Research

Items by Threadgill, Michael

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Number of items: 64.

Articles

Yevglevskis, M., Bowskill, C.R., Chan, C.C.Y., Heng, J.H.-J., Threadgill, M. D., Woodman, T.J. and Lloyd, M.D., 2014. A study on the chiral inversion of mandelic acid in humans. Organic and Biomolecular Chemistry, 12 (34), pp. 6737-6744.

Nathubhai, A., Wood, P. J., Lloyd, M. D., Thompson, A. S. and Threadgill, M. D., 2013. Design and discovery of 2‑arylquinazolin-4-ones as potent and selective inhibitors of tankyrases. ACS Medicinal Chemistry Letters, 4 (12), pp. 1173-1177.

Qu, X., Allan, A., Chui, G., Hutchings, T. J., Jiao, P., Johnson, L., Leung, W. Y., Li, P. K., Steel, G. R., Thompson, A. S., Threadgill, M. D., Woodman, T. J. and Lloyd, M. D., 2013. Hydrolysis of ibuprofenoyl-CoA and other 2-APA-CoA esters by human acyl-CoA thioesterases-1 and -2 and their possible role in the chiral inversion of profens. Biochemical Pharmacology, 86 (11), pp. 1621-1625.

Woon, E. C. Y., Sunderland, P. T., Paine, H. A., Lloyd, M. D., Thompson, A. S. and Threadgill, M. D., 2013. One-pot tandem Hurtley–retro-Claisen–cyclisation reactions in the synthesis of 3-substituted analogues of 5-aminoisoquinolin-1-one (5-AIQ), a water-soluble inhibitor of PARPs. Bioorganic and Medicinal Chemistry, 21 (17), pp. 5218-5227.

Yan, J., Li, M., Threadgill, M.D., Wang, Y. and Fu, W., 2013. Decreasing P-selectin and ICAM-1 via activating Akt : a possible mechanism by which PARG inhibits adhesion of mouse colorectal carcinoma CT26 cells to platelets. Cancer Gene Therapy, 20 (9), pp. 487-492.

Lloyd, M. D., Jevglevskis, M., Lee, G. L., Wood, P. J., Threadgill, M. D. and Woodman, T. J., 2013. α-Methylacyl-CoA racemase (AMACR): Metabolic enzyme, drug metabolizer and cancer marker P504S. Progress in Lipid Research, 52 (2), pp. 220-230.

Twum, E. A., Woodman, T. J., Wang, W. and Threadgill, M. D., 2013. Observation by NMR of cationic Wheland-like intermediates in the deiodination of protected 1-iodo-naphthalene-2,4-diamines in acidic media. Organic and Biomolecular Chemistry, 11 (36), pp. 6208-6214.

Parveen, I., Wilson, T., Donnison, I., Cookson, A.R., Hauck, B. and Threadgill, M., 2013. Potential sources of high value chemicals from leaves, stems and flowers of Miscanthus sinensis 'Goliath' and Miscanthus sacchariflorus. Phytochemistry, 92, pp. 160-167.

Parveen, I., Threadgill, M. D., Hauck, B., Donnison, I. and Winters, A., 2011. Isolation, identification and quantitation of hydroxycinnamic acid conjugates, potential platform chemicals, in the leaves and stems of Miscanthus x giganteus using LC-ESI-MS(n). Phytochemistry, 72 (18), pp. 2376-2384.

Beauchard, A., Twum, E. A., Lloyd, M. D. and Threadgill, M. D., 2011. S-2-Amino-4-cyanobutanoic acid (β-cyanomethyl-L-Ala) as an atom-efficient solubilising synthon for L-glutamine. Tetrahedron Letters, 52 (41), pp. 5311-5314.

Nathubhai, A., Patterson, R., Woodman, T. J., Sharp, H. E. C., Chui, M. T. Y., Chung, H. H. K., Lau, S. W. S., Zheng, J., Lloyd, M. D., Thompson, A. S. and Threadgill, M. D., 2011. N3-Alkylation during formation of quinazolin-4-ones from condensation of anthranilamides and orthoamides. Organic and Biomolecular Chemistry, 9 (17), pp. 6089-6099.

Woodman, T. J., Wood, P. J., Thompson, A. S., Hutchings, T. J., Steel, G. R., Jiao, P., Threadgill, M. D. and Lloyd, M. D., 2011. Chiral inversion of 2-arylpropionyl-CoA esters by human α-methylacyl-CoA racemase 1A (P504S)-a potential mechanism for the anti-cancer effects of ibuprofen. Chemical Communications, 47 (26), pp. 7332-7334.

Holbourn, K. P., Lloyd, M. D., Thompson, A. S., Threadgill, M. D. and Acharya, K. R., 2011. Cloning, purification, crystallization and preliminary crystallographic analysis of the human histone deacetylase sirtuin 1. Acta Crystallographica Section F-Structural Biology and Crystallization Communications, 67 (4), pp. 461-463.

Sunderland, P. T., Dhami, A., Mahon, M. F., Jones, L. A., Tully, S. R., Lloyd, M. D., Thompson, A. S., Javaid, H., Martin, N. M. B. and Threadgill, M. D., 2011. Synthesis of 4-alkyl-, 4-aryl- and 4-arylamino-5-aminoisoquinolin-1-ones and identification of a new PARP-2 selective inhibitor. Organic and Biomolecular Chemistry, 9 (3), pp. 881-891.

Sunderland, P. T., Woon, E. C. Y., Dhami, A., Bergin, A. B., Mahon, M. F., Wood, P. J., Jones, L. A., Tully, S. R., Lloyd, M. D., Thompson, A. S., Javaid, H., Martin, N. M. B. and Threadgill, M. D., 2011. 5-Benzamidoisoquinolin-1-ones and 5-(ω-Carboxyalkyl)isoquinolin-1-ones as Isoform-Selective Inhibitors of Poly(ADP-ribose) Polymerase 2 (PARP-2). Journal of Medicinal Chemistry, 54 (7), pp. 2049-2059.

Suaifan, G., Goodyer, C. L. M. and Threadgill, M. D., 2010. Synthesis of N-(Methoxycarbonylthienylmethyl)thioureas and evaluation of their interaction with inducible and neuronal Nitric Oxide Synthase. Molecules, 15 (5), pp. 3121-3134.

Kee, C. H., Ariffin, A., Awang, K., Takeya, K., Morita, H., Hussain, S. I., Chan, K. M., Wood, P. J., Threadgill, M. D., Lim, C. G., Ng, S., Weber, J. F. F. and Thomas, N. F., 2010. Challenges associated with the synthesis of unusual o-carboxamido stilbenes by the Heck protocol: Intriguing substituent effects, their toxicological and chemopreventive implications. Organic and Biomolecular Chemistry, 8 (24), pp. 5646-5660.

Parveen, I., Threadgill, M. D., Moorby, J. M. and Winters, A., 2010. Oxidative phenols in forage crops containing polyphenol oxidase enzymes. Journal of Agricultural and Food Chemistry, 58 (3), pp. 1371-1382.

Cai, L., Threadgill, M. D., Wang, Y. L. and Li, M., 2009. Effect of poly (ADP-ribose) polymerase-1 inhibition on the proliferation of murine colon carcinoma CT26 cells. Pathology & Oncology Research, 15 (3), pp. 323-328.

Dhami, A., Mahon, M. F., Lloyd, M. D. and Threadgill, M. D., 2009. 4-Substituted 5-nitroisoquinolin-1-ones from intramolecular Pd-catalysed reaction of N-(2-alkenyl)-2-halo-3-nitrobenzamides. Tetrahedron, 65 (24), pp. 4751-4765.

Lord, A.-M., Mahon, M. F., Lloyd, M. D. and Threadgill, M. D., 2009. Design, synthesis, and evaluation in vitro of quinoline-8-carboxamides, a new class of poly(adenosine-diphosphate-ribose)polymerase-1 (PARP-1) inhibitor. Journal of Medicinal Chemistry, 52 (3), pp. 868-877.

Darley, D. J., Butler, D. S., Prideaux, S. J., Thornton, T. W., Wilson, A. D., Woodman, T. J., Threadgill, M. D. and Lloyd, M. D., 2009. Synthesis and use of isotope-labelled substrates for a mechanistic study on human α-methylacyl-CoA racemase 1A (AMACR; P504S). Organic and Biomolecular Chemistry, 7 (3), pp. 543-552.

Li, M., Threadgill, M. D., Wang, Y. L., Cai, L. and Lin, X., 2009. Poly(ADP-Ribose) Polymerase Inhibition Down-Regulates Expression of Metastasis-Related Genes in CT26 Colon Carcinoma Cells. Pathobiology, 76 (3), pp. 108-116.

Beauchard, A., Phillips, V. A., Lloyd, M. D. and Threadgill, M. D., 2009. Synthesis of 2-(4-carboxybutenyl)- and 2-(4-carboxybutynyl)-cyclopentene-1-carboxamides. Tetrahedron, 65 (39), pp. 8176-8184.

Hendryk, S., Czuba, Z. P., Jędrzejowska-Szypułka, H., Szliszka, E., Phillips, V. A., Threadgill, M. D. and Król, W., 2008. Influence of 5-aminoisoquinolin-1-one (5-AIQ) on neutrophil chemiluminescence in rats with transient and prolonged focal cerebral ischaemia and after reperfusion. Journal of Physiology and Pharmacology, 59 (4), pp. 811-822.

Parveen, I., Winters, A., Threadgill, M. D., Hauck, B. and Morris, P., 2008. Extraction, structural characterisation and evaluation of hydroxycinnamate esters of orchard grass (Dactylis glomerata) as substrates for polyphenol oxidase. Phytochemistry, 69 (16), pp. 2799-2806.

Lloyd, M. D., Darley, D. J., Wierzbicki, A. S. and Threadgill, M. D., 2008. α-Methylacyl-CoA racemase - an 'obscure' metabolic enzyme takes centre stage. FEBS Journal, 275, pp. 1089-1102.

Kwong, J. S. W., Mahon, M. F., Lloyd, M. D. and Threadgill, M. D., 2007. Synthesis and conformational and configurational studies of diastereoisomeric O-protected 4-(arylsulfonimidoyl)butane-1,2,3-triols. Tetrahedron, 63 (51), pp. 12601-12607.

El-Hamamsy, M. H. R. I., Smith, A. W., Thompson, A. S. and Threadgill, M. D., 2007. Structure-based design, synthesis and preliminary evaluation of selective inhibitors of dihydrofolate reductase from Mycobacterium tuberculosis. Bioorganic and Medicinal Chemistry, 15 (13), pp. 4552-4576.

Lloyd, M. D., Boardman, K. D. E., Smith, A., van den Brink, D. M., Wanders, R. J. A. and Threadgill, M. D., 2007. Characterisation of recombinant human fatty aldehyde dehydrogenase: implications for Sjögren-Larsson syndrome. Journal of Enzyme Inhibition and Medicinal Chemistry, 22 (5), pp. 584-590.

Powell, C. L., Schulze, M., Black, S. J., Thompson, A. S. and Threadgill, M. D., 2007. Closo --> nido cage degradation of 1-(substituted-phenyl)-1,2-dicarbadodecaborane(12)s in wet DMSO under neutral conditions. Tetrahedron Letters, 48, pp. 1251-1254.

Sunderland, P. T., Thompson, A. S. and Threadgill, M. D., 2007. Formation of 3-aryl-5-nitroisocoumarins from 5-nitroisocoumarins and aromatic acyl chlorides under Friedel-Crafts conditions. Journal of Organic Chemistry, 72, pp. 7409-7412.

Suaifan, G. A. R. Y., Arafat, T. and Threadgill, M. D., 2007. Synthetic approaches to peptides containing the L-Gln-L-Val-D (S) -Dmt motif. Bioorganic and Medicinal Chemistry, 15, pp. 3474-3488.

Woon, E. C. Y., Dhami, A., Mahon, M. F. and Threadgill, M. D., 2006. 5-Nitroisocoumarins from tandem Castro–Stephens coupling—6-endo-dig cyclisation of 2-iodo-3-nitrobenzoic acid and arylethynes and ring-closure of methyl 2-alkynyl-3-nitrobenzoates with electrophiles. Tetrahedron, 62 (20), pp. 4829-4837.

Suaifan, G. A. R. Y., Mahon, M. F., Arafat, T. and Threadgill, M. D., 2006. Effects of steric bulk and stereochemistry on the rates of diketopiperazine formation from N -aminoacyl-2,2-dimethylthiazolidine-4-carboxamides (Dmt dipeptide amides) - a model for a new prodrug linker system. Tetrahedron, 62 (48), pp. 11245-11266.

Woon, E. C. Y., Dhami, A., Sunderland, P. T., Chalkley, D. A. and Threadgill, M. D., 2006. Reductive cyclisation of 2-cyanomethyl-3-nitrobenzoates. Letters in Organic Chemistry, 3, pp. 619-621.

Kwong, J. S. W., Lloyd, M. D. and Threadgill, M. D., 2006. Synthesis of cyclic sulfoximine mimics of 2-deoxyribosides as enzyme inhibitors in cancer. Journal of Pharmacy and Pharmacology, 58, A58-A58.

Genovese, T., Mazzon, E., Muià, C., Patel, N. S. A., Threadgill, M. D., Bramanti, P., De Sarro, A., Thiemermann, C. and Cuzzocrea, S., 2005. Inhibitors of poly(ADP-ribose) polymerase modulate signal transduction pathways and secondary damage in experimental spinal cord trauma. Journal of Pharmacology and Experimental Therapeutics, 312 (2), pp. 449-457.

Genovese, T., Mazzon, E., Di Paola, R., Muià, C., Patel, N. S. A., Threadgill, M. D., Caputi, A. P., Thiemermann, C. and Cuzzocrea, S., 2005. Inhibitors of poly(ADP-ribose) polymerase modulate signal transduction pathways and the development of bleomycin-induced lung injury. Journal of Pharmacology and Experimental Therapeutics, 313 (2), pp. 529-538.

Woon, E. C. Y. and Threadgill, M. D., 2005. Poly(ADP-ribose)polymerase inhibition - where now? Current Medicinal Chemistry, 12, pp. 2373-2392.

Cuzzocrea, S., Mazzon, E., Di Paola, R., Genovese, T., Patel, N. S. A., Muià, C., Threadgill, M. D., De Sarro, A. and Thiemermann, C., 2004. 5-Aminoisoquinolinone reduces colon injury by experimental colitis. Naunyn-Schmiedeberg's Archives of Pharmacology, 370, pp. 464-473.

Chatterjee, P. K., Chatterjee, B. E., Pederson, H., Sivarajah, A., McDonald, M. C., Mota-Filipe, H., Brown, P. A. J., Stewart, K. N., Cuzzocrea, S., Threadgill, M. D. and Thiemermann, C., 2004. 5-Aminoisoquinolinone reduces renal injury and dysfunction caused by experimental ischemia/reperfusion. Kidney International, 65 (2), pp. 499-509.

Di Paola, R., Genovese, T., Caputi, A. P., Threadgill, M. D., Thiemermann, C. and Cuzzocrea, S., 2004. Beneficial effects of 5-aminoisoquinolinone, a novel, potent, water-soluble, inhibitor of poly (ADP-ribose) polymerase, in a rat model of splanchnic artery occlusion and reperfusion. European Journal of Pharmacology, 492, pp. 203-210.

Ferrer, S., Naughton, D. P. and Threadgill, M. D., 2003. 1H NMR studies on the reductively triggered release of heterocyclic and steroid drugs from 4,7-dioxoindole-3-methyl prodrugs. Tetrahedron, 59 (19), pp. 3445-3454.

Ferrer, S., Naughton, D. P. and Threadgill, M. D., 2003. Studies on the reductively triggered release of heterocyclic and steroid drugs from 5-nitrothien-2-ylmethyl prodrugs. Tetrahedron, 59, pp. 3437-3444.

Goodyer, C. L. M., Chinje, E. C., Jaffar, M., Stratford, I. J. and Threadgill, M. D., 2003. Synthesis of N -Benzyl- and N -Phenyl-2-amino-4,5- dihydrothiazoles and thioureas and evaluation as modulators of the isoforms of nitric oxide synthase. Bioorganic and Medicinal Chemistry, 11 (19), pp. 4189-4206.

Frixa, C., Mahon, M. F., Thompson, A. S. and Threadgill, M. D., 2003. Synthesis of meso -substituted porphyrins carrying carboranes and oligo(ethylene glycol) units for potential applications in boron neutron capture therapy. Organic and Biomolecular Chemistry, 1 (2), pp. 306-317.

Goodyer, C. L. M., Chinje, E. C., Jaffar, M., Stratford, I. J. and Threadgill, M. D., 2003. Time-dependence and preliminary SAR studies in inhibition of nitric oxide synthase isoforms by homologues of thiocitrulline. Bioorganic & Medicinal Chemistry Letters, 13, pp. 3679-3680.

Wong, S. M., Shah, B., Shah, P., Butt, I. C., Woon, E. C. Y., Wright, J. A., Thompson, A. S., Upton, C. and Threadgill, M. D., 2002. A new synthesis of "push-pull" naphthalenes by condensation of nitro-2-methylbenzoate esters with dimethylacetamide dimethyl acetal. Tetrahedron Letters, 43 (12), pp. 2299-2302.

Madani, H., Thompson, A. S. and Threadgill, M. D., 2002. An expedient synthesis of 7-0-functionalised pyrrolo[2,1-c][1,4]benzodiazepine-5,11-diones. Tetrahedron, 58 (40), pp. 8107-8111.

Perkins, S., Verschoyle, R. D., Hill, K., Parveen, I., Threadgill, M. D., Sharma, R. A., Williams, M. L., Steward, W. P. and Gescher, A. J., 2002. Chemopreventive efficacy and pharmacokinetics of curcumin in the min/+ mouse, a model of familial adenomatous polyposis. Cancer Epidemiology Biomarkers Prevention, 11, pp. 535-540.

Frixa, C., Mahon, M. F., Thompson, A. S. and Threadgill, M. D., 2002. Direct Cu(I)-catalysed coupling of a carborane to a meso-tetraphenylporphyrin. Tetrahedron Letters, 43 (8), pp. 1557-1559.

Naughton, D. P., Ferrer, S. and Threadgill, M. D., 2002. Drug targeting using bioreductive delivery systems. Proceedings of the Indian National Science Academy (PINSA), B68 (4), pp. 371-378.

Cuzzocrea, S., McDonald, M. C., Mazzon, E., Dugo, L., Serraino, I., Threadgill, M. D., Caputi, A. P. and Thiemermann, C., 2002. Effects of 5-aminoisoquinolinone, a water-soluble, potent inhibitor of the activity of poly (ADP-ribose) polymerase, in a rodent model of lung injury. Biochemical Pharmacology, 63, pp. 293-304.

Frixa, C., Scobie, M., Black, S. J., Thompson, A. S. and Threadgill, M. D., 2002. Formation of a remarkably robust 2:1 complex between β-cyclodextrin and a phenyl-substituted icosahedral carborane. Chemical Communications, 27, pp. 2876-2877.

Ferrer, S., Naughton, D. P. and Threadgill, M. D., 2002. Labelled compounds of interest as antitumour agents - VIII. Synthesis of 2H-isotopomers of pentamethylmelamine and of a potential prodrug thereof. Journal of Labelled Compounds and Radiopharmaceuticals, 45, pp. 479-484.

Ferrer, S., Naughton, D. P., Parveen, I. and Threadgill, M. D., 2002. N- and O-Alkylation of isoquinolin-1-ones in the Mitsunobu reaction: development of potential drug delivery systems. Journal of the Chemical Society - Perkin Transcriptions 1

Wayman, N., McDonald, M. C., Thompson, A. S., Threadgill, M. D. and Thiemermann, C., 2001. 5-Aminoisoquinolinone, a potent inhibitor of poly(adenosine 5'-diphosphate ribose) polymerase, reduces myocardial infarct size. European Journal of Pharmacology, 430 (1), pp. 93-100.

Matthews, S. E., Pouton, C. W. and Threadgill, M. D., 2001. Formation of hybrid polymethylene-poly(oxyethylene) macrocycles. Tetrahedron Letters, 42, pp. 1355-1357.

McDonald, M. C., Mota-Filipe, H., Wright, J. A., Abdelrahman, M., Threadgill, M. D., Thompson, A. S. and Thiemermann, C., 2000. Effects of 5-aminoisoquinolinone, a water-soluble, potent inhibitor of the activity of poly (ADP-ribose) polymerase on the organ injury and dysfunction caused by haemorrhagic shock. British Journal of Pharmacology, 130 (4), pp. 843-850.

Conference or Workshop Items

Kwong, J. S. W., Lloyd, M. D. and Threadgill, M. D., 2006. Design and synthesis of a novel transition state mimic for poly(ADP-ribose) polymerase 1 (PARP-1) inhibition. In: Conférences Européenes du Groupement des Pharmacochimistes de L'Arc Atlantique (GP2A), 2006-09-07 - 2006-09-08, Bath.

Kwong, J. S. W., Lloyd, M. D. and Threadgill, M. D., 2006. Design, synthetic approaches and characterisation of a novel cyclic sulfoximine NAD+ (nicotinamide adenine dinucleotide) analogue. In: American Chemical Society (ACS) 232nd National Meeting, 2006-09-10 - 2006-09-14, San Francisco.

Lloyd, M. D., Boardman, K. D. E. and Threadgill, M. D., 2006. Expression and characterisation of human adehyde dehydrogenase 10: implications for Söjgren-Larsson syndrome. In: Conférences Européenes du Groupement des Pharmacochimistes de L'Arc Atlantique (GP2A), 2006-09-07 - 2006-09-08, Bath.

Lord, A. M., Lloyd, M. D. and Threadgill, M. D., 2006. Quinoline-8-carboxamides as novel PARP-1 inhibitors. In: Conférences Européenes du Groupement des Pharmacochimistes de L'Arc Atlantique (GP2A), 2006-09-07 - 2006-09-08, Bath.

This list was generated on Fri Sep 19 21:15:11 2014 IST.