Research

Items by Threadgill, Michael

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Number of items: 87.

Articles

Tang, Y., Li, M., Threadgill, M., Xiao, M., Mou, C.-F., Song, G.-L., Kuang, J., Yang, X., Yang, L., Gao, X.-J., Wang, Y.-P. and Meng, Y.-P., 2015. ART1 promotes starvation-induced autophagy: a possible protective role in the development of colon carcinoma. American Journal of Cancer Research, 5 (2), pp. 498-513.

Twum, E. A., Nathubhai, A., Wood, P. J., Lloyd, M. D., Thompson, A. S. and Threadgill, M. D., 2015. Initial development of a cytotoxic amino-seco-CBI warhead for delivery by prodrug systems. Bioorganic and Medicinal Chemistry, 23, pp. 3481-3489. Item availability may be restricted.

Parveen, I., Wilson, T., Threadgill, M.D., Luyten, J., Roberts, R.E., Robson, P.R.H., Donnison, I.S., Hauck, B. and Winters, A.L., 2014. Screening for potential co-products in a Miscanthus sinensis mapping family by liquid chromatography with mass spectrometry detection. Phytochemistry, 105, pp. 186-196. Item availability may be restricted.

Yevglevskis, M., Bowskill, C.R., Chan, C.C.Y., Heng, J.H.-J., Threadgill, M. D., Woodman, T.J. and Lloyd, M.D., 2014. A study on the chiral inversion of mandelic acid in humans. Organic and Biomolecular Chemistry, 12 (34), pp. 6737-6744.

Qu, X., Allan, A., Chui, G., Hutchings, T. J., Jiao, P., Johnson, L., Leung, W. Y., Li, P. K., Steel, G. R., Thompson, A. S., Threadgill, M. D., Woodman, T. J. and Lloyd, M. D., 2013. Hydrolysis of ibuprofenoyl-CoA and other 2-APA-CoA esters by human acyl-CoA thioesterases-1 and -2 and their possible role in the chiral inversion of profens. Biochemical Pharmacology, 86 (11), pp. 1621-1625.

Parveen, I., Wilson, T., Donnison, I., Cookson, A.R., Hauck, B. and Threadgill, M., 2013. Potential sources of high value chemicals from leaves, stems and flowers of Miscanthus sinensis 'Goliath' and Miscanthus sacchariflorus. Phytochemistry, 92, pp. 160-167.

Nathubhai, A., Patterson, R., Woodman, T. J., Sharp, H. E. C., Chui, M. T. Y., Chung, H. H. K., Lau, S. W. S., Zheng, J., Lloyd, M. D., Thompson, A. S. and Threadgill, M. D., 2011. N3-Alkylation during formation of quinazolin-4-ones from condensation of anthranilamides and orthoamides. Organic and Biomolecular Chemistry, 9 (17), pp. 6089-6099.

Holbourn, K. P., Lloyd, M. D., Thompson, A. S., Threadgill, M. D. and Acharya, K. R., 2011. Cloning, purification, crystallization and preliminary crystallographic analysis of the human histone deacetylase sirtuin 1. Acta Crystallographica Section F-Structural Biology and Crystallization Communications, 67 (4), pp. 461-463.

Sunderland, P. T., Woon, E. C. Y., Dhami, A., Bergin, A. B., Mahon, M. F., Wood, P. J., Jones, L. A., Tully, S. R., Lloyd, M. D., Thompson, A. S., Javaid, H., Martin, N. M. B. and Threadgill, M. D., 2011. 5-Benzamidoisoquinolin-1-ones and 5-(ω-Carboxyalkyl)isoquinolin-1-ones as Isoform-Selective Inhibitors of Poly(ADP-ribose) Polymerase 2 (PARP-2). Journal of Medicinal Chemistry, 54 (7), pp. 2049-2059.

Kee, C. H., Ariffin, A., Awang, K., Takeya, K., Morita, H., Hussain, S. I., Chan, K. M., Wood, P. J., Threadgill, M. D., Lim, C. G., Ng, S., Weber, J. F. F. and Thomas, N. F., 2010. Challenges associated with the synthesis of unusual o-carboxamido stilbenes by the Heck protocol: Intriguing substituent effects, their toxicological and chemopreventive implications. Organic and Biomolecular Chemistry, 8 (24), pp. 5646-5660.

Parveen, I., Threadgill, M. D., Moorby, J. M. and Winters, A., 2010. Oxidative phenols in forage crops containing polyphenol oxidase enzymes. Journal of Agricultural and Food Chemistry, 58 (3), pp. 1371-1382.

Cai, L., Threadgill, M. D., Wang, Y. L. and Li, M., 2009. Effect of poly (ADP-ribose) polymerase-1 inhibition on the proliferation of murine colon carcinoma CT26 cells. Pathology & Oncology Research, 15 (3), pp. 323-328.

Darley, D. J., Butler, D. S., Prideaux, S. J., Thornton, T. W., Wilson, A. D., Woodman, T. J., Threadgill, M. D. and Lloyd, M. D., 2009. Synthesis and use of isotope-labelled substrates for a mechanistic study on human α-methylacyl-CoA racemase 1A (AMACR; P504S). Organic and Biomolecular Chemistry, 7 (3), pp. 543-552.

Beauchard, A., Phillips, V. A., Lloyd, M. D. and Threadgill, M. D., 2009. Synthesis of 2-(4-carboxybutenyl)- and 2-(4-carboxybutynyl)-cyclopentene-1-carboxamides. Tetrahedron, 65 (39), pp. 8176-8184.

Hendryk, S., Czuba, Z. P., Jędrzejowska-Szypułka, H., Szliszka, E., Phillips, V. A., Threadgill, M. D. and Król, W., 2008. Influence of 5-aminoisoquinolin-1-one (5-AIQ) on neutrophil chemiluminescence in rats with transient and prolonged focal cerebral ischaemia and after reperfusion. Journal of Physiology and Pharmacology, 59 (4), pp. 811-822.

Lloyd, M. D., Darley, D. J., Wierzbicki, A. S. and Threadgill, M. D., 2008. α-Methylacyl-CoA racemase - an 'obscure' metabolic enzyme takes centre stage. FEBS Journal, 275, pp. 1089-1102.

Lloyd, M. D., Boardman, K. D. E., Smith, A., van den Brink, D. M., Wanders, R. J. A. and Threadgill, M. D., 2007. Characterisation of recombinant human fatty aldehyde dehydrogenase: implications for Sjögren-Larsson syndrome. Journal of Enzyme Inhibition and Medicinal Chemistry, 22 (5), pp. 584-590.

Suaifan, G. A. R. Y., Arafat, T. and Threadgill, M. D., 2007. Synthetic approaches to peptides containing the L-Gln-L-Val-D (S) -Dmt motif. Bioorganic and Medicinal Chemistry, 15, pp. 3474-3488.

Woon, E. C. Y., Dhami, A., Sunderland, P. T., Chalkley, D. A. and Threadgill, M. D., 2006. Reductive cyclisation of 2-cyanomethyl-3-nitrobenzoates. Letters in Organic Chemistry, 3, pp. 619-621.

Kwong, J. S. W., Lloyd, M. D. and Threadgill, M. D., 2006. Synthesis of cyclic sulfoximine mimics of 2-deoxyribosides as enzyme inhibitors in cancer. Journal of Pharmacy and Pharmacology, 58, A58-A58.

Genovese, T., Mazzon, E., Muià, C., Patel, N. S. A., Threadgill, M. D., Bramanti, P., De Sarro, A., Thiemermann, C. and Cuzzocrea, S., 2005. Inhibitors of poly(ADP-ribose) polymerase modulate signal transduction pathways and secondary damage in experimental spinal cord trauma. Journal of Pharmacology and Experimental Therapeutics, 312 (2), pp. 449-457.

Genovese, T., Mazzon, E., Di Paola, R., Muià, C., Patel, N. S. A., Threadgill, M. D., Caputi, A. P., Thiemermann, C. and Cuzzocrea, S., 2005. Inhibitors of poly(ADP-ribose) polymerase modulate signal transduction pathways and the development of bleomycin-induced lung injury. Journal of Pharmacology and Experimental Therapeutics, 313 (2), pp. 529-538.

Woon, E. C. Y. and Threadgill, M. D., 2005. Poly(ADP-ribose)polymerase inhibition - where now? Current Medicinal Chemistry, 12, pp. 2373-2392.

Cuzzocrea, S., Mazzon, E., Di Paola, R., Genovese, T., Patel, N. S. A., Muià, C., Threadgill, M. D., De Sarro, A. and Thiemermann, C., 2004. 5-Aminoisoquinolinone reduces colon injury by experimental colitis. Naunyn-Schmiedeberg's Archives of Pharmacology, 370, pp. 464-473.

Chatterjee, P. K., Chatterjee, B. E., Pederson, H., Sivarajah, A., McDonald, M. C., Mota-Filipe, H., Brown, P. A. J., Stewart, K. N., Cuzzocrea, S., Threadgill, M. D. and Thiemermann, C., 2004. 5-Aminoisoquinolinone reduces renal injury and dysfunction caused by experimental ischemia/reperfusion. Kidney International, 65 (2), pp. 499-509.

Di Paola, R., Genovese, T., Caputi, A. P., Threadgill, M. D., Thiemermann, C. and Cuzzocrea, S., 2004. Beneficial effects of 5-aminoisoquinolinone, a novel, potent, water-soluble, inhibitor of poly (ADP-ribose) polymerase, in a rat model of splanchnic artery occlusion and reperfusion. European Journal of Pharmacology, 492, pp. 203-210.

Goodyer, C. L. M., Chinje, E. C., Jaffar, M., Stratford, I. J. and Threadgill, M. D., 2003. Synthesis of N -Benzyl- and N -Phenyl-2-amino-4,5- dihydrothiazoles and thioureas and evaluation as modulators of the isoforms of nitric oxide synthase. Bioorganic and Medicinal Chemistry, 11 (19), pp. 4189-4206.

Goodyer, C. L. M., Chinje, E. C., Jaffar, M., Stratford, I. J. and Threadgill, M. D., 2003. Time-dependence and preliminary SAR studies in inhibition of nitric oxide synthase isoforms by homologues of thiocitrulline. Bioorganic & Medicinal Chemistry Letters, 13, pp. 3679-3680.

Wong, S. M., Shah, B., Shah, P., Butt, I. C., Woon, E. C. Y., Wright, J. A., Thompson, A. S., Upton, C. and Threadgill, M. D., 2002. A new synthesis of "push-pull" naphthalenes by condensation of nitro-2-methylbenzoate esters with dimethylacetamide dimethyl acetal. Tetrahedron Letters, 43 (12), pp. 2299-2302.

Perkins, S., Verschoyle, R. D., Hill, K., Parveen, I., Threadgill, M. D., Sharma, R. A., Williams, M. L., Steward, W. P. and Gescher, A. J., 2002. Chemopreventive efficacy and pharmacokinetics of curcumin in the min/+ mouse, a model of familial adenomatous polyposis. Cancer Epidemiology Biomarkers Prevention, 11, pp. 535-540.

Naughton, D. P., Ferrer, S. and Threadgill, M. D., 2002. Drug targeting using bioreductive delivery systems. Proceedings of the Indian National Science Academy (PINSA), B68 (4), pp. 371-378.

Cuzzocrea, S., McDonald, M. C., Mazzon, E., Dugo, L., Serraino, I., Threadgill, M. D., Caputi, A. P. and Thiemermann, C., 2002. Effects of 5-aminoisoquinolinone, a water-soluble, potent inhibitor of the activity of poly (ADP-ribose) polymerase, in a rodent model of lung injury. Biochemical Pharmacology, 63, pp. 293-304.

Ferrer, S., Naughton, D. P. and Threadgill, M. D., 2002. Labelled compounds of interest as antitumour agents - VIII. Synthesis of 2H-isotopomers of pentamethylmelamine and of a potential prodrug thereof. Journal of Labelled Compounds and Radiopharmaceuticals, 45, pp. 479-484.

Ferrer, S., Naughton, D. P., Parveen, I. and Threadgill, M. D., 2002. N- and O-Alkylation of isoquinolin-1-ones in the Mitsunobu reaction: development of potential drug delivery systems. Journal of the Chemical Society - Perkin Transcriptions 1

Wayman, N., McDonald, M. C., Thompson, A. S., Threadgill, M. D. and Thiemermann, C., 2001. 5-Aminoisoquinolinone, a potent inhibitor of poly(adenosine 5'-diphosphate ribose) polymerase, reduces myocardial infarct size. European Journal of Pharmacology, 430 (1), pp. 93-100.

Matthews, S. E., Pouton, C. W. and Threadgill, M. D., 2001. Formation of hybrid polymethylene-poly(oxyethylene) macrocycles. Tetrahedron Letters, 42, pp. 1355-1357.

McDonald, M. C., Mota-Filipe, H., Wright, J. A., Abdelrahman, M., Threadgill, M. D., Thompson, A. S. and Thiemermann, C., 2000. Effects of 5-aminoisoquinolinone, a water-soluble, potent inhibitor of the activity of poly (ADP-ribose) polymerase on the organ injury and dysfunction caused by haemorrhagic shock. British Journal of Pharmacology, 130 (4), pp. 843-850.

Conference or Workshop Items

Sattar, F. A., Darley, D. J., Politano, F., Woodman, T. J., Threadgill, M. D. and Lloyd, M. D., 2012. Acyl-CoA ∝-proton exchange by ∝-methylacyl-CoA racemase. In: Biochemical Society Conference,2012, 2012-01-01, Cambridge.

Woodman, T. J., Wood, P. J., Thompson, A. S., Hutchings, T. J., Jiao, P., Steel, G. R., Threadgill, M. D. and Lloyd, M. D., 2012. Chiral inversion of NSAID-CoA esters by human ∝-methylacyl-CoA racemase. In: Biochemical Society Conference,2012, 2012-01-01, Cambridge.

Qu, X., Leung, A., Allan, A. C., Chui, G., Hutchings, T. J., Jiao, P., Johnson, L., Leung, W. Y., Li, P. K., Steel, G. R., Thompson, A. S., Threadgill, M. D., Woodman, T. J. and Lloyd, M. D., 2012. Hydrolysis of ibuprofenoyl-CoA and other 2-APA-CoA esters by human Acyl-CoA thioesterases 1 and 2. In: Biochemical Society Conference,2012, 2012-01-01, Cambridge.

Woodman, T.J., Wood, P. J., Thompson, A. S., Hutchings, T. J., Jiao, P., Steel, G. R., Threadgill, M. D. and Lloyd, M. D., 2011. Chiral inversion of NSAID-CoA esters by human ∝-methylacyl-CoA racemase. In: Cancer Research @ Bath Conference, 2011, 2011-05-01, Bath.

Darley, D. J., Butler, D. S., Threadgill, M. D. and Lloyd, M. D., 2008. Characterisation of recombinant alpha-methylacyl-CoA racemase, a novel prostate cancer target. In: RSC Bioorganic Group Annual Post-Graduate Symposium P7, 2008, 2008-03-01.

Darley, D. J., Prideaux, S. J., Thornton, T. W., Wilson, A. D., Threadgill, M. D., Woodman, T. J. and Lloyd, M. D., 2008. Synthesis of 2-[2H]-2-[13C]-S-2-methyldecanoyl-CoA and 13C NMR study of its reaction with ∝-methylacyl-CoA racemase (AMACR. In: RSC Bioorganic Group Annual Post-Graduate Symposium P8, 2008, 2008-03-01.

Beauchard, A., Phillips, V. A., Lloyd, M. D. and Threadgill, M. D., 2008. Synthesis of a mimic of phosphorserylproline as a potential inhibitor of Pin1. In: RSC Bioorganic Group Annual Post-Graduate Symposium P13, 2008, 2008-03-01.

Darley, D. J., Butler, D. S., Threadgill, M. D. and Lloyd, M. D., 2007. Characterisation of recombinant alpha-methylacyl-CoA racemase, a novel prostate cancer target. In: Northern England (and Bristol) Collaborative (PROMPT) and South of England Prostate Collaborative Joint Meeting, 2007, 2007-11-01, Cambridge.

Darley, D. J., Butler, D. S., Threadgill, M. D. and Lloyd, M. D., 2007. Characterisation of recombinant alpha-methylacyl-CoA racemase, a novel prostate cancer target. In: 3rd National Cancer Research Institute (NCRI) Cancer Conference, 2007, 2007-10-01, Birmingham.

Darley, D. J., Butler, D. S., Threadgill, M. D. and Lloyd, M. D., 2007. Characterisation of recombinant alpha-methylacyl-CoA racemase, a novel prostate cancer target. In: Life Sciences Conference,2007, 2007-07-01, Glasgow.

Lloyd, M. D., Boardman, K. D. E., Smith, A., van den Brink, D. M., Wanders, R. J. A. and Threadgill, M. D., 2007. Characterisation of recombinant human fatty aldehyde dehydrogenase: implications for Sjögren-Larsson syndrome. In: Life Sciences Conference,2007, 2007-07-01, Glasgow.

Lloyd, M. D., Boardman, K. D. E. and Threadgill, M. D., 2006. Expression and characterisation of human aldehyde dehydrogenase 10 : implications for Sjögren-Larsson syndrome. In: Conférences Européenes du Groupement Des Pharmacochimistes de L'Arc Atlantique (GP2A), 2006, 2006-09-01, Bath.

Kwong, J. S. W., Lloyd, M. D. and Threadgill, M. D., 2006. Design and synthesis of a novel transition state mimic for poly(ADP-ribose) polymerase 1 (PARP-1) inhibition. In: Conférences Européenes du Groupement des Pharmacochimistes de L'Arc Atlantique (GP2A), 2006-09-07 - 2006-09-08, Bath.

Kwong, J. S. W., Lloyd, M. D. and Threadgill, M. D., 2006. Design, synthetic approaches and characterisation of a novel cyclic sulfoximine NAD+ (nicotinamide adenine dinucleotide) analogue. In: American Chemical Society (ACS) 232nd National Meeting, 2006-09-10 - 2006-09-14, San Francisco.

Lloyd, M. D., Boardman, K. D. E. and Threadgill, M. D., 2006. Expression and characterisation of human adehyde dehydrogenase 10: implications for Söjgren-Larsson syndrome. In: Conférences Européenes du Groupement des Pharmacochimistes de L'Arc Atlantique (GP2A), 2006-09-07 - 2006-09-08, Bath.

Lord, A. M., Lloyd, M. D. and Threadgill, M. D., 2006. Quinoline-8-carboxamides as novel PARP-1 inhibitors. In: Conférences Européenes du Groupement des Pharmacochimistes de L'Arc Atlantique (GP2A), 2006-09-07 - 2006-09-08, Bath.

This list was generated on Thu Jul 30 22:05:24 2015 IST.