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Items by Eggleston, Ian

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Number of items: 44.

Yaghini, E., Giuntini, F., Eggleston, I. M., Suhling, K., Seifalian, A. M. and MacRobert, A. J., 2014. Fluorescence lifetime imaging and FRET-induced intracellular redistribution of tat-conjugated quantum dot nanoparticles through interaction with a phthalocyanine photosensitiser. Small, 10 (4), pp. 782-792.

Schimpl, M., Rush, C. l., Betou, M., Eggleston, I. M., Recklies, A. d. and Van aalten, D. m. F., 2012. Human YKL-39 is a pseudo-chitinase with retained chitooligosaccharide-binding properties. Biochemical Journal, 446 (1), pp. 149-157.

Wang, J. T. -W., Giuntini, F., Eggleston, I. M., Bown, S. G. and MacRobert, A. J., 2012. Photochemical internalisation of a macromolecular protein toxin using a cell penetrating peptide-photosensitiser conjugate. Journal of Controlled Release, 157 (2), pp. 305-313.

Arrowsmith, R. L., Zeglis, B. M., Viola-Villegas, N., Divilov, V., Jones, M., Waghorn, P. A., Phillips, F. L., Mindt, T. L., Eggleston, I. M., Botchway, S. W., Dilworth, J. R., Aigbirhio, F. I., Lewis, J. S. and Pascu, S. I., 2011. Fluorescent copper(II), gallium(III) and indium(III) bis(thiosemicarbazonates): radiolabeling, cellular confocal fluorescence and PET imaging studies. Journal of Labelled Compounds & Radiopharmaceuticals, 54 (Supplement 1), S59.

Sutherland, T. E., Andersen, O. A., Betou, M., Eggleston, I. M., Maizels, R. M., van Aalten, D. and Allen, J. E., 2011. Analyzing airway inflammation with chemical biology: Dissection of acidic mammalian chitinase function with a selective drug-like inhibitor. Chemistry & Biology, 18 (5), pp. 569-579.

Webb, C., Upadhyay, A., Giuntini, F., Eggleston, I., Furutani-Seiki, M., Ishima, R. and Bagby, S., 2011. Structural features and ligand binding properties of tandem WW domains from YAP and TAZ, nuclear effectors of the Hippo pathway. Biochemistry, 50 (16), pp. 3300-3309.

Rush, C. L., Schuttelkopf, A. W., Hurtado-Guerrero, R., Blair, D. E., Ibrahim, A. F. M., Desvergnes, S., Eggleston, I. M. and van Aalten, D. M. F., 2010. Natural Product-Guided Discovery of a Fungal Chitinase Inhibitor. Chemistry & Biology, 17 (12), pp. 1275-1281.

Reelfs, O., Eggleston, I. M. and Pourzand, C., 2010. Skin protection against UVA-induced iron damage by multiantioxidants and iron chelating drugs/prodrugs. Current Drug Metabolism, 11 (3), pp. 242-249.

Bourre, L., Giuntini, F., Eggleston, I. M., Mosse, C. A., MacRobert, A. J. and Wilson, M., 2010. Effective photoinactivation of Gram-positive and Gram-negative bacterial strains using an HIV-1 Tat peptide-porphyrin conjugate. Photochemical & Photobiological Sciences, 9 (12), pp. 1613-1620.

Giuntini, F., Bourre, L., MacRobert, A. J., Wilson, M. and Eggleston, I. M., 2009. Improved peptide prodrugs of 5-ALA for PDT: rationalization of cellular accumulation and protoporphyrin IX production by direct determination of cellular prodrug uptake and prodrug metabolization. Journal of Medicinal Chemistry, 52 (13), pp. 4026-4037.

Higgins, L. G., Kelleher, M. O., Eggleston, I. M., Itoh, K., Yamamoto, M. and Hayes, J. D., 2009. Transcription factor Nrf2 mediates an adaptive response to sulforaphane that protects fibroblasts in vitro against the cytotoxic effects of electrophiles, peroxides and redox-cycling agents. Toxicology and Applied Pharmacology, 237 (3), pp. 267-280.

Dixon, M. J., Nathubhai, A., Andersen, O. A., van Aalten, D. M. F. and Eggleston, I. M., 2009. Solid-phase synthesis of cyclic peptide chitinase inhibitors: SAR of the argifin scaffold. Organic and Biomolecular Chemistry, 7 (2), pp. 259-268.

Kelleher, M. O., McMahon, M., Eggleston, I. M., Dixon, M. J., Taguchi, K., Yamamoto, M. and Hayes, J. D., 2009. 1-Cyano-2,3-epithiopropane is a novel plant-derived chemopreventive agent which induces cytoprotective genes that afford resistance against the genotoxicα,β-unsaturated aldehyde acrolein. Carcinogenesis, 30 (10), pp. 1754-1762.

Bourre, L., Giuntini, F., Eggleston, I. M., Wilson, M. and MacRobert, A. J., 2009. Protoporphyrin IX enhancement by 5-aminolaevulinic acid peptide derivatives and the effect of RNA silencing on intracellular metabolism. British Journal of Cancer, 100 (5), pp. 723-731.

Dixon, M. J., Andersen, O. A., van Aalten, D. M. F. and Eggleston, I. M., 2009. SPPS of the natural product chitinase inhibitor argifin: library generation and biological evaluation. In: Del Valle, S., Escher, E. and Lubell, W. D., eds. Peptides for Youth. Vol. 611. New York: Springer, pp. 143-144. (Advances in Experimental Medicine and Biology)

Dixon, M. J., Nathubhai, A., Andersen, O. A., van Aalten, D. M. F. and Eggleston, I. M., 2009. Synthesis and Structure-based Dissection of Cyclic Peptide Chitinase Inhibitors: New Leads for Antifungal and Anti-inflammatory Drugs. In: DelValle, S., Escher, E. and Lubell, W. D., eds. Peptides for Youth - The Proceedings of the 20th American Peptide Symposium. Springer, pp. 525-526. (Advances in Experimental Medicine and Biology)

Giuntini, F., Bourre, L., Wilson, M., MacRobert, A. J. and Eggleston, I. M., 2008. A novel approach to improve cellular delivery of 5-aminolaevulinic acid: New ALA-containing peptide Prodrugs for photodynamic therapy. Journal of Peptide Science, 14 (8 (Suppl S)), p. 156.

Dixon, M., Giuntini, F., Nathubhai, A., Andersen, O., van Aalten, D. and Eggleston, I., 2008. Synthetic approaches to cyclic peptide natural products as chitinase inhibitors. Journal of Peptide Science, 14 (8), p. 55.

Andersen, O. A., Nathubhai, A., Dixon, M. J., Eggleston, I. M. and van Aalten, D. M. F., 2008. Structure-based dissection of the natural product cyclopentapeptide chitinase inhibitor argifin. Chemistry & Biology, 15 (3), pp. 295-301.

Bourre, L., Giuntini, F., Eggleston, I. M., Wilson, M. and MacRobert, A. J., 2008. 5-aminolaevulinic acid peptide prodrugs enhance photosensitization for photodynamic therapy. Molecular Cancer Therapeutics, 7 (6), pp. 1720-1729.

Paterson, M. J. and Eggleston, I. M., 2008. Convenient preparation of N-maleoyl amino acid succinimido esters using N-trifluoroacetoxysuccinimide. Synthetic Communications, 38 (2), pp. 303-308.

Giuntini, F., Bourre, L., MacRobert, A. J., Wilson, M. and Eggleston, I. M., 2008. Quantitative determination of 5-aminolaevulinic acid and its esters in cell lysates by HPLC-fluorescence. Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences, 875 (2), pp. 562-566.

Dixon, M., Nathubhai, A., Andersen, O., van Aalten, D. and Eggleston, I. M., 2008. Synthesis of cyclic peptide chitinase inhibitors: Natural products,with chemotherapeutic potential. Journal of Peptide Science, 14 (8 (Suppl S)), p. 13.

Hayes, J. D., Kelleher, M. O. and Eggleston, I. M., 2008. The cancer chemopreventive actions of phytochemicals derived from glucosinolates. European Journal of Nutrition, 47, pp. 73-88.

Hayes, J. D., Kelleher, M. O., Eggleston, I. M., Akesson, B. and Merke, P., 2007. Anticarcinogenic effects of glucosinalate breakdown products. In: Dietary vitamins, polyphenols, selenium and probiotics: biomarkers of exposure and mechanisms of anticarcinogenic action. Nofer Institute of Occupational Medicine, pp. 140-160.

Dixon, M. J., Andersen, O. A., van Aalten, D. M. F., Nathubhai, A. and Eggleston, I. M., 2007. Cyclic peptide chitinase inhibitors: new leads for antifungal and anti-inflammatory drugs. Biopolymers, 88, p. 576.

Allwood, M. B., Cannan, B., van Aalten, D. M. F. and Eggleston, I. M., 2007. Efficient synthesis of 1,3,7-substituted xanthines by a safety-catch protection strategy. Tetrahedron, 63, pp. 12294-12302.

Dixon, M. J., Bourre, L., MacRobert, A. J. and Eggleston, I. M., 2007. Novel prodrug approach to photodynamic therapy: Fmoc solid-phase synthesis of a cell permeable peptide incorporating 5-aminolaevulinic acid. Bioorganic & Medicinal Chemistry Letters, 17 (16), pp. 4518-4522.

Dixon, M. J., Andersen, O. A., van Aalten, D. M. F. and Eggleston, I. M., 2006. First synthesis of argadin: A nanomolar inhibitor of family-18 chitinases. European Journal of Organic Chemistry, 22, pp. 5002-5006.

Torrance, L., Ziegler, A., Pittman, H., Paterson, M., Toth, R. and Eggleston, I. M., 2006. Oriented immobilisation of engineered single-chain antibodies to develop biosensors for virus detection. Journal of Virological Methods, 134, pp. 164-170.

Schuettelkopf, A. W., Andersen, O. A., Rao, F. V., Allwood, C., Lloyd, C. and Eggleston, I. M., 2006. Screening-based discovery and structural dissection of a novel family 18 chitinase inhibitor. Journal of Biological Chemistry, 281 (37), pp. 27278-27285.

Ariza, A., Vickers, T. J., Greig, N., Armour, K. A., Dixon, M. J., Eggleston, I. M., Fairlamb, A. H. and Bond, C. S., 2006. Specificity of the trypanothione-dependent Leishmania major glyoxalase 1: structure and biochemical comparison with the human enzyme. Molecular Microbiology, 59 (4), pp. 1239-1248.

Rao, F. V., Dorfmueller, H. C., Villa, F., Allwood, M., Eggleston, I. M. and van Aalten, D. M. F., 2006. Structural insights into the mechanism and inhibition of eukaryotic O-GlcNAc hydrolysis. EMBO Journal, 25 (1569), p. 1578.

Hamilton, C. J., Saravanamuthu, A., Poupat, C., Fairlamb, A. H. and Eggleston, I. M., 2006. Time-dependent inhibitors of trypanothione reductase. Analogues of the spermidine alkaloid lunarine and related natural products. Bioorganic and Medicinal Chemistry, 14, pp. 2266-2278.

Rogers, L. M. A., McGivern, P. G., Butler, A. R., MacRobert, A. J. and Eggleston, I. M., 2005. An efficient synthesis of 5-aminolaevulinic acid (ALA)-containing peptides for use in photodynamic therapy. Tetrahedron, 61, pp. 6951-6958.

Dixon, M. J., Andersen, O. A., van Aalten, D. M. F. and Eggleston, I. M., 2005. An efficient synthesis of argifin: a natural product chitinase inhibitor with chemotherapeutic potential. Bioorganic & Medicinal Chemistry Letters, 15 (21), pp. 4717-4721.

Andersen, O. A., Dixon, M. J., Eggleston, I. M. and van Aalten, D. M. F., 2005. Natural product family 18 chitinase inhibitors. Natural Product Reports, 22, pp. 563-579.

Houston, D. R., Synstad, B., Eijsink, V. G. H., Stark, M. J. R., Eggleston, I. M. and van Aalten, D. M. F., 2004. Structure-based exploration of cyclic dipeptide chitinase inhibitors. Journal of Medicinal Chemistry, 47, pp. 5713-5720.

Garnelis, T., Athanassopoulos, C. M., Papaioannou, D., Eggleston, I. M. and Fairlamb, A. H., 2004. Very short and efficient syntheses of the spermine alkaloid kukoamine A and analogs using isolable succinimidyl cinnamates. Chemistry Letters, 34 (2), pp. 264-265.

Hamilton, C. J., Saravanamuthu, A., Fairlamb, A. H. and Eggleston, I. M., 2003. Benzofuranyl 3,5-bis-polyamine derivatives as time-dependent inhibitors of trypanothione reductase. Bioorganic and Medicinal Chemistry, 11, pp. 3683-3693.

Hamilton, C. J., Saravanamuthu, A., Eggleston, I. M. and Fairlamb, A. H., 2003. Ellman's reagent-mediated regeneration of trypanothione in situ: substrate economoic microplate and time-dependent inhibition assays for trypanothione reductase. Biochemical Journal, 369, pp. 529-537.

Hamilton, C. J., Fairlamb, A. H. and Eggleston, I. M., 2002. Regiocontrolled synthesis of the macrocyclic polyamine alkaloid ( + )-lunarine, a time-dependent inhibitor of trypanothione reductase. Journal of the Chemical Society - Perkin Transcriptions 1, 8, pp. 1115-1123.

Houston, D. R., Eggleston, I. M., Synstad, B., Eijsink, V. G. H. and van Aalten, D. M. F., 2002. The cyclic dipeptide CI-4 [ cyclo- (L-Arg-D-Pro)] inhibits family 18 chitinases by structural mimicry of a reaction intermediate. Biochemical Journal, 368 (27), pp. 23-27.

Bonnesen, C., Eggleston, I. M. and Hayes, J. D., 2001. Dietary indoles and isothiocyanates that are generated from cruciferous vegetables can both stimulate apoptosis and confer protection against DNA damage in human colon cell lines. Cancer Research, 61, pp. 6120-6130.

This list was generated on Sat Apr 19 11:06:05 2014 IST.