Items by Safrany, Stephen

Grint, T., Riley, A. M., Mills, S. J., Potter, B. V. L. and Safrany, S. T., 2012. Fibrinogen—a possible extracellular target for inositol phosphates. Messenger, 1 (2), pp. 160-166.

Brimson, J. M., Brown, C. A. and Safrany, S. T., 2011. Antagonists show GTP-sensitive high affinity binding to the sigma-1 receptor. British Journal of Pharmacology, 164 (2B), pp. 772-780.

Winward, L., Whitfield, W. G. F., Woodman, T. J., McLennan, A. G. and Safrany, S. T., 2007. Characterisation of a bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) from Drosophila melanogaster. The International Journal of Biochemistry & Cell Biology, 39, pp. 943-954.

Ross, S. H., Lindsay, Y., Safrany, S. T., Lorenzo, O., Villa, F., Toth, R., Clague, M. J., Downes, C. P. and Leslie, N. R., 2007. Differential redox regulation within the PTP superfamily. Cellular Signalling, 19, pp. 1521-1530.

Mills, S. J., Komander, D., Trusselle, M. N., Safrany, S. T., van Aalten, D. M. F. and Potter, B. V. L., 2007. Novel inositol phospholipid headgroup surrogate crystallized in the pleckstrin homology domain of protein kinase Bα. ACS Chemical Biology, 2 (4), pp. 242-246.

Orchiston, E. A., Bennett, D., Leslie, N. R., Clarke, R. G., Winward, L., Downes, C. P. and Safrany, S. T., 2004. PTEN M-CBR3, a versatile and selective regulator of Ins(1,3,4,5,6)-Pentakisphosphate (Ins(1,3,4,5,6)P 5 ). Journal of Biological Chemistry, 279, pp. 1116-1122.

Safrany, S. T., 2004. Protocols for regulation and study of diphosphoinositol polyphosphates. Molecular Pharmacology, 66 (6), pp. 1585-1591.

Spruce, B. A., Campbell, L. A., McTavish, N., Cooper, M. A., Appleyard, M. V. L., O'Neill, M., Howie, J., Samson, J., Watt, S., Murray, K., McLean, D., Leslie, N. R., Safrany, S. T., Ferguson, M. J., Peters, J. A., Prescott, A. R., Box, G., Hayes, A., Nutley, B., Raynaud, F., Downes, C. P., Lambert, J. J., Thompson, A. M. and Eccles, S., 2004. Small molecule antagonists of the σ-1 receptor cause selective release of the death program in tumor and self-reliant cells and inhibit tumor growth in vitro and in vivo. Cancer Research, 64, pp. 4875-4886.

Kommander, D., Fairservice, A., Deak, M., Gular, G. S., Prescott, A. R., Downes, C. P., Safrany, S. T., Alessi, D. R. and van Aalten, D. M. F., 2004. Structural insights into the regulation of PDK1 by phosphoinositides and inositol phosphates. EMBO Journal, 23, pp. 3918-3928.

Byrum, J., Jordan, S., Safrany, S. T. and Rodgers, W., 2004. Visualization of inositol phosphate-dependent mobility of Ku: depletion of the DNA-PK cofactor InsP 6 inhibits Ku mobility. Nucleic Acids Research, 32, pp. 2776-2784.

Ingram, S. W., Safrany, S. T. and Barnes, L. D., 2003. Disruption and overexpression of the Schizosaccharomyces pombe aps1 gene and the effects on growth rate, morphology, and intracellular diadenosine 5', 5'''- P 1 , P 5 -pentaphosphate and diphosphoinositol polyphosphate concentrations. Biochemical Journal, 369, pp. 519-528.

Leslie, N. R., McLennan, A. G. and Safrany, S. T., 2002. Cloning and characterisation of hAps1 and hAps2, human diadenosine polyphosphate-metabolising Nudix hydrolases. BMC Biochemistry, 3.

Fisher, D. I., Safrany, S. T., Strike, P., McLennan, A. G. and Cartwright, J. L., 2002. Nudix hydrolases that degrade dinucleoside and diphosphoinositol polyphosphates also have 5-phosphoribosyl 1-pyrophosphate (PRPP) pyrophosphatase activity that generates the glycolytic activator ribose 1,5-biphosphate. Journal of Biological Chemistry, 277 (49), pp. 47313-47317.

Cartwright, J. L., Safrany, S. T., Dixon, L. K., Darzynkiewicz, J., Stepenski, J., Burke, R. and McLennan, A. G., 2002. The g5R (D250) gene of African swine fever virus encodes a Nudix hydrolase that preferentially degrades diphosphoinositol polyphosphates. Journal of Virology, 76, pp. 1415-1421.

Safrany, S. T., Mills, S. J., Liu, C., Lampe, D., Noble, N. J., Nahorski, S. R. and Potter, B. V. L., 1994. Design of potent and selective inhibitors of myo-Inositol 1,4,5-trisphosphate 5-phosphatase. Biochemistry, 33 (35), pp. 10763-10769.

Wilcox, R. A., Safrany, S. T., Lampe, D., Mills, S. J., Nahorski, S. R. and Potter, B. V. L., 1994. Modification at C2 of myo-inositol 1,4,5-trisphosphate produces inositol trisphosphates and tetrakisphosphates with potent biological activities. European Journal of Biochemistry, 223 (1), pp. 115-124.

Mills, S. J., Safrany, S. T., Wilcox, R. A., Nahorski, S. R. and Potter, B. V. L., 1993. Synthesis of myo-inositol 1,2,4,5-tetrakisphosphate, a Ca2+-mobilising tetrakisphosphate with a potency similar to myo-inositol 1,4,5-trisphosphate. Bioorganic & Medicinal Chemistry Letters, 3 (8), pp. 1505-1510.

Liu, C., Safrany, S. T., Nahorski, S. R. and Potter, B. V. L., 1992. Synthesis of L-chiro-inositol 1,4,6-trisphosphorothioate, a potent and selective inhibitor of myo-inositol 1,4,5-trisphosphate 5-phosphatase. Bioorganic & Medicinal Chemistry Letters, 2 (12), pp. 1523-1528.