Research

Items by Lloyd, Matthew

Up a level
Export as [feed] RSS 1.0 [feed] Atom [feed] RSS 2.0
Group by: Item Type | Date | No Grouping
Number of items: 50.

Book Sections

Lloyd, M. D., Mukherji, M., Kershaw, N. J., Chien, W., Wierzbicki, A. S., Schofield, C. J., Roels, F., Baes, M. and De Bie, S., 2005. Role of phytanoyl-CoA 2-hydroxylase in phytanic acid metabolism. In: Peroxisomal disorders and regulation of genes. Ghent: Kluwer Academic/Plenum Publishers, pp. 303-304. (Advances in Experimental Medicine and Biology)

Articles

Yevglevskis, M., Bowskill, C.R., Chan, C.C.Y., Heng, J.H.-J., Threadgill, M. D., Woodman, T.J. and Lloyd, M.D., 2014. A study on the chiral inversion of mandelic acid in humans. Organic and Biomolecular Chemistry, 12 (34), pp. 6737-6744.

Nathubhai, A., Wood, P. J., Lloyd, M. D., Thompson, A. S. and Threadgill, M. D., 2013. Design and discovery of 2‑arylquinazolin-4-ones as potent and selective inhibitors of tankyrases. ACS Medicinal Chemistry Letters, 4 (12), pp. 1173-1177.

Qu, X., Allan, A., Chui, G., Hutchings, T. J., Jiao, P., Johnson, L., Leung, W. Y., Li, P. K., Steel, G. R., Thompson, A. S., Threadgill, M. D., Woodman, T. J. and Lloyd, M. D., 2013. Hydrolysis of ibuprofenoyl-CoA and other 2-APA-CoA esters by human acyl-CoA thioesterases-1 and -2 and their possible role in the chiral inversion of profens. Biochemical Pharmacology, 86 (11), pp. 1621-1625.

Woon, E. C. Y., Sunderland, P. T., Paine, H. A., Lloyd, M. D., Thompson, A. S. and Threadgill, M. D., 2013. One-pot tandem Hurtley–retro-Claisen–cyclisation reactions in the synthesis of 3-substituted analogues of 5-aminoisoquinolin-1-one (5-AIQ), a water-soluble inhibitor of PARPs. Bioorganic and Medicinal Chemistry, 21 (17), pp. 5218-5227.

Griffen, J., White, J., Kociok-Kohn, G., Lloyd, M., Wells, A., Arnot, T. and Lewis, S., 2013. New aminocyclitols with quaternary stereocentres via acylnitroso cycloaddition with an ipso,ortho-arene dihydrodiol. Tetrahedron, 69 (29), pp. 5989-5997.

Lloyd, M. D., Jevglevskis, M., Lee, G. L., Wood, P. J., Threadgill, M. D. and Woodman, T. J., 2013. α-Methylacyl-CoA racemase (AMACR): Metabolic enzyme, drug metabolizer and cancer marker P504S. Progress in Lipid Research, 52 (2), pp. 220-230.

Beauchard, A., Twum, E. A., Lloyd, M. D. and Threadgill, M. D., 2011. S-2-Amino-4-cyanobutanoic acid (β-cyanomethyl-L-Ala) as an atom-efficient solubilising synthon for L-glutamine. Tetrahedron Letters, 52 (41), pp. 5311-5314.

Nathubhai, A., Patterson, R., Woodman, T. J., Sharp, H. E. C., Chui, M. T. Y., Chung, H. H. K., Lau, S. W. S., Zheng, J., Lloyd, M. D., Thompson, A. S. and Threadgill, M. D., 2011. N3-Alkylation during formation of quinazolin-4-ones from condensation of anthranilamides and orthoamides. Organic and Biomolecular Chemistry, 9 (17), pp. 6089-6099.

Woodman, T. J., Wood, P. J., Thompson, A. S., Hutchings, T. J., Steel, G. R., Jiao, P., Threadgill, M. D. and Lloyd, M. D., 2011. Chiral inversion of 2-arylpropionyl-CoA esters by human α-methylacyl-CoA racemase 1A (P504S)-a potential mechanism for the anti-cancer effects of ibuprofen. Chemical Communications, 47 (26), pp. 7332-7334.

Pilgrim, S., Kociok-Kohn, G., Lloyd, M. D. and Lewis, S. E., 2011. "Inosaminoacids": novel inositol-amino acid hybrid structures accessed by microbial arene oxidation. Chemical Communications, 47 (16), pp. 4799-4801.

Holbourn, K. P., Lloyd, M. D., Thompson, A. S., Threadgill, M. D. and Acharya, K. R., 2011. Cloning, purification, crystallization and preliminary crystallographic analysis of the human histone deacetylase sirtuin 1. Acta Crystallographica Section F-Structural Biology and Crystallization Communications, 67 (4), pp. 461-463.

Sunderland, P. T., Dhami, A., Mahon, M. F., Jones, L. A., Tully, S. R., Lloyd, M. D., Thompson, A. S., Javaid, H., Martin, N. M. B. and Threadgill, M. D., 2011. Synthesis of 4-alkyl-, 4-aryl- and 4-arylamino-5-aminoisoquinolin-1-ones and identification of a new PARP-2 selective inhibitor. Organic and Biomolecular Chemistry, 9 (3), pp. 881-891.

Sunderland, P. T., Woon, E. C. Y., Dhami, A., Bergin, A. B., Mahon, M. F., Wood, P. J., Jones, L. A., Tully, S. R., Lloyd, M. D., Thompson, A. S., Javaid, H., Martin, N. M. B. and Threadgill, M. D., 2011. 5-Benzamidoisoquinolin-1-ones and 5-(ω-Carboxyalkyl)isoquinolin-1-ones as Isoform-Selective Inhibitors of Poly(ADP-ribose) Polymerase 2 (PARP-2). Journal of Medicinal Chemistry, 54 (7), pp. 2049-2059.

Sattar, F. A., Darley, D. J., Politano, F., Woodman, T. J., Threadgill, M. D. and Lloyd, M. D., 2010. Unexpected stereoselective exchange of straight-chain fatty acyl-CoA α-protons by human α-methylacyl-CoA racemase 1A (P504S). Chemical Communications, 46 (19), pp. 3348-3350.

Cozier, G. E., Leese, M. P., Lloyd, M. D., Baker, M. D., Thiyagarajan, N., Acharya, K. R. and Potter, B. V. L., 2010. Structures of human carbonic anhydrase II/inhibitor complexes reveal a second binding site for steroidal and nonsteroidal inhibitors. Biochemistry, 49 (16), pp. 3464-3476.

Dhami, A., Mahon, M. F., Lloyd, M. D. and Threadgill, M. D., 2009. 4-Substituted 5-nitroisoquinolin-1-ones from intramolecular Pd-catalysed reaction of N-(2-alkenyl)-2-halo-3-nitrobenzamides. Tetrahedron, 65 (24), pp. 4751-4765.

Lord, A.-M., Mahon, M. F., Lloyd, M. D. and Threadgill, M. D., 2009. Design, synthesis, and evaluation in vitro of quinoline-8-carboxamides, a new class of poly(adenosine-diphosphate-ribose)polymerase-1 (PARP-1) inhibitor. Journal of Medicinal Chemistry, 52 (3), pp. 868-877.

Darley, D. J., Butler, D. S., Prideaux, S. J., Thornton, T. W., Wilson, A. D., Woodman, T. J., Threadgill, M. D. and Lloyd, M. D., 2009. Synthesis and use of isotope-labelled substrates for a mechanistic study on human α-methylacyl-CoA racemase 1A (AMACR; P504S). Organic and Biomolecular Chemistry, 7 (3), pp. 543-552.

Beauchard, A., Phillips, V. A., Lloyd, M. D. and Threadgill, M. D., 2009. Synthesis of 2-(4-carboxybutenyl)- and 2-(4-carboxybutynyl)-cyclopentene-1-carboxamides. Tetrahedron, 65 (39), pp. 8176-8184.

Ball, A. L., Chambers, K. A., Hewinson, M., Navaratnarajah, S., Samrin, L., Thomas, N., Tyler, A. E. H., Wall, A. J. and Lloyd, M. D., 2008. A microtitre plate assay for measuring glycosidase activity. Journal of Enzyme Inhibition and Medicinal Chemistry, 23 (1), pp. 131-135.

Lloyd, M. D., Darley, D. J., Wierzbicki, A. S. and Threadgill, M. D., 2008. α-Methylacyl-CoA racemase - an 'obscure' metabolic enzyme takes centre stage. FEBS Journal, 275, pp. 1089-1102.

Kwong, J. S. W., Mahon, M. F., Lloyd, M. D. and Threadgill, M. D., 2007. Synthesis and conformational and configurational studies of diastereoisomeric O-protected 4-(arylsulfonimidoyl)butane-1,2,3-triols. Tetrahedron, 63 (51), pp. 12601-12607.

Lloyd, M. D., Boardman, K. D. E., Smith, A., van den Brink, D. M., Wanders, R. J. A. and Threadgill, M. D., 2007. Characterisation of recombinant human fatty aldehyde dehydrogenase: implications for Sjögren-Larsson syndrome. Journal of Enzyme Inhibition and Medicinal Chemistry, 22 (5), pp. 584-590.

Wierzbicki, A. S. and Lloyd, M. D., 2007. Dr Brian Gibberd (1931-2006): a pioneering clinician in Refsum's disease. Biochemical Society Transactions, 35 (5), pp. 862-864.

Kwong, J. S. W., Lloyd, M. D. and Threadgill, M. D., 2006. Synthesis of cyclic sulfoximine mimics of 2-deoxyribosides as enzyme inhibitors in cancer. Journal of Pharmacy and Pharmacology, 58, A58-A58.

Lloyd, M. D., Pederick, R. L., Natesh, R., Woo, L. W. L., Purohit, A., Reed, M. J., Acharya, R. and Potter, B. V. L., 2005. Crystal structure of human carbonic anhydrase II at 1.95 Å resolution in complex with 667-coumate, a novel anti-cancer agent. Biochemical Journal, 385 (Pt 3), pp. 715-720.

Lloyd, M. D., Thiyagarajan, N., Ho, Y. T., Woo, L. W. L., Sutcliffe, O. B., Purohit, A., Reed, M. J., Acharya, K. R. and Potter, B. V. L., 2005. First crystal structures of human carbonic anhydrase II in complex with dual aromatase-steroid sulfatase inhibitors. Biochemistry, 44 (18), pp. 6858-6866.

Searls, T., Butler, D., Chien, W., Mukherji, M., Lloyd, M. D. and Schofield, C. J., 2005. Studies on the specificity of unprocessed and mature forms of phytanoyl-CoA 2-hydroxylase and mutation of the iron binding ligands. Journal of Lipid Research, 46, pp. 1660-1667.

Acharya, K. R. and Lloyd, M. D., 2005. The advantages and limitations of protein crystal structures. Trends in Pharmacological Sciences, 26 (1), pp. 10-14.

Lloyd, M. D., Lipscomb, S. J., Hewitson, K. S., Hensgens, C. M. H., Baldwin, J. E. and Schofield, C. J., 2004. Controlling the substrate selectivity of deacetoxy/deacetylcephalosporin C synthase. Journal of Biological Chemistry, 279 (15), pp. 15420-15426.

Wierzbicki, A. S., Mayne, P. D., Lloyd, M. D., Burston, D., Mei, G., Sidey, M. C., Feher, M. D. and Gibberd, F. B., 2003. Metabolism of phytanic acid and 3-methyl-adipic acid excretion in patients with adult Refsum disease. Journal of Lipid Research, 44, pp. 1481-1488.

Wanders, R. J. A., Jansen, G. A. and Lloyd, M. D., 2003. Phytanic acid alpha-oxidation, new insights into an old problem: a review. Biochimica et Biophysica Acta, 1631, pp. 119-135.

Mukherji, M., Schofield, C. J., Wierzbicki, A. S., Jansen, G. A., Wanders, R. J. A. and Lloyd, M. D., 2003. The chemical biology of branched-chain lipid metabolism. Progress in Lipid Research, 42, pp. 359-376.

Lee, H. J., Dai, Y. F., Shiau, C. Y., Schofield, C. J. and Lloyd, M. D., 2003. The kinetic properties of various R258 mutants of deacetoxycephalosporin C synthase. European Journal of Biochemistry, 270, pp. 1301-1307.

Lee, H. J., Schofield, C. J. and Lloyd, M. D., 2002. Active site mutations of recombinant deacetoxycephalosporin C synthase. Biochemical and Biophysical Research Communications, 292, pp. 66-70.

Wierzbicki, A. S., Lloyd, M. D., Schofield, C. J., Feher, M. D. and Gibberd, F. B., 2002. Refsum's disease: a peroxisomal disorder affecting alpha-oxidation of phytanic acid: a mini-review. Journal of Neurochemistry, 80 (5), pp. 727-735.

Lipscomb, S. J., Lee, H. J., Mukherji, M., Baldwin, J. E., Schofield, C. J. and Lloyd, M. D., 2002. The role of arginine residues in substrate binding and catalysis by deacetoxycephalosporin C synthase. European Journal of Biochemistry, 269, pp. 2735-2739.

Mukherji, M., Kershaw, N. J., Schofield, C. J., Wierzbicki, A. S. and Lloyd, M. D., 2002. Utilization of sterol carrier protein-2 by phytanoyl-CoA 2-hydroxylase in the peroxisomal α oxidation of phytanic acid. Chemistry & Biology, 9, pp. 597-605.

Mukherji, M., Kershaw, N. J., MacKinnon, C. H., Clifton, I. J., Wierzbicki, A. S., Schofield, C. J. and Lloyd, M. D., 2001. 'Chemical co-substrate rescue' of phytanoyl-CoA 2-hydroxylase mutants causing Refsum's Disease. Chemical Communications, 2001, pp. 972-973.

Lee, H. J., Lloyd, M. D., Harlos, K., Clifton, I. J., Baldwin, J. E. and Schofield, C. J., 2001. Alteration of the 2-oxoacid cosubstrate selectivity in deacetoxycephalosporin C synthase: the role of arginine-258. Journal of Biological Chemistry, 276, pp. 18290-18295.

Hamilton, C. S., Yasuhara, A., Baldwin, J. E., Lloyd, M. D. and Rutledge, P. J., 2001. Contrasting fates for 6-α-methylpenicillin N upon oxidation by deacetoxycephalosporin C synthase (DAOCS) and deacetoxy/deacetylcephalosporin C synthase (DAOC/DACS). Bioorganic & Medicinal Chemistry Letters, 11, pp. 2511-2514.

Lee, H. J., Lloyd, M. D., Harlos, K., Clifton, I. J., Baldwin, J. E. and Schofield, C. J., 2001. Kinetic and crystallographic studies on deacetoxycephalosporin C synthase. Journal of Molecular Biology, 308, pp. 937-948.

Dubus, A., Lloyd, M. D., Lee, H. J., Schofield, C. J., Baldwin, J. E. and Frere, J. M., 2001. Probing the penicillin sidechain selectivity of recombinant deacetoxycephalosporin C synthase. Cellular and Molecular Life Sciences (CMLS), 58, pp. 835-843.

Mukherji, M., Chien, W., Kershaw, N. J., Clifton, I. J., Schofield, C. J., Wierzbicki, A. S. and Lloyd, M. D., 2001. Structure-function analysis of phytanoyl-CoA 2-hydroxylase mutations causing Refsum's disease. Human Molecular Genetics, 10 (18), pp. 1971-1982.

Kershaw, N. J., Mukherji, M., MacKinnon, C. H., Claridge, T. W. D., Odell, B., Wierzbicki, A. S., Lloyd, M. D. and Schofield, C. J., 2001. Studies on phytanoyl-CoA 2-hydroxylase and synthesis of phytanoyl-coenzyme A. Bioorganic & Medicinal Chemistry Letters, 11, pp. 2545-2548.

Conference or Workshop Items

Kwong, J. S. W., Lloyd, M. D. and Threadgill, M. D., 2006. Design and synthesis of a novel transition state mimic for poly(ADP-ribose) polymerase 1 (PARP-1) inhibition. In: Conférences Européenes du Groupement des Pharmacochimistes de L'Arc Atlantique (GP2A), 2006-09-07 - 2006-09-08, Bath.

Kwong, J. S. W., Lloyd, M. D. and Threadgill, M. D., 2006. Design, synthetic approaches and characterisation of a novel cyclic sulfoximine NAD+ (nicotinamide adenine dinucleotide) analogue. In: American Chemical Society (ACS) 232nd National Meeting, 2006-09-10 - 2006-09-14, San Francisco.

Lloyd, M. D., Boardman, K. D. E. and Threadgill, M. D., 2006. Expression and characterisation of human adehyde dehydrogenase 10: implications for Söjgren-Larsson syndrome. In: Conférences Européenes du Groupement des Pharmacochimistes de L'Arc Atlantique (GP2A), 2006-09-07 - 2006-09-08, Bath.

Lord, A. M., Lloyd, M. D. and Threadgill, M. D., 2006. Quinoline-8-carboxamides as novel PARP-1 inhibitors. In: Conférences Européenes du Groupement des Pharmacochimistes de L'Arc Atlantique (GP2A), 2006-09-07 - 2006-09-08, Bath.

This list was generated on Sat Sep 20 05:00:13 2014 IST.