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Items by Threadgill, Michael

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Number of items: 86.

2015

Tang, Y., Li, M., Threadgill, M., Xiao, M., Mou, C.-F., Song, G.-L., Kuang, J., Yang, X., Yang, L., Gao, X.-J., Wang, Y.-P. and Meng, Y.-P., 2015. ART1 promotes starvation-induced autophagy: a possible protective role in the development of colon carcinoma. American Journal of Cancer Research, 5, pp. 498-513.

Twum, E. A., Nathubhai, A., Wood, P. J., Lloyd, M. D., Thompson, A. S. and Threadgill, M. D., 2015. Initial development of a cytotoxic amino-seco-CBI warhead for delivery by prodrug systems. Bioorganic and Medicinal Chemistry, 23, pp. 3481-3489. Item availability may be restricted.

2014

Parveen, I., Wilson, T., Threadgill, M.D., Luyten, J., Roberts, R.E., Robson, P.R.H., Donnison, I.S., Hauck, B. and Winters, A.L., 2014. Screening for potential co-products in a Miscanthus sinensis mapping family by liquid chromatography with mass spectrometry detection. Phytochemistry, 105, pp. 186-196.

Yevglevskis, M., Bowskill, C.R., Chan, C.C.Y., Heng, J.H.-J., Threadgill, M. D., Woodman, T.J. and Lloyd, M.D., 2014. A study on the chiral inversion of mandelic acid in humans. Organic and Biomolecular Chemistry, 12 (34), pp. 6737-6744. Item availability may be restricted.

2013

Qu, X., Allan, A., Chui, G., Hutchings, T. J., Jiao, P., Johnson, L., Leung, W. Y., Li, P. K., Steel, G. R., Thompson, A. S., Threadgill, M. D., Woodman, T. J. and Lloyd, M. D., 2013. Hydrolysis of ibuprofenoyl-CoA and other 2-APA-CoA esters by human acyl-CoA thioesterases-1 and -2 and their possible role in the chiral inversion of profens. Biochemical Pharmacology, 86 (11), pp. 1621-1625.

Parveen, I., Wilson, T., Donnison, I., Cookson, A.R., Hauck, B. and Threadgill, M., 2013. Potential sources of high value chemicals from leaves, stems and flowers of Miscanthus sinensis 'Goliath' and Miscanthus sacchariflorus. Phytochemistry, 92, pp. 160-167.

2012

Sattar, F. A., Darley, D. J., Politano, F., Woodman, T. J., Threadgill, M. D. and Lloyd, M. D., 2012. Acyl-CoA ∝-proton exchange by ∝-methylacyl-CoA racemase. In: Biochemical Society Conference,2012, 2012-01-01, Cambridge.

Woodman, T. J., Wood, P. J., Thompson, A. S., Hutchings, T. J., Jiao, P., Steel, G. R., Threadgill, M. D. and Lloyd, M. D., 2012. Chiral inversion of NSAID-CoA esters by human ∝-methylacyl-CoA racemase. In: Biochemical Society Conference,2012, 2012-01-01, Cambridge.

Qu, X., Leung, A., Allan, A. C., Chui, G., Hutchings, T. J., Jiao, P., Johnson, L., Leung, W. Y., Li, P. K., Steel, G. R., Thompson, A. S., Threadgill, M. D., Woodman, T. J. and Lloyd, M. D., 2012. Hydrolysis of ibuprofenoyl-CoA and other 2-APA-CoA esters by human Acyl-CoA thioesterases 1 and 2. In: Biochemical Society Conference,2012, 2012-01-01, Cambridge.

2011

Nathubhai, A., Patterson, R., Woodman, T. J., Sharp, H. E. C., Chui, M. T. Y., Chung, H. H. K., Lau, S. W. S., Zheng, J., Lloyd, M. D., Thompson, A. S. and Threadgill, M. D., 2011. N3-Alkylation during formation of quinazolin-4-ones from condensation of anthranilamides and orthoamides. Organic and Biomolecular Chemistry, 9 (17), pp. 6089-6099.

Holbourn, K. P., Lloyd, M. D., Thompson, A. S., Threadgill, M. D. and Acharya, K. R., 2011. Cloning, purification, crystallization and preliminary crystallographic analysis of the human histone deacetylase sirtuin 1. Acta Crystallographica Section F-Structural Biology and Crystallization Communications, 67 (4), pp. 461-463.

Sunderland, P. T., Woon, E. C. Y., Dhami, A., Bergin, A. B., Mahon, M. F., Wood, P. J., Jones, L. A., Tully, S. R., Lloyd, M. D., Thompson, A. S., Javaid, H., Martin, N. M. B. and Threadgill, M. D., 2011. 5-Benzamidoisoquinolin-1-ones and 5-(ω-Carboxyalkyl)isoquinolin-1-ones as Isoform-Selective Inhibitors of Poly(ADP-ribose) Polymerase 2 (PARP-2). Journal of Medicinal Chemistry, 54 (7), pp. 2049-2059.

Woodman, T.J., Wood, P. J., Thompson, A. S., Hutchings, T. J., Jiao, P., Steel, G. R., Threadgill, M. D. and Lloyd, M. D., 2011. Chiral inversion of NSAID-CoA esters by human ∝-methylacyl-CoA racemase. In: Cancer Research @ Bath Conference, 2011, 2011-05-01, Bath.

2010

Kee, C. H., Ariffin, A., Awang, K., Takeya, K., Morita, H., Hussain, S. I., Chan, K. M., Wood, P. J., Threadgill, M. D., Lim, C. G., Ng, S., Weber, J. F. F. and Thomas, N. F., 2010. Challenges associated with the synthesis of unusual o-carboxamido stilbenes by the Heck protocol: Intriguing substituent effects, their toxicological and chemopreventive implications. Organic and Biomolecular Chemistry, 8 (24), pp. 5646-5660.

Parveen, I., Threadgill, M. D., Moorby, J. M. and Winters, A., 2010. Oxidative phenols in forage crops containing polyphenol oxidase enzymes. Journal of Agricultural and Food Chemistry, 58 (3), pp. 1371-1382.

2009

Cai, L., Threadgill, M. D., Wang, Y. L. and Li, M., 2009. Effect of poly (ADP-ribose) polymerase-1 inhibition on the proliferation of murine colon carcinoma CT26 cells. Pathology & Oncology Research, 15 (3), pp. 323-328.

Darley, D. J., Butler, D. S., Prideaux, S. J., Thornton, T. W., Wilson, A. D., Woodman, T. J., Threadgill, M. D. and Lloyd, M. D., 2009. Synthesis and use of isotope-labelled substrates for a mechanistic study on human α-methylacyl-CoA racemase 1A (AMACR; P504S). Organic and Biomolecular Chemistry, 7 (3), pp. 543-552.

Beauchard, A., Phillips, V. A., Lloyd, M. D. and Threadgill, M. D., 2009. Synthesis of 2-(4-carboxybutenyl)- and 2-(4-carboxybutynyl)-cyclopentene-1-carboxamides. Tetrahedron, 65 (39), pp. 8176-8184.

2008

Hendryk, S., Czuba, Z. P., Jędrzejowska-Szypułka, H., Szliszka, E., Phillips, V. A., Threadgill, M. D. and Król, W., 2008. Influence of 5-aminoisoquinolin-1-one (5-AIQ) on neutrophil chemiluminescence in rats with transient and prolonged focal cerebral ischaemia and after reperfusion. Journal of Physiology and Pharmacology, 59 (4), pp. 811-822.

Darley, D. J., Butler, D. S., Threadgill, M. D. and Lloyd, M. D., 2008. Characterisation of recombinant alpha-methylacyl-CoA racemase, a novel prostate cancer target. In: RSC Bioorganic Group Annual Post-Graduate Symposium P7, 2008, 2008-03-01.

Darley, D. J., Prideaux, S. J., Thornton, T. W., Wilson, A. D., Threadgill, M. D., Woodman, T. J. and Lloyd, M. D., 2008. Synthesis of 2-[2H]-2-[13C]-S-2-methyldecanoyl-CoA and 13C NMR study of its reaction with ∝-methylacyl-CoA racemase (AMACR. In: RSC Bioorganic Group Annual Post-Graduate Symposium P8, 2008, 2008-03-01.

Beauchard, A., Phillips, V. A., Lloyd, M. D. and Threadgill, M. D., 2008. Synthesis of a mimic of phosphorserylproline as a potential inhibitor of Pin1. In: RSC Bioorganic Group Annual Post-Graduate Symposium P13, 2008, 2008-03-01.

Lloyd, M. D., Darley, D. J., Wierzbicki, A. S. and Threadgill, M. D., 2008. α-Methylacyl-CoA racemase - an 'obscure' metabolic enzyme takes centre stage. FEBS Journal, 275, pp. 1089-1102.

2007

Darley, D. J., Butler, D. S., Threadgill, M. D. and Lloyd, M. D., 2007. Characterisation of recombinant alpha-methylacyl-CoA racemase, a novel prostate cancer target. In: Northern England (and Bristol) Collaborative (PROMPT) and South of England Prostate Collaborative Joint Meeting, 2007, 2007-11-01, Cambridge.

Darley, D. J., Butler, D. S., Threadgill, M. D. and Lloyd, M. D., 2007. Characterisation of recombinant alpha-methylacyl-CoA racemase, a novel prostate cancer target. In: 3rd National Cancer Research Institute (NCRI) Cancer Conference, 2007, 2007-10-01, Birmingham.

Darley, D. J., Butler, D. S., Threadgill, M. D. and Lloyd, M. D., 2007. Characterisation of recombinant alpha-methylacyl-CoA racemase, a novel prostate cancer target. In: Life Sciences Conference,2007, 2007-07-01, Glasgow.

Lloyd, M. D., Boardman, K. D. E., Smith, A., van den Brink, D. M., Wanders, R. J. A. and Threadgill, M. D., 2007. Characterisation of recombinant human fatty aldehyde dehydrogenase: implications for Sjögren-Larsson syndrome. In: Life Sciences Conference,2007, 2007-07-01, Glasgow.

Lloyd, M. D., Boardman, K. D. E., Smith, A., van den Brink, D. M., Wanders, R. J. A. and Threadgill, M. D., 2007. Characterisation of recombinant human fatty aldehyde dehydrogenase: implications for Sjögren-Larsson syndrome. Journal of Enzyme Inhibition and Medicinal Chemistry, 22 (5), pp. 584-590.

Suaifan, G. A. R. Y., Arafat, T. and Threadgill, M. D., 2007. Synthetic approaches to peptides containing the L-Gln-L-Val-D (S) -Dmt motif. Bioorganic and Medicinal Chemistry, 15, pp. 3474-3488.

2006

Lloyd, M. D., Boardman, K. D. E. and Threadgill, M. D., 2006. Expression and characterisation of human aldehyde dehydrogenase 10 : implications for Sjögren-Larsson syndrome. In: Conférences Européenes du Groupement Des Pharmacochimistes de L'Arc Atlantique (GP2A), 2006, 2006-09-01, Bath.

Kwong, J. S. W., Lloyd, M. D. and Threadgill, M. D., 2006. Design and synthesis of a novel transition state mimic for poly(ADP-ribose) polymerase 1 (PARP-1) inhibition. In: Conférences Européenes du Groupement des Pharmacochimistes de L'Arc Atlantique (GP2A), 2006-09-07 - 2006-09-08, Bath.

Kwong, J. S. W., Lloyd, M. D. and Threadgill, M. D., 2006. Design, synthetic approaches and characterisation of a novel cyclic sulfoximine NAD+ (nicotinamide adenine dinucleotide) analogue. In: American Chemical Society (ACS) 232nd National Meeting, 2006-09-10 - 2006-09-14, San Francisco.

Lloyd, M. D., Boardman, K. D. E. and Threadgill, M. D., 2006. Expression and characterisation of human adehyde dehydrogenase 10: implications for Söjgren-Larsson syndrome. In: Conférences Européenes du Groupement des Pharmacochimistes de L'Arc Atlantique (GP2A), 2006-09-07 - 2006-09-08, Bath.

Lord, A. M., Lloyd, M. D. and Threadgill, M. D., 2006. Quinoline-8-carboxamides as novel PARP-1 inhibitors. In: Conférences Européenes du Groupement des Pharmacochimistes de L'Arc Atlantique (GP2A), 2006-09-07 - 2006-09-08, Bath.

Woon, E. C. Y., Dhami, A., Sunderland, P. T., Chalkley, D. A. and Threadgill, M. D., 2006. Reductive cyclisation of 2-cyanomethyl-3-nitrobenzoates. Letters in Organic Chemistry, 3, pp. 619-621.

Kwong, J. S. W., Lloyd, M. D. and Threadgill, M. D., 2006. Synthesis of cyclic sulfoximine mimics of 2-deoxyribosides as enzyme inhibitors in cancer. Journal of Pharmacy and Pharmacology, 58, A58-A58.

2005

Genovese, T., Mazzon, E., Muià, C., Patel, N. S. A., Threadgill, M. D., Bramanti, P., De Sarro, A., Thiemermann, C. and Cuzzocrea, S., 2005. Inhibitors of poly(ADP-ribose) polymerase modulate signal transduction pathways and secondary damage in experimental spinal cord trauma. Journal of Pharmacology and Experimental Therapeutics, 312 (2), pp. 449-457.

Genovese, T., Mazzon, E., Di Paola, R., Muià, C., Patel, N. S. A., Threadgill, M. D., Caputi, A. P., Thiemermann, C. and Cuzzocrea, S., 2005. Inhibitors of poly(ADP-ribose) polymerase modulate signal transduction pathways and the development of bleomycin-induced lung injury. Journal of Pharmacology and Experimental Therapeutics, 313 (2), pp. 529-538.

Woon, E. C. Y. and Threadgill, M. D., 2005. Poly(ADP-ribose)polymerase inhibition - where now? Current Medicinal Chemistry, 12, pp. 2373-2392.

2004

Cuzzocrea, S., Mazzon, E., Di Paola, R., Genovese, T., Patel, N. S. A., Muià, C., Threadgill, M. D., De Sarro, A. and Thiemermann, C., 2004. 5-Aminoisoquinolinone reduces colon injury by experimental colitis. Naunyn-Schmiedeberg's Archives of Pharmacology, 370, pp. 464-473.

Chatterjee, P. K., Chatterjee, B. E., Pederson, H., Sivarajah, A., McDonald, M. C., Mota-Filipe, H., Brown, P. A. J., Stewart, K. N., Cuzzocrea, S., Threadgill, M. D. and Thiemermann, C., 2004. 5-Aminoisoquinolinone reduces renal injury and dysfunction caused by experimental ischemia/reperfusion. Kidney International, 65 (2), pp. 499-509.

Di Paola, R., Genovese, T., Caputi, A. P., Threadgill, M. D., Thiemermann, C. and Cuzzocrea, S., 2004. Beneficial effects of 5-aminoisoquinolinone, a novel, potent, water-soluble, inhibitor of poly (ADP-ribose) polymerase, in a rat model of splanchnic artery occlusion and reperfusion. European Journal of Pharmacology, 492, pp. 203-210.

2003

Goodyer, C. L. M., Chinje, E. C., Jaffar, M., Stratford, I. J. and Threadgill, M. D., 2003. Synthesis of N -Benzyl- and N -Phenyl-2-amino-4,5- dihydrothiazoles and thioureas and evaluation as modulators of the isoforms of nitric oxide synthase. Bioorganic and Medicinal Chemistry, 11 (19), pp. 4189-4206.

Goodyer, C. L. M., Chinje, E. C., Jaffar, M., Stratford, I. J. and Threadgill, M. D., 2003. Time-dependence and preliminary SAR studies in inhibition of nitric oxide synthase isoforms by homologues of thiocitrulline. Bioorganic & Medicinal Chemistry Letters, 13, pp. 3679-3680.

2002

Wong, S. M., Shah, B., Shah, P., Butt, I. C., Woon, E. C. Y., Wright, J. A., Thompson, A. S., Upton, C. and Threadgill, M. D., 2002. A new synthesis of "push-pull" naphthalenes by condensation of nitro-2-methylbenzoate esters with dimethylacetamide dimethyl acetal. Tetrahedron Letters, 43 (12), pp. 2299-2302.

Perkins, S., Verschoyle, R. D., Hill, K., Parveen, I., Threadgill, M. D., Sharma, R. A., Williams, M. L., Steward, W. P. and Gescher, A. J., 2002. Chemopreventive efficacy and pharmacokinetics of curcumin in the min/+ mouse, a model of familial adenomatous polyposis. Cancer Epidemiology Biomarkers Prevention, 11, pp. 535-540.

Naughton, D. P., Ferrer, S. and Threadgill, M. D., 2002. Drug targeting using bioreductive delivery systems. Proceedings of the Indian National Science Academy (PINSA), B68 (4), pp. 371-378.

Cuzzocrea, S., McDonald, M. C., Mazzon, E., Dugo, L., Serraino, I., Threadgill, M. D., Caputi, A. P. and Thiemermann, C., 2002. Effects of 5-aminoisoquinolinone, a water-soluble, potent inhibitor of the activity of poly (ADP-ribose) polymerase, in a rodent model of lung injury. Biochemical Pharmacology, 63, pp. 293-304.

Ferrer, S., Naughton, D. P. and Threadgill, M. D., 2002. Labelled compounds of interest as antitumour agents - VIII. Synthesis of 2H-isotopomers of pentamethylmelamine and of a potential prodrug thereof. Journal of Labelled Compounds and Radiopharmaceuticals, 45, pp. 479-484.

Ferrer, S., Naughton, D. P., Parveen, I. and Threadgill, M. D., 2002. N- and O-Alkylation of isoquinolin-1-ones in the Mitsunobu reaction: development of potential drug delivery systems. Journal of the Chemical Society - Perkin Transcriptions 1

2001

Wayman, N., McDonald, M. C., Thompson, A. S., Threadgill, M. D. and Thiemermann, C., 2001. 5-Aminoisoquinolinone, a potent inhibitor of poly(adenosine 5'-diphosphate ribose) polymerase, reduces myocardial infarct size. European Journal of Pharmacology, 430 (1), pp. 93-100.

Matthews, S. E., Pouton, C. W. and Threadgill, M. D., 2001. Formation of hybrid polymethylene-poly(oxyethylene) macrocycles. Tetrahedron Letters, 42, pp. 1355-1357.

2000

McDonald, M. C., Mota-Filipe, H., Wright, J. A., Abdelrahman, M., Threadgill, M. D., Thompson, A. S. and Thiemermann, C., 2000. Effects of 5-aminoisoquinolinone, a water-soluble, potent inhibitor of the activity of poly (ADP-ribose) polymerase on the organ injury and dysfunction caused by haemorrhagic shock. British Journal of Pharmacology, 130 (4), pp. 843-850.

This list was generated on Mon Jul 6 12:28:54 2015 IST.