenoyl-CoA and other 2-APA-CoA esters by human acyl-CoA thioesterases-1 and -2 and their possible role in the chiral inversion of profens. Biochemical Pharmacology, 86 (11), pp. 1621-1625.

Nathubhai, A., Patterson, R., Woodman, T. J., Sharp, H. E. C., Chui, M. T. Y., Chung, H. H. K., Lau, S. W. S., Zheng, J., Lloyd, M. D., Thompson, A. S. and Threadgill, M. D., 2011. N3-Alkylation during formation of quinazolin-4-ones from condensation of anthranilamides and orthoamides. Organic and Biomolecular Chemistry, 9 (17), pp. 6089-6099.

Holbourn, K. P., Lloyd, M. D., Thompson, A. S., Threadgill, M. D. and Acharya, K. R., 2011. Cloning, purification, crystallization and preliminary crystallographic analysis of the human histone deacetylase sirtuin 1. Acta Crystallographica Section F-Structural Biology and Crystallization Communications, 67 (4), pp. 461-463.

Sunderland, P. T., Woon, E. C. Y., Dhami, A., Bergin, A. B., Mahon, M. F., Wood, P. J., Jones, L. A., Tully, S. R., Lloyd, M. D., Thompson, A. S., Javaid, H., Martin, N. M. B. and Threadgill, M. D., 2011. 5-Benzamidoisoquinolin-1-ones and 5-(ω-Carboxyalkyl)isoquinolin-1-ones as Isoform-Selective Inhibitors of Poly(ADP-ribose) Polymerase 2 (PARP-2). Journal of Medicinal Chemistry, 54 (7), pp. 2049-2059.

Darley, D. J., Butler, D. S., Prideaux, S. J., Thornton, T. W., Wilson, A. D., Woodman, T. J., Threadgill, M. D. and Lloyd, M. D., 2009. Synthesis and use of isotope-labelled substrates for a mechanistic study on human α-methylacyl-CoA racemase 1A (AMACR; P504S). Organic and Biomolecular Chemistry, 7 (3), pp. 543-552.

Lloyd, M., 2009. NLP Part II : anchoring and managing states. Planet P.U.M.A., 16, pp. 12-13.

Beauchard, A., Phillips, V. A., Lloyd, M. D. and Threadgill, M. D., 2009. Synthesis of 2-(4-carboxybutenyl)- and 2-(4-carboxybutynyl)-cyclopentene-1-carboxamides. Tetrahedron, 65 (39), pp. 8176-8184.

Ball, A. L., Chambers, K. A., Hewinson, M., Navaratnarajah, S., Samrin, L., Thomas, N., Tyler, A. E. H., Wall, A. J. and Lloyd, M. D., 2008. A microtitre plate assay for measuring glycosidase activity. Journal of Enzyme Inhibition and Medicinal Chemistry, 23 (1), pp. 131-135.

Lloyd, M., 2008. Caffeine: The athlete’s friend? Planet P.U.M.A., 12, pp. 12-14.

Lloyd, M. D., Darley, D. J., Wierzbicki, A. S. and Threadgill, M. D., 2008. α-Methylacyl-CoA racemase - an 'obscure' metabolic enzyme takes centre stage. FEBS Journal, 275, pp. 1089-1102.

Lloyd, M. D., Boardman, K. D. E., Smith, A., van den Brink, D. M., Wanders, R. J. A. and Threadgill, M. D., 2007. Characterisation of recombinant human fatty aldehyde dehydrogenase: implications for Sjögren-Larsson syndrome. Journal of Enzyme Inhibition and Medicinal Chemistry, 22 (5), pp. 584-590.

Wierzbicki, A. S. and Lloyd, M. D., 2007. Dr Brian Gibberd (1931-2006): a pioneering clinician in Refsum's disease. Biochemical Society Transactions, 35 (5), pp. 862-864.

Lloyd, M., 2007. The dangers of the sweetener aspartame? Planet P.U.M.A., 9, p. 10.

Lloyd, M., 2007. The science of diets. Planet P.U.M.A., 8, pp. 8-9.

Lloyd, M., 2006. Sports drinks, the science behind the labels. Planet P.U.M.A., 7, pp. 8-9.

Kwong, J. S. W., Lloyd, M. D. and Threadgill, M. D., 2006. Synthesis of cyclic sulfoximine mimics of 2-deoxyribosides as enzyme inhibitors in cancer. Journal of Pharmacy and Pharmacology, 58, A58-A58.

Lloyd, M. D., Pederick, R. L., Natesh, R., Woo, L. W. L., Purohit, A., Reed, M. J., Acharya, R. and Potter, B. V. L., 2005. Crystal structure of human carbonic anhydrase II at 1.95 Å resolution in complex with 667-coumate, a novel anti-cancer agent. Biochemical Journal, 385 (Pt 3), pp. 715-720.

Lloyd, M. D., Thiyagarajan, N., Ho, Y. T., Woo, L. W. L., Sutcliffe, O. B., Purohit, A., Reed, M. J., Acharya, K. R. and Potter, B. V. L., 2005. First crystal structures of human carbonic anhydrase II in complex with dual aromatase-steroid sulfatase inhibitors. Biochemistry, 44 (18), pp. 6858-6866.

Searls, T., Butler, D., Chien, W., Mukherji, M., Lloyd, M. D. and Schofield, C. J., 2005. Studies on the specificity of unprocessed and mature forms of phytanoyl-CoA 2-hydroxylase and mutation of the iron binding ligands. Journal of Lipid Research, 46, pp. 1660-1667.

Acharya, K. R. and Lloyd, M. D., 2005. The advantages and limitations of protein crystal structures. Trends in Pharmacological Sciences, 26 (1), pp. 10-14.

Lloyd, M., 2005. Vitamins, minerals and supplements. Planet P.U.M.A., 3, pp. 16-17.

Lloyd, M. D., Lipscomb, S. J., Hewitson, K. S., Hensgens, C. M. H., Baldwin, J. E. and Schofield, C. J., 2004. Controlling the substrate selectivity of deacetoxy/deacetylcephalosporin C synthase. Journal of Biological Chemistry, 279 (15), pp. 15420-15426.

Wierzbicki, A. S., Mayne, P. D., Lloyd, M. D., Burston, D., Mei, G., Sidey, M. C., Feher, M. D. and Gibberd, F. B., 2003. Metabolism of phytanic acid and 3-methyl-adipic acid excretion in patients with adult Refsum disease. Journal of Lipid Research, 44 (8), pp. 1481-1488.

Wanders, R. J. A., Jansen, G. A. and Lloyd, M. D., 2003. Phytanic acid alpha-oxidation, new insights into an old problem: a review. Biochimica et Biophysica Acta, 1631, pp. 119-135.

Mukherji, M., Schofield, C. J., Wierzbicki, A. S., Jansen, G. A., Wanders, R. J. A. and Lloyd, M. D., 2003. The chemical biology of branched-chain lipid metabolism. Progress in Lipid Research, 42, pp. 359-376.

Lee, H. J., Dai, Y. F., Shiau, C. Y., Schofield, C. J. and Lloyd, M. D., 2003. The kinetic properties of various R258 mutants of deacetoxycephalosporin C synthase. European Journal of Biochemistry, 270, pp. 1301-1307.

Lee, H. J., Schofield, C. J. and Lloyd, M. D., 2002. Active site mutations of recombinant deacetoxycephalosporin C synthase. Biochemical and Biophysical Research Communications, 292, pp. 66-70.

Wierzbicki, A. S., Lloyd, M. D., Schofield, C. J., Feher, M. D. and Gibberd, F. B., 2002. Refsum's disease: a peroxisomal disorder affecting alpha-oxidation of phytanic acid: a mini-review. Journal of Neurochemistry, 80 (5), pp. 727-735.

Lipscomb, S. J., Lee, H. J., Mukherji, M., Baldwin, J. E., Schofield, C. J. and Lloyd, M. D., 2002. The role of arginine residues in substrate binding and catalysis by deacetoxycephalosporin C synthase. European Journal of Biochemistry, 269, pp. 2735-2739.

Mukherji, M., Kershaw, N. J., Schofield, C. J., Wierzbicki, A. S. and Lloyd, M. D., 2002. Utilization of sterol carrier protein-2 by phytanoyl-CoA 2-hydroxylase in the peroxisomal α oxidation of phytanic acid. Chemistry & Biology, 9, pp. 597-605.

Mukherji, M., Chien, W., Kershaw, N. J., Clifton, I. J., Schofield, C. J., Wierzbicki, A. S. and Lloyd, M. D., 2001. Structure-function analysis of phytanoyl-CoA 2-hydroxylase mutations causing Refsum's disease. Human Molecular Genetics, 10 (18), pp. 1971-1982.

Dubus, A., Lloyd, M. D., Lee, H.-J., Schofield, C. J., Baldwin, J. E. and Frere, J.-M., 2001. Probing the penicillin sidechain selectivity of recombinant deacetoxycephalosporin C synthase. Cellular and Molecular Life Sciences (CMLS), 58 (5-6), pp. 835-843.

Mukherji, M., Kershaw, N. J., MacKinnon, C. H., Clifton, I. J., Wierzbicki, A. S., Schofield, C. J. and Lloyd, M. D., 2001. 'Chemical co-substrate rescue' of phytanoyl-CoA 2-hydroxylase mutants causing Refsum's Disease. Chemical Communications, 2001, pp. 972-973.

Lee, H. J., Lloyd, M. D., Harlos, K., Clifton, I. J., Baldwin, J. E. and Schofield, C. J., 2001. Alteration of the 2-oxoacid cosubstrate selectivity in deacetoxycephalosporin C synthase: the role of arginine-258. Journal of Biological Chemistry, 276, pp. 18290-18295.

Hamilton, C. S., Yasuhara, A., Baldwin, J. E., Lloyd, M. D. and Rutledge, P. J., 2001. Contrasting fates for 6-α-methylpenicillin N upon oxidation by deacetoxycephalosporin C synthase (DAOCS) and deacetoxy/deacetylcephalosporin C synthase (DAOC/DACS). Bioorganic & Medicinal Chemistry Letters, 11, pp. 2511-2514.

Lee, H. J., Lloyd, M. D., Harlos, K., Clifton, I. J., Baldwin, J. E. and Schofield, C. J., 2001. Kinetic and crystallographic studies on deacetoxycephalosporin C synthase. Journal of Molecular Biology, 308, pp. 937-948.

Kershaw, N. J., Mukherji, M., MacKinnon, C. H., Claridge, T. W. D., Odell, B., Wierzbicki, A. S., Lloyd, M. D. and Schofield, C. J., 2001. Studies on phytanoyl-CoA 2-hydroxylase and synthesis of phytanoyl-coenzyme A. Bioorganic & Medicinal Chemistry Letters, 11, pp. 2545-2548.

Lloyd, M. D., Mukherji, M., Kershaw, N. J., MacKinnon, C. H., Schofield, C. J. and Wierzbicki, A. S., 2000. Unnatural cosubstrate-based rescue of enzyme activity in Refsum’s Disease resulting from a PAHX mutation. Journal of Inherited Metabolic Diseases, 23 (1), 506-O.

Lee, H.-J., Lloyd, M. D., Harlos, K. and Schofield, C. J., 2000. The effect of cysteine mutations on recombinant deacetoxycephalosporin C synthase from S. clavuligerus. Biochemical and Biophysical Research Communications, 267 (1), pp. 445-448.

Prescott, A. G. and Lloyd, M. D., 2000. The iron(II) and 2-oxoacid-dependent dioxygenases and their role in metabolism (1967 to 1999). Natural Product Reports, 17 (4), pp. 367-383.

Lloyd, M. D., Mukherji, M., Kershaw, N. J., MacKinnon, C. H., Schofield, C. J. and Wierzbicki, A. S., 2000. Unnatural co-substrate-based rescue of enzyme in Refsum’s disease resulting from mutations in R275 of phytanoyl-CoA hydroxylase. American Journal of Human Genetics, 67 (2).

Lloyd, M. D., Merritt, K. D., Lee, V., Sewell, T. J., Wha-Son, B., Baldwin, J. E., Schofield, C. J., Elson, S. W., Baggaley, K. H. and Nicholson, N. H., 1999. Product-substrate engineering by bacteria : studies on clavaminate synthase, a trifunctional dioxygenase. Tetrahedron, 55 (33), pp. 10201-10220.

Conference or Workshop Items

Jolly, P., Formisano, N., Djahanbakhsh Rafiee, S., Bhalla, N., Miodek, A., Dondi, R., Yang, D. K., Chen, L.C., Kasak, P., Tkac, J., Lloyd, M. D., Eggleston, I. M. and Estrela, P., 2014. DNA aptamer-based approaches for detection of multiple prostate cancer biomarkers. In: 22nd Meeting of the EAU Section of Urological Research (ESUR), 2014, 2014-10-09 - 2014-10-11, Glasgow.

Lloyd, M. D., 2014. The role of α-methylacyl-CoA racemase (AMACR; P504S) in prostate cancer. In: Prosense Summer School Meeting, 2014, 2014-09-17, Bath.

Sattar, F. A., Darley, D. J., Politano, F., Woodman, T. J., Threadgill, M. D. and Lloyd, M. D., 2012. Acyl-CoA ∝-proton exchange by ∝-methylacyl-CoA racemase. In: Biochemical Society Conference,2012, 2012-01-01, Cambridge.

Woodman, T. J., Wood, P. J., Thompson, A. S., Hutchings, T. J., Jiao, P., Steel, G. R., Threadgill, M. D. and Lloyd, M. D., 2012. Chiral inversion of NSAID-CoA esters by human ∝-methylacyl-CoA racemase. In: Biochemical Society Conference,2012, 2012-01-01, Cambridge.

Qu, X., Leung, A., Allan, A. C., Chui, G., Hutchings, T. J., Jiao, P., Johnson, L., Leung, W. Y., Li, P. K., Steel, G. R., Thompson, A. S., Threadgill, M. D., Woodman, T. J. and Lloyd, M. D., 2012. Hydrolysis of ibuprofenoyl-CoA and other 2-APA-CoA esters by human Acyl-CoA thioesterases 1 and 2. In: Biochemical Society Conference,2012, 2012-01-01, Cambridge.

Woodman, T.J., Wood, P. J., Thompson, A. S., Hutchings, T. J., Jiao, P., Steel, G. R., Threadgill, M. D. and Lloyd, M. D., 2011. Chiral inversion of NSAID-CoA esters by human ∝-methylacyl-CoA racemase. In: Cancer Research @ Bath Conference, 2011, 2011-05-01, Bath.

Darley, D. J., Butler, D. S., Threadgill, M. D. and Lloyd, M. D., 2008. Characterisation of recombinant alpha-methylacyl-CoA racemase, a novel prostate cancer target. In: RSC Bioorganic Group Annual Post-Graduate Symposium P7, 2008, 2008-03-01.

Darley, D. J., Prideaux, S. J., Thornton, T. W., Wilson, A. D., Threadgill, M. D., Woodman, T. J. and Lloyd, M. D., 2008. Synthesis of 2-[2H]-2-[13C]-S-2-methyldecanoyl-CoA and 13C NMR study of its reaction with ∝-methylacyl-CoA racemase (AMACR. In: RSC Bioorganic Group Annual Post-Graduate Symposium P8, 2008, 2008-03-01.

Beauchard, A., Phillips, V. A., Lloyd, M. D. and Threadgill, M. D., 2008. Synthesis of a mimic of phosphorserylproline as a potential inhibitor of Pin1. In: RSC Bioorganic Group Annual Post-Graduate Symposium P13, 2008, 2008-03-01.

Darley, D. J., Butler, D. S., Threadgill, M. D. and Lloyd, M. D., 2007. Characterisation of recombinant alpha-methylacyl-CoA racemase, a novel prostate cancer target. In: Northern England (and Bristol) Collaborative (PROMPT) and South of England Prostate Collaborative Joint Meeting, 2007, 2007-11-01, Cambridge.

Darley, D. J., Butler, D. S., Threadgill, M. D. and Lloyd, M. D., 2007. Characterisation of recombinant alpha-methylacyl-CoA racemase, a novel prostate cancer target. In: 3rd National Cancer Research Institute (NCRI) Cancer Conference, 2007, 2007-10-01, Birmingham.

Darley, D. J., Butler, D. S., Threadgill, M. D. and Lloyd, M. D., 2007. Characterisation of recombinant alpha-methylacyl-CoA racemase, a novel prostate cancer target. In: Life Sciences Conference,2007, 2007-07-01, Glasgow.

Lloyd, M. D., Boardman, K. D. E., Smith, A., van den Brink, D. M., Wanders, R. J. A. and Threadgill, M. D., 2007. Characterisation of recombinant human fatty aldehyde dehydrogenase: implications for Sjögren-Larsson syndrome. In: Life Sciences Conference,2007, 2007-07-01, Glasgow.

Lloyd, M. D., Boardman, K. D. E. and Threadgill, M. D., 2006. Expression and characterisation of human aldehyde dehydrogenase 10 : implications for Sjögren-Larsson syndrome. In: Conférences Européenes du Groupement Des Pharmacochimistes de L'Arc Atlantique (GP2A), 2006, 2006-09-01, Bath.

Kwong, J. S. W., Lloyd, M. D. and Threadgill, M. D., 2006. Design and synthesis of a novel transition state mimic for poly(ADP-ribose) polymerase 1 (PARP-1) inhibition. In: Conférences Européenes du Groupement des Pharmacochimistes de L'Arc Atlantique (GP2A), 2006-09-07 - 2006-09-08, Bath.

Kwong, J. S. W., Lloyd, M. D. and Threadgill, M. D., 2006. Design, synthetic approaches and characterisation of a novel cyclic sulfoximine NAD+ (nicotinamide adenine dinucleotide) analogue. In: American Chemical Society (ACS) 232nd National Meeting, 2006-09-10 - 2006-09-14, San Francisco.

Lloyd, M. D., Boardman, K. D. E. and Threadgill, M. D., 2006. Expression and characterisation of human adehyde dehydrogenase 10: implications for Söjgren-Larsson syndrome. In: Conférences Européenes du Groupement des Pharmacochimistes de L'Arc Atlantique (GP2A), 2006-09-07 - 2006-09-08, Bath.

Lord, A. M., Lloyd, M. D. and Threadgill, M. D., 2006. Quinoline-8-carboxamides as novel PARP-1 inhibitors. In: Conférences Européenes du Groupement des Pharmacochimistes de L'Arc Atlantique (GP2A), 2006-09-07 - 2006-09-08, Bath.

Lipscomb, S. J., Lloyd, M. D., Schofield, C. J. and Baldwin, J. E., 2002. Studies on deacetoxycephalosporin C synthase. In: 54th Harden Conference (Mechanistic Enzymology), 2002, 2002-08-01, Ambleside.

Lipscomb, S. J., Lloyd, M. D., Schofield, C. J. and Baldwin, J. E., 2002. Studies on deacetoxycephalosporin C synthase. In: Lorne Conference, 2002, 2002-01-01, Victoria.

This list was generated on Mon Aug 3 20:54:07 2015 IST.