Research

Items by Threadgill, Michael

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Number of items: 65.

Articles

Parveen, I., Wilson, T., Threadgill, M.D., Luyten, J., Roberts, R.E., Robson, P.R.H., Donnison, I.S., Hauck, B. and Winters, A.L., 2014. Screening for potential co-products in a Miscanthus sinensis mapping family by liquid chromatography with mass spectrometry detection. Phytochemistry

Nathubhai, A., Wood, P. J., Lloyd, M. D., Thompson, A. S. and Threadgill, M. D., 2013. Design and discovery of 2‑arylquinazolin-4-ones as potent and selective inhibitors of tankyrases. ACS Medicinal Chemistry Letters, 4 (12), pp. 1173-1177.

Qu, X., Allan, A., Chui, G., Hutchings, T. J., Jiao, P., Johnson, L., Leung, W. Y., Li, P. K., Steel, G. R., Thompson, A. S., Threadgill, M. D., Woodman, T. J. and Lloyd, M. D., 2013. Hydrolysis of ibuprofenoyl-CoA and other 2-APA-CoA esters by human acyl-CoA thioesterases-1 and -2 and their possible role in the chiral inversion of profens. Biochemical Pharmacology, 86 (11), pp. 1621-1625.

Woon, E. C. Y., Sunderland, P. T., Paine, H. A., Lloyd, M. D., Thompson, A. S. and Threadgill, M. D., 2013. One-pot tandem Hurtley–retro-Claisen–cyclisation reactions in the synthesis of 3-substituted analogues of 5-aminoisoquinolin-1-one (5-AIQ), a water-soluble inhibitor of PARPs. Bioorganic and Medicinal Chemistry, 21 (17), pp. 5218-5227.

Yan, J., Li, M., Threadgill, M.D., Wang, Y. and Fu, W., 2013. Decreasing P-selectin and ICAM-1 via activating Akt : a possible mechanism by which PARG inhibits adhesion of mouse colorectal carcinoma CT26 cells to platelets. Cancer Gene Therapy, 20 (9), pp. 487-492.

Lloyd, M. D., Jevglevskis, M., Lee, G. L., Wood, P. J., Threadgill, M. D. and Woodman, T. J., 2013. α-Methylacyl-CoA racemase (AMACR): Metabolic enzyme, drug metabolizer and cancer marker P504S. Progress in Lipid Research, 52 (2), pp. 220-230.

Twum, E. A., Woodman, T. J., Wang, W. and Threadgill, M. D., 2013. Observation by NMR of cationic Wheland-like intermediates in the deiodination of protected 1-iodo-naphthalene-2,4-diamines in acidic media. Organic and Biomolecular Chemistry, 11 (36), pp. 6208-6214.

Parveen, I., Wilson, T., Donnison, I., Cookson, A.R., Hauck, B. and Threadgill, M., 2013. Potential sources of high value chemicals from leaves, stems and flowers of Miscanthus sinensis 'Goliath' and Miscanthus sacchariflorus. Phytochemistry, 92, pp. 160-167.

Parveen, I., Threadgill, M. D., Hauck, B., Donnison, I. and Winters, A., 2011. Isolation, identification and quantitation of hydroxycinnamic acid conjugates, potential platform chemicals, in the leaves and stems of Miscanthus x giganteus using LC-ESI-MS(n). Phytochemistry, 72 (18), pp. 2376-2384.

Beauchard, A., Twum, E. A., Lloyd, M. D. and Threadgill, M. D., 2011. S-2-Amino-4-cyanobutanoic acid (β-cyanomethyl-L-Ala) as an atom-efficient solubilising synthon for L-glutamine. Tetrahedron Letters, 52 (41), pp. 5311-5314.

Nathubhai, A., Patterson, R., Woodman, T. J., Sharp, H. E. C., Chui, M. T. Y., Chung, H. H. K., Lau, S. W. S., Zheng, J., Lloyd, M. D., Thompson, A. S. and Threadgill, M. D., 2011. N3-Alkylation during formation of quinazolin-4-ones from condensation of anthranilamides and orthoamides. Organic and Biomolecular Chemistry, 9 (17), pp. 6089-6099.

Woodman, T. J., Wood, P. J., Thompson, A. S., Hutchings, T. J., Steel, G. R., Jiao, P., Threadgill, M. D. and Lloyd, M. D., 2011. Chiral inversion of 2-arylpropionyl-CoA esters by human α-methylacyl-CoA racemase 1A (P504S)-a potential mechanism for the anti-cancer effects of ibuprofen. Chemical Communications, 47 (26), pp. 7332-7334.

Holbourn, K. P., Lloyd, M. D., Thompson, A. S., Threadgill, M. D. and Acharya, K. R., 2011. Cloning, purification, crystallization and preliminary crystallographic analysis of the human histone deacetylase sirtuin 1. Acta Crystallographica Section F-Structural Biology and Crystallization Communications, 67 (4), pp. 461-463.

Sunderland, P. T., Dhami, A., Mahon, M. F., Jones, L. A., Tully, S. R., Lloyd, M. D., Thompson, A. S., Javaid, H., Martin, N. M. B. and Threadgill, M. D., 2011. Synthesis of 4-alkyl-, 4-aryl- and 4-arylamino-5-aminoisoquinolin-1-ones and identification of a new PARP-2 selective inhibitor. Organic and Biomolecular Chemistry, 9 (3), pp. 881-891.

Sunderland, P. T., Woon, E. C. Y., Dhami, A., Bergin, A. B., Mahon, M. F., Wood, P. J., Jones, L. A., Tully, S. R., Lloyd, M. D., Thompson, A. S., Javaid, H., Martin, N. M. B. and Threadgill, M. D., 2011. 5-Benzamidoisoquinolin-1-ones and 5-(ω-Carboxyalkyl)isoquinolin-1-ones as Isoform-Selective Inhibitors of Poly(ADP-ribose) Polymerase 2 (PARP-2). Journal of Medicinal Chemistry, 54 (7), pp. 2049-2059.

Sattar, F. A., Darley, D. J., Politano, F., Woodman, T. J., Threadgill, M. D. and Lloyd, M. D., 2010. Unexpected stereoselective exchange of straight-chain fatty acyl-CoA α-protons by human α-methylacyl-CoA racemase 1A (P504S). Chemical Communications, 46 (19), pp. 3348-3350.

Suaifan, G., Goodyer, C. L. M. and Threadgill, M. D., 2010. Synthesis of N-(Methoxycarbonylthienylmethyl)thioureas and evaluation of their interaction with inducible and neuronal Nitric Oxide Synthase. Molecules, 15 (5), pp. 3121-3134.

Kee, C. H., Ariffin, A., Awang, K., Takeya, K., Morita, H., Hussain, S. I., Chan, K. M., Wood, P. J., Threadgill, M. D., Lim, C. G., Ng, S., Weber, J. F. F. and Thomas, N. F., 2010. Challenges associated with the synthesis of unusual o-carboxamido stilbenes by the Heck protocol: Intriguing substituent effects, their toxicological and chemopreventive implications. Organic and Biomolecular Chemistry, 8 (24), pp. 5646-5660.

Parveen, I., Threadgill, M. D., Moorby, J. M. and Winters, A., 2010. Oxidative phenols in forage crops containing polyphenol oxidase enzymes. Journal of Agricultural and Food Chemistry, 58 (3), pp. 1371-1382.

Cai, L., Threadgill, M. D., Wang, Y. L. and Li, M., 2009. Effect of poly (ADP-ribose) polymerase-1 inhibition on the proliferation of murine colon carcinoma CT26 cells. Pathology & Oncology Research, 15 (3), pp. 323-328.

Dhami, A., Mahon, M. F., Lloyd, M. D. and Threadgill, M. D., 2009. 4-Substituted 5-nitroisoquinolin-1-ones from intramolecular Pd-catalysed reaction of N-(2-alkenyl)-2-halo-3-nitrobenzamides. Tetrahedron, 65 (24), pp. 4751-4765.

Lord, A.-M., Mahon, M. F., Lloyd, M. D. and Threadgill, M. D., 2009. Design, synthesis, and evaluation in vitro of quinoline-8-carboxamides, a new class of poly(adenosine-diphosphate-ribose)polymerase-1 (PARP-1) inhibitor. Journal of Medicinal Chemistry, 52 (3), pp. 868-877.

Darley, D. J., Butler, D. S., Prideaux, S. J., Thornton, T. W., Wilson, A. D., Woodman, T. J., Threadgill, M. D. and Lloyd, M. D., 2009. Synthesis and use of isotope-labelled substrates for a mechanistic study on human α-methylacyl-CoA racemase 1A (AMACR; P504S). Organic and Biomolecular Chemistry, 7 (3), pp. 543-552.

Li, M., Threadgill, M. D., Wang, Y. L., Cai, L. and Lin, X., 2009. Poly(ADP-Ribose) Polymerase Inhibition Down-Regulates Expression of Metastasis-Related Genes in CT26 Colon Carcinoma Cells. Pathobiology, 76 (3), pp. 108-116.

Beauchard, A., Phillips, V. A., Lloyd, M. D. and Threadgill, M. D., 2009. Synthesis of 2-(4-carboxybutenyl)- and 2-(4-carboxybutynyl)-cyclopentene-1-carboxamides. Tetrahedron, 65 (39), pp. 8176-8184.

Hendryk, S., Czuba, Z. P., Jędrzejowska-Szypułka, H., Szliszka, E., Phillips, V. A., Threadgill, M. D. and Król, W., 2008. Influence of 5-aminoisoquinolin-1-one (5-AIQ) on neutrophil chemiluminescence in rats with transient and prolonged focal cerebral ischaemia and after reperfusion. Journal of Physiology and Pharmacology, 59 (4), pp. 811-822.

Parveen, I., Winters, A., Threadgill, M. D., Hauck, B. and Morris, P., 2008. Extraction, structural characterisation and evaluation of hydroxycinnamate esters of orchard grass (Dactylis glomerata) as substrates for polyphenol oxidase. Phytochemistry, 69 (16), pp. 2799-2806.

Lloyd, M. D., Darley, D. J., Wierzbicki, A. S. and Threadgill, M. D., 2008. α-Methylacyl-CoA racemase - an 'obscure' metabolic enzyme takes centre stage. FEBS Journal, 275, pp. 1089-1102.

Kwong, J. S. W., Mahon, M. F., Lloyd, M. D. and Threadgill, M. D., 2007. Synthesis and conformational and configurational studies of diastereoisomeric O-protected 4-(arylsulfonimidoyl)butane-1,2,3-triols. Tetrahedron, 63 (51), pp. 12601-12607.

El-Hamamsy, M. H. R. I., Smith, A. W., Thompson, A. S. and Threadgill, M. D., 2007. Structure-based design, synthesis and preliminary evaluation of selective inhibitors of dihydrofolate reductase from Mycobacterium tuberculosis. Bioorganic and Medicinal Chemistry, 15 (13), pp. 4552-4576.

Lloyd, M. D., Boardman, K. D. E., Smith, A., van den Brink, D. M., Wanders, R. J. A. and Threadgill, M. D., 2007. Characterisation of recombinant human fatty aldehyde dehydrogenase: implications for Sjögren-Larsson syndrome. Journal of Enzyme Inhibition and Medicinal Chemistry, 22 (5), pp. 584-590.

Powell, C. L., Schulze, M., Black, S. J., Thompson, A. S. and Threadgill, M. D., 2007. Closo --> nido cage degradation of 1-(substituted-phenyl)-1,2-dicarbadodecaborane(12)s in wet DMSO under neutral conditions. Tetrahedron Letters, 48, pp. 1251-1254.

Sunderland, P. T., Thompson, A. S. and Threadgill, M. D., 2007. Formation of 3-aryl-5-nitroisocoumarins from 5-nitroisocoumarins and aromatic acyl chlorides under Friedel-Crafts conditions. Journal of Organic Chemistry, 72, pp. 7409-7412.

Suaifan, G. A. R. Y., Arafat, T. and Threadgill, M. D., 2007. Synthetic approaches to peptides containing the L-Gln-L-Val-D (S) -Dmt motif. Bioorganic and Medicinal Chemistry, 15, pp. 3474-3488.

Woon, E. C. Y., Dhami, A., Mahon, M. F. and Threadgill, M. D., 2006. 5-Nitroisocoumarins from tandem Castro–Stephens coupling—6-endo-dig cyclisation of 2-iodo-3-nitrobenzoic acid and arylethynes and ring-closure of methyl 2-alkynyl-3-nitrobenzoates with electrophiles. Tetrahedron, 62 (20), pp. 4829-4837.

Suaifan, G. A. R. Y., Mahon, M. F., Arafat, T. and Threadgill, M. D., 2006. Effects of steric bulk and stereochemistry on the rates of diketopiperazine formation from N -aminoacyl-2,2-dimethylthiazolidine-4-carboxamides (Dmt dipeptide amides) - a model for a new prodrug linker system. Tetrahedron, 62 (48), pp. 11245-11266.

Woon, E. C. Y., Dhami, A., Sunderland, P. T., Chalkley, D. A. and Threadgill, M. D., 2006. Reductive cyclisation of 2-cyanomethyl-3-nitrobenzoates. Letters in Organic Chemistry, 3, pp. 619-621.

Kwong, J. S. W., Lloyd, M. D. and Threadgill, M. D., 2006. Synthesis of cyclic sulfoximine mimics of 2-deoxyribosides as enzyme inhibitors in cancer. Journal of Pharmacy and Pharmacology, 58, A58-A58.

Genovese, T., Mazzon, E., Muià, C., Patel, N. S. A., Threadgill, M. D., Bramanti, P., De Sarro, A., Thiemermann, C. and Cuzzocrea, S., 2005. Inhibitors of poly(ADP-ribose) polymerase modulate signal transduction pathways and secondary damage in experimental spinal cord trauma. Journal of Pharmacology and Experimental Therapeutics, 312 (2), pp. 449-457.

Genovese, T., Mazzon, E., Di Paola, R., Muià, C., Patel, N. S. A., Threadgill, M. D., Caputi, A. P., Thiemermann, C. and Cuzzocrea, S., 2005. Inhibitors of poly(ADP-ribose) polymerase modulate signal transduction pathways and the development of bleomycin-induced lung injury. Journal of Pharmacology and Experimental Therapeutics, 313 (2), pp. 529-538.

Woon, E. C. Y. and Threadgill, M. D., 2005. Poly(ADP-ribose)polymerase inhibition - where now? Current Medicinal Chemistry, 12, pp. 2373-2392.

Cuzzocrea, S., Mazzon, E., Di Paola, R., Genovese, T., Patel, N. S. A., Muià, C., Threadgill, M. D., De Sarro, A. and Thiemermann, C., 2004. 5-Aminoisoquinolinone reduces colon injury by experimental colitis. Naunyn-Schmiedeberg's Archives of Pharmacology, 370, pp. 464-473.

Chatterjee, P. K., Chatterjee, B. E., Pederson, H., Sivarajah, A., McDonald, M. C., Mota-Filipe, H., Brown, P. A. J., Stewart, K. N., Cuzzocrea, S., Threadgill, M. D. and Thiemermann, C., 2004. 5-Aminoisoquinolinone reduces renal injury and dysfunction caused by experimental ischemia/reperfusion. Kidney International, 65 (2), pp. 499-509.

Di Paola, R., Genovese, T., Caputi, A. P., Threadgill, M. D., Thiemermann, C. and Cuzzocrea, S., 2004. Beneficial effects of 5-aminoisoquinolinone, a novel, potent, water-soluble, inhibitor of poly (ADP-ribose) polymerase, in a rat model of splanchnic artery occlusion and reperfusion. European Journal of Pharmacology, 492, pp. 203-210.

Ferrer, S., Naughton, D. P. and Threadgill, M. D., 2003. 1H NMR studies on the reductively triggered release of heterocyclic and steroid drugs from 4,7-dioxoindole-3-methyl prodrugs. Tetrahedron, 59 (19), pp. 3445-3454.

Ferrer, S., Naughton, D. P. and Threadgill, M. D., 2003. Studies on the reductively triggered release of heterocyclic and steroid drugs from 5-nitrothien-2-ylmethyl prodrugs. Tetrahedron, 59, pp. 3437-3444.

Goodyer, C. L. M., Chinje, E. C., Jaffar, M., Stratford, I. J. and Threadgill, M. D., 2003. Synthesis of N -Benzyl- and N -Phenyl-2-amino-4,5- dihydrothiazoles and thioureas and evaluation as modulators of the isoforms of nitric oxide synthase. Bioorganic and Medicinal Chemistry, 11 (19), pp. 4189-4206.

Frixa, C., Mahon, M. F., Thompson, A. S. and Threadgill, M. D., 2003. Synthesis of meso -substituted porphyrins carrying carboranes and oligo(ethylene glycol) units for potential applications in boron neutron capture therapy. Organic and Biomolecular Chemistry, 1 (2), pp. 306-317.

Goodyer, C. L. M., Chinje, E. C., Jaffar, M., Stratford, I. J. and Threadgill, M. D., 2003. Time-dependence and preliminary SAR studies in inhibition of nitric oxide synthase isoforms by homologues of thiocitrulline. Bioorganic & Medicinal Chemistry Letters, 13, pp. 3679-3680.

Wong, S. M., Shah, B., Shah, P., Butt, I. C., Woon, E. C. Y., Wright, J. A., Thompson, A. S., Upton, C. and Threadgill, M. D., 2002. A new synthesis of "push-pull" naphthalenes by condensation of nitro-2-methylbenzoate esters with dimethylacetamide dimethyl acetal. Tetrahedron Letters, 43 (12), pp. 2299-2302.

Madani, H., Thompson, A. S. and Threadgill, M. D., 2002. An expedient synthesis of 7-0-functionalised pyrrolo[2,1-c][1,4]benzodiazepine-5,11-diones. Tetrahedron, 58 (40), pp. 8107-8111.

Perkins, S., Verschoyle, R. D., Hill, K., Parveen, I., Threadgill, M. D., Sharma, R. A., Williams, M. L., Steward, W. P. and Gescher, A. J., 2002. Chemopreventive efficacy and pharmacokinetics of curcumin in the min/+ mouse, a model of familial adenomatous polyposis. Cancer Epidemiology Biomarkers Prevention, 11, pp. 535-540.

Frixa, C., Mahon, M. F., Thompson, A. S. and Threadgill, M. D., 2002. Direct Cu(I)-catalysed coupling of a carborane to a meso-tetraphenylporphyrin. Tetrahedron Letters, 43 (8), pp. 1557-1559.

Naughton, D. P., Ferrer, S. and Threadgill, M. D., 2002. Drug targeting using bioreductive delivery systems. Proceedings of the Indian National Science Academy (PINSA), B68 (4), pp. 371-378.

Cuzzocrea, S., McDonald, M. C., Mazzon, E., Dugo, L., Serraino, I., Threadgill, M. D., Caputi, A. P. and Thiemermann, C., 2002. Effects of 5-aminoisoquinolinone, a water-soluble, potent inhibitor of the activity of poly (ADP-ribose) polymerase, in a rodent model of lung injury. Biochemical Pharmacology, 63, pp. 293-304.

Frixa, C., Scobie, M., Black, S. J., Thompson, A. S. and Threadgill, M. D., 2002. Formation of a remarkably robust 2:1 complex between β-cyclodextrin and a phenyl-substituted icosahedral carborane. Chemical Communications, 27, pp. 2876-2877.

Ferrer, S., Naughton, D. P. and Threadgill, M. D., 2002. Labelled compounds of interest as antitumour agents - VIII. Synthesis of 2H-isotopomers of pentamethylmelamine and of a potential prodrug thereof. Journal of Labelled Compounds and Radiopharmaceuticals, 45, pp. 479-484.

Ferrer, S., Naughton, D. P., Parveen, I. and Threadgill, M. D., 2002. N- and O-Alkylation of isoquinolin-1-ones in the Mitsunobu reaction: development of potential drug delivery systems. Journal of the Chemical Society - Perkin Transcriptions 1

Wayman, N., McDonald, M. C., Thompson, A. S., Threadgill, M. D. and Thiemermann, C., 2001. 5-Aminoisoquinolinone, a potent inhibitor of poly(adenosine 5'-diphosphate ribose) polymerase, reduces myocardial infarct size. European Journal of Pharmacology, 430 (1), pp. 93-100.

Matthews, S. E., Pouton, C. W. and Threadgill, M. D., 2001. Formation of hybrid polymethylene-poly(oxyethylene) macrocycles. Tetrahedron Letters, 42, pp. 1355-1357.

McDonald, M. C., Mota-Filipe, H., Wright, J. A., Abdelrahman, M., Threadgill, M. D., Thompson, A. S. and Thiemermann, C., 2000. Effects of 5-aminoisoquinolinone, a water-soluble, potent inhibitor of the activity of poly (ADP-ribose) polymerase on the organ injury and dysfunction caused by haemorrhagic shock. British Journal of Pharmacology, 130 (4), pp. 843-850.

Conference or Workshop Items

Kwong, J. S. W., Lloyd, M. D. and Threadgill, M. D., 2006. Design and synthesis of a novel transition state mimic for poly(ADP-ribose) polymerase 1 (PARP-1) inhibition. In: Conférences Européenes du Groupement des Pharmacochimistes de L'Arc Atlantique (GP2A), 2006-09-07 - 2006-09-08, Bath.

Kwong, J. S. W., Lloyd, M. D. and Threadgill, M. D., 2006. Design, synthetic approaches and characterisation of a novel cyclic sulfoximine NAD+ (nicotinamide adenine dinucleotide) analogue. In: American Chemical Society (ACS) 232nd National Meeting, 2006-09-10 - 2006-09-14, San Francisco.

Lloyd, M. D., Boardman, K. D. E. and Threadgill, M. D., 2006. Expression and characterisation of human adehyde dehydrogenase 10: implications for Söjgren-Larsson syndrome. In: Conférences Européenes du Groupement des Pharmacochimistes de L'Arc Atlantique (GP2A), 2006-09-07 - 2006-09-08, Bath.

Lord, A. M., Lloyd, M. D. and Threadgill, M. D., 2006. Quinoline-8-carboxamides as novel PARP-1 inhibitors. In: Conférences Européenes du Groupement des Pharmacochimistes de L'Arc Atlantique (GP2A), 2006-09-07 - 2006-09-08, Bath.

This list was generated on Sun Aug 31 10:01:39 2014 IST.