Research

Items by Lloyd, Matthew

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Lloyd, M. D., Mukherji, M., Kershaw, N. J., Chien, W., Wierzbicki, A. S., Schofield, C. J., Roels, F., Baes, M. and De Bie, S., 2005. Role of phytanoyl-CoA 2-hydroxylase in phytanic acid metabolism. In: Peroxisomal disorders and regulation of genes. Ghent: Kluwer Academic/Plenum Publishers, pp. 303-304. (Advances in Experimental Medicine and Biology)

Articles

Yevglevskis, M., Bowskill, C.R., Chan, C.C.Y., Heng, J.H.-J., Threadgill, M. D., Woodman, T.J. and Lloyd, M.D., 2014. A study on the chiral inversion of mandelic acid in humans. Organic and Biomolecular Chemistry, 12 (34), pp. 6737-6744.

Nathubhai, A., Wood, P. J., Lloyd, M. D., Thompson, A. S. and Threadgill, M. D., 2013. Design and discovery of 2‑arylquinazolin-4-ones as potent and selective inhibitors of tankyrases. ACS Medicinal Chemistry Letters, 4 (12), pp. 1173-1177.

Qu, X., Allan, A., Chui, G., Hutchings, T. J., Jiao, P., Johnson, L., Leung, W. Y., Li, P. K., Steel, G. R., Thompson, A. S., Threadgill, M. D., Woodman, T. J. and Lloyd, M. D., 2013. Hydrolysis of ibuprofenoyl-CoA and other 2-APA-CoA esters by human acyl-CoA thioesterases-1 and -2 and their possible role in the chiral inversion of profens. Biochemical Pharmacology, 86 (11), pp. 1621-1625.

Woon, E. C. Y., Sunderland, P. T., Paine, H. A., Lloyd, M. D., Thompson, A. S. and Threadgill, M. D., 2013. One-pot tandem Hurtley–retro-Claisen–cyclisation reactions in the synthesis of 3-substituted analogues of 5-aminoisoquinolin-1-one (5-AIQ), a water-soluble inhibitor of PARPs. Bioorganic and Medicinal Chemistry, 21 (17), pp. 5218-5227.

Griffen, J., White, J., Kociok-Kohn, G., Lloyd, M., Wells, A., Arnot, T. and Lewis, S., 2013. New aminocyclitols with quaternary stereocentres via acylnitroso cycloaddition with an ipso,ortho-arene dihydrodiol. Tetrahedron, 69 (29), pp. 5989-5997.

Lloyd, M. D., Jevglevskis, M., Lee, G. L., Wood, P. J., Threadgill, M. D. and Woodman, T. J., 2013. α-Methylacyl-CoA racemase (AMACR): Metabolic enzyme, drug metabolizer and cancer marker P504S. Progress in Lipid Research, 52 (2), pp. 220-230.

Beauchard, A., Twum, E. A., Lloyd, M. D. and Threadgill, M. D., 2011. S-2-Amino-4-cyanobutanoic acid (β-cyanomethyl-L-Ala) as an atom-efficient solubilising synthon for L-glutamine. Tetrahedron Letters, 52 (41), pp. 5311-5314.

Nathubhai, A., Patterson, R., Woodman, T. J., Sharp, H. E. C., Chui, M. T. Y., Chung, H. H. K., Lau, S. W. S., Zheng, J., Lloyd, M. D., Thompson, A. S. and Threadgill, M. D., 2011. N3-Alkylation during formation of quinazolin-4-ones from condensation of anthranilamides and orthoamides. Organic and Biomolecular Chemistry, 9 (17), pp. 6089-6099.

Woodman, T. J., Wood, P. J., Thompson, A. S., Hutchings, T. J., Steel, G. R., Jiao, P., Threadgill, M. D. and Lloyd, M. D., 2011. Chiral inversion of 2-arylpropionyl-CoA esters by human α-methylacyl-CoA racemase 1A (P504S)-a potential mechanism for the anti-cancer effects of ibuprofen. Chemical Communications, 47 (26), pp. 7332-7334.

Pilgrim, S., Kociok-Kohn, G., Lloyd, M. D. and Lewis, S. E., 2011. "Inosaminoacids": novel inositol-amino acid hybrid structures accessed by microbial arene oxidation. Chemical Communications, 47 (16), pp. 4799-4801.

Holbourn, K. P., Lloyd, M. D., Thompson, A. S., Threadgill, M. D. and Acharya, K. R., 2011. Cloning, purification, crystallization and preliminary crystallographic analysis of the human histone deacetylase sirtuin 1. Acta Crystallographica Section F-Structural Biology and Crystallization Communications, 67 (4), pp. 461-463.

Sunderland, P. T., Dhami, A., Mahon, M. F., Jones, L. A., Tully, S. R., Lloyd, M. D., Thompson, A. S., Javaid, H., Martin, N. M. B. and Threadgill, M. D., 2011. Synthesis of 4-alkyl-, 4-aryl- and 4-arylamino-5-aminoisoquinolin-1-ones and identification of a new PARP-2 selective inhibitor. Organic and Biomolecular Chemistry, 9 (3), pp. 881-891.

Sunderland, P. T., Woon, E. C. Y., Dhami, A., Bergin, A. B., Mahon, M. F., Wood, P. J., Jones, L. A., Tully, S. R., Lloyd, M. D., Thompson, A. S., Javaid, H., Martin, N. M. B. and Threadgill, M. D., 2011. 5-Benzamidoisoquinolin-1-ones and 5-(ω-Carboxyalkyl)isoquinolin-1-ones as Isoform-Selective Inhibitors of Poly(ADP-ribose) Polymerase 2 (PARP-2). Journal of Medicinal Chemistry, 54 (7), pp. 2049-2059.

Sattar, F. A., Darley, D. J., Politano, F., Woodman, T. J., Threadgill, M. D. and Lloyd, M. D., 2010. Unexpected stereoselective exchange of straight-chain fatty acyl-CoA α-protons by human α-methylacyl-CoA racemase 1A (P504S). Chemical Communications, 46 (19), pp. 3348-3350.

Cozier, G. E., Leese, M. P., Lloyd, M. D., Baker, M. D., Thiyagarajan, N., Acharya, K. R. and Potter, B. V. L., 2010. Structures of human carbonic anhydrase II/inhibitor complexes reveal a second binding site for steroidal and nonsteroidal inhibitors. Biochemistry, 49 (16), pp. 3464-3476.

Dhami, A., Mahon, M. F., Lloyd, M. D. and Threadgill, M. D., 2009. 4-Substituted 5-nitroisoquinolin-1-ones from intramolecular Pd-catalysed reaction of N-(2-alkenyl)-2-halo-3-nitrobenzamides. Tetrahedron, 65 (24), pp. 4751-4765.

Lord, A.-M., Mahon, M. F., Lloyd, M. D. and Threadgill, M. D., 2009. Design, synthesis, and evaluation in vitro of quinoline-8-carboxamides, a new class of poly(adenosine-diphosphate-ribose)polymerase-1 (PARP-1) inhibitor. Journal of Medicinal Chemistry, 52 (3), pp. 868-877.

Darley, D. J., Butler, D. S., Prideaux, S. J., Thornton, T. W., Wilson, A. D., Woodman, T. J., Threadgill, M. D. and Lloyd, M. D., 2009. Synthesis and use of isotope-labelled substrates for a mechanistic study on human α-methylacyl-CoA racemase 1A (AMACR; P504S). Organic and Biomolecular Chemistry, 7 (3), pp. 543-552.

Beauchard, A., Phillips, V. A., Lloyd, M. D. and Threadgill, M. D., 2009. Synthesis of 2-(4-carboxybutenyl)- and 2-(4-carboxybutynyl)-cyclopentene-1-carboxamides. Tetrahedron, 65 (39), pp. 8176-8184.

Ball, A. L., Chambers, K. A., Hewinson, M., Navaratnarajah, S., Samrin, L., Thomas, N., Tyler, A. E. H., Wall, A. J. and Lloyd, M. D., 2008. A microtitre plate assay for measuring glycosidase activity. Journal of Enzyme Inhibition and Medicinal Chemistry, 23 (1), pp. 131-135.

Lloyd, M. D., Darley, D. J., Wierzbicki, A. S. and Threadgill, M. D., 2008. α-Methylacyl-CoA racemase - an 'obscure' metabolic enzyme takes centre stage. FEBS Journal, 275, pp. 1089-1102.

Kwong, J. S. W., Mahon, M. F., Lloyd, M. D. and Threadgill, M. D., 2007. Synthesis and conformational and configurational studies of diastereoisomeric O-protected 4-(arylsulfonimidoyl)butane-1,2,3-triols. Tetrahedron, 63 (51), pp. 12601-12607.

Lloyd, M. D., Boardman, K. D. E., Smith, A., van den Brink, D. M., Wanders, R. J. A. and Threadgill, M. D., 2007. Characterisation of recombinant human fatty aldehyde dehydrogenase: implications for Sjögren-Larsson syndrome. Journal of Enzyme Inhibition and Medicinal Chemistry, 22 (5), pp. 584-590.

Wierzbicki, A. S. and Lloyd, M. D., 2007. Dr Brian Gibberd (1931-2006): a pioneering clinician in Refsum's disease. Biochemical Society Transactions, 35 (5), pp. 862-864.

Kwong, J. S. W., Lloyd, M. D. and Threadgill, M. D., 2006. Synthesis of cyclic sulfoximine mimics of 2-deoxyribosides as enzyme inhibitors in cancer. Journal of Pharmacy and Pharmacology, 58, A58-A58.

Lloyd, M. D., Pederick, R. L., Natesh, R., Woo, L. W. L., Purohit, A., Reed, M. J., Acharya, R. and Potter, B. V. L., 2005. Crystal structure of human carbonic anhydrase II at 1.95 Å resolution in complex with 667-coumate, a novel anti-cancer agent. Biochemical Journal, 385 (Pt 3), pp. 715-720.

Lloyd, M. D., Thiyagarajan, N., Ho, Y. T., Woo, L. W. L., Sutcliffe, O. B., Purohit, A., Reed, M. J., Acharya, K. R. and Potter, B. V. L., 2005. First crystal structures of human carbonic anhydrase II in complex with dual aromatase-steroid sulfatase inhibitors. Biochemistry, 44 (18), pp. 6858-6866.

Searls, T., Butler, D., Chien, W., Mukherji, M., Lloyd, M. D. and Schofield, C. J., 2005. Studies on the specificity of unprocessed and mature forms of phytanoyl-CoA 2-hydroxylase and mutation of the iron binding ligands. Journal of Lipid Research, 46, pp. 1660-1667.

Acharya, K. R. and Lloyd, M. D., 2005. The advantages and limitations of protein crystal structures. Trends in Pharmacological Sciences, 26 (1), pp. 10-14.

Lloyd, M. D., Lipscomb, S. J., Hewitson, K. S., Hensgens, C. M. H., Baldwin, J. E. and Schofield, C. J., 2004. Controlling the substrate selectivity of deacetoxy/deacetylcephalosporin C synthase. Journal of Biological Chemistry, 279 (15), pp. 15420-15426.

Wierzbicki, A. S., Mayne, P. D., Lloyd, M. D., Burston, D., Mei, G., Sidey, M. C., Feher, M. D. and Gibberd, F. B., 2003. Metabolism of phytanic acid and 3-methyl-adipic acid excretion in patients with adult Refsum disease. Journal of Lipid Research, 44, pp. 1481-1488.

Wanders, R. J. A., Jansen, G. A. and Lloyd, M. D., 2003. Phytanic acid alpha-oxidation, new insights into an old problem: a review. Biochimica et Biophysica Acta, 1631, pp. 119-135.

Mukherji, M., Schofield, C. J., Wierzbicki, A. S., Jansen, G. A., Wanders, R. J. A. and Lloyd, M. D., 2003. The chemical biology of branched-chain lipid metabolism. Progress in Lipid Research, 42, pp. 359-376.

Lee, H. J., Dai, Y. F., Shiau, C. Y., Schofield, C. J. and Lloyd, M. D., 2003. The kinetic properties of various R258 mutants of deacetoxycephalosporin C synthase. European Journal of Biochemistry, 270, pp. 1301-1307.

Lee, H. J., Schofield, C. J. and Lloyd, M. D., 2002. Active site mutations of recombinant deacetoxycephalosporin C synthase. Biochemical and Biophysical Research Communications, 292, pp. 66-70.

Wierzbicki, A. S., Lloyd, M. D., Schofield, C. J., Feher, M. D. and Gibberd, F. B., 2002. Refsum's disease: a peroxisomal disorder affecting alpha-oxidation of phytanic acid: a mini-review. Journal of Neurochemistry, 80 (5), pp. 727-735.

Lipscomb, S. J., Lee, H. J., Mukherji, M., Baldwin, J. E., Schofield, C. J. and Lloyd, M. D., 2002. The role of arginine residues in substrate binding and catalysis by deacetoxycephalosporin C synthase. European Journal of Biochemistry, 269, pp. 2735-2739.

Mukherji, M., Kershaw, N. J., Schofield, C. J., Wierzbicki, A. S. and Lloyd, M. D., 2002. Utilization of sterol carrier protein-2 by phytanoyl-CoA 2-hydroxylase in the peroxisomal α oxidation of phytanic acid. Chemistry & Biology, 9, pp. 597-605.

Mukherji, M., Kershaw, N. J., MacKinnon, C. H., Clifton, I. J., Wierzbicki, A. S., Schofield, C. J. and Lloyd, M. D., 2001. 'Chemical co-substrate rescue' of phytanoyl-CoA 2-hydroxylase mutants causing Refsum's Disease. Chemical Communications, 2001, pp. 972-973.

Lee, H. J., Lloyd, M. D., Harlos, K., Clifton, I. J., Baldwin, J. E. and Schofield, C. J., 2001. Alteration of the 2-oxoacid cosubstrate selectivity in deacetoxycephalosporin C synthase: the role of arginine-258. Journal of Biological Chemistry, 276, pp. 18290-18295.

Hamilton, C. S., Yasuhara, A., Baldwin, J. E., Lloyd, M. D. and Rutledge, P. J., 2001. Contrasting fates for 6-α-methylpenicillin N upon oxidation by deacetoxycephalosporin C synthase (DAOCS) and deacetoxy/deacetylcephalosporin C synthase (DAOC/DACS). Bioorganic & Medicinal Chemistry Letters, 11, pp. 2511-2514.

Lee, H. J., Lloyd, M. D., Harlos, K., Clifton, I. J., Baldwin, J. E. and Schofield, C. J., 2001. Kinetic and crystallographic studies on deacetoxycephalosporin C synthase. Journal of Molecular Biology, 308, pp. 937-948.

Dubus, A., Lloyd, M. D., Lee, H. J., Schofield, C. J., Baldwin, J. E. and Frere, J. M., 2001. Probing the penicillin sidechain selectivity of recombinant deacetoxycephalosporin C synthase. Cellular and Molecular Life Sciences (CMLS), 58, pp. 835-843.

Mukherji, M., Chien, W., Kershaw, N. J., Clifton, I. J., Schofield, C. J., Wierzbicki, A. S. and Lloyd, M. D., 2001. Structure-function analysis of phytanoyl-CoA 2-hydroxylase mutations causing Refsum's disease. Human Molecular Genetics, 10 (18), pp. 1971-1982.

Kershaw, N. J., Mukherji, M., MacKinnon, C. H., Claridge, T. W. D., Odell, B., Wierzbicki, A. S., Lloyd, M. D. and Schofield, C. J., 2001. Studies on phytanoyl-CoA 2-hydroxylase and synthesis of phytanoyl-coenzyme A. Bioorganic & Medicinal Chemistry Letters, 11, pp. 2545-2548.

Conference or Workshop Items

Jolly, P., Formisano, N., Djahanbakhsh Rafiee, S., Bhalla, N., Miodek, A., Dondi, R., Yang, D. K., Chen, L. C., Kasak, P., Tkac, J., Lloyd, M., Eggleston, I. and Estrela, P., 2014. DNA aptamer-based approaches for detection of multiple prostate cancer biomarkers. In: 22nd Meeting of the EAU Section of Urological Research, 2014-10-09 - 2014-10-11, Glasgow.

Kwong, J. S. W., Lloyd, M. D. and Threadgill, M. D., 2006. Design and synthesis of a novel transition state mimic for poly(ADP-ribose) polymerase 1 (PARP-1) inhibition. In: Conférences Européenes du Groupement des Pharmacochimistes de L'Arc Atlantique (GP2A), 2006-09-07 - 2006-09-08, Bath.

Kwong, J. S. W., Lloyd, M. D. and Threadgill, M. D., 2006. Design, synthetic approaches and characterisation of a novel cyclic sulfoximine NAD+ (nicotinamide adenine dinucleotide) analogue. In: American Chemical Society (ACS) 232nd National Meeting, 2006-09-10 - 2006-09-14, San Francisco.

Lloyd, M. D., Boardman, K. D. E. and Threadgill, M. D., 2006. Expression and characterisation of human adehyde dehydrogenase 10: implications for Söjgren-Larsson syndrome. In: Conférences Européenes du Groupement des Pharmacochimistes de L'Arc Atlantique (GP2A), 2006-09-07 - 2006-09-08, Bath.

Lord, A. M., Lloyd, M. D. and Threadgill, M. D., 2006. Quinoline-8-carboxamides as novel PARP-1 inhibitors. In: Conférences Européenes du Groupement des Pharmacochimistes de L'Arc Atlantique (GP2A), 2006-09-07 - 2006-09-08, Bath.

This list was generated on Sat Nov 22 06:26:20 2014 GMT.