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Items by Acharya, K Ravi

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Number of items: 136.

Book Sections

Holbourn, K. P., Perbal, B. and Acharya, K. R., 2010. Asking the Right Questions: What Can the Structure of the CCN Protein Domains Tell Us? In: CCN Proteins in Health and Disease: An Overview of the Fifth International Workshop on the CCN Family of Genes. Berlin: Springer, pp. 15-40.

Baker, M. D. and Acharya, K. R., 2007. Superantigens. In: Meyers, R. A., ed. Immunology: From Cell Biology to Disease. Weinheim: Wiley-VCH, pp. 27-41.

Baker, M. D. and Acharya, K. R., 2007. Superantigens- Structure, function and diversity. In: Kotb, M. and Fraser, J. D., eds. Superantigens: Molecular Basis for Their Role in Human Diseases. ASM Press, pp. 121-135.

Articles

Bradshaw, W.J., Kirby, J.M., Thiyagarajan, N., Chambers, C.J., Davies, A.H., Roberts, A.K., Shone, C.C. and Acharya, K.R., 2014. The structure of the cysteine protease and lectin-like domains of Cwp84, a surface layer-associated protein from Clostridium difficile. Acta Crystallographica Section D-Biological Crystallography, 70 (7), pp. 1983-1993.

Acharya, K.R. and Ackerman, S.J., 2014. Eosinophil granule proteins : Form and function. Journal of Biological Chemistry, 289 (25), pp. 17406-17415.

Michaud, A., Acharya, K., Masuyer, G., Quenech'du, N., Gribouval, O., Morinière, V., Gubler, M.-C. and Corvol, P., 2014. Absence of cell surface expression of human ACE leads to perinatal death. Human Molecular Genetics, 23 (6), pp. 1479-1491.

Masuyer, G., Mohd, A., Czarny, B., Beau, F., Schwager, S. L. U., Sturrock, E. D., Isaac, R. E., Dive, V. and Acharya, K. R., 2014. Crystal structures of highly specific phosphinic tripeptide enantiomers in complex with the angiotensin-I converting enzyme. FEBS Journal, 281 (3), pp. 943-956.

Yates, C. J., Masuyer, G., Schwager, S. L. U., Mohd, A., Sturrock, E. D. and Acharya, K. R., 2014. Molecular and thermodynamic mechanisms of the chloride-dependent human angiotensin-I-converting enzyme (ACE). Journal of Biological Chemistry, 289 (3), pp. 1798-1814.

Harrison, C. and Acharya, K. R., 2014. Forthcoming. ACE for all : A molecular perspective. Journal of Cell Communication and Signaling

Douglas, R. G., Sharma, R. K., Masuyer, G., Lubbe, L., Zamora, I., Acharya, K. R., Chibale, K. and Sturrock, E. D., 2014. Fragment-based design for the development of N-domain-selective angiotensin-1-converting enzyme inhibitors. Clinical Science, 126 (4), pp. 305-313.

Iyer, S., Holloway, D. E. and Acharya, K. R., 2013. Crystal structures of murine angiogenin-2 and -3 - probing ‘structure - function’ relationships amongst angiogenin homologues. FEBS Journal, 280 (1), pp. 302-318.

Thiyagarajan, N. and Acharya, K.R., 2013. Crystal structure of human angiogenin with an engineered loop exhibits conformational flexibility at the functional regions of the molecule. FEBS Open Bio, 3, pp. 65-70.

Walker, N. J., Clark, E. A., Ford, D. C., Bullifent, H. L., Mcalister, E. V., Duffield, M. L., Acharya, K. R. and Oyston, P. C. F., 2012. Structure and function of cytidine monophosphate kinase from Yersinia pseudotuberculosis, essential for virulence but not for survival. Open Biology, 2 (Dec), 120142.

Akif, M., Masuyer, G., Bingham, R. J., Sturrock, E. D., Isaac, R. E. and Acharya, K. R., 2012. Structural basis of peptide recognition by the angiotensin-1 converting enzyme homologue AnCE from Drosophila melanogaster. FEBS Journal, 279 (24), pp. 4525-4534.

Masuyer, G., Schwager, S. L. U., Sturrock, E. D., Isaac, R. E. and Acharya, K. R., 2012. Molecular recognition and regulation of human angiotensin-I converting enzyme (ACE) activity by natural inhibitory peptides. Scientific Reports, 2, 717.

Thiyagarajan, N., Ferguson, R., Subramanian, V. and Acharya, K. R., 2012. Structural and molecular insights into the mechanism of action of human angiogenin-ALS variants in neurons. Nature Communications, 3, 1121.

Stancombe, P. R., Masuyer, G., Birch-Machin, I., Beard, M., Foster, K. A., Chaddock, J. A. and Acharya, K. R., 2012. Engineering botulinum neurotoxin domains for activation by toxin light chain. FEBS Journal, 279 (3), pp. 515-523.

Masuyer, G., Jabeen, T., Oberg, C. T., Leffler, H., Nilsson, U. J. and Acharya, K. R., 2012. Inhibition mechanism of human galectin-7 by a novel galactose-benzylphosphate inhibitor. FEBS Journal, 279 (2), pp. 193-202.

Anthony, C. S., Masuyer, G., Sturrock, E. D. and Acharya, K. R., 2012. Structure based drug design of angiotensin-i converting enzyme inhibitors. Current Medicinal Chemistry, 19 (6), pp. 845-855.

Thiyagarajan, N., Pham, T. T. K., Stinson, B., Sundriyal, A., Tumbale, P., Lizotte-waniewski, M., Brew, K. and Acharya, K. R., 2012. Structure of a metal-independent bacterial glycosyltransferase that catalyzes the synthesis of histo-blood group A antigen. Scientific Reports, 2, 940.

Masuyer, G., Stancombe, P., Chaddock, J. A. and Acharya, K. R., 2011. Structures of engineered Clostridium botulinum neurotoxin derivatives. Acta Crystallographica Section F-Structural Biology and Crystallization Communications, 67 (12), pp. 1466-1472.

Holloway, D. E., Singh, U. P., Shogen, K. and Acharya, K. R., 2011. Crystal structure of Onconase at 1.1 angstrom resolution - insights into substrate binding and collective motion. FEBS Journal, 278 (21), pp. 4136-4149.

Iyer, S. and Acharya, K. R., 2011. Tying the knot: The cystine signature and molecular-recognition processes of the vascular endothelial growth factor family of angiogenic cytokines. FEBS Journal, 278 (22), pp. 4304-4322.

Akif, M., Masuyer, G., Schwager, S. L. U., Bhuyan, B. J., Mugesh, G., Isaac, R. E., Sturrock, E. D. and Acharya, K. R., 2011. Structural characterization of angiotensin I-converting enzyme in complex with a selenium analogue of captopril. FEBS Journal, 278 (19), pp. 3644-3650.

Kirby, J. M., Thiyagarajan, N., Roberts, A. K., Shone, C. C. and Acharya, K. R., 2011. Expression, purification, crystallization and preliminary crystallographic analysis of a putative Clostridium difficile surface protein Cwp19. Acta Crystallographica Section F-Structural Biology and Crystallization Communications, 67 (7), pp. 762-767.

Holbourn, K. P., Malfois, M. and Acharya, K. R., 2011. First structural glimpse of CCN3 and CCN5 multifunctional signaling regulators elucidated by small angle X-ray scattering. Journal of Biological Chemistry, 286 (25), pp. 22243-22249.

Davies, A. H., Roberts, A. K., Shone, C. C. and Acharya, K. R., 2011. Super toxins from a super bug: structure and function of Clostridium difficile toxins. Biochemical Journal, 436 (3), pp. 517-526.

Akif, M., Schwager, S. L., Anthony, C. S., Czarny, B., Beau, F., Dive, V., Sturrock, E. D. and Acharya, K. R., 2011. Novel mechanism of inhibition of human angiotensin-I-converting enzyme (ACE) by a highly specific phosphinic tripeptide. Biochemical Journal, 436 (1), pp. 53-59.

Holbourn, K. P. and Acharya, K. R., 2011. Cloning, expression and purification of the CCN family of proteins in Escherichia coli. Biochemical and Biophysical Research Communications, 407 (4), pp. 837-841.

Holbourn, K. P., Lloyd, M. D., Thompson, A. S., Threadgill, M. D. and Acharya, K. R., 2011. Cloning, purification, crystallization and preliminary crystallographic analysis of the human histone deacetylase sirtuin 1. Acta Crystallographica Section F-Structural Biology and Crystallization Communications, 67 (4), pp. 461-463.

Chaddock, J. A. and Acharya, K. R., 2011. Engineering toxins for 21st century therapies. FEBS Journal, 278 (6), pp. 899-904.

Masuyer, G., Beard, M., Cadd, V. A., Chaddock, J. A. and Acharya, K. R., 2011. Structure and activity of a functional derivative of Clostridium botulinum neurotoxin B. Journal of Structural Biology, 174 (1), pp. 52-57.

Thiyagarajan, N., Smith, B. D., Raines, R. T. and Acharya, K. R., 2011. Functional and structural analyses of N-acylsulfonamide-linked dinucleoside inhibitors of RNase A. FEBS Journal, 278 (3), pp. 541-549.

Clark, E. A., Walker, N., Ford, D. C., Cooper, I. A., Oyston, P. C. F. and Acharya, K. R., 2011. Molecular Recognition of Chymotrypsin by the Serine Protease Inhibitor Ecotin from Yersinia pestis. Journal of Biological Chemistry, 286 (27), pp. 24015-24022.

Brew, K., Tumbale, P. and Acharya, K. R., 2010. Family 6 Glycosyltransferases in Vertebrates and Bacteria: Inactivation and Horizontal Gene Transfer May Enhance Mutualism between Vertebrates and Bacteria. Journal of Biological Chemistry, 285 (48), pp. 37121-37127.

Anthony, C. S., Corradi, H. R., Schwager, S. L. U., Redelinghuys, P., Georgiadis, D., Dive, V., Acharya, K. R. and Sturrock, E. D., 2010. The N domain of human angiotensin-I-converting enzyme: The role of N-glycosylation and the crystal structure in complex with an N domain-specific phosphinic inhibitor, RXP407. Journal of Biological Chemistry, 285 (46), pp. 35685-35693.

Sundriyal, A., Roberts, A. K., Ling, R., McGlashan, J., Shone, C. C. and Acharya, K. R., 2010. Expression, purification and cell cytotoxicity of actin-modifying binary toxin from Clostridium difficile. Protein Expression and Purification, 74 (1), pp. 42-48.

de Andrade, M. C. C., Affonso, R., Fernandes, F. B., Febba, A. C., da Silva, I., Stella, R. C. R., Marson, O., Jubilut, G. N., Hirata, I. Y., Carmona, A. K., Corradi, H., Acharya, K. R., Sturrock, E. D. and Casarini, D. E., 2010. Spectroscopic and structural analysis of somatic and N-domain angiotensin I-converting enzyme isoforms from mesangial cells from Wistar and spontaneously hypertensive rats. International Journal of Biological Macromolecules, 47 (2), pp. 238-243.

Akif, M., Ntai, I., Sturrock, E. D., Isaac, R. E., Bachmann, B. O. and Acharya, K. R., 2010. Crystal structure of a phosphonotripeptide K-26 in complex with angiotensin converting enzyme homologue (AnCE) from Drosophila melanogaster. Biochemical and Biophysical Research Communications, 398 (3), pp. 532-536.

Iyer, S., Darley, P. I. and Acharya, K. R., 2010. Structural insights into the binding of vascular endothelial growth factor-B by VEGFR-1(D2): recognition and specificity. Journal of Biological Chemistry, 285 (31), pp. 23779-23789.

Akif, M., Georgiadis, D., Mahajan, A., Dive, V., Sturrock, E. D., Isaac, R. E. and Acharya, K. R., 2010. High-resolution crystal structures of drosophila melanogaster angiotensin-converting enzyme in complex with novel inhibitors and antihypertensive drugs. Journal of Molecular Biology, 400 (3), pp. 502-517.

Leese, M. P., Jourdan, F., Kimberley, M. R., Cozier, G. E., Thiyagarajan, N., Stengel, C., Regis-Lydi, S., Foster, P. A., Newman, S. P., Acharya, K. R., Ferrandis, E., Purohit, A., Reed, M. J. and Potter, B. V. L., 2010. Chimeric microtubule disruptors. Chemical Communications, 46 (17), pp. 2907-2909.

Cozier, G. E., Leese, M. P., Lloyd, M. D., Baker, M. D., Thiyagarajan, N., Acharya, K. R. and Potter, B. V. L., 2010. Structures of human carbonic anhydrase II/inhibitor complexes reveal a second binding site for steroidal and nonsteroidal inhibitors. Biochemistry, 49 (16), pp. 3464-3476.

Woo, L. .W. L., Jackson, T., Putey, A., Cozier, G., Leonard, P., Acharya, K. R., Chander, S. K., Purohit, A., Reed, M. J. and Potter, B. V. L., 2010. Highly potent first examples of dual aromatase-steroid sulfatase inhibitors based on a biphenyl template. Journal of Medicinal Chemistry, 53 (5), pp. 2155-2170.

Kirby, J. M., Ahern, H., Roberts, A. K., Kumar, V., Freeman, Z., Acharya, K. R. and Shone, C. C., 2009. Cwp84, a surface-associated Cysteine Protease, plays a role in the maturation of the surface layer of Clostridium difficile. Journal of Biological Chemistry, 284 (50), pp. 34666-34673.

Mitsiki, E., Papageorgiou, A. C., Iyer, S., Thiyagarajan, N., Prior, S. H., Sleep, D., Finnis, C. and Acharya, K. R., 2009. Structures of native human thymidine phosphorylase and in complex with 5-iodouracil. Biochemical and Biophysical Research Communications, 386 (4), pp. 666-670.

Jamaluddin, H., Tumbale, P., Ferns, T. A., Thiyagarajan, N., Brew, K. and Acharya, K. R., 2009. Crystal structure of α-1,3-galactosyltransferase (α3GT) in a complex with p-nitrophenyl-β-galactoside (pNPβGal). Biochemical and Biophysical Research Communications, 385 (4), pp. 601-604.

Masuyer, G., Thiyagarajan, N., James, P. L., Marks, P. M. H., Chaddock, J. A. and Acharya, K. R., 2009. Crystal structure of a catalytically active, non-toxic endopeptidase derivative of Clostridium botulinum toxin A. Biochemical and Biophysical Research Communications, 381 (1), pp. 50-53.

Holbourn, K. P., Perbal, B. and Acharya, K. R., 2009. Proteins on the catwalk : modelling the structural domains of the CCN family of proteins. Journal of Cell Communication and Signaling, 3 (1), pp. 25-41.

Holloway, D. E., Chavali, G. B., Leonidas, D. D., Baker, M. D. and Acharya, K. R., 2009. Influence of Naturally-Occurring 5 '-Pyrophosphate-Linked Substituents on the Binding of Adenylic Inhibitors to Ribonuclease A: An X-Ray Crystallographic Study. Biopolymers, 91 (12), pp. 995-1008.

Sundriyal, A., Roberts, A. K., Shone, C. C. and Acharya, K. R., 2009. Structural basis for substrate recognition in the enzymatic component of ADP-ribosyltransferase toxin CDTa from clostridium difficile. Journal of Biological Chemistry, 284 (42), pp. 28713-28719.

Holbourn, K. P., Acharya, K. R. and Perbal, B., 2008. The CCN family of proteins: structure-function relationships. Trends in Biochemical Sciences, 33 (10), pp. 461-473.

Kazakou, K., Holloway, D. E., Prior, S. H., Subramanian, V. and Acharya, K. R., 2008. Ribonuclease A homologues of the zebrafish: polymorphism, crystal structures of two representatives and their evolutionary implications. Journal of Molecular Biology, 380 (1), pp. 206-222.

Subramanian, V., Crabtree, B. and Acharya, K. R., 2008. Human angiogenin is a neuroprotective factor and amyotrophic lateral sclerosis associated angiogenin variants affect neurite extension/pathfinding and survival of motor neurons. Human Molecular Genetics, 17 (1), pp. 130-149.

Leonard, P., Scotney, P. D., Jabeen, T., Iyer, S., Fabri, L. J., Nash, A. D. and Acharya, K. R., 2008. Crystal Structure of Vascular Endothelial Growth Factor-B in Complex with a Neutralising Antibody Fab Fragment. Journal of Molecular Biology, 384 (5), pp. 1203-1217.

Ulrich, M., Petre, A., Youhnovski, N., Promm, F., Schirle, M., Schumm, M., Pero, R. S., Doyle, A., Checkel, J., Kita, H., Thiyagarajan, N., Acharya, K. R., Schmid-Grendelmeier, P., Simon, H. U., Schwarz, H., Tsutsui, M., Shimokawa, H., Bellon, G., Lee, J. J., Przybylski, M. and Doring, G., 2008. Post-translational tyrosine nitration of eosinophil granule toxins mediated by eosinophil peroxidase. Journal of Biological Chemistry, 283 (42), pp. 28629-28640.

Tumbale, P., Jamaluddin, H., Thiyagarajan, N., Acharya, K. R. and Brew, K., 2008. Screening a limited structure-based library identifies UDP-GalNAc-specific mutants of α-1,3-galactosyltransferase. Glycobiology, 18 (12), pp. 1036-1043.

Tumbale, P., Jamaluddin, H., Thiyagarajan, N., Brew, K. and Acharya, K. R., 2008. Structural Basis of UDP-galactose Binding by α-1,3-Galactosyltransferase (α3GT): Role of Negative Charge on Aspartic Acid 316 in Structure and Activity. Biochemistry, 47 (33), pp. 8711-8718.

Jabeen, T., Leonard, P., Jamaluddin, H. and Acharya, K. R., 2008. Structure of mouse IP-10, a chemokine. Acta Crystallographica Section D-Biological Crystallography, 64, pp. 611-619.

Crabtree, B., Holloway, D. E., Baker, M. D., Acharya, K. R. and Subramanian, V., 2007. Biological and structural features of murine angiogenin-4, an angiogenic protein. Biochemistry, 46 (9), pp. 2431-2443.

Crabtree, B., Thiyagarajan, N., Prior, S. H., Wilson, P., Iyer, S., Ferns, T., Shapiro, R., Brew, K., Subramanian, V. and Acharya, K. R., 2007. Characterization of human angiogenin variants implicated in amyotrophic lateral sclerosis. Biochemistry, 46 (42), pp. 11810-11818.

Riviere, G., Michaud, A., Corradi, H. R., Sturrock, E. D., Acharya, K. R., Cogez, V., Bohin, J. P., Vieau, D. and Corvol, P., 2007. Characterization of the first angiotensin-converting like enzyme in bacteria: Ancestor ACE is already active. Gene, 399 (1), pp. 81-90.

Jamaluddin, H., Tumbale, P., Withers, S. G., Acharya, K. R. and Brew, K., 2007. Conformational changes induced by binding UDP-2F-galactose to alpha-1,3-galactosyltransferase - Implications for catalysis. Journal of Molecular Biology, 369 (5), pp. 1270-1281.

Hamze, A. B., Wei, S., Bahudhanapati, H., Kota, S., Acharya, K. R. and Brew, K., 2007. Constraining specificity in the N-domain of tissue inhibitor of metalloproteinases-1; gelatinase-selective inhibitors. Protein Science, 16 (9), pp. 1905-1913.

Iyer, S., Wei, S., Brew, K. and Acharya, K. R., 2007. Crystal structure of the catalytic domain of matrix metalloproteinase-1 in complex with the inhibitory domain of tissue inhibitor of metalloproteinase-1. Journal of Biological Chemistry, 282 (1), pp. 364-371.

Singh, U. P., Ardelt, W., Saxena, S. K., Holloway, D. E., Vidunas, E., Lee, H. S., Saxena, A., Shogen, K. and Acharya, K. R., 2007. Enzymatic and structural characterisation of amphinase, a novel cytotoxic ribonuclease from Rana pipiens oocytes. Journal of Molecular Biology, 371 (1), pp. 93-111.

Rummel, A., Eichner, T., Weil, T., Karnath, T., Gutcaits, A., Mahrhold, S., Sandhoff, K., Proia, R. L., Acharya, K. R., Bigalke, H. and Binz, T., 2007. Identification of the protein receptor binding site of botulinum neurotoxins B and G oroves the double-receptor concept. Proceedings of the National Academy of Sciences of the United States of America, 104 (1), pp. 359-364.

Corradi, H. R., Chitapi, I., Sewell, B. T., Georgiadis, D., Dive, V., Sturrock, E. D. and Acharya, K. R., 2007. The structure of testis angiotensin-converting enzyme in complex with the C domain-specific inhibitor RXPA380. Biochemistry, 46 (18), pp. 5473-5478.

Holbourn, K. P., Shone, C. C. and Acharya, K. R., 2006. A family of killer toxins - Exploring the mechanism of ADP-ribosylating toxins. FEBS Journal, 273 (20), pp. 4579-4593.

Greenway, M. J., Andersen, P. M., Russ, C., Ennis, S., Cashman, S., Donaghy, C., Patterson, V., Swingler, R., Kieran, D., Prehn, J., Morrison, K. E., Green, A., Acharya, K. R., Brown, R. H. and Hardiman, O., 2006. ANG mutations segregate with familial and 'sporadic' amyotrophic lateral sclerosis. Nature Genetics, 38 (4), pp. 411-413.

Iyer, S., Visse, R., Nagase, H. and Acharya, K. R., 2006. Crystal structure of an active form of human MMP-1. Journal of Molecular Biology, 362 (1), pp. 78-88.

Iyer, S., Scotney, P. D., Nash, A. D. and Acharya, K. R., 2006. Crystal structure of human vascular endothelial growth factor-B: Identification of amino acids important for receptor binding. Journal of Molecular Biology, 359 (1), pp. 76-85.

Corradi, H. R., Corrigall, A. V., Boix, E., Mohan, C. G., Sturrock, E. D., Meissner, P. N. and Acharya, K. R., 2006. Crystal structure of protoporphyrinogen oxidase from Myxococcus xanthus and its complex with the inhibitor acifluorfen. Journal of Biological Chemistry, 281 (50), pp. 38625-38633.

Corradi, H. R., Schwager, S. L. U., Nchinda, A. T., Sturrock, E. D. and Acharya, K. R., 2006. Crystal structure of the N domain of human somatic angiotensin I-converting enzyme provides a structural basis for domain-specific inhibitor design. Journal of Molecular Biology, 357 (3), pp. 964-974.

Baker, M. D., Holloway, D. E., Swaminathan, G. J. and Acharya, K. R., 2006. Crystal structures of eosinophil-derived neurotoxin (EDN) in complex with the inhibitors 5 '-ATP, Ap(3)A Ap(4)A and Ap(5)A. Biochemistry, 45 (2), pp. 416-426.

Mandron, M., Aries, M. F., Brehm, R. D., Tranter, H. S., Acharya, K. R., Charveron, M. and Davrinche, C., 2006. Human dendritic cells conditioned with Staphylococcus aureus enterotoxin B promote T(H)2 cell polarization. Journal of Allergy and Clinical Immunology, 117 (5), pp. 1141-1147.

Brew, K., Jamaluddin, H., Tumbale, P. and Acharya, K. R., 2006. Role of conformational dynamics in the C-terminal region of alpha-1,3 galactosyltransferase in catalysis. Glycobiology, 16 (11), p. 1123.

Watermeyer, J. M., Sewell, B. T., Schwager, S. L., Natesh, R., Corradi, H. R., Acharya, K. R. and Sturrock, E. D., 2006. Structure of testis ACE glycosylation mutants and evidence for conserved domain movement. Biochemistry, 45 (42), pp. 12654-12663.

Jenkins, C. L., Thiyagarajan, N., Sweeney, R. Y., Guy, M. P., Kelemen, B. R., Acharya, K. R. and Raines, R. T., 2005. Binding of non-natural 3 '-nucleotides to ribonuclease A. FEBS Journal, 272 (3), pp. 744-755.

Lloyd, M. D., Pederick, R. L., Natesh, R., Woo, L. W. L., Purohit, A., Reed, M. J., Acharya, R. and Potter, B. V. L., 2005. Crystal structure of human carbonic anhydrase II at 1.95 Å resolution in complex with 667-coumate, a novel anti-cancer agent. Biochemical Journal, 385 (Pt 3), pp. 715-720.

Swaminathan, G. J., Myszka, D. G., Katsamba, P. S., Ohnuki, L. E., Gleich, G. J. and Acharya, K. R., 2005. Eosinophil-granule major basic protein, a C-type lectin, binds heparin. Biochemistry, 44 (43), pp. 14152-14158.

Lloyd, M. D., Thiyagarajan, N., Ho, Y. T., Woo, L. W. L., Sutcliffe, O. B., Purohit, A., Reed, M. J., Acharya, K. R. and Potter, B. V. L., 2005. First crystal structures of human carbonic anhydrase II in complex with dual aromatase-steroid sulfatase inhibitors. Biochemistry, 44 (18), pp. 6858-6866.

Baalaji, N. S., Acharya, K. R., Singh, T. P. and Krishnaswamy, S., 2005. High-resolution diffraction from crystals of a membrane-protein complex: bacterial outer membrane protein OmpC complexed with the antibacterial eukaryotic protein lactoferrin. Acta Crystallographica Section F-Structural Biology and Crystallization Communications, 61, pp. 773-775.

Crabtree, B., Acharya, K. R. and Subramanian, V., 2005. Investigating the potential functions of murine Angiogenin 4. Genetics Research, 86 (3), p. 234.

Holbourn, K. P., Sutton, J. M., Evans, H. R., Shone, C. C. and Acharya, K. R., 2005. Molecular recognition of an ADP-ribosylating Clostridium botulinum C3 exoenzyme by RaIA GTPase. Proceedings of the National Academy of Sciences of the United States of America, 102 (15), pp. 5357-5362.

Iyer, S., Holloway, D. E., Kumar, K., Shapiro, R. and Acharya, K. R., 2005. Molecular recognition of human eosinophil-derived neurotoxin (RNase 2) by placental ribonuclease inhibitor. Journal of Molecular Biology, 347 (3), pp. 637-655.

Holloway, D. E., Chavali, G. B., Hares, M. C., Subramanian, V. and Acharya, K. R., 2005. Structure of murine angiogenin: features of the substrate- and cell-binding regions and prospects for inhibitor-binding studies. Acta Crystallographica Section D-Biological Crystallography, 61, pp. 1568-1578.

Narayanan, S. B., Mathew, M. K., Acharya, K. R. and Krishnaswamy, S., 2005. Structure, function and folding studies on enterobacterial osmoporin, OmpC, from S. typhi and E.coli: Insights from X-ray crystallography, liposome swelling assay and membrane insertion into lipid vesicles. Biophysical Journal, 88 (1), 355A-356A.

Acharya, K. R. and Lloyd, M. D., 2005. The advantages and limitations of protein crystal structures. Trends in Pharmacological Sciences, 26 (1), pp. 10-14.

Evans, H. R., Holloway, D. E., Sutton, J. M., Ayriss, J., Shone, C. C. and Acharya, K. R., 2004. C3 exoenzyme from Clostridium botulinum: structure of a tetragonal crystal form and a reassessment of NAD-induced flexure. Acta Crystallographica Section D-Biological Crystallography, 60, pp. 1502-1505.

Baker, M. D., Gendlina, I., Collins, C. M. and Acharya, K. R., 2004. Crystal structure of a dimeric form of streptococcal pyrogenic exotoxin A (SpeA1). Protein Science, 13 (9), pp. 2285-2290.

Turton, K., Natesh, R., Thiyagarajan, N., Chaddock, J. A. and Acharya, K. R., 2004. Crystal structures of Erythrina cristagalli lectin with bound N-linked oligosaccharide and lactose. Glycobiology, 14 (10), pp. 923-929.

Holloway, D. E., Chavali, G. B., Hares, M. C., Baker, M. D., Subbarao, G. V., Shapiro, R. and Acharya, K. R., 2004. Crystallographic studies on structural features that determine the enzymatic, specificity and potency of human angiogenin: Thr44, Thr80, and residues 38-41. Biochemistry, 43 (5), pp. 1230-1241.

Papageorgiou, A. C., Baker, M. D., McLeod, J. D., Goda, S. K., Manzotti, C. N., Sansom, D. M., Tranter, H. S. and Acharya, K. R., 2004. Identification of a secondary zinc-binding site in staphylococcal enterotoxin C2 - Implications for superantigen recognition. Journal of Biological Chemistry, 279 (2), pp. 1297-1303.

Errico, M., Riccioni, T., Iyer, S., Pisano, C., Acharya, K. R., Persico, M. G. and De Falco, S., 2004. Identification of placenta growth factor determinants for binding and activation of Flt-1 receptor. Journal of Biological Chemistry, 279 (42), pp. 43929-43939.

Zhang, Y. N., Deshpande, A., Xie, Z. H., Natesh, R., Acharya, K. R. and Brew, K., 2004. Roles of active site tryptophans in substrate binding and catalysis by alpha-1,3 galactosyltransferase. Glycobiology, 14 (12), pp. 1295-1302.

Natesh, R., Schwager, S. L. U., Evans, H. R., Sturrock, E. D. and Acharya, K. R., 2004. Structural details on the binding of antihypertensive drugs captopril and enalaprilat to human testicular angiotensin I-converting enzyme. Biochemistry, 43 (27), pp. 8718-8724.

Sturrock, E. D., Natesh, R., van Rooyen, J. M. and Acharya, K. R., 2004. Structure of angiotensin I-converting enzyme. Cellular and Molecular Life Sciences (CMLS), 61 (21), pp. 2677-2686.

Baker, M. D. and Acharya, K. R., 2004. Superantigens: Structure-function relationships. International Journal of Medical Microbiology, 293 (7-8), pp. 529-537.

Acharya, K. R., Sturrock, E. D., Riordan, J. F. and Ehlers, M. R. W., 2003. ACE revisited: A new target for structure-based drug design. Nature Reviews Drug Discovery, 2 (11), pp. 891-902.

Guy, J. L., Jackson, R. M., Acharya, K. R., Sturrock, E. D., Hooper, N. M. and Turner, A. J., 2003. Angiotensin-converting enzyme-2 (ACE2): Comparative modeling of the active site, specificity requirements, and chloride dependence. Biochemistry, 42 (45), pp. 13185-13192.

Natesh, R., Schwager, S. L. U., Sturrock, E. D. and Acharya, K. R., 2003. Crystal structure of the human angiotensin-converting enzyme-lisinopril complex. Nature, 421 (6922), pp. 551-554.

Swaminathan, G. J., Holloway, D. E., Colvin, R. A., Campanella, G. K., Papageorgiou, A. C., Luster, A. D. and Acharya, K. R., 2003. Crystal structures of oligomeric forms of the IP-10/CXCL10 chemokine. Structure, 11 (5), pp. 521-532.

Gordon, K., Redelinghuys, P., Schwager, S. L. U., Ehlers, M. R. W., Papageorgiou, A. C., Natesh, R., Acharya, K. R. and Sturrock, E. D., 2003. Deglycosylation, processing and crystallization of human testis angiotensin-converting enzyme. Biochemical Journal, 371, pp. 437-442.

Leonidas, D. D., Chavali, G. B., Oikonomakos, N. G., Chrysina, E. D., Kosmopoulou, M. N., Vlassi, M., Frankling, C. and Acharya, K. R., 2003. High-resolution crystal structures of ribonuclease A complexed with adenylic and uridylic nucleotide inhibitors. Implications for structure-based design of ribonucleolytic inhibitors. Protein Science, 12 (11), pp. 2559-2574.

Teufel, D. P., Kao, R. Y. T., Acharya, K. R. and Shapiro, R., 2003. Mutational analysis of the complex of human RNase inhibitor and human eosinophil-derived neurotoxin (RNase 2). Biochemistry, 42 (6), pp. 1451-1459.

Zhang, Y. N., Swaminathan, G. J., Deshpande, A., Boix, E., Natesh, R., Xie, Z. H., Acharya, K. R. and Brew, K., 2003. Roles of individual enzyme-substrate interactions by alpha-1,3-galactosyltransferase in catalysis and specificity. Biochemistry, 42 (46), pp. 13512-13521.

Evans, H. R., Sutton, J. M., Holloway, D. E., Ayriss, J., Shone, C. C. and Acharya, K. R., 2003. The crystal structure of C3stau2 from Staphylococcus aureus and its complex with NAD. Journal of Biological Chemistry, 278 (46), pp. 45924-45930.

Chavali, G. B., Papageorgiou, A. C., Olson, K. A., Fett, J. W., Hu, G. F., Shapiro, R. and Acharya, K. R., 2003. The crystal structure of human angiogenin in complex with an antitumor neutralizing antibody. Structure, 11 (7), pp. 875-885.

Mohan, C. G., Boix, E., Evans, H. R., Nikolovski, Z., Nogués, M. V., Cuchillo, C. M. and Acharya, R., 2002. The Crystal Structure of Eosinophil Cationic Protein in Complex with 2‘,5‘-ADP at 2.0 Å Resolution Reveals the Details of the Ribonucleolytic Active Site†,‡. Biochemistry, 41 (40), pp. 12100-12106.

Swaminathan, G. J., Holloway, D. E., Veluraja, K. and Acharya, K. R., 2002. Atomic resolution (0.98 angstrom) structure of eosinophil-derived neurotoxin. Biochemistry, 41 (10), pp. 3341-3352.

Turton, K., Chaddock, J. A. and Acharya, K. R., 2002. Botulinum and tetanus neurotoxins: structure, function and therapeutic utility. Trends in Biochemical Sciences, 27 (11), pp. 552-558.

Ackerman, S. J., Liu, L., Kwatia, M. A., Savage, M. P., Leonidas, D. D., Swaminathan, G. J. and Acharya, K. R., 2002. Charcot-Leyden crystal protein (galectin-10) is not a dual function galectin with lysophospholipase activity but binds a lysophospholipase inhibitor in a novel structural fashion. Journal of Biological Chemistry, 277 (17), pp. 14859-14868.

Swaminathan, G. J., Weaver, A. J., Loegering, D. A., Checkel, J. L., Gleich, G. J. and Acharya, K. R., 2002. Crystal structure of the eosinophil major basic protein at 1.8 angstrom: A C-type lectin with a paradigm shift in specificity. Glycobiology, 12 (10), p. 662.

Leonidas, D. D., Shapiro, R., Subbarao, G. V., Russo, A. and Acharya, K. R., 2002. Crystallographic studies on the role of the C-terminal segment of human angiogenin in defining enzymatic potency. Biochemistry, 41 (8), pp. 2552-2562.

Holloway, D. E., Shapiro, R., Hares, M. C., Leonidas, D. D. and Acharya, K. R., 2002. Guest-host crosstalk in an angiogenin-RNase A chimeric protein. Biochemistry, 41 (33), pp. 10482-10489.

Iyer, S. and Acharya, K. R., 2002. Role of placenta growth factor in cardiovascular health. Trends in Cardiovascular Medicine, 12 (3), pp. 128-134.

Baker, M. D., Papageorgiou, A. C., Titball, R. W., Miller, J., White, S., Lingard, B., Lee, J. J., Cavanagh, D., Kehoe, M. A., Robinson, J. H. and Acharya, K. R., 2002. Structural and functional role of threonine 112 in a superantigen Staphylococcus aureus enterotoxin B. Journal of Biological Chemistry, 277 (4), pp. 2756-2762.

Baker, M. D., Papageorgiou, A. C., Titball, R. W., Miller, J., White, S., Lingard, B., Lee, J. J., Cavanagh, D., Kehoe, M. A., Robinson, J. H. and Acharya, K.-R., 2002. Structural basis for the altered T-cell receptor binding specificity in a superantigenic Staphylococcus aureus enterotoxin-B mutant. Journal of Biological Chemistry, 277, pp. 2756-2763.

Boix, E., Zhang, Y. N., Swaminathan, G. J., Brew, K. and Acharya, K. R., 2002. Structural basis of ordered binding of donor and acceptor substrates to the retaining glycosyltransferase, alpha-1,3-galactosyltransferase. Journal of Biological Chemistry, 277 (31), pp. 28310-28318.

Mohan, C. G., Boix, E., Evans, H. R., Nikolovski, Z., Nogues, M. V., Cuchillo, C. M. and Acharya, K. R., 2002. The crystal structure of eosmophil cationic protein in complex with 2 ',5 '-ADP at 2.0 angstrom resolution reveals the details of the ribonucleolytic active site. Biochemistry, 41 (40), pp. 12100-12106.

Leonidas, D. D., Chavali, G. B., Jardine, A. M., Li, S. L., Shapiro, R. and Acharya, K. R., 2001. Binding of phosphate and pyrophosphate ions at the active site of human angiogenin as revealed by X-ray crystallography. Protein Science, 10 (8), pp. 1669-1676.

Jardine, A. M., Leonidas, D. D., Jenkins, J. L., Park, C., Raines, R. T., Acharya, K. R. and Shapiro, R., 2001. Cleavage of 3 ',5 '-pyrophosphate-linked dinucleotides by ribonuclease A and angiogenin. Biochemistry, 40 (34), pp. 10262-10272.

Poulas, K., Eliopoulos, E., Vatzaki, E., Navaza, J., Kontou, M., Oikonomakos, N., Acharya, K. R. and Tzartos, S. J., 2001. Crystal structure of Fab198, an efficient protector of the acetylcholine receptor against myasthenogenic antibodies. European Journal of Biochemistry, 268 (13), pp. 3685-3693.

Swaminathan, G. J., Weaver, A. J., Loegering, D. A., Checkel, J. L., Leonidas, D. D., Gleich, G. J. and Acharya, K. R., 2001. Crystal structure of the eosinophil major basic protein at 1.8 angstrom - An atypical lectin with a paradigm shift in specificity. Journal of Biological Chemistry, 276 (28), pp. 26197-26203.

Savitha, G., Leonidas, D., Acharya, K. R. and Viswamitra, M. A., 2001. Crystallization and preliminary investigations on a telomeric repeat sequence C(4)A(2)C(4)A(2). Acta Crystallographica Section D-Biological Crystallography, 57, pp. 873-875.

Holloway, D. E., Hares, M. C., Shapiro, R., Subramanian, V. and Acharya, K. R., 2001. High-level expression of three members of the murine angiogenin family in Escherichia coli and purification of the recombinant proteins. Protein Expression and Purification, 22 (2), pp. 307-317.

Leonidas, D. D., Boix, E., Prill, R., Suzuki, M., Turton, R., Minson, K., Swaminathan, G. J., Youle, R. J. and Acharya, K. R., 2001. Mapping the ribonucleolytic active site of eosinophil-derived neurotoxin (EDN) - High resolution crystal structures of EDN complexes with adenylic nucleotide inhibitors. Journal of Biological Chemistry, 276 (18), pp. 15009-15017.

Greene, L. H., Chrysina, E. D., Irons, L. I., Papageorgiou, A. C., Acharya, K. R. and Brew, K., 2001. Role of conserved residues in structure and stability: Tryptophans of human serum retinol-binding protein, a model for the lipocalin superfamily. Protein Science, 10 (11), pp. 2301-2316.

Baker, M., Gutman, D. M., Papageorgiou, A. C., Collins, C. M. and Acharya, K. R., 2001. Structural features of a zinc binding site in the superantigen streptococcal pyrogenic exotoxin A (SpeA1): Implications for MHC class IT recognition. Protein Science, 10 (6), pp. 1268-1273.

Boix, E., Swaminathan, G. J., Zhang, Y. N., Natesh, R., Brew, K. and Acharya, K. R., 2001. Structure of UDP complex of UDP-galactose :beta-galactoside-alpha-1,3-galactosyltransferase at 1.53-angstrom resolution reveals a conformational change in the catalytically important C terminus. Journal of Biological Chemistry, 276 (51), pp. 48608-48614.

Iyer, S., Leonidas, D. D., Swaminathan, G. J., Maglione, D., Battisti, M., Tucci, M., Persico, M. G. and Acharya, K. R., 2001. The crystal structure of human placenta growth factor-1 (PlGF-1), an angiogenic protein, at 2.0 angstrom resolution. Journal of Biological Chemistry, 276 (15), pp. 12153-12161.

Conference or Workshop Items

Evans, H., Sutton, J., Holloway, D., Ayriss, J., Shone, C. and Acharya, K., 2004. The crystal structure of C3stau2 from Staphylococcus aureus and its complex with NAD. In: South West Structural Biology Consortium, 2004-01-01, University of Southampton.

Patent

Sturrock, E. D. and Acharya, R., 2012. Crystal. DK1984008 (T3), 01 October 2012.

Acharya, R. and Sturrock, E., 2010. Crystal Structure of an Angiotensin-Converting Enzyme (ACE) and Uses Thereof. C12Q1/37-US2010160180 (A1), 24 June 2010.

Acharya, R. and Sturrock, E. D., 2009. Ace N-domain crystal. A61K-ZA200806312 (A), 30 December 2009.

This list was generated on Fri Sep 19 12:46:21 2014 IST.