Research

Items by Blagbrough, Ian

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Number of items: 90.

Book Sections

Blagbrough, I. S. and Metwally, A. A., 2013. siRNA and Gene Formulation for Efficient Gene Therapy. In: Molina, F. M., ed. Gene Therapy: Tools and Potential Applications. InTech.

Adjimatera, N., Neal, A. P. and Blagbrough, I. S., 2005. Fluorescence techniques in non-viral gene therapy. In: Hof, M., Hutterer, R. and Fidler, V., eds. Fluorescence Spectroscopy in Biology: Advanced Methods and their Applications to Membranes, Proteins, DNA, and Cells. Vol. 3. Heidelberg: Springer, pp. 201-228. (Springer Series on Fluorescence)

Blagbrough, I. S., Adjimatera, N., Ahmed, O. A. A., Neal, A. P. and Pourzand, C. A., 2004. Spermine and lipopolyamines as gene delivery agents. In: Beadle, D. J., Mellor, I. R. and Usherwood, P. N. R., eds. Neurotox '03: Neurotoxicological targets from Functional Genomics and Proteomics. Society of Chemical Industry, pp. 147-159. (Functional Genomics and Proteomics)

Blagbrough, I. S. and Neal, A. P., 2002. Design and synthesis of fluorescent steroidal lipopolyamine conjugates for monitoring gene delivery. In: Matsoukas, J. and Mavromoustakos, T., eds. Drug Discovery and Design: Medical Aspects. Vol. 55. Amsterdam: IOS Press, pp. 64-75. (Biomedical and Health Research)

Trigg, W. J., Hardick, D. J., Grangier, G., Wonnacott, S., Lewis, T., Rowan, M. G., Potter, B. V. L. and Blagbrough, I. S., 1998. Selective probes for nicotinic acetylcholine receptors from substituted AE-bicyclic analogs of methyllycaconitine. In: Baker, D. R., Fenyes, J. G., Basarab, G. S. and Hunt, D. A., eds. Synthesis and Chemistry of Agrochemicals V. Washington, U. S. A.: ACM, pp. 194-205. (ACS Symposium Series; 686)

Articles

Ghonaim, H. M. and Blagbrough, I. S., 2014. Synthesis and formulations of lipid aminoglycoside conjugates : nanoparticles for efficient gene and sirna delivery. International Journal of Pharmacy and Pharmaceutical Sciences, 6 (2), pp. 153-157.

Mohamed, A. I., El-Assal, M. I. A., Kassem, M. A., Blagbrough, I. S. and Ahmed, O. A. A., 2013. Role of PLGA-nanoparticles formulation to improve drug radioprotective activity in gamma-irradiated mice. Latin American Journal of Pharmacy, 32 (6), pp. 809-816.

Metwally, A. A., Blagbrough, I. S. and Mantell, J. M., 2012. Quantitative silencing of EGFP reporter gene by self-assembled siRNA lipoplexes of LinOS and cholesterol. Molecular Pharmaceutics, 9 (11), pp. 3384-3395.

Stupariu, J., Blagbrough, I., Millar, J. I., Rogers, P. and Sutton, J. W., 2011. Research in pharmacy and the role of the undergraduate programme : Course Directors’ perspectives. International Journal of Pharmacy Practice, 19 (Suppl 2), pp. 10-11.

Metwally, A. A., Pourzand, C. and Blagbrough, I. S., 2010. Efficient siRNA delivery and effective gene silencing by lipoplexes. Drug Discovery Today, 15 (23-24), p. 1090.

Metwally, A. A., Pourzand, C. and Blagbrough, I. S., 2010. Efficient siRNA delivery and gene silencing by unsymmetrical fatty acid amides of spermine. Journal of Pharmacy and Pharmacology, 62 (10), pp. 1220-1221.

Ghonaim, H. M., Soltan, M. K. and Blagbrough, I. S., 2010. Heterocyclic N-4, N-9-diacyl spermines : Nanoparticle lipopolyamine vectors for efficient pDNA and siRNA delivery. Journal of Pharmacy and Pharmacology, 62 (10), pp. 1276-1277.

Ghonaim, H. M., Cheng, Y. X., Pourzand, C. and Blagbrough, I., 2010. Self-assembled complex formulations of lipid-aminoglycoside conjugates : Nanoparticles for efficient gene and siRNA delivery. Journal of Pharmacy and Pharmacology, 62 (10), pp. 1295-1296.

Soltan, M. K., Ghonaim, H. M., El Sadek, M., Abou Kull, M., El-aziz, L. A. and Blagbrough, I. S., 2009. Design and synthesis of N 4,N 9-disubstituted spermines for non-viral siRNA delivery – structure-activity relationship studies of siFection efficiency versus toxicity. Pharmaceutical Research, 26 (2), pp. 286-295.

Elmasry, M. S., Saleh, H. M., Kheir, A. A., Blagbrough, I. and Rogers, P. J., 2009. Quantitative HPLC analysis of mebeverine HCI and other GIT medicines stored in a monitored dosage system for polypharmacy. International Journal of Pharmacy Practice, 17 (Supplement 1), A111-A112.

Blagbrough, I. S., Elmasry, M. S., Woodman, T. J., Saleh, H. M. and Kheir, A. A., 2009. Quantitative determination of mebeverine HCl by NMR chemical shift migration. Tetrahedron, 65 (25), pp. 4930-4936.

Farghaly, H., Causton, B., Blagbrough, I. and Watson, M. L., 2008. The effect of PI3K inhibition on IL-13-induced arginase I expression in mice tracheal segments. Fundamental & Clinical Pharmacology, 22, p. 14.

Ghonaim, H. M., Li, S., Soltan, M. K., Pourzand, C. and Blagbrough, I. S., 2007. Chain length modulation in symmetrical lipopolyamines and the effect on nanoparticle formulations for gene delivery. Journal of Pharmacy and Pharmacology, 59, A36-A36.

Soltan, M. K. and Blagbrough, I. S., 2007. Design and synthesis of nitrogen heterocyclic diacyl lipospermines for gene delivery. Journal of Pharmacy and Pharmacology, 59, A50-A50.

Ghonaim, H. M., Li, S., Pourzand, C. and Blagbrough, I. S., 2007. Efficient novel unsymmetrical lipopolyamine formulations for gene delivery. Journal of Pharmacy and Pharmacology, 59, A37-A37.

Ghonaim, H. M., Li, S., Pourzand, C. and Blagbrough, I. S., 2007. Formulation and delivery of fluorescent siRNA by lipospermine nanoparticle complex formation. Journal of Pharmacy and Pharmacology, 59, A36-A37.

Soltan, M. K. and Blagbrough, I. S., 2006. Design and synthesis of novel diacyl lipospermines. Journal of Pharmacy and Pharmacology, 58, A57-A58.

Ahmed, O. A. A. and Blagbrough, I. S., 2006. Formulation and delivery of p-EGFP DNA condensed by a synthetic lipospermine. Journal of Pharmacy and Pharmacology, 58, A63-A63.

Adjimatera, N., Kral, T., Hof, M. and Blagbrough, I. S., 2006. Lipopolyamine-mediated single nanoparticle formation of calf thymus DNA analyzed by fluorescence correlation spectroscopy. Pharmaceutical Research, 23 (7), pp. 1564-1573.

Adjimatera, N., Neal, A. P., Pourzand, C. and Blagbrough, I. S., 2005. Fluorescent lipopolyamines: A new class of molecular probes in non-viral gene therapy. Abstracts of Papers of the American Chemical Society, 229, U117-U117.

Adjimatera, N., Blagbrough, I. S. and Pourzand, C., 2005. Monitoring formulation and intracellular delivery of plasmids by lipopolyamines. Abstracts of Papers of the American Chemical Society, 229, U211-U211.

Ahmed, O. A. A., Adjimatera, N., Pourzand, C. and Blagbrough, I. S., 2005. N4,N9-dioleoyl spermine is a novel nonviral lipopolyamine vector for plasmid DNA formulation. Pharmaceutical Research, 22 (6), pp. 972-980.

Adjimatera, N., Neal, A. P. and Blagbrough, I. S., 2005. Sensing DNA nanocomplex delivery by fluorescent probes. Abstracts of Papers of the American Chemical Society, 229, U140-U140.

Blagbrough, I. S., Adjimatera, N., Neal, A. P. and Haworth, I. S., 2004. Fluorescence techniques in non-viral gene therapy: Using spermine and lipopolyamines as DNA delivery agents. Abstracts of Papers of the American Chemical Society, 227, U34-U34.

Blagbrough, I. S., Geall, A. J. and Neal, A. P., 2003. Polyamines and novel polyamine conjugates interact with DNA in ways that can be exploited in non-viral gene therapy. Biochemical Society Transactions, 31 (2), pp. 397-406.

Delcros, J. G., Tomasi, S., Carrington, S., Martin, B., Renault, J., Blagbrough, I. S. and Uriac, P., 2002. Effect of spermine conjugation on the cytotoxicity and cellular transport of acridine. Journal of Medicinal Chemistry, 45 (23), pp. 5098-5111.

Geall, A. J., Al-Hadithi, D. and Blagbrough, I. S., 2002. Efficient calf thymus DNA condensation upon binding with novel bile acid polyamine amides. Bioconjugate Chemistry, 13, pp. 481-490.

Neal, A. P. and Blagbrough, I. S., 2002. Hydrdboration of cholesterol carbamates: Novel fluorescent lipopolyamines. Abstracts of Papers of the American Chemical Society, 224, U34-U34.

Blagbrough, I. S. and Geall, A. J., 2002. Synthesis and DNA binding of steroid lipopolyamine conjugates: PKA studies of polyammonium ion ligands. Abstracts of Papers of the American Chemical Society, 224, U40-U40.

Neal, A. P. and Blagbrough, I. S., 2001. Design and synthesis of fluorescent cholesterol and lithocholic acid polyamine conjugates. Abstracts of Papers of the American Chemical Society, 221, U58-U58.

Neal, A. P. and Blagbrough, I. S., 2001. Fluorescent steroidal lipopolyamine conjugates for monitoring gene delivery. Abstracts of Papers of the American Chemical Society, 221, U62-U62.

Rault, S. and Blagbrough, I. S., 2001. Medicinal chemistry within the Atlantic Arc and collaboration within Franco-Belges pharmacochemistry. Journal of Pharmacy and Pharmacology, 53 (7), pp. 921-922.

Blagbrough, I. S., Geall, A. J. and Al-Hadithi, D., 2001. Sar of bile acid polyamine conjugates in binding and condensation of DNA. Abstracts of Papers of the American Chemical Society, 221, U58-U58.

Blagbrough, I. S., Haworth, I. S., Taylor, S. and Carrington, S., 2001. Synthesis and DNA binding studies of 9-anthracenyl and 9-acridinyl-polyamine conjugates: Ligands designed with two discrete binding modes. Abstracts of Papers of the American Chemical Society, 221, U61-U62.

Blagbrough, I. S., Geall, A. J., Taylor, R. J., Earll, M. E. and Eaton, M. W., 2001. Synthesis, DNA binding, and pK(a) studies of cholesterol-polyamine carbamates. Abstracts of Papers of the American Chemical Society, 221, U58-U58.

Lind, R. J., Hardick, D. J., Blagbrough, I. S., Potter, B. V. L., Wolstenholme, A. J., Davies, A. R. L., Clough, M. S., Earley, F. G. P., Reynolds, S. E. and Wonnacott, S., 2001. [3H]-methyllycaconitine : a high affinity radioligand that labels invertebrate nicotinic acetylcholine receptors. Insect Biochemistry and Molecular Biology, 31 (6-7), pp. 533-542.

Blagbrough, I. S., Geall, A. J. and David, S. A., 2000. Lipopolyamines incorporating the tetraamine spermine, bound to an alkyl chain, sequester bacterial lipopolysaccharide. Bioorganic & Medicinal Chemistry Letters, 10 (17), pp. 1959-1962.

Geall, A. J., Taylor, R. J., Earll, M. E., Eaton, M. A. W. and Blagbrough, I. S., 2000. Synthesis of cholesteryl polyamine carbamates: pK(a) studies and condensation of calf thymus DNA. Bioconjugate Chemistry, 11 (3), pp. 314-326.

Whiteaker, P., Davies, A. R. L., Marks, M. J., Blagbrough, I. S., Potter, B. V. L., Wolstenholme, A. J., Collins, A. C. and Wonnacott, S., 1999. An autoradiographic study of the distribution of binding sites for the novel ∝7-selective nicotinic radioligand [3H]-methyllycaconitine in the mouse brain. European Journal of Neuroscience, 11 (8), pp. 2689-2696.

Grangier, G., Trigg, W. J., Lewis, T., Rowan, M. G., Potter, B. V. L. and Blagbrough, I. S., 1998. Synthesis of C5-substituted AE-bicyclic analogues of lycoctonine, inuline and methyllycaconitine. Tetrahedron Letters, 39 (8), pp. 889-892.

Coates, P. A., Blagbrough, I. S., Lewis, T., Potter, B. V. L. and Rowan, M. G., 1995. An HPLC assay for the norditerpenoid alkaloid methyllycaconitine, a potent nicotinic acetylcholine receptor antagonist. Journal of Pharmaceutical and Biomedical Analysis, 13 (12), pp. 1541-1544.

Blagbrough, I. S., Coates, P. A., Hardick, D. J., Lewis, T., Rowan, M. G., Wonnacott, S. and Potter, B. V. L., 1994. Acylation of lycoctonine : semi-synthesis of inuline, delsemine analogues and methyllycaconitine. Tetrahedron Letters, 35 (46), pp. 8705-8708.

Blagbrough, I. S., Hardick, D. J., Wonnacott, S. and Potter, B. V. L., 1994. Regioselective demethylation of aconitine. Tetrahedron Letters, 35 (20), pp. 3367-3370.

This list was generated on Wed May 27 19:57:04 2015 IST.